Full text data of GIPC2
GIPC2
[Confidence: low (only semi-automatic identification from reviews)]
PDZ domain-containing protein GIPC2
Note: presumably soluble (membrane word is not in UniProt keywords or features)
PDZ domain-containing protein GIPC2
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q8TF65
ID GIPC2_HUMAN Reviewed; 315 AA.
AC Q8TF65; Q8IYD3; Q9NXS7;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-2002, sequence version 1.
DT 22-JAN-2014, entry version 79.
DE RecName: Full=PDZ domain-containing protein GIPC2;
GN Name=GIPC2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=11836570;
RA Kirikoshi H., Katoh M.;
RT "Molecular cloning and characterization of human GIPC2, a novel gene
RT homologous to human GIPC1 and Xenopus Kermit.";
RL Int. J. Oncol. 20:571-576(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-206.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 85-315.
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 112-200.
RG Structural genomics consortium (SGC);
RT "Crystal structure of the PDZ domain of PDZ domain-containing protein
RT GIPC2.";
RL Submitted (MAR-2009) to the PDB data bank.
CC -!- SUBUNIT: Probably interacts with SEMA5A (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC -!- TISSUE SPECIFICITY: Expressed at highest levels in ascending colon
CC and at moderate levels in adult kidney. Expressed at low levels in
CC adult pancreas and at very low levels in adult liver. Expression
CC is down-regulated in several primary tumors, such as kidney, colon
CC and rectal tumors.
CC -!- SIMILARITY: Belongs to the GIPC family.
CC -!- SIMILARITY: Contains 1 PDZ (DHR) domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA90933.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AB073737; BAB84711.1; -; mRNA.
DR EMBL; BC036075; AAH36075.1; -; mRNA.
DR EMBL; AK000082; BAA90933.1; ALT_INIT; mRNA.
DR RefSeq; NP_060125.4; NM_017655.4.
DR RefSeq; XP_005271015.1; XM_005270958.1.
DR UniGene; Hs.659356; -.
DR PDB; 3GGE; X-ray; 2.60 A; A/B/C=112-200.
DR PDBsum; 3GGE; -.
DR ProteinModelPortal; Q8TF65; -.
DR SMR; Q8TF65; 113-203.
DR IntAct; Q8TF65; 12.
DR MINT; MINT-1368358; -.
DR PhosphoSite; Q8TF65; -.
DR DMDM; 74716120; -.
DR PaxDb; Q8TF65; -.
DR PRIDE; Q8TF65; -.
DR DNASU; 54810; -.
DR Ensembl; ENST00000370759; ENSP00000359795; ENSG00000137960.
DR GeneID; 54810; -.
DR KEGG; hsa:54810; -.
DR UCSC; uc001dik.3; human.
DR CTD; 54810; -.
DR GeneCards; GC01P078445; -.
DR HGNC; HGNC:18177; GIPC2.
DR HPA; HPA051212; -.
DR neXtProt; NX_Q8TF65; -.
DR PharmGKB; PA142671735; -.
DR eggNOG; NOG313930; -.
DR HOGENOM; HOG000293347; -.
DR HOVERGEN; HBG000898; -.
DR InParanoid; Q8TF65; -.
DR OMA; WRHYDVA; -.
DR OrthoDB; EOG793B86; -.
DR PhylomeDB; Q8TF65; -.
DR EvolutionaryTrace; Q8TF65; -.
DR GeneWiki; GIPC2; -.
DR GenomeRNAi; 54810; -.
DR NextBio; 57529; -.
DR PRO; PR:Q8TF65; -.
DR Bgee; Q8TF65; -.
DR CleanEx; HS_GIPC2; -.
DR Genevestigator; Q8TF65; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR017379; UCP038083_PDZ.
DR Pfam; PF00595; PDZ; 1.
DR PIRSF; PIRSF038083; UCP038083_GIPC; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Complete proteome; Cytoplasm; Polymorphism;
KW Reference proteome.
FT CHAIN 1 315 PDZ domain-containing protein GIPC2.
FT /FTId=PRO_0000247188.
FT DOMAIN 117 197 PDZ.
FT VARIANT 61 61 S -> F (in dbSNP:rs17101180).
FT /FTId=VAR_027084.
FT VARIANT 206 206 L -> P (in dbSNP:rs540742).
FT /FTId=VAR_027085.
FT STRAND 113 121
FT STRAND 129 132
FT STRAND 134 137
FT STRAND 140 144
FT HELIX 149 152
FT STRAND 161 165
FT HELIX 175 184
FT STRAND 190 198
SQ SEQUENCE 315 AA; 34354 MW; 244894C6100C679F CRC64;
MPLKLRGKKK AKSKETAGLV EGEPTGAGGG SLSASRAPAR RLVFHAQLAH GSATGRVEGF
SSIQELYAQI AGAFEISPSE ILYCTLNTPK IDMERLLGGQ LGLEDFIFAH VKGIEKEVNV
YKSEDSLGLT ITDNGVGYAF IKRIKDGGVI DSVKTICVGD HIESINGENI VGWRHYDVAK
KLKELKKEEL FTMKLIEPKK AFEIELRSKA GKSSGEKIGC GRATLRLRSK GPATVEEMPS
ETKAKAIEKI DDVLELYMGI RDIDLATTMF EAGKDKVNPD EFAVALDETL GDFAFPDEFV
FDVWGVIGDA KRRGL
//
ID GIPC2_HUMAN Reviewed; 315 AA.
AC Q8TF65; Q8IYD3; Q9NXS7;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-2002, sequence version 1.
DT 22-JAN-2014, entry version 79.
DE RecName: Full=PDZ domain-containing protein GIPC2;
GN Name=GIPC2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=11836570;
RA Kirikoshi H., Katoh M.;
RT "Molecular cloning and characterization of human GIPC2, a novel gene
RT homologous to human GIPC1 and Xenopus Kermit.";
RL Int. J. Oncol. 20:571-576(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-206.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 85-315.
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 112-200.
RG Structural genomics consortium (SGC);
RT "Crystal structure of the PDZ domain of PDZ domain-containing protein
RT GIPC2.";
RL Submitted (MAR-2009) to the PDB data bank.
CC -!- SUBUNIT: Probably interacts with SEMA5A (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC -!- TISSUE SPECIFICITY: Expressed at highest levels in ascending colon
CC and at moderate levels in adult kidney. Expressed at low levels in
CC adult pancreas and at very low levels in adult liver. Expression
CC is down-regulated in several primary tumors, such as kidney, colon
CC and rectal tumors.
CC -!- SIMILARITY: Belongs to the GIPC family.
CC -!- SIMILARITY: Contains 1 PDZ (DHR) domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA90933.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AB073737; BAB84711.1; -; mRNA.
DR EMBL; BC036075; AAH36075.1; -; mRNA.
DR EMBL; AK000082; BAA90933.1; ALT_INIT; mRNA.
DR RefSeq; NP_060125.4; NM_017655.4.
DR RefSeq; XP_005271015.1; XM_005270958.1.
DR UniGene; Hs.659356; -.
DR PDB; 3GGE; X-ray; 2.60 A; A/B/C=112-200.
DR PDBsum; 3GGE; -.
DR ProteinModelPortal; Q8TF65; -.
DR SMR; Q8TF65; 113-203.
DR IntAct; Q8TF65; 12.
DR MINT; MINT-1368358; -.
DR PhosphoSite; Q8TF65; -.
DR DMDM; 74716120; -.
DR PaxDb; Q8TF65; -.
DR PRIDE; Q8TF65; -.
DR DNASU; 54810; -.
DR Ensembl; ENST00000370759; ENSP00000359795; ENSG00000137960.
DR GeneID; 54810; -.
DR KEGG; hsa:54810; -.
DR UCSC; uc001dik.3; human.
DR CTD; 54810; -.
DR GeneCards; GC01P078445; -.
DR HGNC; HGNC:18177; GIPC2.
DR HPA; HPA051212; -.
DR neXtProt; NX_Q8TF65; -.
DR PharmGKB; PA142671735; -.
DR eggNOG; NOG313930; -.
DR HOGENOM; HOG000293347; -.
DR HOVERGEN; HBG000898; -.
DR InParanoid; Q8TF65; -.
DR OMA; WRHYDVA; -.
DR OrthoDB; EOG793B86; -.
DR PhylomeDB; Q8TF65; -.
DR EvolutionaryTrace; Q8TF65; -.
DR GeneWiki; GIPC2; -.
DR GenomeRNAi; 54810; -.
DR NextBio; 57529; -.
DR PRO; PR:Q8TF65; -.
DR Bgee; Q8TF65; -.
DR CleanEx; HS_GIPC2; -.
DR Genevestigator; Q8TF65; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR017379; UCP038083_PDZ.
DR Pfam; PF00595; PDZ; 1.
DR PIRSF; PIRSF038083; UCP038083_GIPC; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Complete proteome; Cytoplasm; Polymorphism;
KW Reference proteome.
FT CHAIN 1 315 PDZ domain-containing protein GIPC2.
FT /FTId=PRO_0000247188.
FT DOMAIN 117 197 PDZ.
FT VARIANT 61 61 S -> F (in dbSNP:rs17101180).
FT /FTId=VAR_027084.
FT VARIANT 206 206 L -> P (in dbSNP:rs540742).
FT /FTId=VAR_027085.
FT STRAND 113 121
FT STRAND 129 132
FT STRAND 134 137
FT STRAND 140 144
FT HELIX 149 152
FT STRAND 161 165
FT HELIX 175 184
FT STRAND 190 198
SQ SEQUENCE 315 AA; 34354 MW; 244894C6100C679F CRC64;
MPLKLRGKKK AKSKETAGLV EGEPTGAGGG SLSASRAPAR RLVFHAQLAH GSATGRVEGF
SSIQELYAQI AGAFEISPSE ILYCTLNTPK IDMERLLGGQ LGLEDFIFAH VKGIEKEVNV
YKSEDSLGLT ITDNGVGYAF IKRIKDGGVI DSVKTICVGD HIESINGENI VGWRHYDVAK
KLKELKKEEL FTMKLIEPKK AFEIELRSKA GKSSGEKIGC GRATLRLRSK GPATVEEMPS
ETKAKAIEKI DDVLELYMGI RDIDLATTMF EAGKDKVNPD EFAVALDETL GDFAFPDEFV
FDVWGVIGDA KRRGL
//