Full text data of GLOD4
GLOD4
(C17orf25)
[Confidence: low (only semi-automatic identification from reviews)]
Glyoxalase domain-containing protein 4
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Glyoxalase domain-containing protein 4
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q9HC38
ID GLOD4_HUMAN Reviewed; 313 AA.
AC Q9HC38; D3DTG9; D3DTH1; Q96B89; Q9H3J8; Q9HC37; Q9NVN1;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2001, sequence version 1.
DT 22-JAN-2014, entry version 83.
DE RecName: Full=Glyoxalase domain-containing protein 4;
GN Name=GLOD4; Synonyms=C17orf25; ORFNames=CGI-150, My027;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
RX PubMed=11642406; DOI=10.1038/sj.cr.7290088;
RA Qin W.X., Wan D.F., Sun F.Y., Zhang P.P., Han L.W., Huang Y.,
RA Jiang H.Q., Zhao X.T., He M., Ye Y., Cong W.M., Wu M.C., Zhang L.S.,
RA Yang N.W., Gu J.R.;
RT "Cloning and characterization of a novel gene (C17orf25) from the
RT deletion region on chromosome 17p13.3 in hepatocellular carcinoma.";
RL Cell Res. 11:209-216(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Fetal brain;
RA Mao Y.M., Xie Y., Ying K.;
RL Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT
RP ILE-282.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PROTEIN SEQUENCE OF 6-12; 97-116; 156-177; 188-198; 240-252 AND
RP 289-305, AND MASS SPECTROMETRY.
RC TISSUE=Fetal brain cortex;
RA Lubec G., Chen W.-Q., Sun Y.;
RL Submitted (DEC-2008) to UniProtKB.
RN [7]
RP SUBCELLULAR LOCATION, AND INTERACTION WITH NUDT9.
RX PubMed=12897971;
RA Zhang H.-T., Yan Z.-Q., Hu X.-B., Yang S.-L., Gong Y.;
RT "Interaction of C17orf25 with ADP-ribose pyrophosphatase NUDT9
RT detected via yeast two-hybrid method.";
RL Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 35:747-751(2003).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SUBUNIT: Interacts with NUDT9.
CC -!- SUBCELLULAR LOCATION: Mitochondrion (Probable).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9HC38-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9HC38-2; Sequence=VSP_023646;
CC Name=3;
CC IsoId=Q9HC38-3; Sequence=VSP_023646, VSP_023647, VSP_023648;
CC Note=No experimental confirmation available;
CC -!- TISSUE SPECIFICITY: Expressed in heart, brain, liver, kidney,
CC pancreas and placenta. Not expressed in skeletal muscle and lung.
CC -!- MISCELLANEOUS: Expression is decreased in hepatocellular carcinoma
CC samples as compared to adjacent non-cancerous liver tissues from
CC the same patients. Transfection in hepatocellular carcinoma cells
CC and overexpression can inhibit the cell growth.
CC -!- SIMILARITY: Belongs to the glyoxalase I family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF177342; AAG17986.1; -; mRNA.
DR EMBL; AF177343; AAG17987.1; -; mRNA.
DR EMBL; AF061730; AAG43141.1; -; mRNA.
DR EMBL; AK001488; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; CH471108; EAW90645.1; -; Genomic_DNA.
DR EMBL; CH471108; EAW90646.1; -; Genomic_DNA.
DR EMBL; CH471108; EAW90647.1; -; Genomic_DNA.
DR EMBL; CH471108; EAW90649.1; -; Genomic_DNA.
DR EMBL; CH471108; EAW90650.1; -; Genomic_DNA.
DR EMBL; BC008605; AAH08605.1; -; mRNA.
DR EMBL; BC015848; AAH15848.1; -; mRNA.
DR RefSeq; NP_057164.3; NM_016080.3.
DR UniGene; Hs.279061; -.
DR UniGene; Hs.595572; -.
DR PDB; 3ZI1; X-ray; 1.90 A; A=1-287.
DR PDBsum; 3ZI1; -.
DR ProteinModelPortal; Q9HC38; -.
DR SMR; Q9HC38; 1-293.
DR IntAct; Q9HC38; 3.
DR MINT; MINT-6944668; -.
DR STRING; 9606.ENSP00000301329; -.
DR PhosphoSite; Q9HC38; -.
DR DMDM; 74718831; -.
DR REPRODUCTION-2DPAGE; IPI00792035; -.
DR PaxDb; Q9HC38; -.
DR PRIDE; Q9HC38; -.
DR Ensembl; ENST00000301328; ENSP00000301328; ENSG00000167699.
DR Ensembl; ENST00000301329; ENSP00000301329; ENSG00000167699.
DR GeneID; 51031; -.
DR KEGG; hsa:51031; -.
DR UCSC; uc002frt.3; human.
DR CTD; 51031; -.
DR GeneCards; GC17M000698; -.
DR HGNC; HGNC:14111; GLOD4.
DR HPA; HPA021623; -.
DR HPA; HPA023246; -.
DR HPA; HPA023248; -.
DR neXtProt; NX_Q9HC38; -.
DR PharmGKB; PA162389795; -.
DR eggNOG; COG0346; -.
DR HOGENOM; HOG000006776; -.
DR HOVERGEN; HBG056038; -.
DR OMA; DKAMAED; -.
DR OrthoDB; EOG769ZK8; -.
DR ChiTaRS; GLOD4; human.
DR GeneWiki; GLOD4; -.
DR GenomeRNAi; 51031; -.
DR NextBio; 53585; -.
DR PRO; PR:Q9HC38; -.
DR ArrayExpress; Q9HC38; -.
DR Bgee; Q9HC38; -.
DR CleanEx; HS_GLOD4; -.
DR Genevestigator; Q9HC38; -.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR InterPro; IPR025870; Glyoxalase-like_dom.
DR Pfam; PF12681; Glyoxalase_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Complete proteome;
KW Direct protein sequencing; Mitochondrion; Polymorphism;
KW Reference proteome.
FT CHAIN 1 313 Glyoxalase domain-containing protein 4.
FT /FTId=PRO_0000280391.
FT VAR_SEQ 32 62 ESCSVARLECSGAISAHCSDYTRITEDSFSK -> LRHEEF
FT EEGCKAACNG (in isoform 2 and isoform 3).
FT /FTId=VSP_023646.
FT VAR_SEQ 197 203 CKLELQG -> VSNLGEE (in isoform 3).
FT /FTId=VSP_023647.
FT VAR_SEQ 204 313 Missing (in isoform 3).
FT /FTId=VSP_023648.
FT VARIANT 282 282 M -> I (in dbSNP:rs17851349).
FT /FTId=VAR_031128.
FT CONFLICT 295 295 A -> S (in Ref. 1; AAG17987).
FT STRAND 5 12
FT HELIX 16 25
FT STRAND 30 37
FT STRAND 68 76
FT TURN 78 80
FT STRAND 83 89
FT STRAND 99 107
FT HELIX 109 118
FT STRAND 123 126
FT STRAND 129 133
FT STRAND 139 145
FT STRAND 152 161
FT HELIX 163 172
FT STRAND 177 182
FT TURN 183 186
FT STRAND 187 193
FT STRAND 198 203
FT STRAND 216 221
FT HELIX 223 225
FT HELIX 226 235
FT STRAND 239 247
FT STRAND 255 261
FT STRAND 267 272
FT HELIX 273 279
SQ SEQUENCE 313 AA; 34793 MW; 43DB04159153F07C CRC64;
MAARRALHFV FKVGNRFQTA RFYRDVLGMK VESCSVARLE CSGAISAHCS DYTRITEDSF
SKPYDGKWSK TMVGFGPEDD HFVAELTYNY GVGDYKLGND FMGITLASSQ AVSNARKLEW
PLTEVAEGVF ETEAPGGYKF YLQNRSLPQS DPVLKVTLAV SDLQKSLNYW CNLLGMKIYE
KDEEKQRALL GYADNQCKLE LQGVKGGVDH AAAFGRIAFS CPQKELPDLE DLMKRENQKI
LTPLVSLDTP GKATVQVVIL ADPDGHEICF VGDEAFRELS KMDPEGSKLL DDAMAADKSD
EWFAKHNKPK ASG
//
ID GLOD4_HUMAN Reviewed; 313 AA.
AC Q9HC38; D3DTG9; D3DTH1; Q96B89; Q9H3J8; Q9HC37; Q9NVN1;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2001, sequence version 1.
DT 22-JAN-2014, entry version 83.
DE RecName: Full=Glyoxalase domain-containing protein 4;
GN Name=GLOD4; Synonyms=C17orf25; ORFNames=CGI-150, My027;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
RX PubMed=11642406; DOI=10.1038/sj.cr.7290088;
RA Qin W.X., Wan D.F., Sun F.Y., Zhang P.P., Han L.W., Huang Y.,
RA Jiang H.Q., Zhao X.T., He M., Ye Y., Cong W.M., Wu M.C., Zhang L.S.,
RA Yang N.W., Gu J.R.;
RT "Cloning and characterization of a novel gene (C17orf25) from the
RT deletion region on chromosome 17p13.3 in hepatocellular carcinoma.";
RL Cell Res. 11:209-216(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Fetal brain;
RA Mao Y.M., Xie Y., Ying K.;
RL Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT
RP ILE-282.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PROTEIN SEQUENCE OF 6-12; 97-116; 156-177; 188-198; 240-252 AND
RP 289-305, AND MASS SPECTROMETRY.
RC TISSUE=Fetal brain cortex;
RA Lubec G., Chen W.-Q., Sun Y.;
RL Submitted (DEC-2008) to UniProtKB.
RN [7]
RP SUBCELLULAR LOCATION, AND INTERACTION WITH NUDT9.
RX PubMed=12897971;
RA Zhang H.-T., Yan Z.-Q., Hu X.-B., Yang S.-L., Gong Y.;
RT "Interaction of C17orf25 with ADP-ribose pyrophosphatase NUDT9
RT detected via yeast two-hybrid method.";
RL Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 35:747-751(2003).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SUBUNIT: Interacts with NUDT9.
CC -!- SUBCELLULAR LOCATION: Mitochondrion (Probable).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9HC38-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9HC38-2; Sequence=VSP_023646;
CC Name=3;
CC IsoId=Q9HC38-3; Sequence=VSP_023646, VSP_023647, VSP_023648;
CC Note=No experimental confirmation available;
CC -!- TISSUE SPECIFICITY: Expressed in heart, brain, liver, kidney,
CC pancreas and placenta. Not expressed in skeletal muscle and lung.
CC -!- MISCELLANEOUS: Expression is decreased in hepatocellular carcinoma
CC samples as compared to adjacent non-cancerous liver tissues from
CC the same patients. Transfection in hepatocellular carcinoma cells
CC and overexpression can inhibit the cell growth.
CC -!- SIMILARITY: Belongs to the glyoxalase I family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF177342; AAG17986.1; -; mRNA.
DR EMBL; AF177343; AAG17987.1; -; mRNA.
DR EMBL; AF061730; AAG43141.1; -; mRNA.
DR EMBL; AK001488; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; CH471108; EAW90645.1; -; Genomic_DNA.
DR EMBL; CH471108; EAW90646.1; -; Genomic_DNA.
DR EMBL; CH471108; EAW90647.1; -; Genomic_DNA.
DR EMBL; CH471108; EAW90649.1; -; Genomic_DNA.
DR EMBL; CH471108; EAW90650.1; -; Genomic_DNA.
DR EMBL; BC008605; AAH08605.1; -; mRNA.
DR EMBL; BC015848; AAH15848.1; -; mRNA.
DR RefSeq; NP_057164.3; NM_016080.3.
DR UniGene; Hs.279061; -.
DR UniGene; Hs.595572; -.
DR PDB; 3ZI1; X-ray; 1.90 A; A=1-287.
DR PDBsum; 3ZI1; -.
DR ProteinModelPortal; Q9HC38; -.
DR SMR; Q9HC38; 1-293.
DR IntAct; Q9HC38; 3.
DR MINT; MINT-6944668; -.
DR STRING; 9606.ENSP00000301329; -.
DR PhosphoSite; Q9HC38; -.
DR DMDM; 74718831; -.
DR REPRODUCTION-2DPAGE; IPI00792035; -.
DR PaxDb; Q9HC38; -.
DR PRIDE; Q9HC38; -.
DR Ensembl; ENST00000301328; ENSP00000301328; ENSG00000167699.
DR Ensembl; ENST00000301329; ENSP00000301329; ENSG00000167699.
DR GeneID; 51031; -.
DR KEGG; hsa:51031; -.
DR UCSC; uc002frt.3; human.
DR CTD; 51031; -.
DR GeneCards; GC17M000698; -.
DR HGNC; HGNC:14111; GLOD4.
DR HPA; HPA021623; -.
DR HPA; HPA023246; -.
DR HPA; HPA023248; -.
DR neXtProt; NX_Q9HC38; -.
DR PharmGKB; PA162389795; -.
DR eggNOG; COG0346; -.
DR HOGENOM; HOG000006776; -.
DR HOVERGEN; HBG056038; -.
DR OMA; DKAMAED; -.
DR OrthoDB; EOG769ZK8; -.
DR ChiTaRS; GLOD4; human.
DR GeneWiki; GLOD4; -.
DR GenomeRNAi; 51031; -.
DR NextBio; 53585; -.
DR PRO; PR:Q9HC38; -.
DR ArrayExpress; Q9HC38; -.
DR Bgee; Q9HC38; -.
DR CleanEx; HS_GLOD4; -.
DR Genevestigator; Q9HC38; -.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR InterPro; IPR025870; Glyoxalase-like_dom.
DR Pfam; PF12681; Glyoxalase_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Complete proteome;
KW Direct protein sequencing; Mitochondrion; Polymorphism;
KW Reference proteome.
FT CHAIN 1 313 Glyoxalase domain-containing protein 4.
FT /FTId=PRO_0000280391.
FT VAR_SEQ 32 62 ESCSVARLECSGAISAHCSDYTRITEDSFSK -> LRHEEF
FT EEGCKAACNG (in isoform 2 and isoform 3).
FT /FTId=VSP_023646.
FT VAR_SEQ 197 203 CKLELQG -> VSNLGEE (in isoform 3).
FT /FTId=VSP_023647.
FT VAR_SEQ 204 313 Missing (in isoform 3).
FT /FTId=VSP_023648.
FT VARIANT 282 282 M -> I (in dbSNP:rs17851349).
FT /FTId=VAR_031128.
FT CONFLICT 295 295 A -> S (in Ref. 1; AAG17987).
FT STRAND 5 12
FT HELIX 16 25
FT STRAND 30 37
FT STRAND 68 76
FT TURN 78 80
FT STRAND 83 89
FT STRAND 99 107
FT HELIX 109 118
FT STRAND 123 126
FT STRAND 129 133
FT STRAND 139 145
FT STRAND 152 161
FT HELIX 163 172
FT STRAND 177 182
FT TURN 183 186
FT STRAND 187 193
FT STRAND 198 203
FT STRAND 216 221
FT HELIX 223 225
FT HELIX 226 235
FT STRAND 239 247
FT STRAND 255 261
FT STRAND 267 272
FT HELIX 273 279
SQ SEQUENCE 313 AA; 34793 MW; 43DB04159153F07C CRC64;
MAARRALHFV FKVGNRFQTA RFYRDVLGMK VESCSVARLE CSGAISAHCS DYTRITEDSF
SKPYDGKWSK TMVGFGPEDD HFVAELTYNY GVGDYKLGND FMGITLASSQ AVSNARKLEW
PLTEVAEGVF ETEAPGGYKF YLQNRSLPQS DPVLKVTLAV SDLQKSLNYW CNLLGMKIYE
KDEEKQRALL GYADNQCKLE LQGVKGGVDH AAAFGRIAFS CPQKELPDLE DLMKRENQKI
LTPLVSLDTP GKATVQVVIL ADPDGHEICF VGDEAFRELS KMDPEGSKLL DDAMAADKSD
EWFAKHNKPK ASG
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