Full text data of GMFB
GMFB
[Confidence: low (only semi-automatic identification from reviews)]
Glia maturation factor beta; GMF-beta
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Glia maturation factor beta; GMF-beta
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
P60983
ID GMFB_HUMAN Reviewed; 142 AA.
AC P60983; B2R499; P17774;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 2.
DT 22-JAN-2014, entry version 91.
DE RecName: Full=Glia maturation factor beta;
DE Short=GMF-beta;
GN Name=GMFB;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1712830; DOI=10.1111/j.1471-4159.1991.tb03777.x;
RA Kaplan R., Zaheer A., Jaye M., Lim R.;
RT "Molecular cloning and expression of biologically active human glia
RT maturation factor-beta.";
RL J. Neurochem. 57:483-490(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RA Saito T., Tanaka N., Toyomasu T.;
RL Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S.,
RA Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W.,
RA Korn B., Zuo D., Hu Y., LaBaer J.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP PHOSPHORYLATION.
RX PubMed=7598724; DOI=10.1006/bbrc.1995.1901;
RA Lim R., Zaheer A.;
RT "Phorbol ester stimulates rapid intracellular phosphorylation of glia
RT maturation factor.";
RL Biochem. Biophys. Res. Commun. 211:928-934(1995).
RN [7]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [9]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, AND MASS SPECTROMETRY.
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: This protein causes differentiation of brain cells,
CC stimulation of neural regeneration, and inhibition of
CC proliferation of tumor cells.
CC -!- PTM: Phosphorylated; stimulated by phorbol ester.
CC -!- SIMILARITY: Belongs to the actin-binding proteins ADF family. GMF
CC subfamily.
CC -!- SIMILARITY: Contains 1 ADF-H domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; M86492; AAA58614.1; -; mRNA.
DR EMBL; AB001106; BAA19232.1; -; mRNA.
DR EMBL; CR542113; CAG46910.1; -; mRNA.
DR EMBL; AK311753; BAG34696.1; -; mRNA.
DR EMBL; CH471061; EAW80638.1; -; Genomic_DNA.
DR PIR; PT0410; PT0410.
DR RefSeq; NP_004115.1; NM_004124.2.
DR UniGene; Hs.151413; -.
DR ProteinModelPortal; P60983; -.
DR SMR; P60983; 5-139.
DR IntAct; P60983; 1.
DR STRING; 9606.ENSP00000350757; -.
DR PhosphoSite; P60983; -.
DR DMDM; 46577593; -.
DR OGP; P17774; -.
DR PaxDb; P60983; -.
DR PRIDE; P60983; -.
DR DNASU; 2764; -.
DR Ensembl; ENST00000358056; ENSP00000350757; ENSG00000197045.
DR GeneID; 2764; -.
DR KEGG; hsa:2764; -.
DR UCSC; uc021rtf.1; human.
DR CTD; 2764; -.
DR GeneCards; GC14M054941; -.
DR HGNC; HGNC:4373; GMFB.
DR HPA; HPA002954; -.
DR MIM; 601713; gene.
DR neXtProt; NX_P60983; -.
DR PharmGKB; PA28758; -.
DR eggNOG; NOG268251; -.
DR HOGENOM; HOG000175654; -.
DR HOVERGEN; HBG003045; -.
DR OrthoDB; EOG78D7MR; -.
DR PhylomeDB; P60983; -.
DR SignaLink; P60983; -.
DR ChiTaRS; GMFB; human.
DR GenomeRNAi; 2764; -.
DR NextBio; 10872; -.
DR PRO; PR:P60983; -.
DR ArrayExpress; P60983; -.
DR Bgee; P60983; -.
DR CleanEx; HS_GMFB; -.
DR Genevestigator; P60983; -.
DR GO; GO:0005622; C:intracellular; IEA:InterPro.
DR GO; GO:0008047; F:enzyme activator activity; TAS:ProtInc.
DR GO; GO:0004860; F:protein kinase inhibitor activity; TAS:ProtInc.
DR GO; GO:0004871; F:signal transducer activity; TAS:ProtInc.
DR GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR GO; GO:0006468; P:protein phosphorylation; TAS:ProtInc.
DR InterPro; IPR002108; Actin-bd_cofilin/tropomyosin.
DR InterPro; IPR011171; GMF-beta.
DR PANTHER; PTHR11249; PTHR11249; 1.
DR Pfam; PF00241; Cofilin_ADF; 1.
DR PIRSF; PIRSF001788; GMF-beta; 1.
DR SMART; SM00102; ADF; 1.
DR PROSITE; PS51263; ADF_H; 1.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Growth factor; Phosphoprotein;
KW Reference proteome.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 142 Glia maturation factor beta.
FT /FTId=PRO_0000214943.
FT DOMAIN 4 139 ADF-H.
FT MOD_RES 2 2 N-acetylserine.
SQ SEQUENCE 142 AA; 16713 MW; CF2D4A8CB1F37B1F CRC64;
MSESLVVCDV AEDLVEKLRK FRFRKETNNA AIIMKIDKDK RLVVLDEELE GISPDELKDE
LPERQPRFIV YSYKYQHDDG RVSYPLCFIF SSPVGCKPEQ QMMYAGSKNK LVQTAELTKV
FEIRNTEDLT EEWLREKLGF FH
//
ID GMFB_HUMAN Reviewed; 142 AA.
AC P60983; B2R499; P17774;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 2.
DT 22-JAN-2014, entry version 91.
DE RecName: Full=Glia maturation factor beta;
DE Short=GMF-beta;
GN Name=GMFB;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1712830; DOI=10.1111/j.1471-4159.1991.tb03777.x;
RA Kaplan R., Zaheer A., Jaye M., Lim R.;
RT "Molecular cloning and expression of biologically active human glia
RT maturation factor-beta.";
RL J. Neurochem. 57:483-490(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RA Saito T., Tanaka N., Toyomasu T.;
RL Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S.,
RA Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W.,
RA Korn B., Zuo D., Hu Y., LaBaer J.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP PHOSPHORYLATION.
RX PubMed=7598724; DOI=10.1006/bbrc.1995.1901;
RA Lim R., Zaheer A.;
RT "Phorbol ester stimulates rapid intracellular phosphorylation of glia
RT maturation factor.";
RL Biochem. Biophys. Res. Commun. 211:928-934(1995).
RN [7]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [9]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, AND MASS SPECTROMETRY.
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: This protein causes differentiation of brain cells,
CC stimulation of neural regeneration, and inhibition of
CC proliferation of tumor cells.
CC -!- PTM: Phosphorylated; stimulated by phorbol ester.
CC -!- SIMILARITY: Belongs to the actin-binding proteins ADF family. GMF
CC subfamily.
CC -!- SIMILARITY: Contains 1 ADF-H domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; M86492; AAA58614.1; -; mRNA.
DR EMBL; AB001106; BAA19232.1; -; mRNA.
DR EMBL; CR542113; CAG46910.1; -; mRNA.
DR EMBL; AK311753; BAG34696.1; -; mRNA.
DR EMBL; CH471061; EAW80638.1; -; Genomic_DNA.
DR PIR; PT0410; PT0410.
DR RefSeq; NP_004115.1; NM_004124.2.
DR UniGene; Hs.151413; -.
DR ProteinModelPortal; P60983; -.
DR SMR; P60983; 5-139.
DR IntAct; P60983; 1.
DR STRING; 9606.ENSP00000350757; -.
DR PhosphoSite; P60983; -.
DR DMDM; 46577593; -.
DR OGP; P17774; -.
DR PaxDb; P60983; -.
DR PRIDE; P60983; -.
DR DNASU; 2764; -.
DR Ensembl; ENST00000358056; ENSP00000350757; ENSG00000197045.
DR GeneID; 2764; -.
DR KEGG; hsa:2764; -.
DR UCSC; uc021rtf.1; human.
DR CTD; 2764; -.
DR GeneCards; GC14M054941; -.
DR HGNC; HGNC:4373; GMFB.
DR HPA; HPA002954; -.
DR MIM; 601713; gene.
DR neXtProt; NX_P60983; -.
DR PharmGKB; PA28758; -.
DR eggNOG; NOG268251; -.
DR HOGENOM; HOG000175654; -.
DR HOVERGEN; HBG003045; -.
DR OrthoDB; EOG78D7MR; -.
DR PhylomeDB; P60983; -.
DR SignaLink; P60983; -.
DR ChiTaRS; GMFB; human.
DR GenomeRNAi; 2764; -.
DR NextBio; 10872; -.
DR PRO; PR:P60983; -.
DR ArrayExpress; P60983; -.
DR Bgee; P60983; -.
DR CleanEx; HS_GMFB; -.
DR Genevestigator; P60983; -.
DR GO; GO:0005622; C:intracellular; IEA:InterPro.
DR GO; GO:0008047; F:enzyme activator activity; TAS:ProtInc.
DR GO; GO:0004860; F:protein kinase inhibitor activity; TAS:ProtInc.
DR GO; GO:0004871; F:signal transducer activity; TAS:ProtInc.
DR GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR GO; GO:0006468; P:protein phosphorylation; TAS:ProtInc.
DR InterPro; IPR002108; Actin-bd_cofilin/tropomyosin.
DR InterPro; IPR011171; GMF-beta.
DR PANTHER; PTHR11249; PTHR11249; 1.
DR Pfam; PF00241; Cofilin_ADF; 1.
DR PIRSF; PIRSF001788; GMF-beta; 1.
DR SMART; SM00102; ADF; 1.
DR PROSITE; PS51263; ADF_H; 1.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Growth factor; Phosphoprotein;
KW Reference proteome.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 142 Glia maturation factor beta.
FT /FTId=PRO_0000214943.
FT DOMAIN 4 139 ADF-H.
FT MOD_RES 2 2 N-acetylserine.
SQ SEQUENCE 142 AA; 16713 MW; CF2D4A8CB1F37B1F CRC64;
MSESLVVCDV AEDLVEKLRK FRFRKETNNA AIIMKIDKDK RLVVLDEELE GISPDELKDE
LPERQPRFIV YSYKYQHDDG RVSYPLCFIF SSPVGCKPEQ QMMYAGSKNK LVQTAELTKV
FEIRNTEDLT EEWLREKLGF FH
//
MIM
601713
*RECORD*
*FIELD* NO
601713
*FIELD* TI
*601713 GLIA MATURATION FACTOR, BETA; GMFB
GLIA MATURATION FACTOR; GMF
*FIELD* TX
read moreCLONING
Glia maturation factor (GMF) is a 17-kD protein that was initially
identified as a growth and differentiation factor in the vertebrate
brain. Kaplan et al. (1991) obtained a cDNA of the human GMF gene from a
human brainstem library.
Bourgeois et al. (2001) cloned a full-length mouse Gmfb cDNA encoding a
deduced 142-amino acid protein that is identical to human GMFB with the
exception of 2 amino acids. Northern blot analysis detected expression
of a single transcript in heart, brain, spleen, lung, liver, kidney, and
testis. No expression was detected in skeletal muscle. The transcript is
developmentally regulated, with peak expression at embryonic day 15.
RT-PCR analysis and in situ hybridization demonstrated higher expression
of Gmfb in telencephalon than in the posterior parts of the embryonic
brain.
GENE FUNCTION
GMF can be phosphorylated in vitro by protein kinase A (PKA; 188830),
protein kinase C (PKC; 176960), casein kinase II (115440), and ribosomal
S6 kinase (see 300075) (Lim and Zaheer, 1995).
Zaheer and Lim (1996) showed that PKA-phosphorylated GMF is a potent
inhibitor of activity of the extracellular signal-regulated kinase
(ERK1/ERK2; see 601795) subfamily of mitogen-activated protein (MAP)
kinase. Lim and Zaheer (1996) demonstrated that PKA-phosphorylated GMF
is a strong enhancer of p38 MAP kinase activity in vitro. They suggested
that ERK and p38 carry out opposing functions and that GMF is an
intracellular regulator of signal transduction pathways.
*FIELD* RF
1. Bourgeois, F.; Guimiot, F.; Mas, C.; Bulfone, A.; Levacher, B.;
Moalic, J. M.; Simonneau, M.: Identification and isolation of a full-length
clone of mouse GMFB (Gmfb), a putative intracellular kinase regulator,
differentially expressed in telencephalon. Cytogenet. Cell Genet. 92:
304-309, 2001.
2. Kaplan, R.; Zaheer, A.; Jaye, M.; Lim, R.: Molecular cloning and
expression of biologically active human glia maturation factor-beta. J.
Neurochem. 57: 483-490, 1991.
3. Lim, R.; Zaheer, A.: In vitro enhancement of p38 mitogen-activated
protein kinase activity by phosphorylated glia maturation factor. J.
Biol. Chem. 271: 22953-22956, 1996.
4. Lim, R.; Zaheer, A.: Phorbol ester stimulates rapid intracellular
phosphorylation of glia maturation factor. Biochem. Biophys. Res.
Commun. 211: 928-934, 1995.
5. Zaheer, A.; Lim, R.: In vitro inhibition of MAP kinase (ERK1/ERK2)
activity by phosphorylated glia maturation factor (GMF). Biochemistry 35:
6283-6288, 1996.
*FIELD* CN
Carol A. Bocchini - updated: 8/8/2001
*FIELD* CD
Lori M. Kelman: 3/21/1997
*FIELD* ED
carol: 09/15/2009
joanna: 2/2/2009
terry: 3/3/2005
mcapotos: 8/8/2001
alopez: 4/1/1999
terry: 6/3/1998
alopez: 5/27/1997
alopez: 5/21/1997
alopez: 5/5/1997
alopez: 4/21/1997
alopez: 3/21/1997
*RECORD*
*FIELD* NO
601713
*FIELD* TI
*601713 GLIA MATURATION FACTOR, BETA; GMFB
GLIA MATURATION FACTOR; GMF
*FIELD* TX
read moreCLONING
Glia maturation factor (GMF) is a 17-kD protein that was initially
identified as a growth and differentiation factor in the vertebrate
brain. Kaplan et al. (1991) obtained a cDNA of the human GMF gene from a
human brainstem library.
Bourgeois et al. (2001) cloned a full-length mouse Gmfb cDNA encoding a
deduced 142-amino acid protein that is identical to human GMFB with the
exception of 2 amino acids. Northern blot analysis detected expression
of a single transcript in heart, brain, spleen, lung, liver, kidney, and
testis. No expression was detected in skeletal muscle. The transcript is
developmentally regulated, with peak expression at embryonic day 15.
RT-PCR analysis and in situ hybridization demonstrated higher expression
of Gmfb in telencephalon than in the posterior parts of the embryonic
brain.
GENE FUNCTION
GMF can be phosphorylated in vitro by protein kinase A (PKA; 188830),
protein kinase C (PKC; 176960), casein kinase II (115440), and ribosomal
S6 kinase (see 300075) (Lim and Zaheer, 1995).
Zaheer and Lim (1996) showed that PKA-phosphorylated GMF is a potent
inhibitor of activity of the extracellular signal-regulated kinase
(ERK1/ERK2; see 601795) subfamily of mitogen-activated protein (MAP)
kinase. Lim and Zaheer (1996) demonstrated that PKA-phosphorylated GMF
is a strong enhancer of p38 MAP kinase activity in vitro. They suggested
that ERK and p38 carry out opposing functions and that GMF is an
intracellular regulator of signal transduction pathways.
*FIELD* RF
1. Bourgeois, F.; Guimiot, F.; Mas, C.; Bulfone, A.; Levacher, B.;
Moalic, J. M.; Simonneau, M.: Identification and isolation of a full-length
clone of mouse GMFB (Gmfb), a putative intracellular kinase regulator,
differentially expressed in telencephalon. Cytogenet. Cell Genet. 92:
304-309, 2001.
2. Kaplan, R.; Zaheer, A.; Jaye, M.; Lim, R.: Molecular cloning and
expression of biologically active human glia maturation factor-beta. J.
Neurochem. 57: 483-490, 1991.
3. Lim, R.; Zaheer, A.: In vitro enhancement of p38 mitogen-activated
protein kinase activity by phosphorylated glia maturation factor. J.
Biol. Chem. 271: 22953-22956, 1996.
4. Lim, R.; Zaheer, A.: Phorbol ester stimulates rapid intracellular
phosphorylation of glia maturation factor. Biochem. Biophys. Res.
Commun. 211: 928-934, 1995.
5. Zaheer, A.; Lim, R.: In vitro inhibition of MAP kinase (ERK1/ERK2)
activity by phosphorylated glia maturation factor (GMF). Biochemistry 35:
6283-6288, 1996.
*FIELD* CN
Carol A. Bocchini - updated: 8/8/2001
*FIELD* CD
Lori M. Kelman: 3/21/1997
*FIELD* ED
carol: 09/15/2009
joanna: 2/2/2009
terry: 3/3/2005
mcapotos: 8/8/2001
alopez: 4/1/1999
terry: 6/3/1998
alopez: 5/27/1997
alopez: 5/21/1997
alopez: 5/5/1997
alopez: 4/21/1997
alopez: 3/21/1997