Full text data of GOLT1B
GOLT1B
(GCT2, GOT1A)
[Confidence: high (present in two of the MS resources)]
Vesicle transport protein GOT1B (Germ cell tumor 2; Golgi transport 1 homolog B; Putative NF-kappa-B-activating protein 470; hGOT1a)
Vesicle transport protein GOT1B (Germ cell tumor 2; Golgi transport 1 homolog B; Putative NF-kappa-B-activating protein 470; hGOT1a)
hRBCD
IPI00007061
IPI00007061 UPF0198 protein CGI-141 UPF0198 protein CGI-141 membrane n/a n/a 1 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a integral membrane protein n/a found at its expected molecular weight found at molecular weight
IPI00007061 UPF0198 protein CGI-141 UPF0198 protein CGI-141 membrane n/a n/a 1 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a integral membrane protein n/a found at its expected molecular weight found at molecular weight
UniProt
Q9Y3E0
ID GOT1B_HUMAN Reviewed; 138 AA.
AC Q9Y3E0; B2R4R4; Q54A40; Q6I9W6; Q9P1R9;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-NOV-1999, sequence version 1.
DT 22-JAN-2014, entry version 103.
DE RecName: Full=Vesicle transport protein GOT1B;
DE AltName: Full=Germ cell tumor 2;
DE AltName: Full=Golgi transport 1 homolog B;
DE AltName: Full=Putative NF-kappa-B-activating protein 470;
DE AltName: Full=hGOT1a;
GN Name=GOLT1B; Synonyms=GCT2, GOT1A;
GN ORFNames=CGI-141, HDCMA39P, UNQ432/PRO793;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=10810093; DOI=10.1101/gr.10.5.703;
RA Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.;
RT "Identification of novel human genes evolutionarily conserved in
RT Caenorhabditis elegans by comparative proteomics.";
RL Genome Res. 10:703-713(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala;
RX PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA Wambutt R., Korn B., Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and
RT analysis of 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung fibroblast;
RX PubMed=12761501; DOI=10.1038/sj.onc.1206406;
RA Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O.,
RA Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H.,
RA Sugano S.;
RT "Large-scale identification and characterization of human genes that
RT activate NF-kappaB and MAPK signaling pathways.";
RL Oncogene 22:3307-3318(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Dendritic cell;
RA Zhao Z., Huang X., Li N., Zhu X., Cao X.;
RT "A novel gene from human dendritic cell.";
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [10]
RP PUTATIVE FUNCTION, SUBCELLULAR LOCATION, AND TOPOLOGY.
RX PubMed=10406798; DOI=10.1093/emboj/18.14.3934;
RA Conchon S., Cao X., Barlowe C., Pelham H.R.;
RT "Got1p and Sft2p: membrane proteins involved in traffic to the Golgi
RT complex.";
RL EMBO J. 18:3934-3946(1999).
RN [11]
RP TISSUE SPECIFICITY.
RX PubMed=12414650;
RA Bourdon V., Naef F., Rao P.H., Reuter V., Mok S.C., Bosl G.J.,
RA Koul S., Murty V.V., Kucherlapati R.S., Chaganti R.S.;
RT "Genomic and expression analysis of the 12p11-p12 amplicon using EST
RT arrays identifies two novel amplified and overexpressed genes.";
RL Cancer Res. 62:6218-6223(2002).
CC -!- FUNCTION: May be involved in fusion of ER-derived transport
CC vesicles with the Golgi complex.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass
CC membrane protein.
CC -!- TISSUE SPECIFICITY: Widely expressed. Tends to be up-regulated in
CC seminomas compared to normal testis.
CC -!- SIMILARITY: Belongs to the GOT1 family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF65181.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF151899; AAD34136.1; -; mRNA.
DR EMBL; AL136571; CAB66506.1; -; mRNA.
DR EMBL; AB097020; BAC77373.1; -; mRNA.
DR EMBL; AY358975; AAQ89334.1; -; mRNA.
DR EMBL; AF068292; AAF65181.1; ALT_INIT; mRNA.
DR EMBL; CR457389; CAG33670.1; -; mRNA.
DR EMBL; AK311920; BAG34861.1; -; mRNA.
DR EMBL; CH471094; EAW96443.1; -; Genomic_DNA.
DR EMBL; BC012455; AAH12455.1; -; mRNA.
DR PIR; T46908; T46908.
DR RefSeq; NP_057156.1; NM_016072.4.
DR UniGene; Hs.62275; -.
DR ProteinModelPortal; Q9Y3E0; -.
DR IntAct; Q9Y3E0; 1.
DR MINT; MINT-3085932; -.
DR STRING; 9606.ENSP00000229314; -.
DR PhosphoSite; Q9Y3E0; -.
DR DMDM; 20534680; -.
DR PaxDb; Q9Y3E0; -.
DR PRIDE; Q9Y3E0; -.
DR DNASU; 51026; -.
DR Ensembl; ENST00000229314; ENSP00000229314; ENSG00000111711.
DR GeneID; 51026; -.
DR KEGG; hsa:51026; -.
DR UCSC; uc001rez.2; human.
DR CTD; 51026; -.
DR GeneCards; GC12P021654; -.
DR HGNC; HGNC:20175; GOLT1B.
DR MIM; 615078; gene.
DR neXtProt; NX_Q9Y3E0; -.
DR PharmGKB; PA134898810; -.
DR eggNOG; COG5120; -.
DR HOGENOM; HOG000035939; -.
DR HOVERGEN; HBG009362; -.
DR InParanoid; Q9Y3E0; -.
DR OMA; FFPVAIN; -.
DR PhylomeDB; Q9Y3E0; -.
DR GeneWiki; GOLT1B; -.
DR GenomeRNAi; 51026; -.
DR NextBio; 53565; -.
DR PRO; PR:Q9Y3E0; -.
DR ArrayExpress; Q9Y3E0; -.
DR Bgee; Q9Y3E0; -.
DR CleanEx; HS_GOLT1B; -.
DR Genevestigator; Q9Y3E0; -.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0004871; F:signal transducer activity; IMP:UniProtKB.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR007305; Vesicle_transpt_Got1/SFT2.
DR Pfam; PF04178; Got1; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Golgi apparatus; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1 138 Vesicle transport protein GOT1B.
FT /FTId=PRO_0000218582.
FT TOPO_DOM 1 9 Cytoplasmic (Potential).
FT TRANSMEM 10 30 Helical; Name=1; (Potential).
FT TOPO_DOM 31 32 Lumenal (Potential).
FT TRANSMEM 33 53 Helical; Name=2; (Potential).
FT TOPO_DOM 54 68 Cytoplasmic (Potential).
FT TRANSMEM 69 89 Helical; Name=3; (Potential).
FT TOPO_DOM 90 90 Lumenal (Potential).
FT TRANSMEM 91 109 Helical; Name=4; (Potential).
FT TOPO_DOM 110 138 Cytoplasmic (Potential).
FT COMPBIAS 17 108 Phe-rich.
FT CONFLICT 37 37 I -> T (in Ref. 5; AAF65181).
FT CONFLICT 54 54 R -> K (in Ref. 6; CAG33670).
SQ SEQUENCE 138 AA; 15426 MW; 2EB85823C34EFAFA CRC64;
MISLTDTQKI GMGLTGFGVF FLFFGMILFF DKALLAIGNV LFVAGLAFVI GLERTFRFFF
QKHKMKATGF FLGGVFVVLI GWPLIGMIFE IYGFFLLFRG FFPVVVGFIR RVPVLGSLLN
LPGIRSFVDK VGESNNMV
//
ID GOT1B_HUMAN Reviewed; 138 AA.
AC Q9Y3E0; B2R4R4; Q54A40; Q6I9W6; Q9P1R9;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-NOV-1999, sequence version 1.
DT 22-JAN-2014, entry version 103.
DE RecName: Full=Vesicle transport protein GOT1B;
DE AltName: Full=Germ cell tumor 2;
DE AltName: Full=Golgi transport 1 homolog B;
DE AltName: Full=Putative NF-kappa-B-activating protein 470;
DE AltName: Full=hGOT1a;
GN Name=GOLT1B; Synonyms=GCT2, GOT1A;
GN ORFNames=CGI-141, HDCMA39P, UNQ432/PRO793;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=10810093; DOI=10.1101/gr.10.5.703;
RA Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.;
RT "Identification of novel human genes evolutionarily conserved in
RT Caenorhabditis elegans by comparative proteomics.";
RL Genome Res. 10:703-713(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala;
RX PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA Wambutt R., Korn B., Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and
RT analysis of 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung fibroblast;
RX PubMed=12761501; DOI=10.1038/sj.onc.1206406;
RA Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O.,
RA Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H.,
RA Sugano S.;
RT "Large-scale identification and characterization of human genes that
RT activate NF-kappaB and MAPK signaling pathways.";
RL Oncogene 22:3307-3318(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Dendritic cell;
RA Zhao Z., Huang X., Li N., Zhu X., Cao X.;
RT "A novel gene from human dendritic cell.";
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [10]
RP PUTATIVE FUNCTION, SUBCELLULAR LOCATION, AND TOPOLOGY.
RX PubMed=10406798; DOI=10.1093/emboj/18.14.3934;
RA Conchon S., Cao X., Barlowe C., Pelham H.R.;
RT "Got1p and Sft2p: membrane proteins involved in traffic to the Golgi
RT complex.";
RL EMBO J. 18:3934-3946(1999).
RN [11]
RP TISSUE SPECIFICITY.
RX PubMed=12414650;
RA Bourdon V., Naef F., Rao P.H., Reuter V., Mok S.C., Bosl G.J.,
RA Koul S., Murty V.V., Kucherlapati R.S., Chaganti R.S.;
RT "Genomic and expression analysis of the 12p11-p12 amplicon using EST
RT arrays identifies two novel amplified and overexpressed genes.";
RL Cancer Res. 62:6218-6223(2002).
CC -!- FUNCTION: May be involved in fusion of ER-derived transport
CC vesicles with the Golgi complex.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass
CC membrane protein.
CC -!- TISSUE SPECIFICITY: Widely expressed. Tends to be up-regulated in
CC seminomas compared to normal testis.
CC -!- SIMILARITY: Belongs to the GOT1 family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF65181.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF151899; AAD34136.1; -; mRNA.
DR EMBL; AL136571; CAB66506.1; -; mRNA.
DR EMBL; AB097020; BAC77373.1; -; mRNA.
DR EMBL; AY358975; AAQ89334.1; -; mRNA.
DR EMBL; AF068292; AAF65181.1; ALT_INIT; mRNA.
DR EMBL; CR457389; CAG33670.1; -; mRNA.
DR EMBL; AK311920; BAG34861.1; -; mRNA.
DR EMBL; CH471094; EAW96443.1; -; Genomic_DNA.
DR EMBL; BC012455; AAH12455.1; -; mRNA.
DR PIR; T46908; T46908.
DR RefSeq; NP_057156.1; NM_016072.4.
DR UniGene; Hs.62275; -.
DR ProteinModelPortal; Q9Y3E0; -.
DR IntAct; Q9Y3E0; 1.
DR MINT; MINT-3085932; -.
DR STRING; 9606.ENSP00000229314; -.
DR PhosphoSite; Q9Y3E0; -.
DR DMDM; 20534680; -.
DR PaxDb; Q9Y3E0; -.
DR PRIDE; Q9Y3E0; -.
DR DNASU; 51026; -.
DR Ensembl; ENST00000229314; ENSP00000229314; ENSG00000111711.
DR GeneID; 51026; -.
DR KEGG; hsa:51026; -.
DR UCSC; uc001rez.2; human.
DR CTD; 51026; -.
DR GeneCards; GC12P021654; -.
DR HGNC; HGNC:20175; GOLT1B.
DR MIM; 615078; gene.
DR neXtProt; NX_Q9Y3E0; -.
DR PharmGKB; PA134898810; -.
DR eggNOG; COG5120; -.
DR HOGENOM; HOG000035939; -.
DR HOVERGEN; HBG009362; -.
DR InParanoid; Q9Y3E0; -.
DR OMA; FFPVAIN; -.
DR PhylomeDB; Q9Y3E0; -.
DR GeneWiki; GOLT1B; -.
DR GenomeRNAi; 51026; -.
DR NextBio; 53565; -.
DR PRO; PR:Q9Y3E0; -.
DR ArrayExpress; Q9Y3E0; -.
DR Bgee; Q9Y3E0; -.
DR CleanEx; HS_GOLT1B; -.
DR Genevestigator; Q9Y3E0; -.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0004871; F:signal transducer activity; IMP:UniProtKB.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR007305; Vesicle_transpt_Got1/SFT2.
DR Pfam; PF04178; Got1; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Golgi apparatus; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1 138 Vesicle transport protein GOT1B.
FT /FTId=PRO_0000218582.
FT TOPO_DOM 1 9 Cytoplasmic (Potential).
FT TRANSMEM 10 30 Helical; Name=1; (Potential).
FT TOPO_DOM 31 32 Lumenal (Potential).
FT TRANSMEM 33 53 Helical; Name=2; (Potential).
FT TOPO_DOM 54 68 Cytoplasmic (Potential).
FT TRANSMEM 69 89 Helical; Name=3; (Potential).
FT TOPO_DOM 90 90 Lumenal (Potential).
FT TRANSMEM 91 109 Helical; Name=4; (Potential).
FT TOPO_DOM 110 138 Cytoplasmic (Potential).
FT COMPBIAS 17 108 Phe-rich.
FT CONFLICT 37 37 I -> T (in Ref. 5; AAF65181).
FT CONFLICT 54 54 R -> K (in Ref. 6; CAG33670).
SQ SEQUENCE 138 AA; 15426 MW; 2EB85823C34EFAFA CRC64;
MISLTDTQKI GMGLTGFGVF FLFFGMILFF DKALLAIGNV LFVAGLAFVI GLERTFRFFF
QKHKMKATGF FLGGVFVVLI GWPLIGMIFE IYGFFLLFRG FFPVVVGFIR RVPVLGSLLN
LPGIRSFVDK VGESNNMV
//
MIM
615078
*RECORD*
*FIELD* NO
615078
*FIELD* TI
*615078 GOLGI TRANSPORT 1B; GOLT1B
;;GOT1B;;
GERM CELL TUMOR 2; GCT2
*FIELD* TX
CLONING
read more
Using combined comparative genomic hybridization and expression EST
array analysis to identify genes in a region of chromosome 12 amplified
in seminomas and in an ovarian carcinoma cell line compared with normal
tissue, Bourdon et al. (2002) identified GOLT1B, which they designated
GCT2. RT-PCR detected GOLT1B expression in all 16 normal human tissues
examined. Elevated GOLT1B expression was present in a majority of
seminomas compared with normal testis.
GENE STRUCTURE
Bourdon et al. (2002) determined that the GOLT1B gene contains 5 exons
and spans about 14.5 kb.
MAPPING
By genomic sequence analysis, Bourdon et al. (2002) mapped the GOLT1B
gene to chromosome 12p12-p11.
*FIELD* RF
1. Bourdon, V.; Naef, F.; Rao, P. H.; Reuter, V.; Mok, S. C.; Bosl,
G. J.; Koul, S.; Murty, V. V. V. S.; Kucherlapati, R. S.; Chaganti,
R. S. K.: Genomic and expression analysis of the 12p11-p12 amplicon
using EST arrays identifies two novel amplified and overexpressed
genes. Cancer Res. 62: 6218-6223, 2002.
*FIELD* CD
Patricia A. Hartz: 2/13/2013
*FIELD* ED
mgross: 02/13/2013
mgross: 2/13/2013
*RECORD*
*FIELD* NO
615078
*FIELD* TI
*615078 GOLGI TRANSPORT 1B; GOLT1B
;;GOT1B;;
GERM CELL TUMOR 2; GCT2
*FIELD* TX
CLONING
read more
Using combined comparative genomic hybridization and expression EST
array analysis to identify genes in a region of chromosome 12 amplified
in seminomas and in an ovarian carcinoma cell line compared with normal
tissue, Bourdon et al. (2002) identified GOLT1B, which they designated
GCT2. RT-PCR detected GOLT1B expression in all 16 normal human tissues
examined. Elevated GOLT1B expression was present in a majority of
seminomas compared with normal testis.
GENE STRUCTURE
Bourdon et al. (2002) determined that the GOLT1B gene contains 5 exons
and spans about 14.5 kb.
MAPPING
By genomic sequence analysis, Bourdon et al. (2002) mapped the GOLT1B
gene to chromosome 12p12-p11.
*FIELD* RF
1. Bourdon, V.; Naef, F.; Rao, P. H.; Reuter, V.; Mok, S. C.; Bosl,
G. J.; Koul, S.; Murty, V. V. V. S.; Kucherlapati, R. S.; Chaganti,
R. S. K.: Genomic and expression analysis of the 12p11-p12 amplicon
using EST arrays identifies two novel amplified and overexpressed
genes. Cancer Res. 62: 6218-6223, 2002.
*FIELD* CD
Patricia A. Hartz: 2/13/2013
*FIELD* ED
mgross: 02/13/2013
mgross: 2/13/2013