Full text data of GSKIP
GSKIP
(C14orf129)
[Confidence: low (only semi-automatic identification from reviews)]
GSK3-beta interaction protein; GSKIP
Note: presumably soluble (membrane word is not in UniProt keywords or features)
GSK3-beta interaction protein; GSKIP
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q9P0R6
ID GSKIP_HUMAN Reviewed; 139 AA.
AC Q9P0R6; B3KSZ0; Q9BST1; Q9NWK0;
DT 09-SEP-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 09-SEP-2003, sequence version 2.
DT 22-JAN-2014, entry version 98.
DE RecName: Full=GSK3-beta interaction protein;
DE Short=GSKIP;
GN Name=GSKIP; Synonyms=C14orf129; ORFNames=HSPC210;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Umbilical cord blood;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for
RT 300 previously undefined genes expressed in CD34+ hematopoietic
RT stem/progenitor cells.";
RL Genome Res. 10:1546-1560(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala, and Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA Quetier F., Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP INTERACTION WITH GSK3B, SUBCELLULAR LOCATION, MUTAGENESIS OF LEU-130,
RP AND TISSUE SPECIFICITY.
RX PubMed=16981698; DOI=10.1021/bi061147r;
RA Chou H.-Y., Howng S.-L., Cheng T.-S., Hsiao Y.-L., Lieu A.-S.,
RA Loh J.-K., Hwang S.-L., Lin C.-C., Hsu C.-M., Wang C., Lee C.-I.,
RA Lu P.-J., Chou C.-K., Huang C.-Y., Hong Y.-R.;
RT "GSKIP is homologous to the axin GSK3beta interaction domain and
RT functions as a negative regulator of GSK3beta.";
RL Biochemistry 45:11379-11389(2006).
RN [7]
RP STRUCTURE BY NMR.
RG Northeast structural genomics consortium (NESG);
RT "NMR structure of the human C14orf129 gene product, HSPC210. Northeast
RT structural genomics target HR969.";
RL Submitted (JAN-2005) to the PDB data bank.
CC -!- SUBUNIT: Interacts with GSK3B.
CC -!- INTERACTION:
CC P49841:GSK3B; NbExp=1; IntAct=EBI-1052580, EBI-373586;
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- TISSUE SPECIFICITY: Detected in heart, brain, placenta, liver,
CC skeletal muscle, kidney, testis, lung and pancreas.
CC -!- SIMILARITY: Belongs to the UPF0279 family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF36130.1; Type=Frameshift; Positions=132;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF151044; AAF36130.1; ALT_FRAME; mRNA.
DR EMBL; AK000796; BAA91380.1; -; mRNA.
DR EMBL; AK094654; BAG52902.1; -; mRNA.
DR EMBL; AL359240; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471061; EAW81634.1; -; Genomic_DNA.
DR EMBL; BC004818; AAH04818.1; -; mRNA.
DR RefSeq; NP_001258833.1; NM_001271904.1.
DR RefSeq; NP_001258834.1; NM_001271905.1.
DR RefSeq; NP_001258835.1; NM_001271906.1.
DR RefSeq; NP_057556.2; NM_016472.4.
DR UniGene; Hs.4104; -.
DR UniGene; Hs.745067; -.
DR PDB; 1SGO; NMR; -; A=1-139.
DR PDBsum; 1SGO; -.
DR ProteinModelPortal; Q9P0R6; -.
DR SMR; Q9P0R6; 1-139.
DR IntAct; Q9P0R6; 4.
DR STRING; 9606.ENSP00000330180; -.
DR DMDM; 34582343; -.
DR PaxDb; Q9P0R6; -.
DR PRIDE; Q9P0R6; -.
DR Ensembl; ENST00000438650; ENSP00000412315; ENSG00000100744.
DR Ensembl; ENST00000554182; ENSP00000451384; ENSG00000100744.
DR Ensembl; ENST00000555181; ENSP00000450420; ENSG00000100744.
DR Ensembl; ENST00000556095; ENSP00000451188; ENSG00000100744.
DR GeneID; 51527; -.
DR KEGG; hsa:51527; -.
DR UCSC; uc001yfj.5; human.
DR CTD; 51527; -.
DR GeneCards; GC14P096831; -.
DR H-InvDB; HIX0011950; -.
DR HGNC; HGNC:20343; GSKIP.
DR HPA; HPA043054; -.
DR HPA; HPA046782; -.
DR neXtProt; NX_Q9P0R6; -.
DR PharmGKB; PA134987554; -.
DR eggNOG; NOG319081; -.
DR HOGENOM; HOG000007951; -.
DR HOVERGEN; HBG051028; -.
DR InParanoid; Q9P0R6; -.
DR OMA; RERNRYC; -.
DR OrthoDB; EOG783MXF; -.
DR EvolutionaryTrace; Q9P0R6; -.
DR GenomeRNAi; 51527; -.
DR NextBio; 55240; -.
DR PRO; PR:Q9P0R6; -.
DR ArrayExpress; Q9P0R6; -.
DR Bgee; Q9P0R6; -.
DR CleanEx; HS_C14orf129; -.
DR Genevestigator; Q9P0R6; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR007967; DUF727.
DR InterPro; IPR023231; GSKIP_dom.
DR PANTHER; PTHR12490; PTHR12490; 1.
DR Pfam; PF05303; DUF727; 1.
DR ProDom; PD080843; DUF727; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Complete proteome; Cytoplasm; Reference proteome.
FT CHAIN 1 139 GSK3-beta interaction protein.
FT /FTId=PRO_0000220951.
FT REGION 115 139 Interaction with GSK3B.
FT MUTAGEN 130 130 L->P: Loss of interaction with GSK3B.
FT CONFLICT 46 46 F -> S (in Ref. 2; BAA91380).
FT STRAND 10 13
FT HELIX 33 44
FT HELIX 45 47
FT STRAND 48 53
FT STRAND 63 69
FT STRAND 75 81
FT STRAND 84 91
FT STRAND 103 107
FT HELIX 108 114
FT HELIX 116 135
SQ SEQUENCE 139 AA; 15648 MW; A2D8BAF4B458B316 CRC64;
METDCNPMEL SSMSGFEEGS ELNGFEGTDM KDMRLEAEAV VNDVLFAVNN MFVSKSLRCA
DDVAYINVET KERNRYCLEL TEAGLKVVGY AFDQVDDHLQ TPYHETVYSL LDTLSPAYRE
AFGNALLQRL EALKRDGQS
//
ID GSKIP_HUMAN Reviewed; 139 AA.
AC Q9P0R6; B3KSZ0; Q9BST1; Q9NWK0;
DT 09-SEP-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 09-SEP-2003, sequence version 2.
DT 22-JAN-2014, entry version 98.
DE RecName: Full=GSK3-beta interaction protein;
DE Short=GSKIP;
GN Name=GSKIP; Synonyms=C14orf129; ORFNames=HSPC210;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Umbilical cord blood;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for
RT 300 previously undefined genes expressed in CD34+ hematopoietic
RT stem/progenitor cells.";
RL Genome Res. 10:1546-1560(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala, and Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA Quetier F., Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP INTERACTION WITH GSK3B, SUBCELLULAR LOCATION, MUTAGENESIS OF LEU-130,
RP AND TISSUE SPECIFICITY.
RX PubMed=16981698; DOI=10.1021/bi061147r;
RA Chou H.-Y., Howng S.-L., Cheng T.-S., Hsiao Y.-L., Lieu A.-S.,
RA Loh J.-K., Hwang S.-L., Lin C.-C., Hsu C.-M., Wang C., Lee C.-I.,
RA Lu P.-J., Chou C.-K., Huang C.-Y., Hong Y.-R.;
RT "GSKIP is homologous to the axin GSK3beta interaction domain and
RT functions as a negative regulator of GSK3beta.";
RL Biochemistry 45:11379-11389(2006).
RN [7]
RP STRUCTURE BY NMR.
RG Northeast structural genomics consortium (NESG);
RT "NMR structure of the human C14orf129 gene product, HSPC210. Northeast
RT structural genomics target HR969.";
RL Submitted (JAN-2005) to the PDB data bank.
CC -!- SUBUNIT: Interacts with GSK3B.
CC -!- INTERACTION:
CC P49841:GSK3B; NbExp=1; IntAct=EBI-1052580, EBI-373586;
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- TISSUE SPECIFICITY: Detected in heart, brain, placenta, liver,
CC skeletal muscle, kidney, testis, lung and pancreas.
CC -!- SIMILARITY: Belongs to the UPF0279 family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF36130.1; Type=Frameshift; Positions=132;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF151044; AAF36130.1; ALT_FRAME; mRNA.
DR EMBL; AK000796; BAA91380.1; -; mRNA.
DR EMBL; AK094654; BAG52902.1; -; mRNA.
DR EMBL; AL359240; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471061; EAW81634.1; -; Genomic_DNA.
DR EMBL; BC004818; AAH04818.1; -; mRNA.
DR RefSeq; NP_001258833.1; NM_001271904.1.
DR RefSeq; NP_001258834.1; NM_001271905.1.
DR RefSeq; NP_001258835.1; NM_001271906.1.
DR RefSeq; NP_057556.2; NM_016472.4.
DR UniGene; Hs.4104; -.
DR UniGene; Hs.745067; -.
DR PDB; 1SGO; NMR; -; A=1-139.
DR PDBsum; 1SGO; -.
DR ProteinModelPortal; Q9P0R6; -.
DR SMR; Q9P0R6; 1-139.
DR IntAct; Q9P0R6; 4.
DR STRING; 9606.ENSP00000330180; -.
DR DMDM; 34582343; -.
DR PaxDb; Q9P0R6; -.
DR PRIDE; Q9P0R6; -.
DR Ensembl; ENST00000438650; ENSP00000412315; ENSG00000100744.
DR Ensembl; ENST00000554182; ENSP00000451384; ENSG00000100744.
DR Ensembl; ENST00000555181; ENSP00000450420; ENSG00000100744.
DR Ensembl; ENST00000556095; ENSP00000451188; ENSG00000100744.
DR GeneID; 51527; -.
DR KEGG; hsa:51527; -.
DR UCSC; uc001yfj.5; human.
DR CTD; 51527; -.
DR GeneCards; GC14P096831; -.
DR H-InvDB; HIX0011950; -.
DR HGNC; HGNC:20343; GSKIP.
DR HPA; HPA043054; -.
DR HPA; HPA046782; -.
DR neXtProt; NX_Q9P0R6; -.
DR PharmGKB; PA134987554; -.
DR eggNOG; NOG319081; -.
DR HOGENOM; HOG000007951; -.
DR HOVERGEN; HBG051028; -.
DR InParanoid; Q9P0R6; -.
DR OMA; RERNRYC; -.
DR OrthoDB; EOG783MXF; -.
DR EvolutionaryTrace; Q9P0R6; -.
DR GenomeRNAi; 51527; -.
DR NextBio; 55240; -.
DR PRO; PR:Q9P0R6; -.
DR ArrayExpress; Q9P0R6; -.
DR Bgee; Q9P0R6; -.
DR CleanEx; HS_C14orf129; -.
DR Genevestigator; Q9P0R6; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR007967; DUF727.
DR InterPro; IPR023231; GSKIP_dom.
DR PANTHER; PTHR12490; PTHR12490; 1.
DR Pfam; PF05303; DUF727; 1.
DR ProDom; PD080843; DUF727; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Complete proteome; Cytoplasm; Reference proteome.
FT CHAIN 1 139 GSK3-beta interaction protein.
FT /FTId=PRO_0000220951.
FT REGION 115 139 Interaction with GSK3B.
FT MUTAGEN 130 130 L->P: Loss of interaction with GSK3B.
FT CONFLICT 46 46 F -> S (in Ref. 2; BAA91380).
FT STRAND 10 13
FT HELIX 33 44
FT HELIX 45 47
FT STRAND 48 53
FT STRAND 63 69
FT STRAND 75 81
FT STRAND 84 91
FT STRAND 103 107
FT HELIX 108 114
FT HELIX 116 135
SQ SEQUENCE 139 AA; 15648 MW; A2D8BAF4B458B316 CRC64;
METDCNPMEL SSMSGFEEGS ELNGFEGTDM KDMRLEAEAV VNDVLFAVNN MFVSKSLRCA
DDVAYINVET KERNRYCLEL TEAGLKVVGY AFDQVDDHLQ TPYHETVYSL LDTLSPAYRE
AFGNALLQRL EALKRDGQS
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