Full text data of SLC2A14
SLC2A14
(GLUT14, GLUT3)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Solute carrier family 2, facilitated glucose transporter member 14 (Glucose transporter type 14; GLUT-14)
Solute carrier family 2, facilitated glucose transporter member 14 (Glucose transporter type 14; GLUT-14)
Comments
Isoform Q8TDB8-2 was detected.
Isoform Q8TDB8-2 was detected.
UniProt
Q8TDB8
ID GTR14_HUMAN Reviewed; 520 AA.
AC Q8TDB8; B3KVB5; B3KWW7; Q6UY84; Q8TDB9;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-2002, sequence version 1.
DT 22-JAN-2014, entry version 97.
DE RecName: Full=Solute carrier family 2, facilitated glucose transporter member 14;
DE AltName: Full=Glucose transporter type 14;
DE Short=GLUT-14;
GN Name=SLC2A14; Synonyms=GLUT14, GLUT3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=12504846; DOI=10.1006/geno.2002.7010;
RA Wu X., Freeze H.H.;
RT "GLUT14, a duplicon of GLUT3, is specifically expressed in testis as
RT alternative splice forms.";
RL Genomics 80:553-557(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RA Fang X., Wang H., Huo R., Lu L., Xu M., Xu Y.Z., Yin L.L., Li M.J.,
RA Zhou M.Z., Sha H.J.;
RT "Cloning of an isoform of SCL2A14 gene related to spermatogenesis.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Fetal brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Facilitative glucose transporter (By similarity). May
CC have a specific function related to spermatogenesis.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=GLUT14-L;
CC IsoId=Q8TDB8-1; Sequence=Displayed;
CC Name=2; Synonyms=GLUT14-S;
CC IsoId=Q8TDB8-2; Sequence=VSP_014450;
CC Name=3;
CC IsoId=Q8TDB8-3; Sequence=VSP_014449;
CC Note=No experimental confirmation available;
CC -!- TISSUE SPECIFICITY: Expressed mainly in testis.
CC -!- MISCELLANEOUS: GLUT14 is a recent (less than 5 M year old)
CC duplication of GLUT3.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF481878; AAL89709.1; -; mRNA.
DR EMBL; AF481879; AAL89710.1; -; mRNA.
DR EMBL; AL110298; CAB53739.2; -; mRNA.
DR EMBL; AY357941; AAQ63763.1; -; mRNA.
DR EMBL; AK122783; BAG53727.1; -; mRNA.
DR EMBL; AK126026; BAG54279.1; -; mRNA.
DR EMBL; CH471116; EAW88652.1; -; Genomic_DNA.
DR EMBL; CH471116; EAW88653.1; -; Genomic_DNA.
DR EMBL; BC060766; AAH60766.1; -; mRNA.
DR RefSeq; NP_001273162.1; NM_001286233.1.
DR RefSeq; NP_001273163.1; NM_001286234.1.
DR RefSeq; NP_001273164.1; NM_001286235.1.
DR RefSeq; NP_001273165.1; NM_001286236.1.
DR RefSeq; NP_001273166.1; NM_001286237.1.
DR RefSeq; NP_703150.1; NM_153449.3.
DR RefSeq; XP_005253372.1; XM_005253315.1.
DR RefSeq; XP_005253374.1; XM_005253317.1.
DR UniGene; Hs.655169; -.
DR ProteinModelPortal; Q8TDB8; -.
DR SMR; Q8TDB8; 33-490.
DR TCDB; 2.A.1.1.90; the major facilitator superfamily (mfs).
DR PhosphoSite; Q8TDB8; -.
DR DMDM; 68565598; -.
DR PaxDb; Q8TDB8; -.
DR PRIDE; Q8TDB8; -.
DR Ensembl; ENST00000340749; ENSP00000340450; ENSG00000173262.
DR Ensembl; ENST00000396589; ENSP00000379834; ENSG00000173262.
DR Ensembl; ENST00000431042; ENSP00000407287; ENSG00000173262.
DR Ensembl; ENST00000542505; ENSP00000438484; ENSG00000173262.
DR Ensembl; ENST00000543909; ENSP00000440480; ENSG00000173262.
DR GeneID; 144195; -.
DR KEGG; hsa:144195; -.
DR UCSC; uc001qtk.3; human.
DR CTD; 144195; -.
DR GeneCards; GC12M007965; -.
DR HGNC; HGNC:18301; SLC2A14.
DR HPA; HPA006539; -.
DR MIM; 611039; gene.
DR neXtProt; NX_Q8TDB8; -.
DR PharmGKB; PA134885058; -.
DR eggNOG; COG0477; -.
DR HOGENOM; HOG000202871; -.
DR HOVERGEN; HBG014816; -.
DR InParanoid; Q8TDB8; -.
DR OrthoDB; EOG7QVM2R; -.
DR PhylomeDB; Q8TDB8; -.
DR ChiTaRS; SLC2A14; human.
DR GeneWiki; SLC2A14; -.
DR GenomeRNAi; 144195; -.
DR NextBio; 84858; -.
DR PRO; PR:Q8TDB8; -.
DR ArrayExpress; Q8TDB8; -.
DR Bgee; Q8TDB8; -.
DR CleanEx; HS_SLC2A14; -.
DR Genevestigator; Q8TDB8; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005355; F:glucose transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0015758; P:glucose transport; IEA:GOC.
DR GO; GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR002945; Glc_transpt_3.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR016196; MFS_dom_general_subst_transpt.
DR InterPro; IPR005828; Sub_transporter.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR01192; GLUCTRSPORT3.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 2.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; Developmental protein;
KW Differentiation; Glycoprotein; Membrane; Polymorphism;
KW Reference proteome; Spermatogenesis; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1 520 Solute carrier family 2, facilitated
FT glucose transporter member 14.
FT /FTId=PRO_0000050381.
FT TOPO_DOM 1 29 Cytoplasmic (Potential).
FT TRANSMEM 30 50 Helical; Name=1; (Potential).
FT TOPO_DOM 51 88 Extracellular (Potential).
FT TRANSMEM 89 109 Helical; Name=2; (Potential).
FT TOPO_DOM 110 117 Cytoplasmic (Potential).
FT TRANSMEM 118 138 Helical; Name=3; (Potential).
FT TOPO_DOM 139 148 Extracellular (Potential).
FT TRANSMEM 149 169 Helical; Name=4; (Potential).
FT TOPO_DOM 170 177 Cytoplasmic (Potential).
FT TRANSMEM 178 198 Helical; Name=5; (Potential).
FT TOPO_DOM 199 207 Extracellular (Potential).
FT TRANSMEM 208 228 Helical; Name=6; (Potential).
FT TOPO_DOM 229 293 Cytoplasmic (Potential).
FT TRANSMEM 294 314 Helical; Name=7; (Potential).
FT TOPO_DOM 315 328 Extracellular (Potential).
FT TRANSMEM 329 349 Helical; Name=8; (Potential).
FT TOPO_DOM 350 358 Cytoplasmic (Potential).
FT TRANSMEM 359 379 Helical; Name=9; (Potential).
FT TOPO_DOM 380 392 Extracellular (Potential).
FT TRANSMEM 393 413 Helical; Name=10; (Potential).
FT TOPO_DOM 414 423 Cytoplasmic (Potential).
FT TRANSMEM 424 444 Helical; Name=11; (Potential).
FT TOPO_DOM 445 451 Extracellular (Potential).
FT TRANSMEM 452 472 Helical; Name=12; (Potential).
FT TOPO_DOM 473 520 Cytoplasmic (Potential).
FT REGION 301 303 Defines substrate specificity (By
FT similarity).
FT CARBOHYD 67 67 N-linked (GlcNAc...) (Potential).
FT VAR_SEQ 1 359 Missing (in isoform 3).
FT /FTId=VSP_014449.
FT VAR_SEQ 1 29 MEFHNGGHVSGIGGFLVSLTSRMKPHTLA -> MDNRQN
FT (in isoform 2).
FT /FTId=VSP_014450.
FT VARIANT 506 506 G -> E (in dbSNP:rs10845981).
FT /FTId=VAR_059852.
FT CONFLICT 369 369 C -> G (in Ref. 2; AAQ63763).
FT CONFLICT 376 377 SL -> PC (in Ref. 2; AAQ63763).
FT CONFLICT 456 456 F -> L (in Ref. 4; CAB53739).
SQ SEQUENCE 520 AA; 56320 MW; EA304A5189087690 CRC64;
MEFHNGGHVS GIGGFLVSLT SRMKPHTLAV TPALIFAITV ATIGSFQFGY NTGVINAPET
IIKEFINKTL TDKANAPPSE VLLTNLWSLS VAIFSVGGMI GSFSVGLFVN RFGRRNSMLI
VNLLAATGGC LMGLCKIAES VEMLILGRLV IGLFCGLCTG FVPMYIGEIS PTALRGAFGT
LNQLGIVIGI LVAQIFGLEL ILGSEELWPV LLGFTILPAI LQSAALPCCP ESPRFLLINR
KKEENATRIL QRLWGTQDVS QDIQEMKDES ARMSQEKQVT VLELFRVSSY RQPIIISIVL
QLSQQLSGIN AVFYYSTGIF KDAGVQQPIY ATISAGVVNT IFTLLSLFLV ERAGRRTLHM
IGLGGMAFCS TLMTVSLLLK NHYNGMSFVC IGAILVFVAC FEIGPGPIPW FIVAELFSQG
PRPAAMAVAG CSNWTSNFLV GLLFPSAAYY LGAYVFIIFT GFLITFLAFT FFKVPETRGR
TFEDITRAFE GQAHGADRSG KDGVMGMNSI EPAKETTTNV
//
ID GTR14_HUMAN Reviewed; 520 AA.
AC Q8TDB8; B3KVB5; B3KWW7; Q6UY84; Q8TDB9;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-2002, sequence version 1.
DT 22-JAN-2014, entry version 97.
DE RecName: Full=Solute carrier family 2, facilitated glucose transporter member 14;
DE AltName: Full=Glucose transporter type 14;
DE Short=GLUT-14;
GN Name=SLC2A14; Synonyms=GLUT14, GLUT3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=12504846; DOI=10.1006/geno.2002.7010;
RA Wu X., Freeze H.H.;
RT "GLUT14, a duplicon of GLUT3, is specifically expressed in testis as
RT alternative splice forms.";
RL Genomics 80:553-557(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RA Fang X., Wang H., Huo R., Lu L., Xu M., Xu Y.Z., Yin L.L., Li M.J.,
RA Zhou M.Z., Sha H.J.;
RT "Cloning of an isoform of SCL2A14 gene related to spermatogenesis.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Fetal brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Facilitative glucose transporter (By similarity). May
CC have a specific function related to spermatogenesis.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=GLUT14-L;
CC IsoId=Q8TDB8-1; Sequence=Displayed;
CC Name=2; Synonyms=GLUT14-S;
CC IsoId=Q8TDB8-2; Sequence=VSP_014450;
CC Name=3;
CC IsoId=Q8TDB8-3; Sequence=VSP_014449;
CC Note=No experimental confirmation available;
CC -!- TISSUE SPECIFICITY: Expressed mainly in testis.
CC -!- MISCELLANEOUS: GLUT14 is a recent (less than 5 M year old)
CC duplication of GLUT3.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF481878; AAL89709.1; -; mRNA.
DR EMBL; AF481879; AAL89710.1; -; mRNA.
DR EMBL; AL110298; CAB53739.2; -; mRNA.
DR EMBL; AY357941; AAQ63763.1; -; mRNA.
DR EMBL; AK122783; BAG53727.1; -; mRNA.
DR EMBL; AK126026; BAG54279.1; -; mRNA.
DR EMBL; CH471116; EAW88652.1; -; Genomic_DNA.
DR EMBL; CH471116; EAW88653.1; -; Genomic_DNA.
DR EMBL; BC060766; AAH60766.1; -; mRNA.
DR RefSeq; NP_001273162.1; NM_001286233.1.
DR RefSeq; NP_001273163.1; NM_001286234.1.
DR RefSeq; NP_001273164.1; NM_001286235.1.
DR RefSeq; NP_001273165.1; NM_001286236.1.
DR RefSeq; NP_001273166.1; NM_001286237.1.
DR RefSeq; NP_703150.1; NM_153449.3.
DR RefSeq; XP_005253372.1; XM_005253315.1.
DR RefSeq; XP_005253374.1; XM_005253317.1.
DR UniGene; Hs.655169; -.
DR ProteinModelPortal; Q8TDB8; -.
DR SMR; Q8TDB8; 33-490.
DR TCDB; 2.A.1.1.90; the major facilitator superfamily (mfs).
DR PhosphoSite; Q8TDB8; -.
DR DMDM; 68565598; -.
DR PaxDb; Q8TDB8; -.
DR PRIDE; Q8TDB8; -.
DR Ensembl; ENST00000340749; ENSP00000340450; ENSG00000173262.
DR Ensembl; ENST00000396589; ENSP00000379834; ENSG00000173262.
DR Ensembl; ENST00000431042; ENSP00000407287; ENSG00000173262.
DR Ensembl; ENST00000542505; ENSP00000438484; ENSG00000173262.
DR Ensembl; ENST00000543909; ENSP00000440480; ENSG00000173262.
DR GeneID; 144195; -.
DR KEGG; hsa:144195; -.
DR UCSC; uc001qtk.3; human.
DR CTD; 144195; -.
DR GeneCards; GC12M007965; -.
DR HGNC; HGNC:18301; SLC2A14.
DR HPA; HPA006539; -.
DR MIM; 611039; gene.
DR neXtProt; NX_Q8TDB8; -.
DR PharmGKB; PA134885058; -.
DR eggNOG; COG0477; -.
DR HOGENOM; HOG000202871; -.
DR HOVERGEN; HBG014816; -.
DR InParanoid; Q8TDB8; -.
DR OrthoDB; EOG7QVM2R; -.
DR PhylomeDB; Q8TDB8; -.
DR ChiTaRS; SLC2A14; human.
DR GeneWiki; SLC2A14; -.
DR GenomeRNAi; 144195; -.
DR NextBio; 84858; -.
DR PRO; PR:Q8TDB8; -.
DR ArrayExpress; Q8TDB8; -.
DR Bgee; Q8TDB8; -.
DR CleanEx; HS_SLC2A14; -.
DR Genevestigator; Q8TDB8; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005355; F:glucose transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0015758; P:glucose transport; IEA:GOC.
DR GO; GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR002945; Glc_transpt_3.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR016196; MFS_dom_general_subst_transpt.
DR InterPro; IPR005828; Sub_transporter.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR01192; GLUCTRSPORT3.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 2.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; Developmental protein;
KW Differentiation; Glycoprotein; Membrane; Polymorphism;
KW Reference proteome; Spermatogenesis; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1 520 Solute carrier family 2, facilitated
FT glucose transporter member 14.
FT /FTId=PRO_0000050381.
FT TOPO_DOM 1 29 Cytoplasmic (Potential).
FT TRANSMEM 30 50 Helical; Name=1; (Potential).
FT TOPO_DOM 51 88 Extracellular (Potential).
FT TRANSMEM 89 109 Helical; Name=2; (Potential).
FT TOPO_DOM 110 117 Cytoplasmic (Potential).
FT TRANSMEM 118 138 Helical; Name=3; (Potential).
FT TOPO_DOM 139 148 Extracellular (Potential).
FT TRANSMEM 149 169 Helical; Name=4; (Potential).
FT TOPO_DOM 170 177 Cytoplasmic (Potential).
FT TRANSMEM 178 198 Helical; Name=5; (Potential).
FT TOPO_DOM 199 207 Extracellular (Potential).
FT TRANSMEM 208 228 Helical; Name=6; (Potential).
FT TOPO_DOM 229 293 Cytoplasmic (Potential).
FT TRANSMEM 294 314 Helical; Name=7; (Potential).
FT TOPO_DOM 315 328 Extracellular (Potential).
FT TRANSMEM 329 349 Helical; Name=8; (Potential).
FT TOPO_DOM 350 358 Cytoplasmic (Potential).
FT TRANSMEM 359 379 Helical; Name=9; (Potential).
FT TOPO_DOM 380 392 Extracellular (Potential).
FT TRANSMEM 393 413 Helical; Name=10; (Potential).
FT TOPO_DOM 414 423 Cytoplasmic (Potential).
FT TRANSMEM 424 444 Helical; Name=11; (Potential).
FT TOPO_DOM 445 451 Extracellular (Potential).
FT TRANSMEM 452 472 Helical; Name=12; (Potential).
FT TOPO_DOM 473 520 Cytoplasmic (Potential).
FT REGION 301 303 Defines substrate specificity (By
FT similarity).
FT CARBOHYD 67 67 N-linked (GlcNAc...) (Potential).
FT VAR_SEQ 1 359 Missing (in isoform 3).
FT /FTId=VSP_014449.
FT VAR_SEQ 1 29 MEFHNGGHVSGIGGFLVSLTSRMKPHTLA -> MDNRQN
FT (in isoform 2).
FT /FTId=VSP_014450.
FT VARIANT 506 506 G -> E (in dbSNP:rs10845981).
FT /FTId=VAR_059852.
FT CONFLICT 369 369 C -> G (in Ref. 2; AAQ63763).
FT CONFLICT 376 377 SL -> PC (in Ref. 2; AAQ63763).
FT CONFLICT 456 456 F -> L (in Ref. 4; CAB53739).
SQ SEQUENCE 520 AA; 56320 MW; EA304A5189087690 CRC64;
MEFHNGGHVS GIGGFLVSLT SRMKPHTLAV TPALIFAITV ATIGSFQFGY NTGVINAPET
IIKEFINKTL TDKANAPPSE VLLTNLWSLS VAIFSVGGMI GSFSVGLFVN RFGRRNSMLI
VNLLAATGGC LMGLCKIAES VEMLILGRLV IGLFCGLCTG FVPMYIGEIS PTALRGAFGT
LNQLGIVIGI LVAQIFGLEL ILGSEELWPV LLGFTILPAI LQSAALPCCP ESPRFLLINR
KKEENATRIL QRLWGTQDVS QDIQEMKDES ARMSQEKQVT VLELFRVSSY RQPIIISIVL
QLSQQLSGIN AVFYYSTGIF KDAGVQQPIY ATISAGVVNT IFTLLSLFLV ERAGRRTLHM
IGLGGMAFCS TLMTVSLLLK NHYNGMSFVC IGAILVFVAC FEIGPGPIPW FIVAELFSQG
PRPAAMAVAG CSNWTSNFLV GLLFPSAAYY LGAYVFIIFT GFLITFLAFT FFKVPETRGR
TFEDITRAFE GQAHGADRSG KDGVMGMNSI EPAKETTTNV
//
MIM
611039
*RECORD*
*FIELD* NO
611039
*FIELD* TI
*611039 SOLUTE CARRIER FAMILY 2 (FACILITATED GLUCOSE TRANSPORTER), MEMBER
14; SLC2A14
read more;;GLUCOSE TRANSPORTER 14; GLUT14
*FIELD* TX
DESCRIPTION
Members of the glucose transporter (GLUT) family, including SLC2A14, are
highly conserved integral membrane proteins that transport hexoses such
as glucose and fructose into all mammalian cells. GLUTs show tissue and
cell-type specific expression (Wu and Freeze, 2002).
CLONING
By database analysis, followed by PCR of a human testis cDNA library, Wu
and Freeze (2002) cloned SLC2A14. They identified 2 alternatively
spliced forms. The short isoform has 10 exons and encodes a 497-amino
acid protein that shares 94.5% identity with SLC2A3 (138170). The long
isoform has 11 exons and encodes a 520-amino acid protein that differs
from the short isoform by inclusion of exon 1b. SLC2A14 contains 12
transmembrane domains, a putative glycosylation site, and sugar
transporter signature motifs. RT-PCR analysis showed that both isoforms
were expressed in testis only.
GENE STRUCTURE
Wu and Freeze (2002) determined that the SLC2A14 gene contains 11 exons.
Exon 1b of the long isoform disrupts the reading frame, but a secondary
ATG codon within exon 1b allows synthesis of a functional protein.
MAPPING
By genomic sequence analysis, Wu and Freeze (2002) mapped the SLC2A14
gene to chromosome 12p13.3, about 10 Mb upstream of SLC2A3.
EVOLUTION
Wu and Freeze (2002) performed sequence comparison of SLC2A14 and SLC2A3
and concluded that SLC2A14 likely resulted from gene duplication of
SLC2A3.
*FIELD* RF
1. Wu, X.; Freeze, H. H.: GLUT14, a duplicon of GLUT3, is specifically
expressed in testis as alternative splice forms. Genomics 80: 553-557,
2002. Note: Erratum: Genomics 81: 347 only, 2003.
*FIELD* CD
Stefanie A. Nelson: 5/17/2007
*FIELD* ED
joanna: 08/27/2007
wwang: 5/17/2007
*RECORD*
*FIELD* NO
611039
*FIELD* TI
*611039 SOLUTE CARRIER FAMILY 2 (FACILITATED GLUCOSE TRANSPORTER), MEMBER
14; SLC2A14
read more;;GLUCOSE TRANSPORTER 14; GLUT14
*FIELD* TX
DESCRIPTION
Members of the glucose transporter (GLUT) family, including SLC2A14, are
highly conserved integral membrane proteins that transport hexoses such
as glucose and fructose into all mammalian cells. GLUTs show tissue and
cell-type specific expression (Wu and Freeze, 2002).
CLONING
By database analysis, followed by PCR of a human testis cDNA library, Wu
and Freeze (2002) cloned SLC2A14. They identified 2 alternatively
spliced forms. The short isoform has 10 exons and encodes a 497-amino
acid protein that shares 94.5% identity with SLC2A3 (138170). The long
isoform has 11 exons and encodes a 520-amino acid protein that differs
from the short isoform by inclusion of exon 1b. SLC2A14 contains 12
transmembrane domains, a putative glycosylation site, and sugar
transporter signature motifs. RT-PCR analysis showed that both isoforms
were expressed in testis only.
GENE STRUCTURE
Wu and Freeze (2002) determined that the SLC2A14 gene contains 11 exons.
Exon 1b of the long isoform disrupts the reading frame, but a secondary
ATG codon within exon 1b allows synthesis of a functional protein.
MAPPING
By genomic sequence analysis, Wu and Freeze (2002) mapped the SLC2A14
gene to chromosome 12p13.3, about 10 Mb upstream of SLC2A3.
EVOLUTION
Wu and Freeze (2002) performed sequence comparison of SLC2A14 and SLC2A3
and concluded that SLC2A14 likely resulted from gene duplication of
SLC2A3.
*FIELD* RF
1. Wu, X.; Freeze, H. H.: GLUT14, a duplicon of GLUT3, is specifically
expressed in testis as alternative splice forms. Genomics 80: 553-557,
2002. Note: Erratum: Genomics 81: 347 only, 2003.
*FIELD* CD
Stefanie A. Nelson: 5/17/2007
*FIELD* ED
joanna: 08/27/2007
wwang: 5/17/2007