Full text data of HIST1H1D
HIST1H1D
(H1F3)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Histone H1.3 (Histone H1c; Histone H1s-2)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Histone H1.3 (Histone H1c; Histone H1s-2)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
P16402
ID H13_HUMAN Reviewed; 221 AA.
AC P16402; B2R751; Q2M2I2;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 2.
DT 22-JAN-2014, entry version 128.
DE RecName: Full=Histone H1.3;
DE AltName: Full=Histone H1c;
DE AltName: Full=Histone H1s-2;
GN Name=HIST1H1D; Synonyms=H1F3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1916825; DOI=10.1016/0888-7543(91)90183-F;
RA Albig W., Kardalinou E., Drabent B., Zimmer A., Doenecke D.;
RT "Isolation and characterization of two human H1 histone genes within
RT clusters of core histone genes.";
RL Genomics 10:940-948(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12408966; DOI=10.1016/S0888-7543(02)96850-3;
RA Marzluff W.F., Gongidi P., Woods K.R., Jin J., Maltais L.J.;
RT "The human and mouse replication-dependent histone genes.";
RL Genomics 80:487-498(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PROTEIN SEQUENCE OF 2-221.
RC TISSUE=Spleen;
RX PubMed=2613692;
RA Ohe Y., Hayashi H., Iwai K.;
RT "Human spleen histone H1. Isolation and amino acid sequences of three
RT minor variants, H1a, H1c, and H1d.";
RL J. Biochem. 106:844-857(1989).
RN [8]
RP NOMENCLATURE.
RX PubMed=8003976; DOI=10.1002/pro.5560030406;
RA Parseghian M.H., Henschen A.H., Krieglstein K.G., Hamkalo B.A.;
RT "A proposal for a coherent mammalian histone H1 nomenclature
RT correlated with amino acid sequences.";
RL Protein Sci. 3:575-587(1994).
RN [9]
RP SUBCELLULAR LOCATION.
RX PubMed=10997781; DOI=10.1023/A:1009262819961;
RA Parseghian M.H., Newcomb R.L., Winokur S.T., Hamkalo B.A.;
RT "The distribution of somatic H1 subtypes is non-random on active vs.
RT inactive chromatin: distribution in human fetal fibroblasts.";
RL Chromosome Res. 8:405-424(2000).
RN [10]
RP SUBCELLULAR LOCATION.
RX PubMed=11746507; DOI=10.1002/jcb.1224;
RA Parseghian M.H., Newcomb R.L., Hamkalo B.A.;
RT "Distribution of somatic H1 subtypes is non-random on active vs.
RT inactive chromatin II: distribution in human adult fibroblasts.";
RL J. Cell. Biochem. 83:643-659(2001).
RN [11]
RP SUBCELLULAR LOCATION.
RX PubMed=15911621; DOI=10.1074/jbc.M501627200;
RA Th'ng J.P., Sung R., Ye M., Hendzel M.J.;
RT "H1 family histones in the nucleus. Control of binding and
RT localization by the C-terminal domain.";
RL J. Biol. Chem. 280:27809-27814(2005).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,
RA Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in
RT signaling networks.";
RL Cell 127:635-648(2006).
RN [13]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [14]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [15]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE
RP SCALE ANALYSIS] AT SER-2 AND THR-18, AND MASS SPECTROMETRY.
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA Blagoev B.;
RT "System-wide temporal characterization of the proteome and
RT phosphoproteome of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
CC -!- FUNCTION: Histone H1 protein binds to linker DNA between
CC nucleosomes forming the macromolecular structure known as the
CC chromatin fiber. Histones H1 are necessary for the condensation of
CC nucleosome chains into higher-order structured fibers. Acts also
CC as a regulator of individual gene transcription through chromatin
CC remodeling, nucleosome spacing and DNA methylation (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=According to
CC PubMed:15911621 more commonly found in euchromatin. According to
CC PubMed:10997781 is associated with inactive chromatin.
CC -!- DOMAIN: The C-terminal domain is required for high-affinity
CC binding to chromatin (By similarity).
CC -!- PTM: H1 histones are progressively phosphorylated during the cell
CC cycle, becoming maximally phosphorylated during late G2 phase and
CC M phase, and being dephosphorylated sharply thereafter (By
CC similarity).
CC -!- SIMILARITY: Belongs to the histone H1/H5 family.
CC -!- SIMILARITY: Contains 1 H15 (linker histone H1/H5 globular) domain.
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DR EMBL; M60747; AAA63186.1; -; Genomic_DNA.
DR EMBL; AF531303; AAN06703.1; -; Genomic_DNA.
DR EMBL; AK312845; BAG35698.1; -; mRNA.
DR EMBL; AL031777; CAB39189.1; -; Genomic_DNA.
DR EMBL; CH471087; EAW55548.1; -; Genomic_DNA.
DR EMBL; BC104874; AAI04875.1; -; mRNA.
DR EMBL; BC111971; AAI11972.1; -; mRNA.
DR PIR; B40335; B40335.
DR RefSeq; NP_005311.1; NM_005320.2.
DR UniGene; Hs.136857; -.
DR ProteinModelPortal; P16402; -.
DR SMR; P16402; 37-110.
DR IntAct; P16402; 8.
DR MINT; MINT-3008589; -.
DR STRING; 9606.ENSP00000244534; -.
DR PhosphoSite; P16402; -.
DR DMDM; 121925; -.
DR PaxDb; P16402; -.
DR PRIDE; P16402; -.
DR DNASU; 3007; -.
DR Ensembl; ENST00000244534; ENSP00000244534; ENSG00000124575.
DR GeneID; 3007; -.
DR KEGG; hsa:3007; -.
DR UCSC; uc003nhd.3; human.
DR CTD; 3007; -.
DR GeneCards; GC06M026234; -.
DR HGNC; HGNC:4717; HIST1H1D.
DR HPA; HPA055907; -.
DR MIM; 142210; gene.
DR neXtProt; NX_P16402; -.
DR PharmGKB; PA29095; -.
DR eggNOG; NOG258621; -.
DR HOGENOM; HOG000251627; -.
DR HOVERGEN; HBG009035; -.
DR InParanoid; P16402; -.
DR KO; K11275; -.
DR OrthoDB; EOG74TX2T; -.
DR Reactome; REACT_578; Apoptosis.
DR ChiTaRS; HIST1H1D; human.
DR GeneWiki; HIST1H1D; -.
DR GenomeRNAi; 3007; -.
DR NextBio; 11924; -.
DR PRO; PR:P16402; -.
DR Bgee; P16402; -.
DR CleanEx; HS_HIST1H1D; -.
DR Genevestigator; P16402; -.
DR GO; GO:0000790; C:nuclear chromatin; IDA:UniProtKB.
DR GO; GO:0000786; C:nucleosome; NAS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; NAS:UniProtKB.
DR GO; GO:0006334; P:nucleosome assembly; NAS:UniProtKB.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005818; Histone_H1/H5_H15.
DR InterPro; IPR005819; Histone_H5.
DR InterPro; IPR011991; WHTH_DNA-bd_dom.
DR Pfam; PF00538; Linker_histone; 1.
DR PRINTS; PR00624; HISTONEH5.
DR SMART; SM00526; H15; 1.
DR PROSITE; PS51504; H15; 1.
PE 1: Evidence at protein level;
KW Acetylation; Chromosome; Complete proteome; Direct protein sequencing;
KW DNA-binding; Nucleus; Phosphoprotein; Polymorphism;
KW Reference proteome.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 221 Histone H1.3.
FT /FTId=PRO_0000195907.
FT DOMAIN 37 110 H15.
FT MOD_RES 2 2 N-acetylserine.
FT MOD_RES 2 2 Phosphoserine.
FT MOD_RES 18 18 Phosphothreonine.
FT MOD_RES 37 37 Phosphoserine (By similarity).
FT MOD_RES 105 105 Phosphoserine; by PKC (By similarity).
FT VARIANT 75 75 E -> K (in dbSNP:rs2050949).
FT /FTId=VAR_049306.
SQ SEQUENCE 221 AA; 22350 MW; DB987FE8DE034D12 CRC64;
MSETAPLAPT IPAPAEKTPV KKKAKKAGAT AGKRKASGPP VSELITKAVA ASKERSGVSL
AALKKALAAA GYDVEKNNSR IKLGLKSLVS KGTLVQTKGT GASGSFKLNK KAASGEGKPK
AKKAGAAKPR KPAGAAKKPK KVAGAATPKK SIKKTPKKVK KPATAAGTKK VAKSAKKVKT
PQPKKAAKSP AKAKAPKPKA AKPKSGKPKV TKAKKAAPKK K
//
ID H13_HUMAN Reviewed; 221 AA.
AC P16402; B2R751; Q2M2I2;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 2.
DT 22-JAN-2014, entry version 128.
DE RecName: Full=Histone H1.3;
DE AltName: Full=Histone H1c;
DE AltName: Full=Histone H1s-2;
GN Name=HIST1H1D; Synonyms=H1F3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1916825; DOI=10.1016/0888-7543(91)90183-F;
RA Albig W., Kardalinou E., Drabent B., Zimmer A., Doenecke D.;
RT "Isolation and characterization of two human H1 histone genes within
RT clusters of core histone genes.";
RL Genomics 10:940-948(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12408966; DOI=10.1016/S0888-7543(02)96850-3;
RA Marzluff W.F., Gongidi P., Woods K.R., Jin J., Maltais L.J.;
RT "The human and mouse replication-dependent histone genes.";
RL Genomics 80:487-498(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PROTEIN SEQUENCE OF 2-221.
RC TISSUE=Spleen;
RX PubMed=2613692;
RA Ohe Y., Hayashi H., Iwai K.;
RT "Human spleen histone H1. Isolation and amino acid sequences of three
RT minor variants, H1a, H1c, and H1d.";
RL J. Biochem. 106:844-857(1989).
RN [8]
RP NOMENCLATURE.
RX PubMed=8003976; DOI=10.1002/pro.5560030406;
RA Parseghian M.H., Henschen A.H., Krieglstein K.G., Hamkalo B.A.;
RT "A proposal for a coherent mammalian histone H1 nomenclature
RT correlated with amino acid sequences.";
RL Protein Sci. 3:575-587(1994).
RN [9]
RP SUBCELLULAR LOCATION.
RX PubMed=10997781; DOI=10.1023/A:1009262819961;
RA Parseghian M.H., Newcomb R.L., Winokur S.T., Hamkalo B.A.;
RT "The distribution of somatic H1 subtypes is non-random on active vs.
RT inactive chromatin: distribution in human fetal fibroblasts.";
RL Chromosome Res. 8:405-424(2000).
RN [10]
RP SUBCELLULAR LOCATION.
RX PubMed=11746507; DOI=10.1002/jcb.1224;
RA Parseghian M.H., Newcomb R.L., Hamkalo B.A.;
RT "Distribution of somatic H1 subtypes is non-random on active vs.
RT inactive chromatin II: distribution in human adult fibroblasts.";
RL J. Cell. Biochem. 83:643-659(2001).
RN [11]
RP SUBCELLULAR LOCATION.
RX PubMed=15911621; DOI=10.1074/jbc.M501627200;
RA Th'ng J.P., Sung R., Ye M., Hendzel M.J.;
RT "H1 family histones in the nucleus. Control of binding and
RT localization by the C-terminal domain.";
RL J. Biol. Chem. 280:27809-27814(2005).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,
RA Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in
RT signaling networks.";
RL Cell 127:635-648(2006).
RN [13]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [14]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [15]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE
RP SCALE ANALYSIS] AT SER-2 AND THR-18, AND MASS SPECTROMETRY.
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA Blagoev B.;
RT "System-wide temporal characterization of the proteome and
RT phosphoproteome of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
CC -!- FUNCTION: Histone H1 protein binds to linker DNA between
CC nucleosomes forming the macromolecular structure known as the
CC chromatin fiber. Histones H1 are necessary for the condensation of
CC nucleosome chains into higher-order structured fibers. Acts also
CC as a regulator of individual gene transcription through chromatin
CC remodeling, nucleosome spacing and DNA methylation (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=According to
CC PubMed:15911621 more commonly found in euchromatin. According to
CC PubMed:10997781 is associated with inactive chromatin.
CC -!- DOMAIN: The C-terminal domain is required for high-affinity
CC binding to chromatin (By similarity).
CC -!- PTM: H1 histones are progressively phosphorylated during the cell
CC cycle, becoming maximally phosphorylated during late G2 phase and
CC M phase, and being dephosphorylated sharply thereafter (By
CC similarity).
CC -!- SIMILARITY: Belongs to the histone H1/H5 family.
CC -!- SIMILARITY: Contains 1 H15 (linker histone H1/H5 globular) domain.
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DR EMBL; M60747; AAA63186.1; -; Genomic_DNA.
DR EMBL; AF531303; AAN06703.1; -; Genomic_DNA.
DR EMBL; AK312845; BAG35698.1; -; mRNA.
DR EMBL; AL031777; CAB39189.1; -; Genomic_DNA.
DR EMBL; CH471087; EAW55548.1; -; Genomic_DNA.
DR EMBL; BC104874; AAI04875.1; -; mRNA.
DR EMBL; BC111971; AAI11972.1; -; mRNA.
DR PIR; B40335; B40335.
DR RefSeq; NP_005311.1; NM_005320.2.
DR UniGene; Hs.136857; -.
DR ProteinModelPortal; P16402; -.
DR SMR; P16402; 37-110.
DR IntAct; P16402; 8.
DR MINT; MINT-3008589; -.
DR STRING; 9606.ENSP00000244534; -.
DR PhosphoSite; P16402; -.
DR DMDM; 121925; -.
DR PaxDb; P16402; -.
DR PRIDE; P16402; -.
DR DNASU; 3007; -.
DR Ensembl; ENST00000244534; ENSP00000244534; ENSG00000124575.
DR GeneID; 3007; -.
DR KEGG; hsa:3007; -.
DR UCSC; uc003nhd.3; human.
DR CTD; 3007; -.
DR GeneCards; GC06M026234; -.
DR HGNC; HGNC:4717; HIST1H1D.
DR HPA; HPA055907; -.
DR MIM; 142210; gene.
DR neXtProt; NX_P16402; -.
DR PharmGKB; PA29095; -.
DR eggNOG; NOG258621; -.
DR HOGENOM; HOG000251627; -.
DR HOVERGEN; HBG009035; -.
DR InParanoid; P16402; -.
DR KO; K11275; -.
DR OrthoDB; EOG74TX2T; -.
DR Reactome; REACT_578; Apoptosis.
DR ChiTaRS; HIST1H1D; human.
DR GeneWiki; HIST1H1D; -.
DR GenomeRNAi; 3007; -.
DR NextBio; 11924; -.
DR PRO; PR:P16402; -.
DR Bgee; P16402; -.
DR CleanEx; HS_HIST1H1D; -.
DR Genevestigator; P16402; -.
DR GO; GO:0000790; C:nuclear chromatin; IDA:UniProtKB.
DR GO; GO:0000786; C:nucleosome; NAS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; NAS:UniProtKB.
DR GO; GO:0006334; P:nucleosome assembly; NAS:UniProtKB.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005818; Histone_H1/H5_H15.
DR InterPro; IPR005819; Histone_H5.
DR InterPro; IPR011991; WHTH_DNA-bd_dom.
DR Pfam; PF00538; Linker_histone; 1.
DR PRINTS; PR00624; HISTONEH5.
DR SMART; SM00526; H15; 1.
DR PROSITE; PS51504; H15; 1.
PE 1: Evidence at protein level;
KW Acetylation; Chromosome; Complete proteome; Direct protein sequencing;
KW DNA-binding; Nucleus; Phosphoprotein; Polymorphism;
KW Reference proteome.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 221 Histone H1.3.
FT /FTId=PRO_0000195907.
FT DOMAIN 37 110 H15.
FT MOD_RES 2 2 N-acetylserine.
FT MOD_RES 2 2 Phosphoserine.
FT MOD_RES 18 18 Phosphothreonine.
FT MOD_RES 37 37 Phosphoserine (By similarity).
FT MOD_RES 105 105 Phosphoserine; by PKC (By similarity).
FT VARIANT 75 75 E -> K (in dbSNP:rs2050949).
FT /FTId=VAR_049306.
SQ SEQUENCE 221 AA; 22350 MW; DB987FE8DE034D12 CRC64;
MSETAPLAPT IPAPAEKTPV KKKAKKAGAT AGKRKASGPP VSELITKAVA ASKERSGVSL
AALKKALAAA GYDVEKNNSR IKLGLKSLVS KGTLVQTKGT GASGSFKLNK KAASGEGKPK
AKKAGAAKPR KPAGAAKKPK KVAGAATPKK SIKKTPKKVK KPATAAGTKK VAKSAKKVKT
PQPKKAAKSP AKAKAPKPKA AKPKSGKPKV TKAKKAAPKK K
//
MIM
142210
*RECORD*
*FIELD* NO
142210
*FIELD* TI
*142210 HISTONE GENE CLUSTER 1, H1 HISTONE FAMILY, MEMBER D; HIST1H1D
;;HISTONE GENE CLUSTER 1, H1D;;
read moreHIST1 ClUSTER, H1D;;
H1D;;
H1.3;;
H1 HISTONE FAMILY, MEMBER 3, FORMERLY; H1F3, FORMERLY
*FIELD* TX
For background information on histones, histone gene clusters, and the
H1 histone family, see HIST1H1A (142709).
CLONING
Albig et al. (1991) identified a gene encoding a member of the H1 class
of histones and designated it H1.3.
GENE FUNCTION
See HIST1H1A (142709) for functional information on H1 histones.
MAPPING
By in situ hybridization, Tanguay et al. (1987) mapped the histone H1.3
gene to chromosome 6p12-q21.
By PCR analysis of chromosomal DNA from a panel of human/rodent somatic
cell hybrids and by fluorescence in situ hybridization, Albig et al.
(1993) demonstrated that 6 human H1 histone genes, including H1.3, are
located on chromosome 6p22.2-p21.1. By analysis of a YAC contig, Albig
et al. (1997) mapped the H1.3 gene to chromosome 6p21.3 within a cluster
of 35 histone genes, including H1.1 (HIST1H1A; 142709) to H1.4
(HIST1H1E; 142220) and H1T (HIST1H1T; 142712). The H1.5 gene (HIST1H1B;
142711) is part of a separate subcluster within the same chromosomal
region.
By genomic sequence analysis, Marzluff et al. (2002) determined that the
histone gene cluster on chromosome 6p22-p21, which they called histone
gene cluster-1 (HIST1), contains 55 histone genes, including HIST1H1D.
*FIELD* RF
1. Albig, W.; Drabent, B.; Kunz, J.; Kalff-Suske, M.; Grzeschik, K.-H.;
Doenecke, D.: All known human H1 histone genes except the H1(0) gene
are clustered on chromosome 6. Genomics 16: 649-654, 1993.
2. Albig, W.; Kardalinou, E.; Drabent, B.; Zimmer, A.; Doenecke, D.
: Isolation and characterization of two human H1 histone genes within
clusters of core histone genes. Genomics 10: 940-948, 1991.
3. Albig, W.; Kioschis, P.; Poustka, A.; Meergans, K.; Doenecke, D.
: Human histone gene organization: nonregular arrangement within a
large cluster. Genomics 40: 314-322, 1997.
4. Marzluff, W. F.; Gongidi, P.; Woods, K. R.; Jin, J.; Maltais, L.
J.: The human and mouse replication-dependent histone genes. Genomics 80:
487-498, 2002.
5. Tanguay, R. M.; Berube, D.; Gagne, R.: Localization of histone
genes to chromosomes 6, 12, and 1 by in situ hybridization. (Abstract) Cytogenet.
Cell Genet. 46: 702 only, 1987.
*FIELD* CN
Matthew B. Gross - updated: 6/24/2010
Rebekah S. Rasooly - updated: 7/8/1998
*FIELD* CD
Victor A. McKusick: 9/13/1989
*FIELD* ED
mgross: 06/24/2010
mgross: 6/24/2010
mgross: 5/26/2010
tkritzer: 3/31/2003
alopez: 7/9/1998
alopez: 7/8/1998
alopez: 2/11/1998
mark: 9/22/1996
carol: 6/28/1993
carol: 6/25/1993
supermim: 3/16/1992
supermim: 3/20/1990
ddp: 10/27/1989
root: 9/13/1989
*RECORD*
*FIELD* NO
142210
*FIELD* TI
*142210 HISTONE GENE CLUSTER 1, H1 HISTONE FAMILY, MEMBER D; HIST1H1D
;;HISTONE GENE CLUSTER 1, H1D;;
read moreHIST1 ClUSTER, H1D;;
H1D;;
H1.3;;
H1 HISTONE FAMILY, MEMBER 3, FORMERLY; H1F3, FORMERLY
*FIELD* TX
For background information on histones, histone gene clusters, and the
H1 histone family, see HIST1H1A (142709).
CLONING
Albig et al. (1991) identified a gene encoding a member of the H1 class
of histones and designated it H1.3.
GENE FUNCTION
See HIST1H1A (142709) for functional information on H1 histones.
MAPPING
By in situ hybridization, Tanguay et al. (1987) mapped the histone H1.3
gene to chromosome 6p12-q21.
By PCR analysis of chromosomal DNA from a panel of human/rodent somatic
cell hybrids and by fluorescence in situ hybridization, Albig et al.
(1993) demonstrated that 6 human H1 histone genes, including H1.3, are
located on chromosome 6p22.2-p21.1. By analysis of a YAC contig, Albig
et al. (1997) mapped the H1.3 gene to chromosome 6p21.3 within a cluster
of 35 histone genes, including H1.1 (HIST1H1A; 142709) to H1.4
(HIST1H1E; 142220) and H1T (HIST1H1T; 142712). The H1.5 gene (HIST1H1B;
142711) is part of a separate subcluster within the same chromosomal
region.
By genomic sequence analysis, Marzluff et al. (2002) determined that the
histone gene cluster on chromosome 6p22-p21, which they called histone
gene cluster-1 (HIST1), contains 55 histone genes, including HIST1H1D.
*FIELD* RF
1. Albig, W.; Drabent, B.; Kunz, J.; Kalff-Suske, M.; Grzeschik, K.-H.;
Doenecke, D.: All known human H1 histone genes except the H1(0) gene
are clustered on chromosome 6. Genomics 16: 649-654, 1993.
2. Albig, W.; Kardalinou, E.; Drabent, B.; Zimmer, A.; Doenecke, D.
: Isolation and characterization of two human H1 histone genes within
clusters of core histone genes. Genomics 10: 940-948, 1991.
3. Albig, W.; Kioschis, P.; Poustka, A.; Meergans, K.; Doenecke, D.
: Human histone gene organization: nonregular arrangement within a
large cluster. Genomics 40: 314-322, 1997.
4. Marzluff, W. F.; Gongidi, P.; Woods, K. R.; Jin, J.; Maltais, L.
J.: The human and mouse replication-dependent histone genes. Genomics 80:
487-498, 2002.
5. Tanguay, R. M.; Berube, D.; Gagne, R.: Localization of histone
genes to chromosomes 6, 12, and 1 by in situ hybridization. (Abstract) Cytogenet.
Cell Genet. 46: 702 only, 1987.
*FIELD* CN
Matthew B. Gross - updated: 6/24/2010
Rebekah S. Rasooly - updated: 7/8/1998
*FIELD* CD
Victor A. McKusick: 9/13/1989
*FIELD* ED
mgross: 06/24/2010
mgross: 6/24/2010
mgross: 5/26/2010
tkritzer: 3/31/2003
alopez: 7/9/1998
alopez: 7/8/1998
alopez: 2/11/1998
mark: 9/22/1996
carol: 6/28/1993
carol: 6/25/1993
supermim: 3/16/1992
supermim: 3/20/1990
ddp: 10/27/1989
root: 9/13/1989