Full text data of HRNR
HRNR
(S100A18)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Hornerin
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Hornerin
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q86YZ3
ID HORN_HUMAN Reviewed; 2850 AA.
AC Q86YZ3; Q5U1F4;
DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 15-MAR-2004, sequence version 2.
DT 22-JAN-2014, entry version 94.
DE RecName: Full=Hornerin;
GN Name=HRNR; Synonyms=S100A18;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Skin;
RX PubMed=15507446; DOI=10.1074/jbc.M409026200;
RA Takaishi M., Makino T., Morohashi M., Huh N.-H.;
RT "Identification of human hornerin and its expression in regenerating
RT and psoriatic skin.";
RL J. Biol. Chem. 280:4696-4703(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19369195; DOI=10.1074/mcp.M800588-MCP200;
RA Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,
RA Mann M., Daub H.;
RT "Large-scale proteomics analysis of the human kinome.";
RL Mol. Cell. Proteomics 8:1751-1764(2009).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-775; SER-890; SER-1242
RP AND SER-2182, AND MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May play a role in cornification.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic granule (By similarity).
CC Note=Found in keratohyalin granules in the granular cells of the
CC epidermis (By similarity).
CC -!- TISSUE SPECIFICITY: Expressed in psoriatic and regenerating skin
CC after wounding.
CC -!- PTM: Processed during the process of epidermal differentiation (By
CC similarity).
CC -!- SIMILARITY: Belongs to the S100-fused protein family.
CC -!- SIMILARITY: In the N-terminal section; belongs to the S-100
CC family.
CC -!- SIMILARITY: Contains 2 EF-hand domains.
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DR EMBL; AB104446; BAC57496.1; -; mRNA.
DR EMBL; BR000036; FAA00004.1; -; mRNA.
DR EMBL; AL589986; CAH70026.1; -; Genomic_DNA.
DR RefSeq; NP_001009931.1; NM_001009931.2.
DR UniGene; Hs.490162; -.
DR ProteinModelPortal; Q86YZ3; -.
DR SMR; Q86YZ3; 10-86.
DR IntAct; Q86YZ3; 8.
DR MINT; MINT-2809380; -.
DR STRING; 9606.ENSP00000357791; -.
DR PhosphoSite; Q86YZ3; -.
DR DMDM; 45476906; -.
DR UCD-2DPAGE; Q86YZ3; -.
DR PaxDb; Q86YZ3; -.
DR PRIDE; Q86YZ3; -.
DR Ensembl; ENST00000368801; ENSP00000357791; ENSG00000197915.
DR GeneID; 388697; -.
DR KEGG; hsa:388697; -.
DR UCSC; uc001ezt.2; human.
DR CTD; 388697; -.
DR GeneCards; GC01M152184; -.
DR H-InvDB; HIX0200013; -.
DR HGNC; HGNC:20846; HRNR.
DR HPA; HPA031469; -.
DR neXtProt; NX_Q86YZ3; -.
DR PharmGKB; PA134936141; -.
DR eggNOG; NOG12793; -.
DR HOGENOM; HOG000112590; -.
DR InParanoid; Q86YZ3; -.
DR OMA; GSGHFCS; -.
DR OrthoDB; EOG7QC7VH; -.
DR GenomeRNAi; 388697; -.
DR NextBio; 102292; -.
DR PRO; PR:Q86YZ3; -.
DR ArrayExpress; Q86YZ3; -.
DR Bgee; Q86YZ3; -.
DR CleanEx; HS_HRNR; -.
DR Genevestigator; Q86YZ3; -.
DR GO; GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR Gene3D; 1.10.238.10; -; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR001751; S100/CaBP-9k_CS.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR Pfam; PF01023; S_100; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00303; S100_CABP; 1.
PE 1: Evidence at protein level;
KW Calcium; Complete proteome; Developmental protein; Keratinization;
KW Metal-binding; Phosphoprotein; Polymorphism; Reference proteome;
KW Repeat.
FT CHAIN 1 2850 Hornerin.
FT /FTId=PRO_0000144038.
FT DOMAIN 13 48 EF-hand 1.
FT DOMAIN 49 84 EF-hand 2.
FT REPEAT 97 187 1.
FT REPEAT 188 278 2.
FT REPEAT 279 369 3.
FT REPEAT 370 460 4.
FT REPEAT 474 566 5.
FT REPEAT 593 683 6.
FT REPEAT 685 747 7.
FT REPEAT 748 836 8.
FT REPEAT 839 875 9.
FT REPEAT 876 965 10.
FT REPEAT 966 1004 11.
FT REPEAT 1007 1097 12.
FT REPEAT 1098 1188 13.
FT REPEAT 1215 1305 14.
FT REPEAT 1332 1422 15.
FT REPEAT 1423 1474 16.
FT REPEAT 1477 1567 17.
FT REPEAT 1568 1658 18.
FT REPEAT 1685 1775 19.
FT REPEAT 1802 1892 20.
FT REPEAT 1893 1944 21.
FT REPEAT 1947 2037 22.
FT REPEAT 2038 2128 23.
FT REPEAT 2155 2245 24.
FT REPEAT 2272 2362 25.
FT REPEAT 2363 2414 26.
FT REPEAT 2417 2507 27.
FT REPEAT 2508 2598 28.
FT REPEAT 2625 2715 29.
FT REPEAT 2716 2806 30.
FT CA_BIND 19 32 1 (Potential).
FT CA_BIND 62 73 2 (Potential).
FT REGION 1 81 S-100-like.
FT MOD_RES 775 775 Phosphoserine.
FT MOD_RES 890 890 Phosphoserine.
FT MOD_RES 1242 1242 Phosphoserine.
FT MOD_RES 2182 2182 Phosphoserine.
FT VARIANT 85 85 R -> H (in dbSNP:rs11204937).
FT /FTId=VAR_048494.
FT VARIANT 122 122 R -> W (in dbSNP:rs57277761).
FT /FTId=VAR_061053.
FT VARIANT 167 167 G -> D (in dbSNP:rs12741518).
FT /FTId=VAR_048495.
FT VARIANT 273 273 H -> Q (in dbSNP:rs7545406).
FT /FTId=VAR_059174.
FT VARIANT 376 376 Q -> R (in dbSNP:rs6587649).
FT /FTId=VAR_061054.
FT VARIANT 427 427 G -> D (in dbSNP:rs6666097).
FT /FTId=VAR_061055.
FT VARIANT 473 473 E -> G (in dbSNP:rs6587648).
FT /FTId=VAR_048496.
FT VARIANT 492 492 G -> R (in dbSNP:rs6587647).
FT /FTId=VAR_048497.
FT VARIANT 517 517 Y -> C (in dbSNP:rs41266134).
FT /FTId=VAR_061056.
FT VARIANT 664 664 R -> Q (in dbSNP:rs7520249).
FT /FTId=VAR_048498.
FT VARIANT 799 799 S -> T (in dbSNP:rs6662450).
FT /FTId=VAR_048499.
FT VARIANT 2435 2435 S -> G (in dbSNP:rs4248393).
FT /FTId=VAR_059175.
FT VARIANT 2461 2461 G -> S (in dbSNP:rs6659183).
FT /FTId=VAR_059176.
FT CONFLICT 2382 2382 R -> Q (in Ref. 1; BAC57496).
FT CONFLICT 2539 2539 G -> S (in Ref. 1; BAC57496).
FT CONFLICT 2688 2688 L -> S (in Ref. 1; BAC57496).
SQ SEQUENCE 2850 AA; 282390 MW; F25D8028C5AB6701 CRC64;
MPKLLQGVIT VIDVFYQYAT QHGEYDTLNK AELKELLENE FHQILKNPND PDTVDIILQS
LDRDHNKKVD FTEYLLMIFK LVQARNKIIG KDYCQVSGSK LRDDTHQHQE EQEETEKEEN
KRQESSFSHS SWSAGENDSY SRNVRGSLKP GTESISRRLS FQRDFSGQHN SYSGQSSSYG
EQNSDSHQSS GRGQCGSGSG QSPNYGQHGS GSGQSSSNDT HGSGSGQSSG FSQHKSSSGQ
SSGYSQHGSG SGHSSGYGQH GSRSGQSSRG ERHRSSSGSS SSYGQHGSGS RQSLGHGRQG
SGSRQSPSHV RHGSGSGHSS SHGQHGSGSS YSYSRGHYES GSGQTSGFGQ HESGSGQSSG
YSKHGSGSGH SSSQGQHGST SGQASSSGQH GSSSRQSSSY GQHESASRHS SGRGQHSSGS
GQSPGHGQRG SGSGQSPSSG QHGTGFGRSS SSGPYVSGSG YSSGFGHHES SSEHSSGYTQ
HGSGSGHSSG HGQHGSRSGQ SSRGERQGSS AGSSSSYGQH GSGSRQSLGH SRHGSGSGQS
PSPSRGRHES GSRQSSSYGP HGYGSGRSSS RGPYESGSGH SSGLGHQESR SGQSSGYGQH
GSSSGHSSTH GQHGSTSGQS SSCGQHGATS GQSSSHGQHG SGSSQSSRYG QQGSGSGQSP
SRGRHGSDFG HSSSYGQHGS GSGWSSSNGP HGSVSGQSSG FGHKSGSGQS SGYSQHGSGS
SHSSGYRKHG SRSGQSSRSE QHGSSSGLSS SYGQHGSGSH QSSGHGRQGS GSGHSPSRVR
HGSSSGHSSS HGQHGSGTSC SSSCGHYESG SGQASGFGQH ESGSGQGYSQ HGSASGHFSS
QGRHGSTSGQ SSSSGQHDSS SGQSSSYGQH ESASHHASGR GRHGSGSGQS PGHGQRGSGS
GQSPSYGRHG SGSGRSSSSG RHGSGSGQSS GFGHKSSSGQ SSGYTQHGSG SGHSSSYEQH
GSRSGQSSRS EQHGSSSGSS SSYGQHGSGS RQSLGHGQHG SGSGQSPSPS RGRHGSGSGQ
SSSYGPYRSG SGWSSSRGPY ESGSGHSSGL GHRESRSGQS SGYGQHGSSS GHSSTHGQHG
STSGQSSSCG QHGASSGQSS SHGQHGSGSS QSSGYGRQGS GSGQSPGHGQ RGSGSRQSPS
YGRHGSGSGR SSSSGQHGSG LGESSGFGHH ESSSGQSSSY SQHGSGSGHS SGYGQHGSRS
GQSSRGERHG SSSGSSSHYG QHGSGSRQSS GHGRQGSGSG HSPSRGRHGS GLGHSSSHGQ
HGSGSGRSSS RGPYESRSGH SSVFGQHESG SGHSSAYSQH GSGSGHFCSQ GQHGSTSGQS
STFDQEGSST GQSSSYGHRG SGSSQSSGYG RHGAGSGQSP SRGRHGSGSG HSSSYGQHGS
GSGWSSSSGR HGSGSGQSSG FGHHESSSWQ SSGCTQHGSG SGHSSSYEQH GSRSGQSSRG
ERHGSSSGSS SSYGQHGSGS RQSLGHGQHG SGSGQSPSPS RGRHGSGSGQ SSSYSPYGSG
SGWSSSRGPY ESGSSHSSGL GHRESRSGQS SGYGQHGSSS GHSSTHGQHG STSGQSSSCG
QHGASSGQSS SHGQHGSGSS QSSGYGRQGS GSGQSPGHGQ RGSGSRQSPS YGRHGSGSGR
SSSSGQHGSG LGESSGFGHH ESSSGQSSSY SQHGSGSGHS SGYGQHGSRS GQSSRGERHG
SSSRSSSRYG QHGSGSRQSS GHGRQGSGSG QSPSRGRHGS GLGHSSSHGQ HGSGSGRSSS
RGPYESRSGH SSVFGQHESG SGHSSAYSQH GSGSGHFCSQ GQHGSTSGQS STFDQEGSST
GQSSSHGQHG SGSSQSSSYG QQGSGSGQSP SRGRHGSGSG HSSSYGQHGS GSGWSSSSGR
HGSGSGQSSG FGHHESSSWQ SSGYTQHGSG SGHSSSYEQH GSRSGQSSRG EQHGSSSGSS
SSYGQHGSGS RQSLGHGQHG SGSGQSPSPS RGRHGSGSGQ SSSYGPYGSG SGWSSSRGPY
ESGSGHSSGL GHRESRSGQS SGYGQHGSSS GHSSTHGQHG SASGQSSSCG QHGASSGQSS
SHGQHGSGSS QSSGYGRQGS GSGQSPGHGQ RGSGSRQSPS YGRHGSGSGR SSSSGQHGPG
LGESSGFGHH ESSSGQSSSY SQHGSGSGHS SGYGQHGSRS GQSSRGERHG SSSGSSSRYG
QHGSGSRQSS GHGRQGSGSG HSPSRGRHGS GSGHSSSHGQ HGSGSGRSSS RGPYESRSGH
SSVFGQHESG SGHSSAYSQH GSGSGHFCSQ GQHGSTSGQS STFDQEGSST GQSSSHGQHG
SGSSQSSSYG QQGSGSGQSP SRGRHGSGSG HSSSYGQHGS GSGWSSSSGR HGSGSGQSSG
FGHHESSSWQ SSGYTQHGSG SGHSSSYEQH GSRSGQSSRG ERHGSSSGSS SSYGQHGSGS
RQSLGHGQHG SGSGQSPSPS RGRHGSGSGQ SSSYSPYGSG SGWSSSRGPY ESGSGHSSGL
GHRESRSGQS SGYGQHGSSS GHSSTHGQHG STSGQSSSCG QHGASSGQSS SHGQHGSGSS
QSSGYGRQGS GSGQSPGHGQ RGSGSRQSPS YGRHGSGSGR SSSSGQHGSG LGESSGFGHH
ESSSGQSSSY SQHGSGSGHS SGYGQHGSRS GQSSRGERHG SSSGSSSHYG QHGSGSRQSS
GHGRQGSGSG QSPSRGRHGS GLGHSSSHGQ HGSGSGRSSS RGPYESRLGH SSVFGQHESG
SGHSSAYSQH GSGSGHFCSQ GQHGSTSGQS STFDQEGSST GQSSSYGHRG SGSSQSSGYG
RHGAGSGQSL SHGRHGSGSG QSSSYGQHGS GSGQSSGYSQ HGSGSGQDGY SYCKGGSNHD
GGSSGSYFLS FPSSTSPYEY VQEQRCYFYQ
//
ID HORN_HUMAN Reviewed; 2850 AA.
AC Q86YZ3; Q5U1F4;
DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 15-MAR-2004, sequence version 2.
DT 22-JAN-2014, entry version 94.
DE RecName: Full=Hornerin;
GN Name=HRNR; Synonyms=S100A18;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Skin;
RX PubMed=15507446; DOI=10.1074/jbc.M409026200;
RA Takaishi M., Makino T., Morohashi M., Huh N.-H.;
RT "Identification of human hornerin and its expression in regenerating
RT and psoriatic skin.";
RL J. Biol. Chem. 280:4696-4703(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19369195; DOI=10.1074/mcp.M800588-MCP200;
RA Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,
RA Mann M., Daub H.;
RT "Large-scale proteomics analysis of the human kinome.";
RL Mol. Cell. Proteomics 8:1751-1764(2009).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-775; SER-890; SER-1242
RP AND SER-2182, AND MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May play a role in cornification.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic granule (By similarity).
CC Note=Found in keratohyalin granules in the granular cells of the
CC epidermis (By similarity).
CC -!- TISSUE SPECIFICITY: Expressed in psoriatic and regenerating skin
CC after wounding.
CC -!- PTM: Processed during the process of epidermal differentiation (By
CC similarity).
CC -!- SIMILARITY: Belongs to the S100-fused protein family.
CC -!- SIMILARITY: In the N-terminal section; belongs to the S-100
CC family.
CC -!- SIMILARITY: Contains 2 EF-hand domains.
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DR EMBL; AB104446; BAC57496.1; -; mRNA.
DR EMBL; BR000036; FAA00004.1; -; mRNA.
DR EMBL; AL589986; CAH70026.1; -; Genomic_DNA.
DR RefSeq; NP_001009931.1; NM_001009931.2.
DR UniGene; Hs.490162; -.
DR ProteinModelPortal; Q86YZ3; -.
DR SMR; Q86YZ3; 10-86.
DR IntAct; Q86YZ3; 8.
DR MINT; MINT-2809380; -.
DR STRING; 9606.ENSP00000357791; -.
DR PhosphoSite; Q86YZ3; -.
DR DMDM; 45476906; -.
DR UCD-2DPAGE; Q86YZ3; -.
DR PaxDb; Q86YZ3; -.
DR PRIDE; Q86YZ3; -.
DR Ensembl; ENST00000368801; ENSP00000357791; ENSG00000197915.
DR GeneID; 388697; -.
DR KEGG; hsa:388697; -.
DR UCSC; uc001ezt.2; human.
DR CTD; 388697; -.
DR GeneCards; GC01M152184; -.
DR H-InvDB; HIX0200013; -.
DR HGNC; HGNC:20846; HRNR.
DR HPA; HPA031469; -.
DR neXtProt; NX_Q86YZ3; -.
DR PharmGKB; PA134936141; -.
DR eggNOG; NOG12793; -.
DR HOGENOM; HOG000112590; -.
DR InParanoid; Q86YZ3; -.
DR OMA; GSGHFCS; -.
DR OrthoDB; EOG7QC7VH; -.
DR GenomeRNAi; 388697; -.
DR NextBio; 102292; -.
DR PRO; PR:Q86YZ3; -.
DR ArrayExpress; Q86YZ3; -.
DR Bgee; Q86YZ3; -.
DR CleanEx; HS_HRNR; -.
DR Genevestigator; Q86YZ3; -.
DR GO; GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR Gene3D; 1.10.238.10; -; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR001751; S100/CaBP-9k_CS.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR Pfam; PF01023; S_100; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00303; S100_CABP; 1.
PE 1: Evidence at protein level;
KW Calcium; Complete proteome; Developmental protein; Keratinization;
KW Metal-binding; Phosphoprotein; Polymorphism; Reference proteome;
KW Repeat.
FT CHAIN 1 2850 Hornerin.
FT /FTId=PRO_0000144038.
FT DOMAIN 13 48 EF-hand 1.
FT DOMAIN 49 84 EF-hand 2.
FT REPEAT 97 187 1.
FT REPEAT 188 278 2.
FT REPEAT 279 369 3.
FT REPEAT 370 460 4.
FT REPEAT 474 566 5.
FT REPEAT 593 683 6.
FT REPEAT 685 747 7.
FT REPEAT 748 836 8.
FT REPEAT 839 875 9.
FT REPEAT 876 965 10.
FT REPEAT 966 1004 11.
FT REPEAT 1007 1097 12.
FT REPEAT 1098 1188 13.
FT REPEAT 1215 1305 14.
FT REPEAT 1332 1422 15.
FT REPEAT 1423 1474 16.
FT REPEAT 1477 1567 17.
FT REPEAT 1568 1658 18.
FT REPEAT 1685 1775 19.
FT REPEAT 1802 1892 20.
FT REPEAT 1893 1944 21.
FT REPEAT 1947 2037 22.
FT REPEAT 2038 2128 23.
FT REPEAT 2155 2245 24.
FT REPEAT 2272 2362 25.
FT REPEAT 2363 2414 26.
FT REPEAT 2417 2507 27.
FT REPEAT 2508 2598 28.
FT REPEAT 2625 2715 29.
FT REPEAT 2716 2806 30.
FT CA_BIND 19 32 1 (Potential).
FT CA_BIND 62 73 2 (Potential).
FT REGION 1 81 S-100-like.
FT MOD_RES 775 775 Phosphoserine.
FT MOD_RES 890 890 Phosphoserine.
FT MOD_RES 1242 1242 Phosphoserine.
FT MOD_RES 2182 2182 Phosphoserine.
FT VARIANT 85 85 R -> H (in dbSNP:rs11204937).
FT /FTId=VAR_048494.
FT VARIANT 122 122 R -> W (in dbSNP:rs57277761).
FT /FTId=VAR_061053.
FT VARIANT 167 167 G -> D (in dbSNP:rs12741518).
FT /FTId=VAR_048495.
FT VARIANT 273 273 H -> Q (in dbSNP:rs7545406).
FT /FTId=VAR_059174.
FT VARIANT 376 376 Q -> R (in dbSNP:rs6587649).
FT /FTId=VAR_061054.
FT VARIANT 427 427 G -> D (in dbSNP:rs6666097).
FT /FTId=VAR_061055.
FT VARIANT 473 473 E -> G (in dbSNP:rs6587648).
FT /FTId=VAR_048496.
FT VARIANT 492 492 G -> R (in dbSNP:rs6587647).
FT /FTId=VAR_048497.
FT VARIANT 517 517 Y -> C (in dbSNP:rs41266134).
FT /FTId=VAR_061056.
FT VARIANT 664 664 R -> Q (in dbSNP:rs7520249).
FT /FTId=VAR_048498.
FT VARIANT 799 799 S -> T (in dbSNP:rs6662450).
FT /FTId=VAR_048499.
FT VARIANT 2435 2435 S -> G (in dbSNP:rs4248393).
FT /FTId=VAR_059175.
FT VARIANT 2461 2461 G -> S (in dbSNP:rs6659183).
FT /FTId=VAR_059176.
FT CONFLICT 2382 2382 R -> Q (in Ref. 1; BAC57496).
FT CONFLICT 2539 2539 G -> S (in Ref. 1; BAC57496).
FT CONFLICT 2688 2688 L -> S (in Ref. 1; BAC57496).
SQ SEQUENCE 2850 AA; 282390 MW; F25D8028C5AB6701 CRC64;
MPKLLQGVIT VIDVFYQYAT QHGEYDTLNK AELKELLENE FHQILKNPND PDTVDIILQS
LDRDHNKKVD FTEYLLMIFK LVQARNKIIG KDYCQVSGSK LRDDTHQHQE EQEETEKEEN
KRQESSFSHS SWSAGENDSY SRNVRGSLKP GTESISRRLS FQRDFSGQHN SYSGQSSSYG
EQNSDSHQSS GRGQCGSGSG QSPNYGQHGS GSGQSSSNDT HGSGSGQSSG FSQHKSSSGQ
SSGYSQHGSG SGHSSGYGQH GSRSGQSSRG ERHRSSSGSS SSYGQHGSGS RQSLGHGRQG
SGSRQSPSHV RHGSGSGHSS SHGQHGSGSS YSYSRGHYES GSGQTSGFGQ HESGSGQSSG
YSKHGSGSGH SSSQGQHGST SGQASSSGQH GSSSRQSSSY GQHESASRHS SGRGQHSSGS
GQSPGHGQRG SGSGQSPSSG QHGTGFGRSS SSGPYVSGSG YSSGFGHHES SSEHSSGYTQ
HGSGSGHSSG HGQHGSRSGQ SSRGERQGSS AGSSSSYGQH GSGSRQSLGH SRHGSGSGQS
PSPSRGRHES GSRQSSSYGP HGYGSGRSSS RGPYESGSGH SSGLGHQESR SGQSSGYGQH
GSSSGHSSTH GQHGSTSGQS SSCGQHGATS GQSSSHGQHG SGSSQSSRYG QQGSGSGQSP
SRGRHGSDFG HSSSYGQHGS GSGWSSSNGP HGSVSGQSSG FGHKSGSGQS SGYSQHGSGS
SHSSGYRKHG SRSGQSSRSE QHGSSSGLSS SYGQHGSGSH QSSGHGRQGS GSGHSPSRVR
HGSSSGHSSS HGQHGSGTSC SSSCGHYESG SGQASGFGQH ESGSGQGYSQ HGSASGHFSS
QGRHGSTSGQ SSSSGQHDSS SGQSSSYGQH ESASHHASGR GRHGSGSGQS PGHGQRGSGS
GQSPSYGRHG SGSGRSSSSG RHGSGSGQSS GFGHKSSSGQ SSGYTQHGSG SGHSSSYEQH
GSRSGQSSRS EQHGSSSGSS SSYGQHGSGS RQSLGHGQHG SGSGQSPSPS RGRHGSGSGQ
SSSYGPYRSG SGWSSSRGPY ESGSGHSSGL GHRESRSGQS SGYGQHGSSS GHSSTHGQHG
STSGQSSSCG QHGASSGQSS SHGQHGSGSS QSSGYGRQGS GSGQSPGHGQ RGSGSRQSPS
YGRHGSGSGR SSSSGQHGSG LGESSGFGHH ESSSGQSSSY SQHGSGSGHS SGYGQHGSRS
GQSSRGERHG SSSGSSSHYG QHGSGSRQSS GHGRQGSGSG HSPSRGRHGS GLGHSSSHGQ
HGSGSGRSSS RGPYESRSGH SSVFGQHESG SGHSSAYSQH GSGSGHFCSQ GQHGSTSGQS
STFDQEGSST GQSSSYGHRG SGSSQSSGYG RHGAGSGQSP SRGRHGSGSG HSSSYGQHGS
GSGWSSSSGR HGSGSGQSSG FGHHESSSWQ SSGCTQHGSG SGHSSSYEQH GSRSGQSSRG
ERHGSSSGSS SSYGQHGSGS RQSLGHGQHG SGSGQSPSPS RGRHGSGSGQ SSSYSPYGSG
SGWSSSRGPY ESGSSHSSGL GHRESRSGQS SGYGQHGSSS GHSSTHGQHG STSGQSSSCG
QHGASSGQSS SHGQHGSGSS QSSGYGRQGS GSGQSPGHGQ RGSGSRQSPS YGRHGSGSGR
SSSSGQHGSG LGESSGFGHH ESSSGQSSSY SQHGSGSGHS SGYGQHGSRS GQSSRGERHG
SSSRSSSRYG QHGSGSRQSS GHGRQGSGSG QSPSRGRHGS GLGHSSSHGQ HGSGSGRSSS
RGPYESRSGH SSVFGQHESG SGHSSAYSQH GSGSGHFCSQ GQHGSTSGQS STFDQEGSST
GQSSSHGQHG SGSSQSSSYG QQGSGSGQSP SRGRHGSGSG HSSSYGQHGS GSGWSSSSGR
HGSGSGQSSG FGHHESSSWQ SSGYTQHGSG SGHSSSYEQH GSRSGQSSRG EQHGSSSGSS
SSYGQHGSGS RQSLGHGQHG SGSGQSPSPS RGRHGSGSGQ SSSYGPYGSG SGWSSSRGPY
ESGSGHSSGL GHRESRSGQS SGYGQHGSSS GHSSTHGQHG SASGQSSSCG QHGASSGQSS
SHGQHGSGSS QSSGYGRQGS GSGQSPGHGQ RGSGSRQSPS YGRHGSGSGR SSSSGQHGPG
LGESSGFGHH ESSSGQSSSY SQHGSGSGHS SGYGQHGSRS GQSSRGERHG SSSGSSSRYG
QHGSGSRQSS GHGRQGSGSG HSPSRGRHGS GSGHSSSHGQ HGSGSGRSSS RGPYESRSGH
SSVFGQHESG SGHSSAYSQH GSGSGHFCSQ GQHGSTSGQS STFDQEGSST GQSSSHGQHG
SGSSQSSSYG QQGSGSGQSP SRGRHGSGSG HSSSYGQHGS GSGWSSSSGR HGSGSGQSSG
FGHHESSSWQ SSGYTQHGSG SGHSSSYEQH GSRSGQSSRG ERHGSSSGSS SSYGQHGSGS
RQSLGHGQHG SGSGQSPSPS RGRHGSGSGQ SSSYSPYGSG SGWSSSRGPY ESGSGHSSGL
GHRESRSGQS SGYGQHGSSS GHSSTHGQHG STSGQSSSCG QHGASSGQSS SHGQHGSGSS
QSSGYGRQGS GSGQSPGHGQ RGSGSRQSPS YGRHGSGSGR SSSSGQHGSG LGESSGFGHH
ESSSGQSSSY SQHGSGSGHS SGYGQHGSRS GQSSRGERHG SSSGSSSHYG QHGSGSRQSS
GHGRQGSGSG QSPSRGRHGS GLGHSSSHGQ HGSGSGRSSS RGPYESRLGH SSVFGQHESG
SGHSSAYSQH GSGSGHFCSQ GQHGSTSGQS STFDQEGSST GQSSSYGHRG SGSSQSSGYG
RHGAGSGQSL SHGRHGSGSG QSSSYGQHGS GSGQSSGYSQ HGSGSGQDGY SYCKGGSNHD
GGSSGSYFLS FPSSTSPYEY VQEQRCYFYQ
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