Full text data of HPCAL1
HPCAL1
(BDR1)
[Confidence: low (only semi-automatic identification from reviews)]
Hippocalcin-like protein 1 (Calcium-binding protein BDR-1; HLP2; Visinin-like protein 3; VILIP-3)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Hippocalcin-like protein 1 (Calcium-binding protein BDR-1; HLP2; Visinin-like protein 3; VILIP-3)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
P37235
ID HPCL1_HUMAN Reviewed; 193 AA.
AC P37235; Q969S5;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 3.
DT 22-JAN-2014, entry version 124.
DE RecName: Full=Hippocalcin-like protein 1;
DE AltName: Full=Calcium-binding protein BDR-1;
DE AltName: Full=HLP2;
DE AltName: Full=Visinin-like protein 3;
DE Short=VILIP-3;
GN Name=HPCAL1; Synonyms=BDR1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=8038222; DOI=10.1016/0167-4889(94)90062-0;
RA Kobayashi M., Takamatsu K., Fujishiro M., Saitoh S., Noguchi T.;
RT "Molecular cloning of a novel calcium-binding protein structurally
RT related to hippocalcin from human brain and chromosomal mapping of its
RT gene.";
RL Biochim. Biophys. Acta 1222:515-518(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May be involved in the calcium-dependent regulation of
CC rhodopsin phosphorylation.
CC -!- MISCELLANEOUS: Probably binds two or three calcium ions (By
CC similarity).
CC -!- SIMILARITY: Belongs to the recoverin family.
CC -!- SIMILARITY: Contains 4 EF-hand domains.
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DR EMBL; D16227; BAA03754.1; -; mRNA.
DR EMBL; BC009846; AAH09846.1; -; mRNA.
DR EMBL; BC017028; AAH17028.1; -; mRNA.
DR EMBL; BC017482; AAH17482.1; -; mRNA.
DR PIR; S47565; S47565.
DR RefSeq; NP_001245286.1; NM_001258357.1.
DR RefSeq; NP_001245287.1; NM_001258358.1.
DR RefSeq; NP_001245288.1; NM_001258359.1.
DR RefSeq; NP_002140.2; NM_002149.3.
DR RefSeq; NP_602293.1; NM_134421.2.
DR RefSeq; XP_005246217.1; XM_005246160.1.
DR RefSeq; XP_005246218.1; XM_005246161.1.
DR RefSeq; XP_005246219.1; XM_005246162.1.
DR RefSeq; XP_005246220.1; XM_005246163.1.
DR UniGene; Hs.580427; -.
DR UniGene; Hs.741268; -.
DR ProteinModelPortal; P37235; -.
DR SMR; P37235; 5-185.
DR IntAct; P37235; 6.
DR MINT; MINT-1436151; -.
DR STRING; 9606.ENSP00000310749; -.
DR PhosphoSite; P37235; -.
DR DMDM; 20455519; -.
DR PaxDb; P37235; -.
DR PRIDE; P37235; -.
DR DNASU; 3241; -.
DR Ensembl; ENST00000307845; ENSP00000310749; ENSG00000115756.
DR Ensembl; ENST00000381765; ENSP00000371184; ENSG00000115756.
DR GeneID; 3241; -.
DR KEGG; hsa:3241; -.
DR UCSC; uc002raj.4; human.
DR CTD; 3241; -.
DR GeneCards; GC02P010443; -.
DR HGNC; HGNC:5145; HPCAL1.
DR HPA; HPA043245; -.
DR MIM; 600207; gene.
DR neXtProt; NX_P37235; -.
DR PharmGKB; PA29418; -.
DR eggNOG; COG5126; -.
DR HOGENOM; HOG000233019; -.
DR HOVERGEN; HBG108179; -.
DR InParanoid; P37235; -.
DR OMA; LEIVQXK; -.
DR PhylomeDB; P37235; -.
DR ChiTaRS; HPCAL1; human.
DR GeneWiki; HPCAL1; -.
DR GenomeRNAi; 3241; -.
DR NextBio; 12899; -.
DR PRO; PR:P37235; -.
DR ArrayExpress; P37235; -.
DR Bgee; P37235; -.
DR CleanEx; HS_HPCAL1; -.
DR Genevestigator; P37235; -.
DR GO; GO:0005509; F:calcium ion binding; TAS:ProtInc.
DR Gene3D; 1.10.238.10; -; 3.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR001125; Recoverin_like.
DR Pfam; PF13499; EF-hand_7; 2.
DR PRINTS; PR00450; RECOVERIN.
DR SMART; SM00054; EFh; 3.
DR PROSITE; PS00018; EF_HAND_1; 3.
DR PROSITE; PS50222; EF_HAND_2; 4.
PE 1: Evidence at protein level;
KW Calcium; Complete proteome; Lipoprotein; Metal-binding; Myristate;
KW Reference proteome; Repeat.
FT INIT_MET 1 1 Removed (By similarity).
FT CHAIN 2 193 Hippocalcin-like protein 1.
FT /FTId=PRO_0000073771.
FT DOMAIN 23 58 EF-hand 1.
FT DOMAIN 60 95 EF-hand 2.
FT DOMAIN 96 131 EF-hand 3.
FT DOMAIN 144 179 EF-hand 4.
FT CA_BIND 73 84 1 (Potential).
FT CA_BIND 109 120 2 (Potential).
FT CA_BIND 157 168 3 (Potential).
FT LIPID 2 2 N-myristoyl glycine (By similarity).
FT CONFLICT 19 19 N -> K (in Ref. 1; BAA03754).
FT CONFLICT 88 88 A -> G (in Ref. 1; BAA03754).
FT CONFLICT 93 94 SR -> RG (in Ref. 1; BAA03754).
SQ SEQUENCE 193 AA; 22313 MW; 87DCE938DCAD5E1F CRC64;
MGKQNSKLRP EVLQDLRENT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK IYANFFPYGD
ASKFAEHVFR TFDTNGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISRSE
MLEIVQAIYK MVSSVMKMPE DESTPEKRTD KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV
RLLQCDPSSA SQF
//
ID HPCL1_HUMAN Reviewed; 193 AA.
AC P37235; Q969S5;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 3.
DT 22-JAN-2014, entry version 124.
DE RecName: Full=Hippocalcin-like protein 1;
DE AltName: Full=Calcium-binding protein BDR-1;
DE AltName: Full=HLP2;
DE AltName: Full=Visinin-like protein 3;
DE Short=VILIP-3;
GN Name=HPCAL1; Synonyms=BDR1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=8038222; DOI=10.1016/0167-4889(94)90062-0;
RA Kobayashi M., Takamatsu K., Fujishiro M., Saitoh S., Noguchi T.;
RT "Molecular cloning of a novel calcium-binding protein structurally
RT related to hippocalcin from human brain and chromosomal mapping of its
RT gene.";
RL Biochim. Biophys. Acta 1222:515-518(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May be involved in the calcium-dependent regulation of
CC rhodopsin phosphorylation.
CC -!- MISCELLANEOUS: Probably binds two or three calcium ions (By
CC similarity).
CC -!- SIMILARITY: Belongs to the recoverin family.
CC -!- SIMILARITY: Contains 4 EF-hand domains.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; D16227; BAA03754.1; -; mRNA.
DR EMBL; BC009846; AAH09846.1; -; mRNA.
DR EMBL; BC017028; AAH17028.1; -; mRNA.
DR EMBL; BC017482; AAH17482.1; -; mRNA.
DR PIR; S47565; S47565.
DR RefSeq; NP_001245286.1; NM_001258357.1.
DR RefSeq; NP_001245287.1; NM_001258358.1.
DR RefSeq; NP_001245288.1; NM_001258359.1.
DR RefSeq; NP_002140.2; NM_002149.3.
DR RefSeq; NP_602293.1; NM_134421.2.
DR RefSeq; XP_005246217.1; XM_005246160.1.
DR RefSeq; XP_005246218.1; XM_005246161.1.
DR RefSeq; XP_005246219.1; XM_005246162.1.
DR RefSeq; XP_005246220.1; XM_005246163.1.
DR UniGene; Hs.580427; -.
DR UniGene; Hs.741268; -.
DR ProteinModelPortal; P37235; -.
DR SMR; P37235; 5-185.
DR IntAct; P37235; 6.
DR MINT; MINT-1436151; -.
DR STRING; 9606.ENSP00000310749; -.
DR PhosphoSite; P37235; -.
DR DMDM; 20455519; -.
DR PaxDb; P37235; -.
DR PRIDE; P37235; -.
DR DNASU; 3241; -.
DR Ensembl; ENST00000307845; ENSP00000310749; ENSG00000115756.
DR Ensembl; ENST00000381765; ENSP00000371184; ENSG00000115756.
DR GeneID; 3241; -.
DR KEGG; hsa:3241; -.
DR UCSC; uc002raj.4; human.
DR CTD; 3241; -.
DR GeneCards; GC02P010443; -.
DR HGNC; HGNC:5145; HPCAL1.
DR HPA; HPA043245; -.
DR MIM; 600207; gene.
DR neXtProt; NX_P37235; -.
DR PharmGKB; PA29418; -.
DR eggNOG; COG5126; -.
DR HOGENOM; HOG000233019; -.
DR HOVERGEN; HBG108179; -.
DR InParanoid; P37235; -.
DR OMA; LEIVQXK; -.
DR PhylomeDB; P37235; -.
DR ChiTaRS; HPCAL1; human.
DR GeneWiki; HPCAL1; -.
DR GenomeRNAi; 3241; -.
DR NextBio; 12899; -.
DR PRO; PR:P37235; -.
DR ArrayExpress; P37235; -.
DR Bgee; P37235; -.
DR CleanEx; HS_HPCAL1; -.
DR Genevestigator; P37235; -.
DR GO; GO:0005509; F:calcium ion binding; TAS:ProtInc.
DR Gene3D; 1.10.238.10; -; 3.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR001125; Recoverin_like.
DR Pfam; PF13499; EF-hand_7; 2.
DR PRINTS; PR00450; RECOVERIN.
DR SMART; SM00054; EFh; 3.
DR PROSITE; PS00018; EF_HAND_1; 3.
DR PROSITE; PS50222; EF_HAND_2; 4.
PE 1: Evidence at protein level;
KW Calcium; Complete proteome; Lipoprotein; Metal-binding; Myristate;
KW Reference proteome; Repeat.
FT INIT_MET 1 1 Removed (By similarity).
FT CHAIN 2 193 Hippocalcin-like protein 1.
FT /FTId=PRO_0000073771.
FT DOMAIN 23 58 EF-hand 1.
FT DOMAIN 60 95 EF-hand 2.
FT DOMAIN 96 131 EF-hand 3.
FT DOMAIN 144 179 EF-hand 4.
FT CA_BIND 73 84 1 (Potential).
FT CA_BIND 109 120 2 (Potential).
FT CA_BIND 157 168 3 (Potential).
FT LIPID 2 2 N-myristoyl glycine (By similarity).
FT CONFLICT 19 19 N -> K (in Ref. 1; BAA03754).
FT CONFLICT 88 88 A -> G (in Ref. 1; BAA03754).
FT CONFLICT 93 94 SR -> RG (in Ref. 1; BAA03754).
SQ SEQUENCE 193 AA; 22313 MW; 87DCE938DCAD5E1F CRC64;
MGKQNSKLRP EVLQDLRENT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK IYANFFPYGD
ASKFAEHVFR TFDTNGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISRSE
MLEIVQAIYK MVSSVMKMPE DESTPEKRTD KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV
RLLQCDPSSA SQF
//
MIM
600207
*RECORD*
*FIELD* NO
600207
*FIELD* TI
*600207 HIPPOCALCIN-LIKE 1; HPCAL1
*FIELD* TX
Hippocalcin-like-1 is a member of a family of neuron-specific
read moreCa(2+)-binding proteins found in the retina and brain.
CLONING
Using rat hippocalcin (142622) cDNA as a probe in the screening of a
human hippocampus cDNA library under low stringency conditions,
Kobayashi et al. (1994) isolated a clone that encoded a novel
calcium-binding protein structurally related to hippocalcin. They showed
that this hippocalcin-like protein has a primary structure of 193 amino
acids and contains 3 EF-hand structures and a possible NH2-terminal
myristoylation site. A single transcript of 1.7 kb was detected only in
the brain.
MAPPING
By analysis of somatic cell hybrids, Kobayashi et al. (1994) mapped the
HPCAL1 gene to chromosome 2.
*FIELD* RF
1. Kobayashi, M.; Takamatsu, K.; Fujishiro, M.; Saitoh, S.; Noguchi,
T.: Molecular cloning of a novel calcium-binding protein structurally
related to hippocalcin from human brain and chromosomal mapping of
its gene. Biochim. Biophys. Acta 1222: 515-518, 1994.
*FIELD* CD
Victor A. McKusick: 11/23/1994
*FIELD* ED
carol: 02/27/2002
carol: 11/23/1994
*RECORD*
*FIELD* NO
600207
*FIELD* TI
*600207 HIPPOCALCIN-LIKE 1; HPCAL1
*FIELD* TX
Hippocalcin-like-1 is a member of a family of neuron-specific
read moreCa(2+)-binding proteins found in the retina and brain.
CLONING
Using rat hippocalcin (142622) cDNA as a probe in the screening of a
human hippocampus cDNA library under low stringency conditions,
Kobayashi et al. (1994) isolated a clone that encoded a novel
calcium-binding protein structurally related to hippocalcin. They showed
that this hippocalcin-like protein has a primary structure of 193 amino
acids and contains 3 EF-hand structures and a possible NH2-terminal
myristoylation site. A single transcript of 1.7 kb was detected only in
the brain.
MAPPING
By analysis of somatic cell hybrids, Kobayashi et al. (1994) mapped the
HPCAL1 gene to chromosome 2.
*FIELD* RF
1. Kobayashi, M.; Takamatsu, K.; Fujishiro, M.; Saitoh, S.; Noguchi,
T.: Molecular cloning of a novel calcium-binding protein structurally
related to hippocalcin from human brain and chromosomal mapping of
its gene. Biochim. Biophys. Acta 1222: 515-518, 1994.
*FIELD* CD
Victor A. McKusick: 11/23/1994
*FIELD* ED
carol: 02/27/2002
carol: 11/23/1994