Full text data of HOXB7
HOXB7
(HOX2C)
[Confidence: low (only semi-automatic identification from reviews)]
Homeobox protein Hox-B7 (Homeobox protein HHO.C1; Homeobox protein Hox-2C)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Homeobox protein Hox-B7 (Homeobox protein HHO.C1; Homeobox protein Hox-2C)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
P09629
ID HXB7_HUMAN Reviewed; 217 AA.
AC P09629; A8K3N8; Q15957; Q53FN3; Q96BQ6;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
read moreDT 02-NOV-2010, sequence version 4.
DT 22-JAN-2014, entry version 135.
DE RecName: Full=Homeobox protein Hox-B7;
DE AltName: Full=Homeobox protein HHO.C1;
DE AltName: Full=Homeobox protein Hox-2C;
GN Name=HOXB7; Synonyms=HOX2C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ALA-9.
RX PubMed=2885844; DOI=10.1073/pnas.84.14.4914;
RA Simeone A., Mavilio F., Acampora D., Giampaolo A., Faiella A.,
RA Zappavigna V., D'Esposito M., Pannese M., Russo G., Boncinelli E.,
RA Peschle C.;
RT "Two human homeobox genes, c1 and c8: structure analysis and
RT expression in embryonic development.";
RL Proc. Natl. Acad. Sci. U.S.A. 84:4914-4918(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-9.
RC TISSUE=Embryo;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-9.
RC TISSUE=Gastric mucosa;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ALA-9.
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT the human lineage.";
RL Nature 440:1045-1049(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-9.
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 98-217.
RX PubMed=1678287;
RA Baier L.J., Hannibal M.C., Hanley E.W., Nabel G.J.;
RT "Lymphoid expression and TATAA binding of a human protein containing
RT an Antennapedia homeodomain.";
RL Blood 78:1047-1055(1991).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 119-217.
RX PubMed=2573064; DOI=10.1073/pnas.86.21.8536;
RA Shen W.-F., Largman C., Lowney P., Corral J.C., Detmer K.,
RA Hauser C.A., Simonitch T.A., Hack F.M., Lawrence H.J.;
RT "Lineage-restricted expression of homeobox-containing genes in human
RT hematopoietic cell lines.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:8536-8540(1989).
RN [9]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 137-202.
RX PubMed=2576652;
RA Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R.,
RA Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.;
RT "Organization of human class I homeobox genes.";
RL Genome 31:745-756(1989).
RN [10]
RP UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-191 AND LYS-193, AND MASS
RP SPECTROMETRY.
RC TISSUE=Lung adenocarcinoma;
RX PubMed=17203973; DOI=10.1021/pr060438j;
RA Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M.,
RA Haines D.S., Figeys D.;
RT "The proteomic reactor facilitates the analysis of affinity-purified
RT proteins by mass spectrometry: application for identifying
RT ubiquitinated proteins in human cells.";
RL J. Proteome Res. 6:298-305(2007).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of
CC a developmental regulatory system that provides cells with
CC specific positional identities on the anterior-posterior axis.
CC -!- INTERACTION:
CC P78527:PRKDC; NbExp=2; IntAct=EBI-1248457, EBI-352053;
CC P13010:XRCC5; NbExp=9; IntAct=EBI-1248457, EBI-357997;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Antp homeobox family.
CC -!- SIMILARITY: Contains 1 homeobox DNA-binding domain.
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DR EMBL; M16937; AAA36003.1; -; mRNA.
DR EMBL; AK290653; BAF83342.1; -; mRNA.
DR EMBL; AK223249; BAD96969.1; -; mRNA.
DR EMBL; AC103702; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; CH471109; EAW94725.1; -; Genomic_DNA.
DR EMBL; BC015345; AAH15345.1; -; mRNA.
DR EMBL; S49765; AAB19469.2; -; mRNA.
DR EMBL; M30598; AAA36005.1; -; mRNA.
DR PIR; A28030; WJHU2C.
DR RefSeq; NP_004493.3; NM_004502.3.
DR UniGene; Hs.436181; -.
DR ProteinModelPortal; P09629; -.
DR SMR; P09629; 141-196.
DR IntAct; P09629; 4.
DR STRING; 9606.ENSP00000239165; -.
DR PhosphoSite; P09629; -.
DR DMDM; 311033482; -.
DR PaxDb; P09629; -.
DR PRIDE; P09629; -.
DR DNASU; 3217; -.
DR Ensembl; ENST00000239165; ENSP00000239165; ENSG00000260027.
DR GeneID; 3217; -.
DR KEGG; hsa:3217; -.
DR UCSC; uc002inv.3; human.
DR CTD; 3217; -.
DR GeneCards; GC17M046684; -.
DR HGNC; HGNC:5118; HOXB7.
DR HPA; HPA049940; -.
DR MIM; 142962; gene.
DR neXtProt; NX_P09629; -.
DR eggNOG; NOG238660; -.
DR HOGENOM; HOG000231181; -.
DR HOVERGEN; HBG016849; -.
DR InParanoid; P09629; -.
DR KO; K09307; -.
DR OMA; SMQGLYP; -.
DR OrthoDB; EOG780RP4; -.
DR PhylomeDB; P09629; -.
DR GeneWiki; HOXB7; -.
DR GenomeRNAi; 3217; -.
DR NextBio; 12800; -.
DR PRO; PR:P09629; -.
DR ArrayExpress; P09629; -.
DR Bgee; P09629; -.
DR CleanEx; HS_HOXB7; -.
DR Genevestigator; P09629; -.
DR GO; GO:0005737; C:cytoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:UniProtKB.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl.
DR GO; GO:0007275; P:multicellular organismal development; NAS:UniProtKB.
DR GO; GO:0030099; P:myeloid cell differentiation; IEA:Ensembl.
DR GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IEA:Ensembl.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.60; -; 1.
DR InterPro; IPR017995; Homeobox_antennapedia.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR009057; Homeodomain-like.
DR Pfam; PF00046; Homeobox; 1.
DR PRINTS; PR00025; ANTENNAPEDIA.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Developmental protein; DNA-binding; Homeobox;
KW Isopeptide bond; Nucleus; Polymorphism; Reference proteome;
KW Transcription; Transcription regulation; Ubl conjugation.
FT CHAIN 1 217 Homeobox protein Hox-B7.
FT /FTId=PRO_0000200142.
FT DNA_BIND 137 196 Homeobox.
FT MOTIF 126 131 Antp-type hexapeptide.
FT COMPBIAS 212 217 Glu-rich (acidic).
FT CROSSLNK 191 191 Glycyl lysine isopeptide (Lys-Gly)
FT (interchain with G-Cter in ubiquitin).
FT CROSSLNK 193 193 Glycyl lysine isopeptide (Lys-Gly)
FT (interchain with G-Cter in ubiquitin).
FT VARIANT 9 9 T -> A (in dbSNP:rs7406910).
FT /FTId=VAR_058204.
FT CONFLICT 49 49 A -> V (in Ref. 2; BAF83342 and 3;
FT BAD96969).
FT CONFLICT 53 53 A -> G (in Ref. 1; AAA36003).
FT CONFLICT 94 94 Q -> L (in Ref. 3; BAD96969).
FT CONFLICT 108 108 A -> G (in Ref. 7; AAB19469).
FT CONFLICT 118 118 L -> F (in Ref. 7; AAB19469).
FT CONFLICT 129 129 W -> S (in Ref. 1; AAA36003).
FT CONFLICT 153 153 E -> G (in Ref. 3; BAD96969).
FT CONFLICT 154 154 K -> N (in Ref. 7; AAB19469).
FT CONFLICT 173 173 T -> A (in Ref. 1; AAA36003 and 7;
FT AAB19469).
FT CONFLICT 194 194 K -> N (in Ref. 7; AAB19469).
FT CONFLICT 200 202 GPG -> APA (in Ref. 7; AAB19469).
SQ SEQUENCE 217 AA; 24015 MW; E92D63F437D34628 CRC64;
MSSLYYANTL FSKYPASSSV FATGAFPEQT SCAFASNPQR PGYGAGSGAS FAASMQGLYP
GGGGMAGQSA AGVYAAGYGL EPSSFNMHCA PFEQNLSGVC PGDSAKAAGA KEQRDSDLAA
ESNFRIYPWM RSSGTDRKRG RQTYTRYQTL ELEKEFHYNR YLTRRRRIEI AHTLCLTERQ
IKIWFQNRRM KWKKENKTAG PGTTGQDRAE AEEEEEE
//
ID HXB7_HUMAN Reviewed; 217 AA.
AC P09629; A8K3N8; Q15957; Q53FN3; Q96BQ6;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
read moreDT 02-NOV-2010, sequence version 4.
DT 22-JAN-2014, entry version 135.
DE RecName: Full=Homeobox protein Hox-B7;
DE AltName: Full=Homeobox protein HHO.C1;
DE AltName: Full=Homeobox protein Hox-2C;
GN Name=HOXB7; Synonyms=HOX2C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ALA-9.
RX PubMed=2885844; DOI=10.1073/pnas.84.14.4914;
RA Simeone A., Mavilio F., Acampora D., Giampaolo A., Faiella A.,
RA Zappavigna V., D'Esposito M., Pannese M., Russo G., Boncinelli E.,
RA Peschle C.;
RT "Two human homeobox genes, c1 and c8: structure analysis and
RT expression in embryonic development.";
RL Proc. Natl. Acad. Sci. U.S.A. 84:4914-4918(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-9.
RC TISSUE=Embryo;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-9.
RC TISSUE=Gastric mucosa;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ALA-9.
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT the human lineage.";
RL Nature 440:1045-1049(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-9.
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 98-217.
RX PubMed=1678287;
RA Baier L.J., Hannibal M.C., Hanley E.W., Nabel G.J.;
RT "Lymphoid expression and TATAA binding of a human protein containing
RT an Antennapedia homeodomain.";
RL Blood 78:1047-1055(1991).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 119-217.
RX PubMed=2573064; DOI=10.1073/pnas.86.21.8536;
RA Shen W.-F., Largman C., Lowney P., Corral J.C., Detmer K.,
RA Hauser C.A., Simonitch T.A., Hack F.M., Lawrence H.J.;
RT "Lineage-restricted expression of homeobox-containing genes in human
RT hematopoietic cell lines.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:8536-8540(1989).
RN [9]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 137-202.
RX PubMed=2576652;
RA Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R.,
RA Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.;
RT "Organization of human class I homeobox genes.";
RL Genome 31:745-756(1989).
RN [10]
RP UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-191 AND LYS-193, AND MASS
RP SPECTROMETRY.
RC TISSUE=Lung adenocarcinoma;
RX PubMed=17203973; DOI=10.1021/pr060438j;
RA Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M.,
RA Haines D.S., Figeys D.;
RT "The proteomic reactor facilitates the analysis of affinity-purified
RT proteins by mass spectrometry: application for identifying
RT ubiquitinated proteins in human cells.";
RL J. Proteome Res. 6:298-305(2007).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of
CC a developmental regulatory system that provides cells with
CC specific positional identities on the anterior-posterior axis.
CC -!- INTERACTION:
CC P78527:PRKDC; NbExp=2; IntAct=EBI-1248457, EBI-352053;
CC P13010:XRCC5; NbExp=9; IntAct=EBI-1248457, EBI-357997;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Antp homeobox family.
CC -!- SIMILARITY: Contains 1 homeobox DNA-binding domain.
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DR EMBL; M16937; AAA36003.1; -; mRNA.
DR EMBL; AK290653; BAF83342.1; -; mRNA.
DR EMBL; AK223249; BAD96969.1; -; mRNA.
DR EMBL; AC103702; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; CH471109; EAW94725.1; -; Genomic_DNA.
DR EMBL; BC015345; AAH15345.1; -; mRNA.
DR EMBL; S49765; AAB19469.2; -; mRNA.
DR EMBL; M30598; AAA36005.1; -; mRNA.
DR PIR; A28030; WJHU2C.
DR RefSeq; NP_004493.3; NM_004502.3.
DR UniGene; Hs.436181; -.
DR ProteinModelPortal; P09629; -.
DR SMR; P09629; 141-196.
DR IntAct; P09629; 4.
DR STRING; 9606.ENSP00000239165; -.
DR PhosphoSite; P09629; -.
DR DMDM; 311033482; -.
DR PaxDb; P09629; -.
DR PRIDE; P09629; -.
DR DNASU; 3217; -.
DR Ensembl; ENST00000239165; ENSP00000239165; ENSG00000260027.
DR GeneID; 3217; -.
DR KEGG; hsa:3217; -.
DR UCSC; uc002inv.3; human.
DR CTD; 3217; -.
DR GeneCards; GC17M046684; -.
DR HGNC; HGNC:5118; HOXB7.
DR HPA; HPA049940; -.
DR MIM; 142962; gene.
DR neXtProt; NX_P09629; -.
DR eggNOG; NOG238660; -.
DR HOGENOM; HOG000231181; -.
DR HOVERGEN; HBG016849; -.
DR InParanoid; P09629; -.
DR KO; K09307; -.
DR OMA; SMQGLYP; -.
DR OrthoDB; EOG780RP4; -.
DR PhylomeDB; P09629; -.
DR GeneWiki; HOXB7; -.
DR GenomeRNAi; 3217; -.
DR NextBio; 12800; -.
DR PRO; PR:P09629; -.
DR ArrayExpress; P09629; -.
DR Bgee; P09629; -.
DR CleanEx; HS_HOXB7; -.
DR Genevestigator; P09629; -.
DR GO; GO:0005737; C:cytoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:UniProtKB.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl.
DR GO; GO:0007275; P:multicellular organismal development; NAS:UniProtKB.
DR GO; GO:0030099; P:myeloid cell differentiation; IEA:Ensembl.
DR GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IEA:Ensembl.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.60; -; 1.
DR InterPro; IPR017995; Homeobox_antennapedia.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR009057; Homeodomain-like.
DR Pfam; PF00046; Homeobox; 1.
DR PRINTS; PR00025; ANTENNAPEDIA.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Developmental protein; DNA-binding; Homeobox;
KW Isopeptide bond; Nucleus; Polymorphism; Reference proteome;
KW Transcription; Transcription regulation; Ubl conjugation.
FT CHAIN 1 217 Homeobox protein Hox-B7.
FT /FTId=PRO_0000200142.
FT DNA_BIND 137 196 Homeobox.
FT MOTIF 126 131 Antp-type hexapeptide.
FT COMPBIAS 212 217 Glu-rich (acidic).
FT CROSSLNK 191 191 Glycyl lysine isopeptide (Lys-Gly)
FT (interchain with G-Cter in ubiquitin).
FT CROSSLNK 193 193 Glycyl lysine isopeptide (Lys-Gly)
FT (interchain with G-Cter in ubiquitin).
FT VARIANT 9 9 T -> A (in dbSNP:rs7406910).
FT /FTId=VAR_058204.
FT CONFLICT 49 49 A -> V (in Ref. 2; BAF83342 and 3;
FT BAD96969).
FT CONFLICT 53 53 A -> G (in Ref. 1; AAA36003).
FT CONFLICT 94 94 Q -> L (in Ref. 3; BAD96969).
FT CONFLICT 108 108 A -> G (in Ref. 7; AAB19469).
FT CONFLICT 118 118 L -> F (in Ref. 7; AAB19469).
FT CONFLICT 129 129 W -> S (in Ref. 1; AAA36003).
FT CONFLICT 153 153 E -> G (in Ref. 3; BAD96969).
FT CONFLICT 154 154 K -> N (in Ref. 7; AAB19469).
FT CONFLICT 173 173 T -> A (in Ref. 1; AAA36003 and 7;
FT AAB19469).
FT CONFLICT 194 194 K -> N (in Ref. 7; AAB19469).
FT CONFLICT 200 202 GPG -> APA (in Ref. 7; AAB19469).
SQ SEQUENCE 217 AA; 24015 MW; E92D63F437D34628 CRC64;
MSSLYYANTL FSKYPASSSV FATGAFPEQT SCAFASNPQR PGYGAGSGAS FAASMQGLYP
GGGGMAGQSA AGVYAAGYGL EPSSFNMHCA PFEQNLSGVC PGDSAKAAGA KEQRDSDLAA
ESNFRIYPWM RSSGTDRKRG RQTYTRYQTL ELEKEFHYNR YLTRRRRIEI AHTLCLTERQ
IKIWFQNRRM KWKKENKTAG PGTTGQDRAE AEEEEEE
//
MIM
142962
*RECORD*
*FIELD* NO
142962
*FIELD* TI
*142962 HOMEOBOX B7; HOXB7
;;HOMEOBOX 2C; HOX2C;;
Hox-2.3, MOUSE, HOMOLOG OF
*FIELD* TX
read moreFor background information on homeobox genes, see 142950.
CLONING
Simeone et al. (1987) characterized 2 human cDNA clones, each containing
a homeobox region. The corresponding genes, termed c1 (HOXB7) and c8
(HOXC6; 142972), were evaluated in different organs and body parts
during human embryonic and fetal development. Differential expression
suggested that the genes play a key role in a variety of developmental
processes.
GENE FUNCTION
In mouse, Hoxb7 expression is confined to macrophages. Using RT-PCR,
Lill et al. (1995) detected expression of HOXB7 in monocytes
differentiated from HL60 cells by stimulation with vitamin D3.
Overexpression of HOXB7 inhibited differentiation into granulocytes but
not monocytes. However, RT-PCR analysis failed to detect HOXB7
expression in mature monocytes.
BIOCHEMICAL FEATURES
HOX proteins have a conserved DNA-binding homeodomain, a pentapeptide
motif that mediates interactions with PBX proteins (e.g., PBX1; 176310),
and an N-terminal octapeptide motif. Yaron et al. (2001) found that
wildtype HOXB7 inhibited differentiation of a murine myelomonocytic cell
line, 32D, but that mutations in any of the conserved regions blocked
this inhibitory effect. Mutations in casein kinase phosphorylation
sites, the glutamate-rich C terminus, or the N-terminal 14 residues of
HOXB7 enhanced 32D differentiation.
MAPPING
As reviewed by Acampora et al. (1989), the homeobox region 2 contains 9
homeobox genes in 180 kb of DNA on chromosome 17. The order, from
5-prime to 3-prime, is HOXB9 (HOX2E), HOXB8 (HOX2D), HOXB7 (HOX2C),
HOXB6 (HOX2B), HOXB5 (HOX2A), HOXB4 (HOX2F), HOXB3 (HOX2G), HOXB2
(HOX2H), HOXB1 (HOX2I).
*FIELD* RF
1. Acampora, D.; D'Esposito, M.; Faiella, A.; Pannese, M.; Migliaccio,
E.; Morelli, F.; Stornaiuolo, A.; Nigro, V.; Simeone, A.; Boncinelli,
E.: The human HOX gene family. Nucleic Acids Res. 17: 10385-10402,
1989.
2. Lill, M. C.; Fuller, J. F.; Herzig, R.; Crooks, G. M.; Gasson,
J. C.: The role of the homeobox gene, HOX B7, in human myelomonocytic
differentiation. Blood 85: 692-697, 1995.
3. Simeone, A.; Mavilio, F.; Acampora, D.; Giampaolo, A.; Faiella,
A.; Zappavigna, V.; D'Esposito, M.; Pannese, M.; Russo, G.; Boncinelli,
E.; Peschle, C.: Two human homeobox genes, c1 and c8: structure analysis
and expression in embryonic development. Proc. Nat. Acad. Sci. 84:
4914-4918, 1987.
4. Yaron, Y.; McAdara, J. K.; Lynch, M.; Hughes, E.; Gasson, J. C.
: Identification of novel functional regions important for the activity
of HOXB7 in mammalian cells. J. Immun. 166: 5058-5067, 2001.
*FIELD* CN
Paul J. Converse - updated: 11/29/2001
*FIELD* CD
Victor A. McKusick: 8/22/1990
*FIELD* ED
terry: 03/18/2004
mgross: 12/4/2001
terry: 11/29/2001
alopez: 4/11/2000
carol: 3/27/2000
dkim: 7/21/1998
dkim: 6/26/1998
alopez: 6/4/1997
mark: 8/19/1996
marlene: 8/15/1996
supermim: 3/16/1992
carol: 8/22/1990
*RECORD*
*FIELD* NO
142962
*FIELD* TI
*142962 HOMEOBOX B7; HOXB7
;;HOMEOBOX 2C; HOX2C;;
Hox-2.3, MOUSE, HOMOLOG OF
*FIELD* TX
read moreFor background information on homeobox genes, see 142950.
CLONING
Simeone et al. (1987) characterized 2 human cDNA clones, each containing
a homeobox region. The corresponding genes, termed c1 (HOXB7) and c8
(HOXC6; 142972), were evaluated in different organs and body parts
during human embryonic and fetal development. Differential expression
suggested that the genes play a key role in a variety of developmental
processes.
GENE FUNCTION
In mouse, Hoxb7 expression is confined to macrophages. Using RT-PCR,
Lill et al. (1995) detected expression of HOXB7 in monocytes
differentiated from HL60 cells by stimulation with vitamin D3.
Overexpression of HOXB7 inhibited differentiation into granulocytes but
not monocytes. However, RT-PCR analysis failed to detect HOXB7
expression in mature monocytes.
BIOCHEMICAL FEATURES
HOX proteins have a conserved DNA-binding homeodomain, a pentapeptide
motif that mediates interactions with PBX proteins (e.g., PBX1; 176310),
and an N-terminal octapeptide motif. Yaron et al. (2001) found that
wildtype HOXB7 inhibited differentiation of a murine myelomonocytic cell
line, 32D, but that mutations in any of the conserved regions blocked
this inhibitory effect. Mutations in casein kinase phosphorylation
sites, the glutamate-rich C terminus, or the N-terminal 14 residues of
HOXB7 enhanced 32D differentiation.
MAPPING
As reviewed by Acampora et al. (1989), the homeobox region 2 contains 9
homeobox genes in 180 kb of DNA on chromosome 17. The order, from
5-prime to 3-prime, is HOXB9 (HOX2E), HOXB8 (HOX2D), HOXB7 (HOX2C),
HOXB6 (HOX2B), HOXB5 (HOX2A), HOXB4 (HOX2F), HOXB3 (HOX2G), HOXB2
(HOX2H), HOXB1 (HOX2I).
*FIELD* RF
1. Acampora, D.; D'Esposito, M.; Faiella, A.; Pannese, M.; Migliaccio,
E.; Morelli, F.; Stornaiuolo, A.; Nigro, V.; Simeone, A.; Boncinelli,
E.: The human HOX gene family. Nucleic Acids Res. 17: 10385-10402,
1989.
2. Lill, M. C.; Fuller, J. F.; Herzig, R.; Crooks, G. M.; Gasson,
J. C.: The role of the homeobox gene, HOX B7, in human myelomonocytic
differentiation. Blood 85: 692-697, 1995.
3. Simeone, A.; Mavilio, F.; Acampora, D.; Giampaolo, A.; Faiella,
A.; Zappavigna, V.; D'Esposito, M.; Pannese, M.; Russo, G.; Boncinelli,
E.; Peschle, C.: Two human homeobox genes, c1 and c8: structure analysis
and expression in embryonic development. Proc. Nat. Acad. Sci. 84:
4914-4918, 1987.
4. Yaron, Y.; McAdara, J. K.; Lynch, M.; Hughes, E.; Gasson, J. C.
: Identification of novel functional regions important for the activity
of HOXB7 in mammalian cells. J. Immun. 166: 5058-5067, 2001.
*FIELD* CN
Paul J. Converse - updated: 11/29/2001
*FIELD* CD
Victor A. McKusick: 8/22/1990
*FIELD* ED
terry: 03/18/2004
mgross: 12/4/2001
terry: 11/29/2001
alopez: 4/11/2000
carol: 3/27/2000
dkim: 7/21/1998
dkim: 6/26/1998
alopez: 6/4/1997
mark: 8/19/1996
marlene: 8/15/1996
supermim: 3/16/1992
carol: 8/22/1990