Full text data of ABCC1
ABCC1
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
I3L4X2
ID I3L4X2_HUMAN Unreviewed; 1440 AA.
AC I3L4X2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
read moreDT 22-JAN-2014, entry version 12.
DE SubName: Full=Multidrug resistance-associated protein 1;
DE Flags: Fragment;
GN Name=ABCC1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [2]
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2012) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily.
CC -!- SIMILARITY: Contains ABC transmembrane type-1 domains.
CC -!- SIMILARITY: Contains ABC transmembrane type-domains.
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data.
CC -----------------------------------------------------------------------
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DR EMBL; AC025778; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC130651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC136624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR ProteinModelPortal; I3L4X2; -.
DR PRIDE; I3L4X2; -.
DR Ensembl; ENST00000572882; ENSP00000461615; ENSG00000103222.
DR UCSC; uc002del.4; human.
DR HGNC; HGNC:51; ABCC1.
DR ChiTaRS; ABCC1; human.
DR NextBio; 35533403; -.
DR GO; GO:0016021; C:integral to membrane; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro.
DR GO; GO:0006200; P:ATP catabolic process; IEA:GOC.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR003439; ABC_transporter-like.
DR InterPro; IPR017871; ABC_transporter_CS.
DR InterPro; IPR001140; ABC_transptr_TM_dom.
DR InterPro; IPR005292; Multidrug-R_assoc.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR SUPFAM; SSF90123; SSF90123; 2.
DR TIGRFAMs; TIGR00957; MRP_assoc_pro; 1.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Nucleotide-binding;
KW Reference proteome; Repeat.
FT NON_TER 1 1
SQ SEQUENCE 1440 AA; 160550 MW; AA3B6BCE032D19BA CRC64;
XAPVFLVSPT LLGITMLLAT FLIQLERRKG VQSSGIMLTF WLVALVCALA ILRSKIMTAL
KEDAQVDLFR DITFYVYFSL LLIQLVLSCF SDRSPLFSET IHDPNPCPES SASFLSRITF
WWITGLIVRG YRQPLEGSDL WSLNKEDTSE QVVPVLVKNW KKECAKTRKQ PVKVVYSSKD
PAQPKESSKV DANEEVEALI VKSPQKEWNP SLFKVLYKTF GPYFLMSFFF KAIHDLMMFS
GPQILKLLIK FVNDTKAPDW QGYFYTVLLF VTACLQTLVL HQYFHICFVS GMRIKTAVIG
AVYRKALVIT NSARKSSTVG EIVNLMSVDA QRFMDLATYI NMIWSAPLQV ILALYLLWLN
LGPSVLAGVA VMVLMVPVNA VMAMKTKTYQ VAHMKSKDNR IKLMNEILNG IKVLKLYAWE
LAFKDKVLAI RQEELKVLKK SAYLSAVGTF TWVCTPFLVA LCTFAVYVTI DENNILDAQT
AFVSLALFNI LRFPLNILPM VISSIVQASV SLKRLRIFLS HEELEPDSIE RRPVKDGGGT
NSITVRNATF TWARSDPPTL NGITFSIPEG ALVAVVGQVG CGKSSLLSAL LAEMDKVEGH
VAIKGSVAYV PQQAWIQNDS LRENILFGCQ LEEPYYRSVI QACALLPDLE ILPSGDRTEI
GEKGVNLSGG QKQRVSLARA VYSNADIYLF DDPLSAVDAH VGKHIFENVI GPKGMLKNKT
RILVTHSMSY LPQVDVIIVM SGGKISEMGS YQELLARDGA FAEFLRTYAS TEQEQDAEEN
GSTVMDEEEA GVTGVSGPGK EAKQMENGML VTDSAGKQLQ RQLSSSSSYS GDISRHHNST
AELQKAEAKK EETWKLMEAD KAQTGQVKLS VYWDYMKAIG LFISFLSIFL FMCNHVSALA
SNYWLSLWTD DPIVNGTQEH TKVRLSVYGA LGISQGIAVF GYSMAVSIGG ILASRCLHVD
LLHSILRSPM SFFERTPSGN LVNRFSKELD TVDSMIPEVI KMFMGSLFNV IGACIVILLA
TPIAAIIIPP LGLIYFFVQR FYVASSRQLK RLESVSRSPV YSHFNETLLG VSVIRAFEEQ
ERFIHQSDLK VDENQKAYYP SIVANRWLAV RLECVGNCIV LFAALFAVIS RHSLSAGLVG
LSVSYSLQVT TYLNWLVRMS SEMETNIVAV ERLKEYSETE KEAPWQIQET APPSSWPQVG
RVEFRNYCLR YREDLDFVLR HINVTINGGE KVGIVGRTGA GKSSLTLGLF RINESAEGEI
IIDGINIAKI GLHDLRFKIT IIPQDPVLFS GSLRMNLDPF SQYSDEEVWT SLELAHLKDF
VSALPDKLDH ECAEGGENLS VGQRQLVCLA RALLRKTKIL VLDEATAAVD LETDDLIQST
IRTQFEDCTV LTIAHRLNTI MDYTRVIVLD KGEIQEYGAP SDLLQQRGLF YSMAKDAGLV
//
ID I3L4X2_HUMAN Unreviewed; 1440 AA.
AC I3L4X2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
read moreDT 22-JAN-2014, entry version 12.
DE SubName: Full=Multidrug resistance-associated protein 1;
DE Flags: Fragment;
GN Name=ABCC1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [2]
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2012) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily.
CC -!- SIMILARITY: Contains ABC transmembrane type-1 domains.
CC -!- SIMILARITY: Contains ABC transmembrane type-domains.
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AC025778; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC130651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC136624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR ProteinModelPortal; I3L4X2; -.
DR PRIDE; I3L4X2; -.
DR Ensembl; ENST00000572882; ENSP00000461615; ENSG00000103222.
DR UCSC; uc002del.4; human.
DR HGNC; HGNC:51; ABCC1.
DR ChiTaRS; ABCC1; human.
DR NextBio; 35533403; -.
DR GO; GO:0016021; C:integral to membrane; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro.
DR GO; GO:0006200; P:ATP catabolic process; IEA:GOC.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR003439; ABC_transporter-like.
DR InterPro; IPR017871; ABC_transporter_CS.
DR InterPro; IPR001140; ABC_transptr_TM_dom.
DR InterPro; IPR005292; Multidrug-R_assoc.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR SUPFAM; SSF90123; SSF90123; 2.
DR TIGRFAMs; TIGR00957; MRP_assoc_pro; 1.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Nucleotide-binding;
KW Reference proteome; Repeat.
FT NON_TER 1 1
SQ SEQUENCE 1440 AA; 160550 MW; AA3B6BCE032D19BA CRC64;
XAPVFLVSPT LLGITMLLAT FLIQLERRKG VQSSGIMLTF WLVALVCALA ILRSKIMTAL
KEDAQVDLFR DITFYVYFSL LLIQLVLSCF SDRSPLFSET IHDPNPCPES SASFLSRITF
WWITGLIVRG YRQPLEGSDL WSLNKEDTSE QVVPVLVKNW KKECAKTRKQ PVKVVYSSKD
PAQPKESSKV DANEEVEALI VKSPQKEWNP SLFKVLYKTF GPYFLMSFFF KAIHDLMMFS
GPQILKLLIK FVNDTKAPDW QGYFYTVLLF VTACLQTLVL HQYFHICFVS GMRIKTAVIG
AVYRKALVIT NSARKSSTVG EIVNLMSVDA QRFMDLATYI NMIWSAPLQV ILALYLLWLN
LGPSVLAGVA VMVLMVPVNA VMAMKTKTYQ VAHMKSKDNR IKLMNEILNG IKVLKLYAWE
LAFKDKVLAI RQEELKVLKK SAYLSAVGTF TWVCTPFLVA LCTFAVYVTI DENNILDAQT
AFVSLALFNI LRFPLNILPM VISSIVQASV SLKRLRIFLS HEELEPDSIE RRPVKDGGGT
NSITVRNATF TWARSDPPTL NGITFSIPEG ALVAVVGQVG CGKSSLLSAL LAEMDKVEGH
VAIKGSVAYV PQQAWIQNDS LRENILFGCQ LEEPYYRSVI QACALLPDLE ILPSGDRTEI
GEKGVNLSGG QKQRVSLARA VYSNADIYLF DDPLSAVDAH VGKHIFENVI GPKGMLKNKT
RILVTHSMSY LPQVDVIIVM SGGKISEMGS YQELLARDGA FAEFLRTYAS TEQEQDAEEN
GSTVMDEEEA GVTGVSGPGK EAKQMENGML VTDSAGKQLQ RQLSSSSSYS GDISRHHNST
AELQKAEAKK EETWKLMEAD KAQTGQVKLS VYWDYMKAIG LFISFLSIFL FMCNHVSALA
SNYWLSLWTD DPIVNGTQEH TKVRLSVYGA LGISQGIAVF GYSMAVSIGG ILASRCLHVD
LLHSILRSPM SFFERTPSGN LVNRFSKELD TVDSMIPEVI KMFMGSLFNV IGACIVILLA
TPIAAIIIPP LGLIYFFVQR FYVASSRQLK RLESVSRSPV YSHFNETLLG VSVIRAFEEQ
ERFIHQSDLK VDENQKAYYP SIVANRWLAV RLECVGNCIV LFAALFAVIS RHSLSAGLVG
LSVSYSLQVT TYLNWLVRMS SEMETNIVAV ERLKEYSETE KEAPWQIQET APPSSWPQVG
RVEFRNYCLR YREDLDFVLR HINVTINGGE KVGIVGRTGA GKSSLTLGLF RINESAEGEI
IIDGINIAKI GLHDLRFKIT IIPQDPVLFS GSLRMNLDPF SQYSDEEVWT SLELAHLKDF
VSALPDKLDH ECAEGGENLS VGQRQLVCLA RALLRKTKIL VLDEATAAVD LETDDLIQST
IRTQFEDCTV LTIAHRLNTI MDYTRVIVLD KGEIQEYGAP SDLLQQRGLF YSMAKDAGLV
//