Full text data of IFI35
IFI35
(IFP35)
[Confidence: low (only semi-automatic identification from reviews)]
Interferon-induced 35 kDa protein; IFP 35; Ifi-35
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Interferon-induced 35 kDa protein; IFP 35; Ifi-35
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
P80217
ID IN35_HUMAN Reviewed; 286 AA.
AC P80217; C9JGX1; Q92984; Q99537; Q9BV98;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
read moreDT 02-NOV-2010, sequence version 5.
DT 22-JAN-2014, entry version 112.
DE RecName: Full=Interferon-induced 35 kDa protein;
DE Short=IFP 35;
DE Short=Ifi-35;
GN Name=IFI35; Synonyms=IFP35;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE (ISOFORM 1).
RX PubMed=8288566;
RA Bange F.-C., Vogel U., Flohr T., Kiekenbeck M., Denecke B.,
RA Boettger E.C.;
RT "IFP 35 is an interferon-induced leucine zipper protein that undergoes
RT interferon-regulated cellular redistribution.";
RL J. Biol. Chem. 269:1091-1098(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT VAL-128 (ISOFORM
RP 2).
RX PubMed=8954125; DOI=10.1006/bbrc.1996.1799;
RA Wang X., Johansen L.M., Tae H.-J., Taparowsky E.J.;
RT "IFP 35 forms complexes with B-ATF, a member of the AP1 family of
RT transcription factors.";
RL Biochem. Biophys. Res. Commun. 229:316-322(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT the human lineage.";
RL Nature 440:1045-1049(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT
RP VAL-128 (ISOFORM 2).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-283 (ISOFORM 1), AND VARIANT
RP VAL-126.
RX PubMed=8938427;
RA Smith T.M., Lee M.K., Szabo C.I., Jerome N., McEuen M., Taylor M.,
RA Hood L., King M.-C.;
RT "Complete genomic sequence and analysis of 117 kb of human DNA
RT containing the gene BRCA1.";
RL Genome Res. 6:1029-1049(1996).
RN [6]
RP PROTEIN SEQUENCE OF 2-18.
RC TISSUE=Platelet;
RX PubMed=12665801; DOI=10.1038/nbt810;
RA Gevaert K., Goethals M., Martens L., Van Damme J., Staes A.,
RA Thomas G.R., Vandekerckhove J.;
RT "Exploring proteomes and analyzing protein processing by mass
RT spectrometric identification of sorted N-terminal peptides.";
RL Nat. Biotechnol. 21:566-569(2003).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Not yet known.
CC -!- SUBUNIT: Homodimer. Also interacts with B-ATF.
CC -!- INTERACTION:
CC Q6UXB4:CLEC4G; NbExp=4; IntAct=EBI-2115067, EBI-2114729;
CC -!- SUBCELLULAR LOCATION: Nucleus. Note=Nuclear following IFN
CC treatment.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P80217-1; Sequence=Displayed;
CC Note=No experimental confirmation available;
CC Name=2;
CC IsoId=P80217-2; Sequence=VSP_003569;
CC Note=Variant in position: 128:M->V (in dbSNP:rs588703). Due to a
CC polymorphism at the 3'-splice acceptor site of intron 4;
CC -!- TISSUE SPECIFICITY: In a wide range of cell types, including
CC fibroblasts, macrophages, and epithelial cells.
CC -!- INDUCTION: By interferon gamma.
CC -!- SIMILARITY: Belongs to the NMI family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB61703.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; U72882; AAB61703.1; ALT_SEQ; mRNA.
DR EMBL; AC055866; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC001356; AAH01356.1; -; mRNA.
DR EMBL; L78833; AAC37597.1; -; Genomic_DNA.
DR PIR; JC5262; JC5262.
DR RefSeq; NP_005524.2; NM_005533.4.
DR RefSeq; XP_005257359.1; XM_005257302.1.
DR UniGene; Hs.632258; -.
DR ProteinModelPortal; P80217; -.
DR SMR; P80217; 76-284.
DR IntAct; P80217; 4.
DR MINT; MINT-2804911; -.
DR STRING; 9606.ENSP00000246911; -.
DR PhosphoSite; P80217; -.
DR DMDM; 311033494; -.
DR PaxDb; P80217; -.
DR PRIDE; P80217; -.
DR DNASU; 3430; -.
DR Ensembl; ENST00000415816; ENSP00000394579; ENSG00000068079.
DR Ensembl; ENST00000438323; ENSP00000395590; ENSG00000068079.
DR GeneID; 3430; -.
DR KEGG; hsa:3430; -.
DR CTD; 3430; -.
DR GeneCards; GC17P041158; -.
DR HGNC; HGNC:5399; IFI35.
DR MIM; 600735; gene.
DR neXtProt; NX_P80217; -.
DR PharmGKB; PA29645; -.
DR eggNOG; NOG28883; -.
DR HOGENOM; HOG000230968; -.
DR HOVERGEN; HBG052125; -.
DR InParanoid; P80217; -.
DR OMA; HFQKPTR; -.
DR OrthoDB; EOG7SR4N0; -.
DR Reactome; REACT_6900; Immune System.
DR GeneWiki; IFI35; -.
DR GenomeRNAi; 3430; -.
DR NextBio; 13524; -.
DR PRO; PR:P80217; -.
DR Bgee; P80217; -.
DR CleanEx; HS_IFI35; -.
DR Genevestigator; P80217; -.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0009615; P:response to virus; NAS:UniProtKB.
DR GO; GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome.
DR InterPro; IPR009909; Nmi/IFP35_dom.
DR InterPro; IPR009938; Nmi/IFP35_N.
DR Pfam; PF07334; IFP_35_N; 1.
DR Pfam; PF07292; NID; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Direct protein sequencing;
KW Nucleus; Polymorphism; Reference proteome.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 286 Interferon-induced 35 kDa protein.
FT /FTId=PRO_0000159704.
FT REGION 5 26 Leucine-zipper.
FT VAR_SEQ 126 126 M -> VMM (in isoform 2).
FT /FTId=VSP_003569.
FT VARIANT 126 126 M -> V (in dbSNP:rs588703).
FT /FTId=VAR_063758.
FT CONFLICT 264 286 EVEALTVVPQGQQGLAVFTSESG -> GRGPDSRTPRTAGP
FT SSLHL (in Ref. 1; no nucleotide entry).
SQ SEQUENCE 286 AA; 31546 MW; 3FCAB26E97317508 CRC64;
MSAPLDAALH ALQEEQARLK MRLWDLQQLR KELGDSPKDK VPFSVPKIPL VFRGHTQQDP
EVPKSLVSNL RIHCPLLAGS ALITFDDPKV AEQVLQQKEH TINMEECRLR VQVQPLELPM
VTTIQMSSQL SGRRVLVTGF PASLRLSEEE LLDKLEIFFG KTRNGGGDVD VRELLPGSVM
LGFARDGVAQ RLCQIGQFTV PLGGQQVPLR VSPYVNGEIQ KAEIRSQPVP RSVLVLNIPD
ILDGPELHDV LEIHFQKPTR GGGEVEALTV VPQGQQGLAV FTSESG
//
ID IN35_HUMAN Reviewed; 286 AA.
AC P80217; C9JGX1; Q92984; Q99537; Q9BV98;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
read moreDT 02-NOV-2010, sequence version 5.
DT 22-JAN-2014, entry version 112.
DE RecName: Full=Interferon-induced 35 kDa protein;
DE Short=IFP 35;
DE Short=Ifi-35;
GN Name=IFI35; Synonyms=IFP35;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE (ISOFORM 1).
RX PubMed=8288566;
RA Bange F.-C., Vogel U., Flohr T., Kiekenbeck M., Denecke B.,
RA Boettger E.C.;
RT "IFP 35 is an interferon-induced leucine zipper protein that undergoes
RT interferon-regulated cellular redistribution.";
RL J. Biol. Chem. 269:1091-1098(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT VAL-128 (ISOFORM
RP 2).
RX PubMed=8954125; DOI=10.1006/bbrc.1996.1799;
RA Wang X., Johansen L.M., Tae H.-J., Taparowsky E.J.;
RT "IFP 35 forms complexes with B-ATF, a member of the AP1 family of
RT transcription factors.";
RL Biochem. Biophys. Res. Commun. 229:316-322(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT the human lineage.";
RL Nature 440:1045-1049(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT
RP VAL-128 (ISOFORM 2).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-283 (ISOFORM 1), AND VARIANT
RP VAL-126.
RX PubMed=8938427;
RA Smith T.M., Lee M.K., Szabo C.I., Jerome N., McEuen M., Taylor M.,
RA Hood L., King M.-C.;
RT "Complete genomic sequence and analysis of 117 kb of human DNA
RT containing the gene BRCA1.";
RL Genome Res. 6:1029-1049(1996).
RN [6]
RP PROTEIN SEQUENCE OF 2-18.
RC TISSUE=Platelet;
RX PubMed=12665801; DOI=10.1038/nbt810;
RA Gevaert K., Goethals M., Martens L., Van Damme J., Staes A.,
RA Thomas G.R., Vandekerckhove J.;
RT "Exploring proteomes and analyzing protein processing by mass
RT spectrometric identification of sorted N-terminal peptides.";
RL Nat. Biotechnol. 21:566-569(2003).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Not yet known.
CC -!- SUBUNIT: Homodimer. Also interacts with B-ATF.
CC -!- INTERACTION:
CC Q6UXB4:CLEC4G; NbExp=4; IntAct=EBI-2115067, EBI-2114729;
CC -!- SUBCELLULAR LOCATION: Nucleus. Note=Nuclear following IFN
CC treatment.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P80217-1; Sequence=Displayed;
CC Note=No experimental confirmation available;
CC Name=2;
CC IsoId=P80217-2; Sequence=VSP_003569;
CC Note=Variant in position: 128:M->V (in dbSNP:rs588703). Due to a
CC polymorphism at the 3'-splice acceptor site of intron 4;
CC -!- TISSUE SPECIFICITY: In a wide range of cell types, including
CC fibroblasts, macrophages, and epithelial cells.
CC -!- INDUCTION: By interferon gamma.
CC -!- SIMILARITY: Belongs to the NMI family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB61703.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; U72882; AAB61703.1; ALT_SEQ; mRNA.
DR EMBL; AC055866; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC001356; AAH01356.1; -; mRNA.
DR EMBL; L78833; AAC37597.1; -; Genomic_DNA.
DR PIR; JC5262; JC5262.
DR RefSeq; NP_005524.2; NM_005533.4.
DR RefSeq; XP_005257359.1; XM_005257302.1.
DR UniGene; Hs.632258; -.
DR ProteinModelPortal; P80217; -.
DR SMR; P80217; 76-284.
DR IntAct; P80217; 4.
DR MINT; MINT-2804911; -.
DR STRING; 9606.ENSP00000246911; -.
DR PhosphoSite; P80217; -.
DR DMDM; 311033494; -.
DR PaxDb; P80217; -.
DR PRIDE; P80217; -.
DR DNASU; 3430; -.
DR Ensembl; ENST00000415816; ENSP00000394579; ENSG00000068079.
DR Ensembl; ENST00000438323; ENSP00000395590; ENSG00000068079.
DR GeneID; 3430; -.
DR KEGG; hsa:3430; -.
DR CTD; 3430; -.
DR GeneCards; GC17P041158; -.
DR HGNC; HGNC:5399; IFI35.
DR MIM; 600735; gene.
DR neXtProt; NX_P80217; -.
DR PharmGKB; PA29645; -.
DR eggNOG; NOG28883; -.
DR HOGENOM; HOG000230968; -.
DR HOVERGEN; HBG052125; -.
DR InParanoid; P80217; -.
DR OMA; HFQKPTR; -.
DR OrthoDB; EOG7SR4N0; -.
DR Reactome; REACT_6900; Immune System.
DR GeneWiki; IFI35; -.
DR GenomeRNAi; 3430; -.
DR NextBio; 13524; -.
DR PRO; PR:P80217; -.
DR Bgee; P80217; -.
DR CleanEx; HS_IFI35; -.
DR Genevestigator; P80217; -.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0009615; P:response to virus; NAS:UniProtKB.
DR GO; GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome.
DR InterPro; IPR009909; Nmi/IFP35_dom.
DR InterPro; IPR009938; Nmi/IFP35_N.
DR Pfam; PF07334; IFP_35_N; 1.
DR Pfam; PF07292; NID; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Direct protein sequencing;
KW Nucleus; Polymorphism; Reference proteome.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 286 Interferon-induced 35 kDa protein.
FT /FTId=PRO_0000159704.
FT REGION 5 26 Leucine-zipper.
FT VAR_SEQ 126 126 M -> VMM (in isoform 2).
FT /FTId=VSP_003569.
FT VARIANT 126 126 M -> V (in dbSNP:rs588703).
FT /FTId=VAR_063758.
FT CONFLICT 264 286 EVEALTVVPQGQQGLAVFTSESG -> GRGPDSRTPRTAGP
FT SSLHL (in Ref. 1; no nucleotide entry).
SQ SEQUENCE 286 AA; 31546 MW; 3FCAB26E97317508 CRC64;
MSAPLDAALH ALQEEQARLK MRLWDLQQLR KELGDSPKDK VPFSVPKIPL VFRGHTQQDP
EVPKSLVSNL RIHCPLLAGS ALITFDDPKV AEQVLQQKEH TINMEECRLR VQVQPLELPM
VTTIQMSSQL SGRRVLVTGF PASLRLSEEE LLDKLEIFFG KTRNGGGDVD VRELLPGSVM
LGFARDGVAQ RLCQIGQFTV PLGGQQVPLR VSPYVNGEIQ KAEIRSQPVP RSVLVLNIPD
ILDGPELHDV LEIHFQKPTR GGGEVEALTV VPQGQQGLAV FTSESG
//
MIM
600735
*RECORD*
*FIELD* NO
600735
*FIELD* TI
*600735 INTERFERON-INDUCED PROTEIN 35; IFI35
;;INTERFERON INDUCIBLE PROTEIN, 35-KD; IFP35
read more*FIELD* TX
Interferons ( e.g., 147660) affect cellular functions by altering the
expression of a number of specific genes. Bange et al. (1994) reported a
human cDNA, designated IFP35 by them (interferon inducible protein of 35
kD), which they cloned from interferon-gamma induced HeLa cell mRNA
screened by differential hybridization. The cDNA encodes a 282-amino
acid predicted protein containing a leucine zipper motif at the amino
terminus. Unlike most other leucine zipper proteins, IFP35 lacks a basic
domain associated with DNA binding. Bange et al. (1994) found that in
vitro translation of IFP35 mRNA resulted in the synthesis of a 35-kD
protein. Northern blots showed that the 1.4-kb IFP35 mRNA occurs in
fibroblasts, macrophages, and epithelial cells following interferon
treatment. Western blots indicated that the IFP35 gene product can form
homodimers and that there was increased nuclear localization following
interferon treatment. Brown et al. (1995), as part of an effort to clone
the BRCA1 gene (113705), used exon trapping to identify genes in a
500-kb region on 17q21. Among the exons identified from a phage P1
artificial chromosome (PAC) that included regions from BRCA1 were
several coding regions with 100% identity to IFP35. Smith et al. (1996)
likewise found the IFP35 gene situated centromeric to the BRCA1 gene in
the course of sequencing and analyzing 117 kb of DNA from the 17q21
region.
*FIELD* RF
1. Bange, F.-C.; Vogel, U.; Flohr, T.; Kiekenbeck, M.; Denecke, B.;
Boettger, E. C.: IFP 35 is an interferon-induced leucine zipper protein
that undergoes interferon-regulated cellular redistribution. J. Biol.
Chem. 269: 1091-1098, 1994.
2. Brown, M. A.; Jones, K. A.; Nicolai, H.; Bonjardim, M.; Black,
D.; McFarlane, R.; De Jong, P.; Quirk, J. P.; Lehrach, H.; Solomon,
E.: Physical mapping, cloning, and identification of genes within
a 500-kb region containing BRCA1. Proc. Nat. Acad. Sci. 92: 4362-4366,
1995.
3. Smith, T. M.; Lee, M. K.; Szabo, C. I.; Jerome, N.; McEuen, M.;
Taylor, M.; Hood, L.; King, M.-C.: Complete genomic sequence and
analysis of 117 kb of human DNA containing the gene BRCA1. Genomic
Res. 6: 1029-1049, 1996.
*FIELD* CD
Alan F. Scott: 8/22/1995
*FIELD* ED
joanna: 01/08/1997
mark: 12/21/1996
terry: 12/16/1996
mark: 3/10/1996
mark: 10/2/1995
*RECORD*
*FIELD* NO
600735
*FIELD* TI
*600735 INTERFERON-INDUCED PROTEIN 35; IFI35
;;INTERFERON INDUCIBLE PROTEIN, 35-KD; IFP35
read more*FIELD* TX
Interferons ( e.g., 147660) affect cellular functions by altering the
expression of a number of specific genes. Bange et al. (1994) reported a
human cDNA, designated IFP35 by them (interferon inducible protein of 35
kD), which they cloned from interferon-gamma induced HeLa cell mRNA
screened by differential hybridization. The cDNA encodes a 282-amino
acid predicted protein containing a leucine zipper motif at the amino
terminus. Unlike most other leucine zipper proteins, IFP35 lacks a basic
domain associated with DNA binding. Bange et al. (1994) found that in
vitro translation of IFP35 mRNA resulted in the synthesis of a 35-kD
protein. Northern blots showed that the 1.4-kb IFP35 mRNA occurs in
fibroblasts, macrophages, and epithelial cells following interferon
treatment. Western blots indicated that the IFP35 gene product can form
homodimers and that there was increased nuclear localization following
interferon treatment. Brown et al. (1995), as part of an effort to clone
the BRCA1 gene (113705), used exon trapping to identify genes in a
500-kb region on 17q21. Among the exons identified from a phage P1
artificial chromosome (PAC) that included regions from BRCA1 were
several coding regions with 100% identity to IFP35. Smith et al. (1996)
likewise found the IFP35 gene situated centromeric to the BRCA1 gene in
the course of sequencing and analyzing 117 kb of DNA from the 17q21
region.
*FIELD* RF
1. Bange, F.-C.; Vogel, U.; Flohr, T.; Kiekenbeck, M.; Denecke, B.;
Boettger, E. C.: IFP 35 is an interferon-induced leucine zipper protein
that undergoes interferon-regulated cellular redistribution. J. Biol.
Chem. 269: 1091-1098, 1994.
2. Brown, M. A.; Jones, K. A.; Nicolai, H.; Bonjardim, M.; Black,
D.; McFarlane, R.; De Jong, P.; Quirk, J. P.; Lehrach, H.; Solomon,
E.: Physical mapping, cloning, and identification of genes within
a 500-kb region containing BRCA1. Proc. Nat. Acad. Sci. 92: 4362-4366,
1995.
3. Smith, T. M.; Lee, M. K.; Szabo, C. I.; Jerome, N.; McEuen, M.;
Taylor, M.; Hood, L.; King, M.-C.: Complete genomic sequence and
analysis of 117 kb of human DNA containing the gene BRCA1. Genomic
Res. 6: 1029-1049, 1996.
*FIELD* CD
Alan F. Scott: 8/22/1995
*FIELD* ED
joanna: 01/08/1997
mark: 12/21/1996
terry: 12/16/1996
mark: 3/10/1996
mark: 10/2/1995