Full text data of INTS4
INTS4
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Integrator complex subunit 4; Int4
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Integrator complex subunit 4; Int4
Note: presumably soluble (membrane word is not in UniProt keywords or features)
hRBCD
IPI00446765
IPI00446765 MGC16733 protein MGC16733 protein membrane n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 1 n/a n/a not mentioned n/a found at its expected molecular weight found at molecular weight
IPI00446765 MGC16733 protein MGC16733 protein membrane n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 1 n/a n/a not mentioned n/a found at its expected molecular weight found at molecular weight
UniProt
Q96HW7
ID INT4_HUMAN Reviewed; 963 AA.
AC Q96HW7; Q2YD62; Q6PJG4; Q7Z4E7; Q96G32; Q96GA1; Q9BRC0;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 31-OCT-2006, sequence version 2.
DT 22-JAN-2014, entry version 82.
DE RecName: Full=Integrator complex subunit 4;
DE Short=Int4;
GN Name=INTS4; ORFNames=MSTP093;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Aorta;
RA Sheng H., Qin B.M., Liu Y.Q., Zhao B., Liu B., Wang X.Y., Zhang Q.,
RA Song L., Gao Y., Zhang C.L., Ye J., Ji X.J., Liu B.H., Lu H., Xu H.S.,
RA Chen J.Z., Cai M.Q., Zheng W.Y., Teng C.Y., Liu Q., Yu L.T., Lin J.,
RA Gong J., Zhang A.M., Gao R.L., Hui R.T.;
RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 174-963 (ISOFORM 1).
RC TISSUE=Brain, Muscle, Ovary, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION (ISOFORM 1), IDENTIFICATION BY MASS SPECTROMETRY, AND
RP IDENTIFICATION IN THE INTEGRATOR COMPLEX.
RX PubMed=16239144; DOI=10.1016/j.cell.2005.08.019;
RA Baillat D., Hakimi M.-A., Naeaer A.M., Shilatifard A., Cooch N.,
RA Shiekhattar R.;
RT "Integrator, a multiprotein mediator of small nuclear RNA processing,
RT associates with the C-terminal repeat of RNA polymerase II.";
RL Cell 123:265-276(2005).
CC -!- FUNCTION: Component of the Integrator complex, a complex involved
CC in the small nuclear RNAs (snRNA) U1 and U2 transcription and in
CC their 3'-box-dependent processing. The Integrator complex is
CC associated with the C-terminal domain (CTD) of RNA polymerase II
CC largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs
CC genes.
CC -!- SUBUNIT: Belongs to the multiprotein complex Integrator, at least
CC composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7,
CC INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.
CC -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q96HW7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96HW7-2; Sequence=VSP_021450;
CC Name=3;
CC IsoId=Q96HW7-3; Sequence=VSP_021448, VSP_021449, VSP_021452,
CC VSP_021453;
CC Note=No experimental confirmation available;
CC Name=4;
CC IsoId=Q96HW7-4; Sequence=VSP_021447, VSP_021451;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the Integrator subunit 4 family.
CC -!- SIMILARITY: Contains 8 HEAT repeats.
CC -----------------------------------------------------------------------
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CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF172822; AAQ13616.1; -; mRNA.
DR EMBL; BC006369; AAH06369.1; -; mRNA.
DR EMBL; BC008013; AAH08013.1; -; mRNA.
DR EMBL; BC009859; AAH09859.2; -; mRNA.
DR EMBL; BC009995; AAH09995.1; -; mRNA.
DR EMBL; BC015664; AAH15664.1; -; mRNA.
DR EMBL; BK005723; DAA05723.1; -; mRNA.
DR RefSeq; NP_291025.3; NM_033547.3.
DR UniGene; Hs.533723; -.
DR ProteinModelPortal; Q96HW7; -.
DR SMR; Q96HW7; 377-410.
DR IntAct; Q96HW7; 1.
DR STRING; 9606.ENSP00000346913; -.
DR PhosphoSite; Q96HW7; -.
DR DMDM; 118572560; -.
DR PRIDE; Q96HW7; -.
DR DNASU; 92105; -.
DR Ensembl; ENST00000529807; ENSP00000433644; ENSG00000149262.
DR Ensembl; ENST00000534064; ENSP00000434466; ENSG00000149262.
DR Ensembl; ENST00000535943; ENSP00000441084; ENSG00000149262.
DR GeneID; 92105; -.
DR KEGG; hsa:92105; -.
DR UCSC; uc001oys.3; human.
DR CTD; 92105; -.
DR GeneCards; GC11M077589; -.
DR H-InvDB; HIX0022772; -.
DR H-InvDB; HIX0023207; -.
DR H-InvDB; HIX0058362; -.
DR HGNC; HGNC:25048; INTS4.
DR HPA; HPA042378; -.
DR MIM; 611348; gene.
DR neXtProt; NX_Q96HW7; -.
DR PharmGKB; PA144596421; -.
DR HOVERGEN; HBG081801; -.
DR InParanoid; Q96HW7; -.
DR KO; K13141; -.
DR OMA; EDPSHQF; -.
DR OrthoDB; EOG70CR6Q; -.
DR ChiTaRS; IntS4; human.
DR GenomeRNAi; 92105; -.
DR NextBio; 77589; -.
DR PRO; PR:Q96HW7; -.
DR ArrayExpress; Q96HW7; -.
DR Bgee; Q96HW7; -.
DR CleanEx; HS_INTS4; -.
DR Genevestigator; Q96HW7; -.
DR GO; GO:0032039; C:integrator complex; IDA:HGNC.
DR GO; GO:0016180; P:snRNA processing; IDA:HGNC.
DR Gene3D; 1.25.10.10; -; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR SUPFAM; SSF48371; SSF48371; 2.
DR PROSITE; PS50077; HEAT_REPEAT; FALSE_NEG.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Nucleus; Reference proteome;
KW Repeat.
FT CHAIN 1 963 Integrator complex subunit 4.
FT /FTId=PRO_0000259538.
FT REPEAT 66 105 HEAT 1.
FT REPEAT 145 183 HEAT 2.
FT REPEAT 190 228 HEAT 3.
FT REPEAT 229 263 HEAT 4.
FT REPEAT 277 313 HEAT 5.
FT REPEAT 369 405 HEAT 6.
FT REPEAT 406 444 HEAT 7.
FT REPEAT 446 484 HEAT 8.
FT VAR_SEQ 1 626 Missing (in isoform 4).
FT /FTId=VSP_021447.
FT VAR_SEQ 1 148 Missing (in isoform 3).
FT /FTId=VSP_021448.
FT VAR_SEQ 149 156 MRLVDVAC -> MPSTSCRM (in isoform 3).
FT /FTId=VSP_021449.
FT VAR_SEQ 506 963 Missing (in isoform 2).
FT /FTId=VSP_021450.
FT VAR_SEQ 627 640 LDPQGAQELLEFTI -> MPALKQTASQVTQTL (in
FT isoform 4).
FT /FTId=VSP_021451.
FT VAR_SEQ 642 659 DLQRLGELQSELAGVADF -> VEVSPWWPGWSQTPELK
FT (in isoform 3).
FT /FTId=VSP_021452.
FT VAR_SEQ 660 963 Missing (in isoform 3).
FT /FTId=VSP_021453.
FT CONFLICT 584 584 V -> M (in Ref. 1; AAQ13616).
FT CONFLICT 900 901 HT -> PP (in Ref. 1; AAQ13616).
SQ SEQUENCE 963 AA; 108171 MW; D56D6480EFC962D7 CRC64;
MAAHLKKRVY EEFTKVVQPQ EEIATKKLRL TKPSKSAALH IDLCKATSPA DALQYLLQFA
RKPVEAESVE GVVRILLEHY YKENDPSVRL KIASLLGLLS KTAGFSPDCI MDDAINILQN
EKSHQVLAQL LDTLLAIGTK LPENQAIQMR LVDVACKHLT DTSHGVRNKC LQLLGNLGSL
EKSVTKDAEG LAARDVQKII GDYFSDQDPR VRTAAIKAML QLHERGLKLH QTIYNQACKL
LSDDYEQVRS AAVQLIWVVS QLYPESIVPI PSSNEEIRLV DDAFGKICHM VSDGSWVVRV
QAAKLLGSME QVSSHFLEQT LDKKLMSDLR RKRTAHERAK ELYSSGEFSS GRKWGDDAPK
EEVDTGAVNL IESGACGAFV HGLEDEMYEV RIAAVEALCM LAQSSPSFAE KCLDFLVDMF
NDEIEEVRLQ SIHTMRKISN NITLREDQLD TVLAVLEDSS RDIREALHEL LCCTNVSTKE
GIHLALVELL KNLTKYPTDR DSIWKCLKFL GSRHPTLVLP LVPELLSTHP FFDTAEPDMD
DPAYIAVLVL IFNAAKTCPT MPALFSDHTF RHYAYLRDSL SHLVPALRLP GRKLVSSAVS
PSIIPQEDPS QQFLQQSLER VYSLQHLDPQ GAQELLEFTI RDLQRLGELQ SELAGVADFS
ATYLRCQLLL IKALQEKLWN VAAPLYLKQS DLASAAAKQI MEETYKMEFM YSGVENKQVV
IIHHMRLQAK ALQLIVTART TRGLDPLFGM CEKFLQEVDF FQRYFIADLP HLQDSFVDKL
LDLMPRLMTS KPAEVVKILQ TMLRQSAFLH LPLPEQIHKA SATIIEPAGE SDNPLRFTSG
LVVALDVDAT LEHVQDPQNT VKVQVLYPDG QAQMIHPKPA DFRNPGPGRH RLITQVYLSH
TAWTEACQVE VRLLLAYNSS ARIPKCPWME GGEMSPQVET SIEGTIPFSK PVKVYIMPKP
ARR
//
ID INT4_HUMAN Reviewed; 963 AA.
AC Q96HW7; Q2YD62; Q6PJG4; Q7Z4E7; Q96G32; Q96GA1; Q9BRC0;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 31-OCT-2006, sequence version 2.
DT 22-JAN-2014, entry version 82.
DE RecName: Full=Integrator complex subunit 4;
DE Short=Int4;
GN Name=INTS4; ORFNames=MSTP093;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Aorta;
RA Sheng H., Qin B.M., Liu Y.Q., Zhao B., Liu B., Wang X.Y., Zhang Q.,
RA Song L., Gao Y., Zhang C.L., Ye J., Ji X.J., Liu B.H., Lu H., Xu H.S.,
RA Chen J.Z., Cai M.Q., Zheng W.Y., Teng C.Y., Liu Q., Yu L.T., Lin J.,
RA Gong J., Zhang A.M., Gao R.L., Hui R.T.;
RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 174-963 (ISOFORM 1).
RC TISSUE=Brain, Muscle, Ovary, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION (ISOFORM 1), IDENTIFICATION BY MASS SPECTROMETRY, AND
RP IDENTIFICATION IN THE INTEGRATOR COMPLEX.
RX PubMed=16239144; DOI=10.1016/j.cell.2005.08.019;
RA Baillat D., Hakimi M.-A., Naeaer A.M., Shilatifard A., Cooch N.,
RA Shiekhattar R.;
RT "Integrator, a multiprotein mediator of small nuclear RNA processing,
RT associates with the C-terminal repeat of RNA polymerase II.";
RL Cell 123:265-276(2005).
CC -!- FUNCTION: Component of the Integrator complex, a complex involved
CC in the small nuclear RNAs (snRNA) U1 and U2 transcription and in
CC their 3'-box-dependent processing. The Integrator complex is
CC associated with the C-terminal domain (CTD) of RNA polymerase II
CC largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs
CC genes.
CC -!- SUBUNIT: Belongs to the multiprotein complex Integrator, at least
CC composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7,
CC INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.
CC -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q96HW7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96HW7-2; Sequence=VSP_021450;
CC Name=3;
CC IsoId=Q96HW7-3; Sequence=VSP_021448, VSP_021449, VSP_021452,
CC VSP_021453;
CC Note=No experimental confirmation available;
CC Name=4;
CC IsoId=Q96HW7-4; Sequence=VSP_021447, VSP_021451;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the Integrator subunit 4 family.
CC -!- SIMILARITY: Contains 8 HEAT repeats.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF172822; AAQ13616.1; -; mRNA.
DR EMBL; BC006369; AAH06369.1; -; mRNA.
DR EMBL; BC008013; AAH08013.1; -; mRNA.
DR EMBL; BC009859; AAH09859.2; -; mRNA.
DR EMBL; BC009995; AAH09995.1; -; mRNA.
DR EMBL; BC015664; AAH15664.1; -; mRNA.
DR EMBL; BK005723; DAA05723.1; -; mRNA.
DR RefSeq; NP_291025.3; NM_033547.3.
DR UniGene; Hs.533723; -.
DR ProteinModelPortal; Q96HW7; -.
DR SMR; Q96HW7; 377-410.
DR IntAct; Q96HW7; 1.
DR STRING; 9606.ENSP00000346913; -.
DR PhosphoSite; Q96HW7; -.
DR DMDM; 118572560; -.
DR PRIDE; Q96HW7; -.
DR DNASU; 92105; -.
DR Ensembl; ENST00000529807; ENSP00000433644; ENSG00000149262.
DR Ensembl; ENST00000534064; ENSP00000434466; ENSG00000149262.
DR Ensembl; ENST00000535943; ENSP00000441084; ENSG00000149262.
DR GeneID; 92105; -.
DR KEGG; hsa:92105; -.
DR UCSC; uc001oys.3; human.
DR CTD; 92105; -.
DR GeneCards; GC11M077589; -.
DR H-InvDB; HIX0022772; -.
DR H-InvDB; HIX0023207; -.
DR H-InvDB; HIX0058362; -.
DR HGNC; HGNC:25048; INTS4.
DR HPA; HPA042378; -.
DR MIM; 611348; gene.
DR neXtProt; NX_Q96HW7; -.
DR PharmGKB; PA144596421; -.
DR HOVERGEN; HBG081801; -.
DR InParanoid; Q96HW7; -.
DR KO; K13141; -.
DR OMA; EDPSHQF; -.
DR OrthoDB; EOG70CR6Q; -.
DR ChiTaRS; IntS4; human.
DR GenomeRNAi; 92105; -.
DR NextBio; 77589; -.
DR PRO; PR:Q96HW7; -.
DR ArrayExpress; Q96HW7; -.
DR Bgee; Q96HW7; -.
DR CleanEx; HS_INTS4; -.
DR Genevestigator; Q96HW7; -.
DR GO; GO:0032039; C:integrator complex; IDA:HGNC.
DR GO; GO:0016180; P:snRNA processing; IDA:HGNC.
DR Gene3D; 1.25.10.10; -; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR SUPFAM; SSF48371; SSF48371; 2.
DR PROSITE; PS50077; HEAT_REPEAT; FALSE_NEG.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Nucleus; Reference proteome;
KW Repeat.
FT CHAIN 1 963 Integrator complex subunit 4.
FT /FTId=PRO_0000259538.
FT REPEAT 66 105 HEAT 1.
FT REPEAT 145 183 HEAT 2.
FT REPEAT 190 228 HEAT 3.
FT REPEAT 229 263 HEAT 4.
FT REPEAT 277 313 HEAT 5.
FT REPEAT 369 405 HEAT 6.
FT REPEAT 406 444 HEAT 7.
FT REPEAT 446 484 HEAT 8.
FT VAR_SEQ 1 626 Missing (in isoform 4).
FT /FTId=VSP_021447.
FT VAR_SEQ 1 148 Missing (in isoform 3).
FT /FTId=VSP_021448.
FT VAR_SEQ 149 156 MRLVDVAC -> MPSTSCRM (in isoform 3).
FT /FTId=VSP_021449.
FT VAR_SEQ 506 963 Missing (in isoform 2).
FT /FTId=VSP_021450.
FT VAR_SEQ 627 640 LDPQGAQELLEFTI -> MPALKQTASQVTQTL (in
FT isoform 4).
FT /FTId=VSP_021451.
FT VAR_SEQ 642 659 DLQRLGELQSELAGVADF -> VEVSPWWPGWSQTPELK
FT (in isoform 3).
FT /FTId=VSP_021452.
FT VAR_SEQ 660 963 Missing (in isoform 3).
FT /FTId=VSP_021453.
FT CONFLICT 584 584 V -> M (in Ref. 1; AAQ13616).
FT CONFLICT 900 901 HT -> PP (in Ref. 1; AAQ13616).
SQ SEQUENCE 963 AA; 108171 MW; D56D6480EFC962D7 CRC64;
MAAHLKKRVY EEFTKVVQPQ EEIATKKLRL TKPSKSAALH IDLCKATSPA DALQYLLQFA
RKPVEAESVE GVVRILLEHY YKENDPSVRL KIASLLGLLS KTAGFSPDCI MDDAINILQN
EKSHQVLAQL LDTLLAIGTK LPENQAIQMR LVDVACKHLT DTSHGVRNKC LQLLGNLGSL
EKSVTKDAEG LAARDVQKII GDYFSDQDPR VRTAAIKAML QLHERGLKLH QTIYNQACKL
LSDDYEQVRS AAVQLIWVVS QLYPESIVPI PSSNEEIRLV DDAFGKICHM VSDGSWVVRV
QAAKLLGSME QVSSHFLEQT LDKKLMSDLR RKRTAHERAK ELYSSGEFSS GRKWGDDAPK
EEVDTGAVNL IESGACGAFV HGLEDEMYEV RIAAVEALCM LAQSSPSFAE KCLDFLVDMF
NDEIEEVRLQ SIHTMRKISN NITLREDQLD TVLAVLEDSS RDIREALHEL LCCTNVSTKE
GIHLALVELL KNLTKYPTDR DSIWKCLKFL GSRHPTLVLP LVPELLSTHP FFDTAEPDMD
DPAYIAVLVL IFNAAKTCPT MPALFSDHTF RHYAYLRDSL SHLVPALRLP GRKLVSSAVS
PSIIPQEDPS QQFLQQSLER VYSLQHLDPQ GAQELLEFTI RDLQRLGELQ SELAGVADFS
ATYLRCQLLL IKALQEKLWN VAAPLYLKQS DLASAAAKQI MEETYKMEFM YSGVENKQVV
IIHHMRLQAK ALQLIVTART TRGLDPLFGM CEKFLQEVDF FQRYFIADLP HLQDSFVDKL
LDLMPRLMTS KPAEVVKILQ TMLRQSAFLH LPLPEQIHKA SATIIEPAGE SDNPLRFTSG
LVVALDVDAT LEHVQDPQNT VKVQVLYPDG QAQMIHPKPA DFRNPGPGRH RLITQVYLSH
TAWTEACQVE VRLLLAYNSS ARIPKCPWME GGEMSPQVET SIEGTIPFSK PVKVYIMPKP
ARR
//
MIM
611348
*RECORD*
*FIELD* NO
611348
*FIELD* TI
*611348 INTEGRATOR COMPLEX SUBUNIT 4; INTS4
;;INT4
*FIELD* TX
DESCRIPTION
INTS4 is a subunit of the Integrator complex, which associates with the
read moreC-terminal domain of RNA polymerase II large subunit (POLR2A; 180660)
and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1;
180680) and U2 (RNU2; 180690) (Baillat et al., 2005).
GENE FUNCTION
By SDS-PAGE of proteins that copurified with INTS11 (CPSF3L; 611354) in
HEK293 cells, Baillat et al. (2005) identified INTS4 as a subunit of the
Integrator complex.
MAPPING
The International Radiation Hybrid Mapping Consortium mapped the INTS4
gene to chromosome 11 (TMAP RH12075).
*FIELD* RF
1. Baillat, D.; Hakimi, M.-A.; Naar, A. M.; Shilatifard, A.; Cooch,
N.; Shiekhattar, R.: Integrator, a multiprotein mediator of small
nuclear RNA processing, associates with the C-terminal repeat of RNA
polymerase II. Cell 123: 265-276, 2005.
*FIELD* CD
Patricia A. Hartz: 8/17/2007
*FIELD* ED
wwang: 08/17/2007
*RECORD*
*FIELD* NO
611348
*FIELD* TI
*611348 INTEGRATOR COMPLEX SUBUNIT 4; INTS4
;;INT4
*FIELD* TX
DESCRIPTION
INTS4 is a subunit of the Integrator complex, which associates with the
read moreC-terminal domain of RNA polymerase II large subunit (POLR2A; 180660)
and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1;
180680) and U2 (RNU2; 180690) (Baillat et al., 2005).
GENE FUNCTION
By SDS-PAGE of proteins that copurified with INTS11 (CPSF3L; 611354) in
HEK293 cells, Baillat et al. (2005) identified INTS4 as a subunit of the
Integrator complex.
MAPPING
The International Radiation Hybrid Mapping Consortium mapped the INTS4
gene to chromosome 11 (TMAP RH12075).
*FIELD* RF
1. Baillat, D.; Hakimi, M.-A.; Naar, A. M.; Shilatifard, A.; Cooch,
N.; Shiekhattar, R.: Integrator, a multiprotein mediator of small
nuclear RNA processing, associates with the C-terminal repeat of RNA
polymerase II. Cell 123: 265-276, 2005.
*FIELD* CD
Patricia A. Hartz: 8/17/2007
*FIELD* ED
wwang: 08/17/2007