Full text data of JAGN1
JAGN1
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Protein jagunal homolog 1
Protein jagunal homolog 1
UniProt
Q8N5M9
ID JAGN1_HUMAN Reviewed; 183 AA.
AC Q8N5M9; Q8NCF6; Q96SW1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-2002, sequence version 1.
DT 22-JAN-2014, entry version 79.
DE RecName: Full=Protein jagunal homolog 1;
GN Name=JAGN1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=17389229; DOI=10.1083/jcb.200701048;
RA Lee S., Cooley L.;
RT "Jagunal is required for reorganizing the endoplasmic reticulum during
RT Drosophila oogenesis.";
RL J. Cell Biol. 176:941-952(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May be required for endoplasmic reticulum organization
CC (By similarity).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC membrane protein (By similarity).
CC -!- SIMILARITY: Belongs to the jagunal family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK027508; BAB55163.1; -; mRNA.
DR EMBL; AK074760; BAC11188.1; -; mRNA.
DR EMBL; CH471055; EAW64015.1; -; Genomic_DNA.
DR EMBL; BC032101; AAH32101.1; -; mRNA.
DR RefSeq; NP_115881.3; NM_032492.3.
DR UniGene; Hs.24054; -.
DR ProteinModelPortal; Q8N5M9; -.
DR STRING; 9606.ENSP00000306106; -.
DR PhosphoSite; Q8N5M9; -.
DR DMDM; 74729022; -.
DR PaxDb; Q8N5M9; -.
DR PRIDE; Q8N5M9; -.
DR DNASU; 84522; -.
DR Ensembl; ENST00000307768; ENSP00000306106; ENSG00000171135.
DR GeneID; 84522; -.
DR KEGG; hsa:84522; -.
DR UCSC; uc003btt.4; human.
DR CTD; 84522; -.
DR GeneCards; GC03P009932; -.
DR H-InvDB; HIX0003036; -.
DR H-InvDB; HIX0163471; -.
DR HGNC; HGNC:26926; JAGN1.
DR neXtProt; NX_Q8N5M9; -.
DR PharmGKB; PA134954931; -.
DR eggNOG; NOG284965; -.
DR HOGENOM; HOG000008063; -.
DR HOVERGEN; HBG056502; -.
DR InParanoid; Q8N5M9; -.
DR OMA; MEMFPMA; -.
DR OrthoDB; EOG7QZGBR; -.
DR PhylomeDB; Q8N5M9; -.
DR GenomeRNAi; 84522; -.
DR NextBio; 74343; -.
DR PRO; PR:Q8N5M9; -.
DR Bgee; Q8N5M9; -.
DR CleanEx; HS_JAGN1; -.
DR Genevestigator; Q8N5M9; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0007029; P:endoplasmic reticulum organization; IEA:InterPro.
DR InterPro; IPR009787; Jagunal.
DR PANTHER; PTHR20955; PTHR20955; 1.
DR Pfam; PF07086; DUF1352; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Endoplasmic reticulum; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1 183 Protein jagunal homolog 1.
FT /FTId=PRO_0000313608.
FT TOPO_DOM 1 39 Cytoplasmic (Potential).
FT TRANSMEM 40 60 Helical; (Potential).
FT TOPO_DOM 61 71 Lumenal (Potential).
FT TRANSMEM 72 92 Helical; (Potential).
FT TOPO_DOM 93 96 Cytoplasmic (Potential).
FT TRANSMEM 97 117 Helical; (Potential).
FT TOPO_DOM 118 137 Lumenal (Potential).
FT TRANSMEM 138 158 Helical; (Potential).
FT TOPO_DOM 159 183 Cytoplasmic (Potential).
FT MOD_RES 3 3 Phosphoserine.
FT CONFLICT 9 9 A -> T (in Ref. 1; BAC11188).
FT CONFLICT 58 58 G -> E (in Ref. 1; BAB55163).
FT CONFLICT 61 61 R -> G (in Ref. 1; BAB55163).
FT CONFLICT 149 149 Y -> H (in Ref. 1; BAB55163).
SQ SEQUENCE 183 AA; 21125 MW; 5F203B99E670D7A7 CRC64;
MASRAGPRAA GTDGSDFQHR ERVAMHYQMS VTLKYEIKKL IYVHLVIWLL LVAKMSVGHL
RLLSHDQVAM PYQWEYPYLL SILPSLLGLL SFPRNNISYL VLSMISMGLF SIAPLIYGSM
EMFPAAQQLY RHGKAYRFLF GFSAVSIMYL VLVLAVQVHA WQLYYSKKLL DSWFTSTQEK
KHK
//
ID JAGN1_HUMAN Reviewed; 183 AA.
AC Q8N5M9; Q8NCF6; Q96SW1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-2002, sequence version 1.
DT 22-JAN-2014, entry version 79.
DE RecName: Full=Protein jagunal homolog 1;
GN Name=JAGN1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=17389229; DOI=10.1083/jcb.200701048;
RA Lee S., Cooley L.;
RT "Jagunal is required for reorganizing the endoplasmic reticulum during
RT Drosophila oogenesis.";
RL J. Cell Biol. 176:941-952(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May be required for endoplasmic reticulum organization
CC (By similarity).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC membrane protein (By similarity).
CC -!- SIMILARITY: Belongs to the jagunal family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK027508; BAB55163.1; -; mRNA.
DR EMBL; AK074760; BAC11188.1; -; mRNA.
DR EMBL; CH471055; EAW64015.1; -; Genomic_DNA.
DR EMBL; BC032101; AAH32101.1; -; mRNA.
DR RefSeq; NP_115881.3; NM_032492.3.
DR UniGene; Hs.24054; -.
DR ProteinModelPortal; Q8N5M9; -.
DR STRING; 9606.ENSP00000306106; -.
DR PhosphoSite; Q8N5M9; -.
DR DMDM; 74729022; -.
DR PaxDb; Q8N5M9; -.
DR PRIDE; Q8N5M9; -.
DR DNASU; 84522; -.
DR Ensembl; ENST00000307768; ENSP00000306106; ENSG00000171135.
DR GeneID; 84522; -.
DR KEGG; hsa:84522; -.
DR UCSC; uc003btt.4; human.
DR CTD; 84522; -.
DR GeneCards; GC03P009932; -.
DR H-InvDB; HIX0003036; -.
DR H-InvDB; HIX0163471; -.
DR HGNC; HGNC:26926; JAGN1.
DR neXtProt; NX_Q8N5M9; -.
DR PharmGKB; PA134954931; -.
DR eggNOG; NOG284965; -.
DR HOGENOM; HOG000008063; -.
DR HOVERGEN; HBG056502; -.
DR InParanoid; Q8N5M9; -.
DR OMA; MEMFPMA; -.
DR OrthoDB; EOG7QZGBR; -.
DR PhylomeDB; Q8N5M9; -.
DR GenomeRNAi; 84522; -.
DR NextBio; 74343; -.
DR PRO; PR:Q8N5M9; -.
DR Bgee; Q8N5M9; -.
DR CleanEx; HS_JAGN1; -.
DR Genevestigator; Q8N5M9; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0007029; P:endoplasmic reticulum organization; IEA:InterPro.
DR InterPro; IPR009787; Jagunal.
DR PANTHER; PTHR20955; PTHR20955; 1.
DR Pfam; PF07086; DUF1352; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Endoplasmic reticulum; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1 183 Protein jagunal homolog 1.
FT /FTId=PRO_0000313608.
FT TOPO_DOM 1 39 Cytoplasmic (Potential).
FT TRANSMEM 40 60 Helical; (Potential).
FT TOPO_DOM 61 71 Lumenal (Potential).
FT TRANSMEM 72 92 Helical; (Potential).
FT TOPO_DOM 93 96 Cytoplasmic (Potential).
FT TRANSMEM 97 117 Helical; (Potential).
FT TOPO_DOM 118 137 Lumenal (Potential).
FT TRANSMEM 138 158 Helical; (Potential).
FT TOPO_DOM 159 183 Cytoplasmic (Potential).
FT MOD_RES 3 3 Phosphoserine.
FT CONFLICT 9 9 A -> T (in Ref. 1; BAC11188).
FT CONFLICT 58 58 G -> E (in Ref. 1; BAB55163).
FT CONFLICT 61 61 R -> G (in Ref. 1; BAB55163).
FT CONFLICT 149 149 Y -> H (in Ref. 1; BAB55163).
SQ SEQUENCE 183 AA; 21125 MW; 5F203B99E670D7A7 CRC64;
MASRAGPRAA GTDGSDFQHR ERVAMHYQMS VTLKYEIKKL IYVHLVIWLL LVAKMSVGHL
RLLSHDQVAM PYQWEYPYLL SILPSLLGLL SFPRNNISYL VLSMISMGLF SIAPLIYGSM
EMFPAAQQLY RHGKAYRFLF GFSAVSIMYL VLVLAVQVHA WQLYYSKKLL DSWFTSTQEK
KHK
//