Full text data of LACTB2
LACTB2
[Confidence: low (only semi-automatic identification from reviews)]
Beta-lactamase-like protein 2; 3.-.-.-
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Beta-lactamase-like protein 2; 3.-.-.-
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q53H82
ID LACB2_HUMAN Reviewed; 288 AA.
AC Q53H82; Q9Y392;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 15-JAN-2008, sequence version 2.
DT 22-JAN-2014, entry version 68.
DE RecName: Full=Beta-lactamase-like protein 2;
DE EC=3.-.-.-;
GN Name=LACTB2; ORFNames=CGI-83;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=10810093; DOI=10.1101/gr.10.5.703;
RA Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.;
RT "Identification of novel human genes evolutionarily conserved in
RT Caenorhabditis elegans by comparative proteomics.";
RL Genome Res. 10:703-713(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily.
CC Glyoxalase II family.
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DR EMBL; AF151841; AAD34078.1; -; mRNA.
DR EMBL; AK222699; BAD96419.1; -; mRNA.
DR EMBL; CH471068; EAW86969.1; -; Genomic_DNA.
DR EMBL; BC000878; AAH00878.1; -; mRNA.
DR PIR; T44603; T44603.
DR RefSeq; NP_057111.1; NM_016027.2.
DR UniGene; Hs.118554; -.
DR PDB; 4AD9; X-ray; 2.60 A; A/B/C/D/E/F=1-288.
DR PDBsum; 4AD9; -.
DR ProteinModelPortal; Q53H82; -.
DR SMR; Q53H82; 1-288.
DR IntAct; Q53H82; 1.
DR STRING; 9606.ENSP00000276590; -.
DR DMDM; 166223244; -.
DR REPRODUCTION-2DPAGE; IPI00006952; -.
DR PaxDb; Q53H82; -.
DR PeptideAtlas; Q53H82; -.
DR PRIDE; Q53H82; -.
DR DNASU; 51110; -.
DR Ensembl; ENST00000276590; ENSP00000276590; ENSG00000147592.
DR Ensembl; ENST00000522447; ENSP00000428801; ENSG00000147592.
DR GeneID; 51110; -.
DR KEGG; hsa:51110; -.
DR UCSC; uc003xyp.3; human.
DR CTD; 51110; -.
DR GeneCards; GC08M071549; -.
DR HGNC; HGNC:18512; LACTB2.
DR HPA; HPA044391; -.
DR neXtProt; NX_Q53H82; -.
DR PharmGKB; PA134952605; -.
DR eggNOG; COG0491; -.
DR HOGENOM; HOG000246879; -.
DR HOVERGEN; HBG099837; -.
DR InParanoid; Q53H82; -.
DR OMA; KGRAYPG; -.
DR OrthoDB; EOG7XM2ZK; -.
DR GenomeRNAi; 51110; -.
DR NextBio; 53861; -.
DR PRO; PR:Q53H82; -.
DR Bgee; Q53H82; -.
DR CleanEx; HS_LACTB2; -.
DR Genevestigator; Q53H82; -.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.60.15.10; -; 1.
DR InterPro; IPR001279; Beta-lactamas-like.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Complete proteome; Hydrolase;
KW Metal-binding; Reference proteome; Zinc.
FT CHAIN 1 288 Beta-lactamase-like protein 2.
FT /FTId=PRO_0000315743.
FT METAL 77 77 Zinc 1 (By similarity).
FT METAL 79 79 Zinc 1 (By similarity).
FT METAL 81 81 Zinc 2 (By similarity).
FT METAL 82 82 Zinc 2 (By similarity).
FT METAL 145 145 Zinc 1 (By similarity).
FT METAL 164 164 Zinc 1 (By similarity).
FT METAL 164 164 Zinc 2 (By similarity).
FT METAL 199 199 Zinc 2 (By similarity).
FT MOD_RES 102 102 N6-acetyllysine (By similarity).
FT MOD_RES 282 282 N6-acetyllysine (By similarity).
FT CONFLICT 268 268 L -> P (in Ref. 2; BAD96419).
FT STRAND 7 10
FT STRAND 12 19
FT TURN 25 27
FT STRAND 32 36
FT STRAND 38 45
FT HELIX 53 65
FT STRAND 70 74
FT HELIX 80 83
FT HELIX 86 92
FT STRAND 101 103
FT TURN 115 118
FT STRAND 121 123
FT STRAND 129 132
FT STRAND 135 141
FT STRAND 144 146
FT STRAND 150 154
FT TURN 155 158
FT STRAND 159 163
FT STRAND 168 170
FT HELIX 177 190
FT STRAND 193 201
FT HELIX 206 230
FT TURN 231 233
FT HELIX 238 245
FT TURN 246 248
FT HELIX 251 253
FT HELIX 254 270
FT STRAND 273 276
FT STRAND 284 286
SQ SEQUENCE 288 AA; 32806 MW; F569C7DFB070D52C CRC64;
MAAVLQRVER LSNRVVRVLG CNPGPMTLQG TNTYLVGTGP RRILIDTGEP AIPEYISCLK
QALTEFNTAI QEIVVTHWHR DHSGGIGDIC KSINNDTTYC IKKLPRNPQR EEIIGNGEQQ
YVYLKDGDVI KTEGATLRVL YTPGHTDDHM ALLLEEENAI FSGDCILGEG TTVFEDLYDY
MNSLKELLKI KADIIYPGHG PVIHNAEAKI QQYISHRNIR EQQILTLFRE NFEKSFTVME
LVKIIYKNTP ENLHEMAKHN LLLHLKKLEK EGKIFSNTDP DKKWKAHL
//
ID LACB2_HUMAN Reviewed; 288 AA.
AC Q53H82; Q9Y392;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 15-JAN-2008, sequence version 2.
DT 22-JAN-2014, entry version 68.
DE RecName: Full=Beta-lactamase-like protein 2;
DE EC=3.-.-.-;
GN Name=LACTB2; ORFNames=CGI-83;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=10810093; DOI=10.1101/gr.10.5.703;
RA Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.;
RT "Identification of novel human genes evolutionarily conserved in
RT Caenorhabditis elegans by comparative proteomics.";
RL Genome Res. 10:703-713(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily.
CC Glyoxalase II family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF151841; AAD34078.1; -; mRNA.
DR EMBL; AK222699; BAD96419.1; -; mRNA.
DR EMBL; CH471068; EAW86969.1; -; Genomic_DNA.
DR EMBL; BC000878; AAH00878.1; -; mRNA.
DR PIR; T44603; T44603.
DR RefSeq; NP_057111.1; NM_016027.2.
DR UniGene; Hs.118554; -.
DR PDB; 4AD9; X-ray; 2.60 A; A/B/C/D/E/F=1-288.
DR PDBsum; 4AD9; -.
DR ProteinModelPortal; Q53H82; -.
DR SMR; Q53H82; 1-288.
DR IntAct; Q53H82; 1.
DR STRING; 9606.ENSP00000276590; -.
DR DMDM; 166223244; -.
DR REPRODUCTION-2DPAGE; IPI00006952; -.
DR PaxDb; Q53H82; -.
DR PeptideAtlas; Q53H82; -.
DR PRIDE; Q53H82; -.
DR DNASU; 51110; -.
DR Ensembl; ENST00000276590; ENSP00000276590; ENSG00000147592.
DR Ensembl; ENST00000522447; ENSP00000428801; ENSG00000147592.
DR GeneID; 51110; -.
DR KEGG; hsa:51110; -.
DR UCSC; uc003xyp.3; human.
DR CTD; 51110; -.
DR GeneCards; GC08M071549; -.
DR HGNC; HGNC:18512; LACTB2.
DR HPA; HPA044391; -.
DR neXtProt; NX_Q53H82; -.
DR PharmGKB; PA134952605; -.
DR eggNOG; COG0491; -.
DR HOGENOM; HOG000246879; -.
DR HOVERGEN; HBG099837; -.
DR InParanoid; Q53H82; -.
DR OMA; KGRAYPG; -.
DR OrthoDB; EOG7XM2ZK; -.
DR GenomeRNAi; 51110; -.
DR NextBio; 53861; -.
DR PRO; PR:Q53H82; -.
DR Bgee; Q53H82; -.
DR CleanEx; HS_LACTB2; -.
DR Genevestigator; Q53H82; -.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.60.15.10; -; 1.
DR InterPro; IPR001279; Beta-lactamas-like.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Complete proteome; Hydrolase;
KW Metal-binding; Reference proteome; Zinc.
FT CHAIN 1 288 Beta-lactamase-like protein 2.
FT /FTId=PRO_0000315743.
FT METAL 77 77 Zinc 1 (By similarity).
FT METAL 79 79 Zinc 1 (By similarity).
FT METAL 81 81 Zinc 2 (By similarity).
FT METAL 82 82 Zinc 2 (By similarity).
FT METAL 145 145 Zinc 1 (By similarity).
FT METAL 164 164 Zinc 1 (By similarity).
FT METAL 164 164 Zinc 2 (By similarity).
FT METAL 199 199 Zinc 2 (By similarity).
FT MOD_RES 102 102 N6-acetyllysine (By similarity).
FT MOD_RES 282 282 N6-acetyllysine (By similarity).
FT CONFLICT 268 268 L -> P (in Ref. 2; BAD96419).
FT STRAND 7 10
FT STRAND 12 19
FT TURN 25 27
FT STRAND 32 36
FT STRAND 38 45
FT HELIX 53 65
FT STRAND 70 74
FT HELIX 80 83
FT HELIX 86 92
FT STRAND 101 103
FT TURN 115 118
FT STRAND 121 123
FT STRAND 129 132
FT STRAND 135 141
FT STRAND 144 146
FT STRAND 150 154
FT TURN 155 158
FT STRAND 159 163
FT STRAND 168 170
FT HELIX 177 190
FT STRAND 193 201
FT HELIX 206 230
FT TURN 231 233
FT HELIX 238 245
FT TURN 246 248
FT HELIX 251 253
FT HELIX 254 270
FT STRAND 273 276
FT STRAND 284 286
SQ SEQUENCE 288 AA; 32806 MW; F569C7DFB070D52C CRC64;
MAAVLQRVER LSNRVVRVLG CNPGPMTLQG TNTYLVGTGP RRILIDTGEP AIPEYISCLK
QALTEFNTAI QEIVVTHWHR DHSGGIGDIC KSINNDTTYC IKKLPRNPQR EEIIGNGEQQ
YVYLKDGDVI KTEGATLRVL YTPGHTDDHM ALLLEEENAI FSGDCILGEG TTVFEDLYDY
MNSLKELLKI KADIIYPGHG PVIHNAEAKI QQYISHRNIR EQQILTLFRE NFEKSFTVME
LVKIIYKNTP ENLHEMAKHN LLLHLKKLEK EGKIFSNTDP DKKWKAHL
//