Full text data of LRRC40
LRRC40
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Leucine-rich repeat-containing protein 40
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Leucine-rich repeat-containing protein 40
Note: presumably soluble (membrane word is not in UniProt keywords or features)
hRBCD
IPI00152998
IPI00152998 Leucine-rich repeat, typical subtype containing protein Leucine-rich repeat, typical subtype containing protein membrane n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 1 n/a n/a not mentioned n/a found at its expected molecular weight found at molecular weight
IPI00152998 Leucine-rich repeat, typical subtype containing protein Leucine-rich repeat, typical subtype containing protein membrane n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 1 n/a n/a not mentioned n/a found at its expected molecular weight found at molecular weight
UniProt
Q9H9A6
ID LRC40_HUMAN Reviewed; 602 AA.
AC Q9H9A6; Q9BTR7; Q9NSK1; Q9NXC1;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2001, sequence version 1.
DT 22-JAN-2014, entry version 115.
DE RecName: Full=Leucine-rich repeat-containing protein 40;
GN Name=LRRC40;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 430-602.
RC TISSUE=Melanoma;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SIMILARITY: Contains 20 LRR (leucine-rich) repeats.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91094.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK000338; BAA91094.1; ALT_INIT; mRNA.
DR EMBL; AK022951; BAB14326.1; -; mRNA.
DR EMBL; AL353771; CAI22332.1; -; Genomic_DNA.
DR EMBL; BC003407; AAH03407.2; -; mRNA.
DR EMBL; BC008586; AAH08586.1; -; mRNA.
DR EMBL; AL162076; CAB82410.1; -; mRNA.
DR PIR; T47176; T47176.
DR RefSeq; NP_060238.3; NM_017768.4.
DR UniGene; Hs.147836; -.
DR ProteinModelPortal; Q9H9A6; -.
DR SMR; Q9H9A6; 10-597.
DR IntAct; Q9H9A6; 2.
DR MINT; MINT-7944638; -.
DR STRING; 9606.ENSP00000359990; -.
DR PhosphoSite; Q9H9A6; -.
DR DMDM; 74761553; -.
DR REPRODUCTION-2DPAGE; IPI00152998; -.
DR PaxDb; Q9H9A6; -.
DR PeptideAtlas; Q9H9A6; -.
DR PRIDE; Q9H9A6; -.
DR DNASU; 55631; -.
DR Ensembl; ENST00000370952; ENSP00000359990; ENSG00000066557.
DR GeneID; 55631; -.
DR KEGG; hsa:55631; -.
DR UCSC; uc001der.2; human.
DR CTD; 55631; -.
DR GeneCards; GC01M070610; -.
DR HGNC; HGNC:26004; LRRC40.
DR HPA; HPA026553; -.
DR HPA; HPA026564; -.
DR neXtProt; NX_Q9H9A6; -.
DR PharmGKB; PA142671528; -.
DR eggNOG; COG4886; -.
DR HOGENOM; HOG000005761; -.
DR HOVERGEN; HBG081930; -.
DR InParanoid; Q9H9A6; -.
DR OMA; WRINVDV; -.
DR OrthoDB; EOG7WX07X; -.
DR PhylomeDB; Q9H9A6; -.
DR ChiTaRS; LRRC40; human.
DR GeneWiki; LRRC40; -.
DR GenomeRNAi; 55631; -.
DR NextBio; 60271; -.
DR PRO; PR:Q9H9A6; -.
DR Bgee; Q9H9A6; -.
DR CleanEx; HS_LRRC40; -.
DR Genevestigator; Q9H9A6; -.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF12799; LRR_4; 1.
DR SMART; SM00369; LRR_TYP; 3.
DR PROSITE; PS51450; LRR; 17.
PE 1: Evidence at protein level;
KW Complete proteome; Leucine-rich repeat; Phosphoprotein; Polymorphism;
KW Reference proteome; Repeat.
FT CHAIN 1 602 Leucine-rich repeat-containing protein
FT 40.
FT /FTId=PRO_0000226257.
FT REPEAT 83 104 LRR 1.
FT REPEAT 106 127 LRR 2.
FT REPEAT 129 150 LRR 3.
FT REPEAT 152 173 LRR 4.
FT REPEAT 175 196 LRR 5.
FT REPEAT 198 219 LRR 6.
FT REPEAT 221 242 LRR 7.
FT REPEAT 244 265 LRR 8.
FT REPEAT 266 286 LRR 9.
FT REPEAT 290 311 LRR 10.
FT REPEAT 313 335 LRR 11.
FT REPEAT 336 356 LRR 12.
FT REPEAT 400 421 LRR 13.
FT REPEAT 426 447 LRR 14.
FT REPEAT 450 472 LRR 15.
FT REPEAT 473 494 LRR 16.
FT REPEAT 496 517 LRR 17.
FT REPEAT 519 540 LRR 18.
FT REPEAT 543 564 LRR 19.
FT REPEAT 566 586 LRR 20.
FT MOD_RES 71 71 Phosphoserine.
FT VARIANT 53 53 Q -> P (in dbSNP:rs270495).
FT /FTId=VAR_034088.
FT VARIANT 500 500 I -> V (in dbSNP:rs3180401).
FT /FTId=VAR_034089.
FT CONFLICT 368 368 K -> T (in Ref. 1; BAA91094).
SQ SEQUENCE 602 AA; 68250 MW; BB126CAC02749C8A CRC64;
MSRLKRIAGQ DLRAGFKAGG RDCGTSVPQG LLKAARKSGQ LNLSGRNLSE VPQCVWRINV
DIPEEANQNL SFGATERWWE QTDLTKLIIS NNKLQSLTDD LRLLPALTVL DIHDNQLTSL
PSAIRELENL QKLNVSHNKL KILPEEITNL RNLKCLYLQH NELTCISEGF EQLSNLEDLD
LSNNHLTTVP ASFSSLSSLV RLNLSSNELK SLPAEINRMK RLKHLDCNSN LLETIPPELA
GMESLELLYL RRNKLRFLPE FPSCSLLKEL HVGENQIEML EAEHLKHLNS ILVLDLRDNK
LKSVPDEIIL LRSLERLDLS NNDISSLPYS LGNLHLKFLA LEGNPLRTIR REIISKGTQE
VLKYLRSKIK DDGPSQSESA TETAMTLPSE SRVNIHAIIT LKILDYSDKQ ATLIPDEVFD
AVKSNIVTSI NFSKNQLCEI PKRMVELKEM VSDVDLSFNK LSFISLELCV LQKLTFLDLR
NNFLNSLPEE MESLVRLQTI NLSFNRFKML PEVLYRIFTL ETILISNNQV GSVDPQKMKM
MENLTTLDLQ NNDLLQIPPE LGNCVNLRTL LLDGNPFRVP RAAILMKGTA AILEYLRDRI
PT
//
ID LRC40_HUMAN Reviewed; 602 AA.
AC Q9H9A6; Q9BTR7; Q9NSK1; Q9NXC1;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2001, sequence version 1.
DT 22-JAN-2014, entry version 115.
DE RecName: Full=Leucine-rich repeat-containing protein 40;
GN Name=LRRC40;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 430-602.
RC TISSUE=Melanoma;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SIMILARITY: Contains 20 LRR (leucine-rich) repeats.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91094.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK000338; BAA91094.1; ALT_INIT; mRNA.
DR EMBL; AK022951; BAB14326.1; -; mRNA.
DR EMBL; AL353771; CAI22332.1; -; Genomic_DNA.
DR EMBL; BC003407; AAH03407.2; -; mRNA.
DR EMBL; BC008586; AAH08586.1; -; mRNA.
DR EMBL; AL162076; CAB82410.1; -; mRNA.
DR PIR; T47176; T47176.
DR RefSeq; NP_060238.3; NM_017768.4.
DR UniGene; Hs.147836; -.
DR ProteinModelPortal; Q9H9A6; -.
DR SMR; Q9H9A6; 10-597.
DR IntAct; Q9H9A6; 2.
DR MINT; MINT-7944638; -.
DR STRING; 9606.ENSP00000359990; -.
DR PhosphoSite; Q9H9A6; -.
DR DMDM; 74761553; -.
DR REPRODUCTION-2DPAGE; IPI00152998; -.
DR PaxDb; Q9H9A6; -.
DR PeptideAtlas; Q9H9A6; -.
DR PRIDE; Q9H9A6; -.
DR DNASU; 55631; -.
DR Ensembl; ENST00000370952; ENSP00000359990; ENSG00000066557.
DR GeneID; 55631; -.
DR KEGG; hsa:55631; -.
DR UCSC; uc001der.2; human.
DR CTD; 55631; -.
DR GeneCards; GC01M070610; -.
DR HGNC; HGNC:26004; LRRC40.
DR HPA; HPA026553; -.
DR HPA; HPA026564; -.
DR neXtProt; NX_Q9H9A6; -.
DR PharmGKB; PA142671528; -.
DR eggNOG; COG4886; -.
DR HOGENOM; HOG000005761; -.
DR HOVERGEN; HBG081930; -.
DR InParanoid; Q9H9A6; -.
DR OMA; WRINVDV; -.
DR OrthoDB; EOG7WX07X; -.
DR PhylomeDB; Q9H9A6; -.
DR ChiTaRS; LRRC40; human.
DR GeneWiki; LRRC40; -.
DR GenomeRNAi; 55631; -.
DR NextBio; 60271; -.
DR PRO; PR:Q9H9A6; -.
DR Bgee; Q9H9A6; -.
DR CleanEx; HS_LRRC40; -.
DR Genevestigator; Q9H9A6; -.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF12799; LRR_4; 1.
DR SMART; SM00369; LRR_TYP; 3.
DR PROSITE; PS51450; LRR; 17.
PE 1: Evidence at protein level;
KW Complete proteome; Leucine-rich repeat; Phosphoprotein; Polymorphism;
KW Reference proteome; Repeat.
FT CHAIN 1 602 Leucine-rich repeat-containing protein
FT 40.
FT /FTId=PRO_0000226257.
FT REPEAT 83 104 LRR 1.
FT REPEAT 106 127 LRR 2.
FT REPEAT 129 150 LRR 3.
FT REPEAT 152 173 LRR 4.
FT REPEAT 175 196 LRR 5.
FT REPEAT 198 219 LRR 6.
FT REPEAT 221 242 LRR 7.
FT REPEAT 244 265 LRR 8.
FT REPEAT 266 286 LRR 9.
FT REPEAT 290 311 LRR 10.
FT REPEAT 313 335 LRR 11.
FT REPEAT 336 356 LRR 12.
FT REPEAT 400 421 LRR 13.
FT REPEAT 426 447 LRR 14.
FT REPEAT 450 472 LRR 15.
FT REPEAT 473 494 LRR 16.
FT REPEAT 496 517 LRR 17.
FT REPEAT 519 540 LRR 18.
FT REPEAT 543 564 LRR 19.
FT REPEAT 566 586 LRR 20.
FT MOD_RES 71 71 Phosphoserine.
FT VARIANT 53 53 Q -> P (in dbSNP:rs270495).
FT /FTId=VAR_034088.
FT VARIANT 500 500 I -> V (in dbSNP:rs3180401).
FT /FTId=VAR_034089.
FT CONFLICT 368 368 K -> T (in Ref. 1; BAA91094).
SQ SEQUENCE 602 AA; 68250 MW; BB126CAC02749C8A CRC64;
MSRLKRIAGQ DLRAGFKAGG RDCGTSVPQG LLKAARKSGQ LNLSGRNLSE VPQCVWRINV
DIPEEANQNL SFGATERWWE QTDLTKLIIS NNKLQSLTDD LRLLPALTVL DIHDNQLTSL
PSAIRELENL QKLNVSHNKL KILPEEITNL RNLKCLYLQH NELTCISEGF EQLSNLEDLD
LSNNHLTTVP ASFSSLSSLV RLNLSSNELK SLPAEINRMK RLKHLDCNSN LLETIPPELA
GMESLELLYL RRNKLRFLPE FPSCSLLKEL HVGENQIEML EAEHLKHLNS ILVLDLRDNK
LKSVPDEIIL LRSLERLDLS NNDISSLPYS LGNLHLKFLA LEGNPLRTIR REIISKGTQE
VLKYLRSKIK DDGPSQSESA TETAMTLPSE SRVNIHAIIT LKILDYSDKQ ATLIPDEVFD
AVKSNIVTSI NFSKNQLCEI PKRMVELKEM VSDVDLSFNK LSFISLELCV LQKLTFLDLR
NNFLNSLPEE MESLVRLQTI NLSFNRFKML PEVLYRIFTL ETILISNNQV GSVDPQKMKM
MENLTTLDLQ NNDLLQIPPE LGNCVNLRTL LLDGNPFRVP RAAILMKGTA AILEYLRDRI
PT
//