Full text data of LRRC47
LRRC47
(KIAA1185)
[Confidence: low (only semi-automatic identification from reviews)]
Leucine-rich repeat-containing protein 47
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Leucine-rich repeat-containing protein 47
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q8N1G4
ID LRC47_HUMAN Reviewed; 583 AA.
AC Q8N1G4; Q9ULN5;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-2002, sequence version 1.
DT 22-JAN-2014, entry version 104.
DE RecName: Full=Leucine-rich repeat-containing protein 47;
GN Name=LRRC47; Synonyms=KIAA1185;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 2-18; 23-34; 65-83; 85-102; 371-381 AND 494-502,
RP CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, AND MASS
RP SPECTROMETRY.
RC TISSUE=Hepatoma;
RA Bienvenut W.V., Boldt K., von Kriegsheim A.F., Kolch W.;
RL Submitted (JUL-2007) to UniProtKB.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 181-583.
RC TISSUE=Brain;
RX PubMed=10574461; DOI=10.1093/dnares/6.5.329;
RA Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.;
RT "Characterization of cDNA clones selected by the GeneMark analysis
RT from size-fractionated cDNA libraries from human brain.";
RL DNA Res. 6:329-336(1999).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-520, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-509 AND SER-520, AND
RP MASS SPECTROMETRY.
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-431, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-431 AND SER-520, AND
RP MASS SPECTROMETRY.
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA Blagoev B.;
RT "System-wide temporal characterization of the proteome and
RT phosphoproteome of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [11]
RP VARIANT [LARGE SCALE ANALYSIS] ASP-193.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
RA Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
RA Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
RA Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
RA Vogelstein B., Kinzler K.W., Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal
RT cancers.";
RL Science 314:268-274(2006).
CC -!- INTERACTION:
CC P04591:gag (xeno); NbExp=2; IntAct=EBI-2509921, EBI-6179727;
CC -!- SIMILARITY: Contains 7 LRR (leucine-rich) repeats.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AL365330; CAI42528.1; -; Genomic_DNA.
DR EMBL; BC031301; AAH31301.1; -; mRNA.
DR EMBL; AB033011; BAA86499.1; -; mRNA.
DR RefSeq; NP_065761.1; NM_020710.2.
DR UniGene; Hs.268488; -.
DR ProteinModelPortal; Q8N1G4; -.
DR SMR; Q8N1G4; 41-271, 321-515.
DR IntAct; Q8N1G4; 8.
DR MINT; MINT-3039182; -.
DR STRING; 9606.ENSP00000367498; -.
DR PhosphoSite; Q8N1G4; -.
DR DMDM; 74750895; -.
DR PaxDb; Q8N1G4; -.
DR PeptideAtlas; Q8N1G4; -.
DR PRIDE; Q8N1G4; -.
DR Ensembl; ENST00000378251; ENSP00000367498; ENSG00000130764.
DR GeneID; 57470; -.
DR KEGG; hsa:57470; -.
DR UCSC; uc001akx.1; human.
DR CTD; 57470; -.
DR GeneCards; GC01M003696; -.
DR HGNC; HGNC:29207; LRRC47.
DR HPA; HPA008512; -.
DR HPA; HPA012018; -.
DR neXtProt; NX_Q8N1G4; -.
DR PharmGKB; PA142671507; -.
DR eggNOG; COG4886; -.
DR HOGENOM; HOG000007166; -.
DR HOVERGEN; HBG066309; -.
DR InParanoid; Q8N1G4; -.
DR OMA; VRPYLVC; -.
DR OrthoDB; EOG7JDQXJ; -.
DR PhylomeDB; Q8N1G4; -.
DR ChiTaRS; LRRC47; human.
DR GenomeRNAi; 57470; -.
DR NextBio; 63693; -.
DR PMAP-CutDB; Q8N1G4; -.
DR PRO; PR:Q8N1G4; -.
DR Bgee; Q8N1G4; -.
DR CleanEx; HS_LRRC47; -.
DR Genevestigator; Q8N1G4; -.
DR GO; GO:0004826; F:phenylalanine-tRNA ligase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR InterPro; IPR005146; B3/B4_tRNA-bd.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR Pfam; PF03483; B3_4; 1.
DR Pfam; PF12799; LRR_4; 3.
DR SMART; SM00873; B3_4; 1.
DR SMART; SM00369; LRR_TYP; 3.
DR PROSITE; PS51450; LRR; 6.
PE 1: Evidence at protein level;
KW Acetylation; Coiled coil; Complete proteome;
KW Direct protein sequencing; Leucine-rich repeat; Phosphoprotein;
KW Polymorphism; Reference proteome; Repeat.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 583 Leucine-rich repeat-containing protein
FT 47.
FT /FTId=PRO_0000223926.
FT REPEAT 76 95 LRR 1.
FT REPEAT 100 121 LRR 2.
FT REPEAT 130 152 LRR 3.
FT REPEAT 154 175 LRR 4.
FT REPEAT 180 202 LRR 5.
FT REPEAT 203 225 LRR 6.
FT REPEAT 226 246 LRR 7.
FT COILED 402 437 Potential.
FT COMPBIAS 2 5 Poly-Ala.
FT MOD_RES 2 2 N-acetylalanine.
FT MOD_RES 431 431 Phosphoserine.
FT MOD_RES 509 509 Phosphotyrosine.
FT MOD_RES 520 520 Phosphoserine.
FT VARIANT 193 193 E -> D (in a colorectal cancer sample;
FT somatic mutation).
FT /FTId=VAR_035471.
FT VARIANT 545 545 P -> L (in dbSNP:rs11547614).
FT /FTId=VAR_051118.
FT VARIANT 581 581 V -> I (in dbSNP:rs11547615).
FT /FTId=VAR_051119.
SQ SEQUENCE 583 AA; 63473 MW; BCCFAE89BCD46031 CRC64;
MAAAAVSESW PELELAERER RRELLLTGPG LEERVRAAGG QLPPRLFTLP LLHYLEVSGC
GSLRAPGPGL AQGLPQLHSL VLRRNALGPG LSPELGPLPA LRVLDLSGNA LEALPPGQGL
GPAEPPGLPQ LQSLNLSGNR LRELPADLAR CAPRLQSLNL TGNCLDSFPA ELFRPGALPL
LSELAAADNC LRELSPDIAH LASLKTLDLS NNQLSEIPAE LADCPKLKEI NFRGNKLRDK
RLEKMVSGCQ TRSILEYLRV GGRGGGKGKG RAEGSEKEES RRKRRERKQR REGGDGEEQD
VGDAGRLLLR VLHVSENPVP LTVRVSPEVR DVRPYIVGAV VRGMDLQPGN ALKRFLTSQT
KLHEDLCEKR TAATLATHEL RAVKGPLLYC ARPPQDLKIV PLGRKEAKAK ELVRQLQLEA
EEQRKQKKRQ SVSGLHRYLH LLDGNENYPC LVDADGDVIS FPPITNSEKT KVKKTTSDLF
LEVTSATSLQ ICKDVMDALI LKMAEMKKYT LENKEEGSLS DTEADAVSGQ LPDPTTNPSA
GKDGPSLLVV EQVRVVDLEG SLKVVYPSKA DLATAPPHVT VVR
//
ID LRC47_HUMAN Reviewed; 583 AA.
AC Q8N1G4; Q9ULN5;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-2002, sequence version 1.
DT 22-JAN-2014, entry version 104.
DE RecName: Full=Leucine-rich repeat-containing protein 47;
GN Name=LRRC47; Synonyms=KIAA1185;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 2-18; 23-34; 65-83; 85-102; 371-381 AND 494-502,
RP CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, AND MASS
RP SPECTROMETRY.
RC TISSUE=Hepatoma;
RA Bienvenut W.V., Boldt K., von Kriegsheim A.F., Kolch W.;
RL Submitted (JUL-2007) to UniProtKB.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 181-583.
RC TISSUE=Brain;
RX PubMed=10574461; DOI=10.1093/dnares/6.5.329;
RA Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.;
RT "Characterization of cDNA clones selected by the GeneMark analysis
RT from size-fractionated cDNA libraries from human brain.";
RL DNA Res. 6:329-336(1999).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-520, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-509 AND SER-520, AND
RP MASS SPECTROMETRY.
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-431, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-431 AND SER-520, AND
RP MASS SPECTROMETRY.
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA Blagoev B.;
RT "System-wide temporal characterization of the proteome and
RT phosphoproteome of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [11]
RP VARIANT [LARGE SCALE ANALYSIS] ASP-193.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
RA Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
RA Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
RA Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
RA Vogelstein B., Kinzler K.W., Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal
RT cancers.";
RL Science 314:268-274(2006).
CC -!- INTERACTION:
CC P04591:gag (xeno); NbExp=2; IntAct=EBI-2509921, EBI-6179727;
CC -!- SIMILARITY: Contains 7 LRR (leucine-rich) repeats.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AL365330; CAI42528.1; -; Genomic_DNA.
DR EMBL; BC031301; AAH31301.1; -; mRNA.
DR EMBL; AB033011; BAA86499.1; -; mRNA.
DR RefSeq; NP_065761.1; NM_020710.2.
DR UniGene; Hs.268488; -.
DR ProteinModelPortal; Q8N1G4; -.
DR SMR; Q8N1G4; 41-271, 321-515.
DR IntAct; Q8N1G4; 8.
DR MINT; MINT-3039182; -.
DR STRING; 9606.ENSP00000367498; -.
DR PhosphoSite; Q8N1G4; -.
DR DMDM; 74750895; -.
DR PaxDb; Q8N1G4; -.
DR PeptideAtlas; Q8N1G4; -.
DR PRIDE; Q8N1G4; -.
DR Ensembl; ENST00000378251; ENSP00000367498; ENSG00000130764.
DR GeneID; 57470; -.
DR KEGG; hsa:57470; -.
DR UCSC; uc001akx.1; human.
DR CTD; 57470; -.
DR GeneCards; GC01M003696; -.
DR HGNC; HGNC:29207; LRRC47.
DR HPA; HPA008512; -.
DR HPA; HPA012018; -.
DR neXtProt; NX_Q8N1G4; -.
DR PharmGKB; PA142671507; -.
DR eggNOG; COG4886; -.
DR HOGENOM; HOG000007166; -.
DR HOVERGEN; HBG066309; -.
DR InParanoid; Q8N1G4; -.
DR OMA; VRPYLVC; -.
DR OrthoDB; EOG7JDQXJ; -.
DR PhylomeDB; Q8N1G4; -.
DR ChiTaRS; LRRC47; human.
DR GenomeRNAi; 57470; -.
DR NextBio; 63693; -.
DR PMAP-CutDB; Q8N1G4; -.
DR PRO; PR:Q8N1G4; -.
DR Bgee; Q8N1G4; -.
DR CleanEx; HS_LRRC47; -.
DR Genevestigator; Q8N1G4; -.
DR GO; GO:0004826; F:phenylalanine-tRNA ligase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR InterPro; IPR005146; B3/B4_tRNA-bd.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR Pfam; PF03483; B3_4; 1.
DR Pfam; PF12799; LRR_4; 3.
DR SMART; SM00873; B3_4; 1.
DR SMART; SM00369; LRR_TYP; 3.
DR PROSITE; PS51450; LRR; 6.
PE 1: Evidence at protein level;
KW Acetylation; Coiled coil; Complete proteome;
KW Direct protein sequencing; Leucine-rich repeat; Phosphoprotein;
KW Polymorphism; Reference proteome; Repeat.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 583 Leucine-rich repeat-containing protein
FT 47.
FT /FTId=PRO_0000223926.
FT REPEAT 76 95 LRR 1.
FT REPEAT 100 121 LRR 2.
FT REPEAT 130 152 LRR 3.
FT REPEAT 154 175 LRR 4.
FT REPEAT 180 202 LRR 5.
FT REPEAT 203 225 LRR 6.
FT REPEAT 226 246 LRR 7.
FT COILED 402 437 Potential.
FT COMPBIAS 2 5 Poly-Ala.
FT MOD_RES 2 2 N-acetylalanine.
FT MOD_RES 431 431 Phosphoserine.
FT MOD_RES 509 509 Phosphotyrosine.
FT MOD_RES 520 520 Phosphoserine.
FT VARIANT 193 193 E -> D (in a colorectal cancer sample;
FT somatic mutation).
FT /FTId=VAR_035471.
FT VARIANT 545 545 P -> L (in dbSNP:rs11547614).
FT /FTId=VAR_051118.
FT VARIANT 581 581 V -> I (in dbSNP:rs11547615).
FT /FTId=VAR_051119.
SQ SEQUENCE 583 AA; 63473 MW; BCCFAE89BCD46031 CRC64;
MAAAAVSESW PELELAERER RRELLLTGPG LEERVRAAGG QLPPRLFTLP LLHYLEVSGC
GSLRAPGPGL AQGLPQLHSL VLRRNALGPG LSPELGPLPA LRVLDLSGNA LEALPPGQGL
GPAEPPGLPQ LQSLNLSGNR LRELPADLAR CAPRLQSLNL TGNCLDSFPA ELFRPGALPL
LSELAAADNC LRELSPDIAH LASLKTLDLS NNQLSEIPAE LADCPKLKEI NFRGNKLRDK
RLEKMVSGCQ TRSILEYLRV GGRGGGKGKG RAEGSEKEES RRKRRERKQR REGGDGEEQD
VGDAGRLLLR VLHVSENPVP LTVRVSPEVR DVRPYIVGAV VRGMDLQPGN ALKRFLTSQT
KLHEDLCEKR TAATLATHEL RAVKGPLLYC ARPPQDLKIV PLGRKEAKAK ELVRQLQLEA
EEQRKQKKRQ SVSGLHRYLH LLDGNENYPC LVDADGDVIS FPPITNSEKT KVKKTTSDLF
LEVTSATSLQ ICKDVMDALI LKMAEMKKYT LENKEEGSLS DTEADAVSGQ LPDPTTNPSA
GKDGPSLLVV EQVRVVDLEG SLKVVYPSKA DLATAPPHVT VVR
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