Full text data of LRRC57
LRRC57
[Confidence: high (present in two of the MS resources)]
Leucine-rich repeat-containing protein 57
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Leucine-rich repeat-containing protein 57
Note: presumably soluble (membrane word is not in UniProt keywords or features)
hRBCD
IPI00470576
IPI00470576 Leucine-rich repeat, typical subtype containing protein Leucine-rich repeat, typical subtype containing protein membrane n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 1 n/a n/a not mentioned n/a expected molecular weight found in band ~ 14 kDa
IPI00470576 Leucine-rich repeat, typical subtype containing protein Leucine-rich repeat, typical subtype containing protein membrane n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 1 n/a n/a not mentioned n/a expected molecular weight found in band ~ 14 kDa
UniProt
Q8N9N7
ID LRC57_HUMAN Reviewed; 239 AA.
AC Q8N9N7; Q7Z2Z6; Q8N1T6;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-2002, sequence version 1.
DT 22-JAN-2014, entry version 103.
DE RecName: Full=Leucine-rich repeat-containing protein 57;
GN Name=LRRC57;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Corpus callosum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Endometrium, and Uterine endothelium;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SIMILARITY: Contains 8 LRR (leucine-rich) repeats.
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DR EMBL; AK094131; BAC04294.1; -; mRNA.
DR EMBL; AK094891; BAC04451.1; -; mRNA.
DR EMBL; CR749223; CAH18079.1; -; mRNA.
DR EMBL; BX538324; CAD98097.1; -; mRNA.
DR EMBL; BC058935; AAH58935.1; -; mRNA.
DR RefSeq; NP_694992.2; NM_153260.2.
DR UniGene; Hs.234681; -.
DR ProteinModelPortal; Q8N9N7; -.
DR SMR; Q8N9N7; 10-229.
DR MINT; MINT-5003364; -.
DR STRING; 9606.ENSP00000326817; -.
DR PhosphoSite; Q8N9N7; -.
DR DMDM; 74760039; -.
DR PaxDb; Q8N9N7; -.
DR PRIDE; Q8N9N7; -.
DR DNASU; 255252; -.
DR Ensembl; ENST00000323443; ENSP00000326817; ENSG00000180979.
DR Ensembl; ENST00000397130; ENSP00000380319; ENSG00000180979.
DR Ensembl; ENST00000563454; ENSP00000455445; ENSG00000180979.
DR GeneID; 255252; -.
DR KEGG; hsa:255252; -.
DR UCSC; uc001zqc.3; human.
DR CTD; 255252; -.
DR GeneCards; GC15M042836; -.
DR HGNC; HGNC:26719; LRRC57.
DR HPA; HPA040894; -.
DR neXtProt; NX_Q8N9N7; -.
DR PharmGKB; PA142671516; -.
DR eggNOG; COG4886; -.
DR HOGENOM; HOG000116557; -.
DR HOVERGEN; HBG054710; -.
DR InParanoid; Q8N9N7; -.
DR OMA; ATKKKMY; -.
DR OrthoDB; EOG7VTDP7; -.
DR PhylomeDB; Q8N9N7; -.
DR ChiTaRS; LRRC57; human.
DR GeneWiki; LRRC57; -.
DR GenomeRNAi; 255252; -.
DR NextBio; 92531; -.
DR PRO; PR:Q8N9N7; -.
DR ArrayExpress; Q8N9N7; -.
DR Bgee; Q8N9N7; -.
DR CleanEx; HS_LRRC57; -.
DR Genevestigator; Q8N9N7; -.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR Pfam; PF12799; LRR_4; 1.
DR SMART; SM00369; LRR_TYP; 1.
DR PROSITE; PS51450; LRR; 7.
PE 1: Evidence at protein level;
KW Complete proteome; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1 239 Leucine-rich repeat-containing protein
FT 57.
FT /FTId=PRO_0000227778.
FT REPEAT 39 60 LRR 1.
FT REPEAT 63 84 LRR 2.
FT REPEAT 86 107 LRR 3.
FT REPEAT 109 131 LRR 4.
FT REPEAT 132 153 LRR 5.
FT REPEAT 154 175 LRR 6.
FT REPEAT 177 197 LRR 7.
FT REPEAT 202 222 LRR 8.
FT CONFLICT 71 71 N -> S (in Ref. 2; CAD98097).
FT CONFLICT 237 237 K -> N (in Ref. 1; BAC04451).
SQ SEQUENCE 239 AA; 26754 MW; 8CA6E06075D10E3D CRC64;
MGNSALRAHV ETAQKTGVFQ LKDRGLTEFP ADLQKLTSNL RTIDLSNNKI ESLPPLLIGK
FTLLKSLSLN NNKLTVLPDE ICNLKKLETL SLNNNHLREL PSTFGQLSAL KTLSLSGNQL
GALPPQLCSL RHLDVMDLSK NQIRSIPDSV GELQVIELNL NQNQISQISV KISCCPRLKI
LRLEENCLEL SMLPQSILSD SQICLLAVEG NLFEIKKLRE LEGYDKYMER FTATKKKFA
//
ID LRC57_HUMAN Reviewed; 239 AA.
AC Q8N9N7; Q7Z2Z6; Q8N1T6;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-2002, sequence version 1.
DT 22-JAN-2014, entry version 103.
DE RecName: Full=Leucine-rich repeat-containing protein 57;
GN Name=LRRC57;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Corpus callosum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Endometrium, and Uterine endothelium;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SIMILARITY: Contains 8 LRR (leucine-rich) repeats.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK094131; BAC04294.1; -; mRNA.
DR EMBL; AK094891; BAC04451.1; -; mRNA.
DR EMBL; CR749223; CAH18079.1; -; mRNA.
DR EMBL; BX538324; CAD98097.1; -; mRNA.
DR EMBL; BC058935; AAH58935.1; -; mRNA.
DR RefSeq; NP_694992.2; NM_153260.2.
DR UniGene; Hs.234681; -.
DR ProteinModelPortal; Q8N9N7; -.
DR SMR; Q8N9N7; 10-229.
DR MINT; MINT-5003364; -.
DR STRING; 9606.ENSP00000326817; -.
DR PhosphoSite; Q8N9N7; -.
DR DMDM; 74760039; -.
DR PaxDb; Q8N9N7; -.
DR PRIDE; Q8N9N7; -.
DR DNASU; 255252; -.
DR Ensembl; ENST00000323443; ENSP00000326817; ENSG00000180979.
DR Ensembl; ENST00000397130; ENSP00000380319; ENSG00000180979.
DR Ensembl; ENST00000563454; ENSP00000455445; ENSG00000180979.
DR GeneID; 255252; -.
DR KEGG; hsa:255252; -.
DR UCSC; uc001zqc.3; human.
DR CTD; 255252; -.
DR GeneCards; GC15M042836; -.
DR HGNC; HGNC:26719; LRRC57.
DR HPA; HPA040894; -.
DR neXtProt; NX_Q8N9N7; -.
DR PharmGKB; PA142671516; -.
DR eggNOG; COG4886; -.
DR HOGENOM; HOG000116557; -.
DR HOVERGEN; HBG054710; -.
DR InParanoid; Q8N9N7; -.
DR OMA; ATKKKMY; -.
DR OrthoDB; EOG7VTDP7; -.
DR PhylomeDB; Q8N9N7; -.
DR ChiTaRS; LRRC57; human.
DR GeneWiki; LRRC57; -.
DR GenomeRNAi; 255252; -.
DR NextBio; 92531; -.
DR PRO; PR:Q8N9N7; -.
DR ArrayExpress; Q8N9N7; -.
DR Bgee; Q8N9N7; -.
DR CleanEx; HS_LRRC57; -.
DR Genevestigator; Q8N9N7; -.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR Pfam; PF12799; LRR_4; 1.
DR SMART; SM00369; LRR_TYP; 1.
DR PROSITE; PS51450; LRR; 7.
PE 1: Evidence at protein level;
KW Complete proteome; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1 239 Leucine-rich repeat-containing protein
FT 57.
FT /FTId=PRO_0000227778.
FT REPEAT 39 60 LRR 1.
FT REPEAT 63 84 LRR 2.
FT REPEAT 86 107 LRR 3.
FT REPEAT 109 131 LRR 4.
FT REPEAT 132 153 LRR 5.
FT REPEAT 154 175 LRR 6.
FT REPEAT 177 197 LRR 7.
FT REPEAT 202 222 LRR 8.
FT CONFLICT 71 71 N -> S (in Ref. 2; CAD98097).
FT CONFLICT 237 237 K -> N (in Ref. 1; BAC04451).
SQ SEQUENCE 239 AA; 26754 MW; 8CA6E06075D10E3D CRC64;
MGNSALRAHV ETAQKTGVFQ LKDRGLTEFP ADLQKLTSNL RTIDLSNNKI ESLPPLLIGK
FTLLKSLSLN NNKLTVLPDE ICNLKKLETL SLNNNHLREL PSTFGQLSAL KTLSLSGNQL
GALPPQLCSL RHLDVMDLSK NQIRSIPDSV GELQVIELNL NQNQISQISV KISCCPRLKI
LRLEENCLEL SMLPQSILSD SQICLLAVEG NLFEIKKLRE LEGYDKYMER FTATKKKFA
//