Full text data of LRRIQ1
LRRIQ1
(KIAA1801)
[Confidence: low (only semi-automatic identification from reviews)]
Leucine-rich repeat and IQ domain-containing protein 1
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Leucine-rich repeat and IQ domain-containing protein 1
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q96JM4
ID LRIQ1_HUMAN Reviewed; 1722 AA.
AC Q96JM4; Q567P4; Q9BS17; Q9HA36;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 08-FEB-2011, sequence version 3.
DT 22-JAN-2014, entry version 77.
DE RecName: Full=Leucine-rich repeat and IQ domain-containing protein 1;
GN Name=LRRIQ1; Synonyms=KIAA1801;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
RA Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
RA Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D.,
RA Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
RA Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
RA Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
RA Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V.,
RA Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J.,
RA Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
RA Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
RA Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
RA Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
RA Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
RA Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
RA Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
RA Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
RA Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
RA Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
RA Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
RA Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
RA Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
RA Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
RA Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
RA Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
RA Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
RA Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
RA Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
RA Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
RA Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
RA Kucherlapati R., Weinstock G., Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-534 (ISOFORM 1), AND
RP VARIANTS ASN-29 AND TYR-83.
RC TISSUE=Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-310 (ISOFORM 2).
RC TISSUE=Spinal cord;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 118-1335 (ISOFORM 1), AND
RP VARIANT THR-912.
RC TISSUE=Brain;
RX PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XX.
RT The complete sequences of 100 new cDNA clones from brain which code
RT for large proteins in vitro.";
RL DNA Res. 8:85-95(2001).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96JM4-4; Sequence=Displayed;
CC Note=No experimental confirmation available. Gene prediction
CC based on EST data;
CC Name=2;
CC IsoId=Q96JM4-2; Sequence=VSP_030065;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Contains 3 IQ domains.
CC -!- SIMILARITY: Contains 10 LRR (leucine-rich) repeats.
CC -!- SIMILARITY: Contains 1 LRRCT domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH93088.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
CC Sequence=BAB47430.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
CC Sequence=BAB47430.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
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DR EMBL; AC025418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC079631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC133794; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK022365; BAB14022.1; -; mRNA.
DR EMBL; BC093088; AAH93088.1; ALT_SEQ; mRNA.
DR EMBL; AB058704; BAB47430.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001073379.1; NM_001079910.1.
DR UniGene; Hs.402200; -.
DR ProteinModelPortal; Q96JM4; -.
DR IntAct; Q96JM4; 1.
DR PhosphoSite; Q96JM4; -.
DR DMDM; 166232938; -.
DR PaxDb; Q96JM4; -.
DR PRIDE; Q96JM4; -.
DR Ensembl; ENST00000393217; ENSP00000376910; ENSG00000133640.
DR GeneID; 84125; -.
DR KEGG; hsa:84125; -.
DR UCSC; uc001tac.3; human.
DR CTD; 84125; -.
DR GeneCards; GC12P085430; -.
DR H-InvDB; HIX0010860; -.
DR HGNC; HGNC:25708; LRRIQ1.
DR HPA; HPA046162; -.
DR neXtProt; NX_Q96JM4; -.
DR PharmGKB; PA134962087; -.
DR eggNOG; NOG119359; -.
DR HOGENOM; HOG000113381; -.
DR HOVERGEN; HBG095533; -.
DR OMA; IKSFKPW; -.
DR OrthoDB; EOG78PV83; -.
DR GenomeRNAi; 84125; -.
DR NextBio; 73389; -.
DR PRO; PR:Q96JM4; -.
DR ArrayExpress; Q96JM4; -.
DR Bgee; Q96JM4; -.
DR CleanEx; HS_LRRIQ1; -.
DR Genevestigator; Q96JM4; -.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF12799; LRR_4; 1.
DR SMART; SM00015; IQ; 3.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50096; IQ; 3.
DR PROSITE; PS51450; LRR; 11.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; Leucine-rich repeat;
KW Polymorphism; Reference proteome; Repeat.
FT CHAIN 1 1722 Leucine-rich repeat and IQ domain-
FT containing protein 1.
FT /FTId=PRO_0000313625.
FT DOMAIN 283 312 IQ 1.
FT REPEAT 819 840 LRR 1.
FT REPEAT 841 861 LRR 2.
FT REPEAT 862 883 LRR 3.
FT REPEAT 884 905 LRR 4.
FT REPEAT 970 991 LRR 5.
FT REPEAT 992 1013 LRR 6.
FT REPEAT 1014 1035 LRR 7.
FT REPEAT 1036 1057 LRR 8.
FT REPEAT 1060 1081 LRR 9.
FT REPEAT 1082 1103 LRR 10.
FT DOMAIN 1117 1157 LRRCT.
FT DOMAIN 1335 1364 IQ 2.
FT DOMAIN 1395 1424 IQ 3.
FT COMPBIAS 162 376 Glu-rich.
FT VAR_SEQ 227 251 Missing (in isoform 2).
FT /FTId=VSP_030065.
FT VARIANT 29 29 I -> N (in dbSNP:rs7312075).
FT /FTId=VAR_037672.
FT VARIANT 83 83 C -> Y (in dbSNP:rs3765044).
FT /FTId=VAR_037673.
FT VARIANT 912 912 A -> T (in dbSNP:rs17012533).
FT /FTId=VAR_037674.
SQ SEQUENCE 1722 AA; 199300 MW; 5FFE2E824F6F7B1D CRC64;
MDDDDAKLKA EIEAELDKLS ISSLEKEDIE SDAKSETQSD DSDTDSVELP ESVLHCINII
KNRSKAVEEL ILQDLEDTDI LSCSYGAVSN NHMHLRTGLS TEYEESSEQL IKILSEIEKE
EFMRSKTDCA TPDFVPEPSP HDLPMDEHVL PDDADINFGY CEVEEKCRQS FEAWQEKQKE
LEDKEKQTLK AQRDREEKQF QEEEEKRHCW MKQFKVEKKK LENIQKQEQD KMNDELYKEE
KIWKEKFKQH EEYIRNLHLQ MEEERTRFKD QQEKEKNSLL KQQNNAAVKI QAKYKAFVAY
QKYGPIIKEQ IESKKRKAQE WKEKEAKIRQ KEEENRKRLE EEQRIKEERK KQKEEERKRR
EKEYEEKKNI VKQEREQLIS KEKIILREDA SQQLIISSAL KKSGYNNKHL SLEDISNDKG
DIAKNLVDEN SKKQEDVLLW LVEESNMKEN VDRQTILKES IQVKLKESIS SQTILADFKM
EEKNENLAKK RCSEELVKQE RKYENTDNKT ELGNSDLKGN LKEQFPLQEL KSDAQKEEKI
MKHVINENTG QKTQIILGHN QEISEVKTNE EQKIIKDNQQ KKIQKVEKEE IQEQNGLLYK
DKDTLVISVK QRSLSLTSEN SKDVRENVIL QEKEIYSKSK EIEENPKDNA WNSGIVIFNT
TDTMINIEGK RNDQDYVLGR HAPCEGLSNY NAESSMVSKE VNSLKSEIRN ISEKCHENAP
EPDSMTCCVS ESTLLYSIEE RRLAWIKSFK PWLEIFKQNQ QKKIVRRKRP VKCPANMTPA
LDKLEILRCG PWDTLQQVTT VTFQDLPGCV LSTLAECTNL QFLSLRRCGL TSLHSLSNCK
KLKYIDAQEN HIEAIECENL ENLCVVLLNK NQLTSLHGLD GCTNIQCLEL SYNKITRIGY
SFFLEEKLVD NAGFCHHLGT STSYLSLAQV WIPTGLCWSW IPITSLTKNS DCNFLISHLY
WNCGLESLKN LQQLILDHNQ LINTKGLCDT PTIVYLDCSH NHLTDVEGVE NCGLLQILKL
QGNYLSELPS LENLVLLREL HLDDNSISTV EAFSSYWLPL LQNITISQNS LTKIVPLFHF
VSLEKLDVSH NCLSDLKSAI KWFDACYSLH ELSLTGNPLL QETNWRDSLL KVLPALRILN
GNILNSNSES RTEEHNQLGS AGFLALCQSQ IREFNLLIEN YITGKGDVFT LDTAENLCHY
FKKLMILSTE YRHAHERGDV TITKKDESEA QKNHLAPTNS DSTLQNGVFY SCAREGEPDS
PDIPEKWMDS VSSHSPLSKS ATCENMEGRH QEILVCQKRE DSKASSIPTI RIPFKEVVMT
NSLLRNHQNI EPSEKIMAAV VIQSYWRGYL MRRQTHFSTR LHTAATEGLP NSSIKNQTIL
KKGKRENIVN IRKQREKAAI LIQAVWKGFI LRKKLTTALE AIKNEESDEE YREIDLEDFI
FDEAALEEEW LALDSTRFPS QTLLLSNQLH WPKIPGNLKW DDTSFNLPSN PAQAWLCNDK
ENLSSSEHTQ FNSRSENKTS SWTPESKTSR KSLLKSEKEK KISEEWGFKD ISTAQQMLKR
AQKMKSKKLK KKIDSTVRLA LFKNNENKVS LPKSPKMVQP RRDGYFEGIE EDPIHKDTTA
NEKLERNREY TYQWLHTQVG VHETTSSRNM KCNHFLPELD PDVLNGGRVQ LVARLVSRED
TDLDLFSMTN GSALSVNREK KNQAHRHSAG SSSKLWFPSK LI
//
ID LRIQ1_HUMAN Reviewed; 1722 AA.
AC Q96JM4; Q567P4; Q9BS17; Q9HA36;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 08-FEB-2011, sequence version 3.
DT 22-JAN-2014, entry version 77.
DE RecName: Full=Leucine-rich repeat and IQ domain-containing protein 1;
GN Name=LRRIQ1; Synonyms=KIAA1801;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
RA Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
RA Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D.,
RA Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
RA Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
RA Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
RA Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V.,
RA Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J.,
RA Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
RA Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
RA Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
RA Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
RA Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
RA Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
RA Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
RA Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
RA Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
RA Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
RA Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
RA Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
RA Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
RA Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
RA Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
RA Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
RA Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
RA Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
RA Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
RA Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
RA Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
RA Kucherlapati R., Weinstock G., Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-534 (ISOFORM 1), AND
RP VARIANTS ASN-29 AND TYR-83.
RC TISSUE=Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-310 (ISOFORM 2).
RC TISSUE=Spinal cord;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 118-1335 (ISOFORM 1), AND
RP VARIANT THR-912.
RC TISSUE=Brain;
RX PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XX.
RT The complete sequences of 100 new cDNA clones from brain which code
RT for large proteins in vitro.";
RL DNA Res. 8:85-95(2001).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96JM4-4; Sequence=Displayed;
CC Note=No experimental confirmation available. Gene prediction
CC based on EST data;
CC Name=2;
CC IsoId=Q96JM4-2; Sequence=VSP_030065;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Contains 3 IQ domains.
CC -!- SIMILARITY: Contains 10 LRR (leucine-rich) repeats.
CC -!- SIMILARITY: Contains 1 LRRCT domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH93088.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
CC Sequence=BAB47430.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
CC Sequence=BAB47430.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
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DR EMBL; AC025418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC079631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC133794; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK022365; BAB14022.1; -; mRNA.
DR EMBL; BC093088; AAH93088.1; ALT_SEQ; mRNA.
DR EMBL; AB058704; BAB47430.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001073379.1; NM_001079910.1.
DR UniGene; Hs.402200; -.
DR ProteinModelPortal; Q96JM4; -.
DR IntAct; Q96JM4; 1.
DR PhosphoSite; Q96JM4; -.
DR DMDM; 166232938; -.
DR PaxDb; Q96JM4; -.
DR PRIDE; Q96JM4; -.
DR Ensembl; ENST00000393217; ENSP00000376910; ENSG00000133640.
DR GeneID; 84125; -.
DR KEGG; hsa:84125; -.
DR UCSC; uc001tac.3; human.
DR CTD; 84125; -.
DR GeneCards; GC12P085430; -.
DR H-InvDB; HIX0010860; -.
DR HGNC; HGNC:25708; LRRIQ1.
DR HPA; HPA046162; -.
DR neXtProt; NX_Q96JM4; -.
DR PharmGKB; PA134962087; -.
DR eggNOG; NOG119359; -.
DR HOGENOM; HOG000113381; -.
DR HOVERGEN; HBG095533; -.
DR OMA; IKSFKPW; -.
DR OrthoDB; EOG78PV83; -.
DR GenomeRNAi; 84125; -.
DR NextBio; 73389; -.
DR PRO; PR:Q96JM4; -.
DR ArrayExpress; Q96JM4; -.
DR Bgee; Q96JM4; -.
DR CleanEx; HS_LRRIQ1; -.
DR Genevestigator; Q96JM4; -.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF12799; LRR_4; 1.
DR SMART; SM00015; IQ; 3.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50096; IQ; 3.
DR PROSITE; PS51450; LRR; 11.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; Leucine-rich repeat;
KW Polymorphism; Reference proteome; Repeat.
FT CHAIN 1 1722 Leucine-rich repeat and IQ domain-
FT containing protein 1.
FT /FTId=PRO_0000313625.
FT DOMAIN 283 312 IQ 1.
FT REPEAT 819 840 LRR 1.
FT REPEAT 841 861 LRR 2.
FT REPEAT 862 883 LRR 3.
FT REPEAT 884 905 LRR 4.
FT REPEAT 970 991 LRR 5.
FT REPEAT 992 1013 LRR 6.
FT REPEAT 1014 1035 LRR 7.
FT REPEAT 1036 1057 LRR 8.
FT REPEAT 1060 1081 LRR 9.
FT REPEAT 1082 1103 LRR 10.
FT DOMAIN 1117 1157 LRRCT.
FT DOMAIN 1335 1364 IQ 2.
FT DOMAIN 1395 1424 IQ 3.
FT COMPBIAS 162 376 Glu-rich.
FT VAR_SEQ 227 251 Missing (in isoform 2).
FT /FTId=VSP_030065.
FT VARIANT 29 29 I -> N (in dbSNP:rs7312075).
FT /FTId=VAR_037672.
FT VARIANT 83 83 C -> Y (in dbSNP:rs3765044).
FT /FTId=VAR_037673.
FT VARIANT 912 912 A -> T (in dbSNP:rs17012533).
FT /FTId=VAR_037674.
SQ SEQUENCE 1722 AA; 199300 MW; 5FFE2E824F6F7B1D CRC64;
MDDDDAKLKA EIEAELDKLS ISSLEKEDIE SDAKSETQSD DSDTDSVELP ESVLHCINII
KNRSKAVEEL ILQDLEDTDI LSCSYGAVSN NHMHLRTGLS TEYEESSEQL IKILSEIEKE
EFMRSKTDCA TPDFVPEPSP HDLPMDEHVL PDDADINFGY CEVEEKCRQS FEAWQEKQKE
LEDKEKQTLK AQRDREEKQF QEEEEKRHCW MKQFKVEKKK LENIQKQEQD KMNDELYKEE
KIWKEKFKQH EEYIRNLHLQ MEEERTRFKD QQEKEKNSLL KQQNNAAVKI QAKYKAFVAY
QKYGPIIKEQ IESKKRKAQE WKEKEAKIRQ KEEENRKRLE EEQRIKEERK KQKEEERKRR
EKEYEEKKNI VKQEREQLIS KEKIILREDA SQQLIISSAL KKSGYNNKHL SLEDISNDKG
DIAKNLVDEN SKKQEDVLLW LVEESNMKEN VDRQTILKES IQVKLKESIS SQTILADFKM
EEKNENLAKK RCSEELVKQE RKYENTDNKT ELGNSDLKGN LKEQFPLQEL KSDAQKEEKI
MKHVINENTG QKTQIILGHN QEISEVKTNE EQKIIKDNQQ KKIQKVEKEE IQEQNGLLYK
DKDTLVISVK QRSLSLTSEN SKDVRENVIL QEKEIYSKSK EIEENPKDNA WNSGIVIFNT
TDTMINIEGK RNDQDYVLGR HAPCEGLSNY NAESSMVSKE VNSLKSEIRN ISEKCHENAP
EPDSMTCCVS ESTLLYSIEE RRLAWIKSFK PWLEIFKQNQ QKKIVRRKRP VKCPANMTPA
LDKLEILRCG PWDTLQQVTT VTFQDLPGCV LSTLAECTNL QFLSLRRCGL TSLHSLSNCK
KLKYIDAQEN HIEAIECENL ENLCVVLLNK NQLTSLHGLD GCTNIQCLEL SYNKITRIGY
SFFLEEKLVD NAGFCHHLGT STSYLSLAQV WIPTGLCWSW IPITSLTKNS DCNFLISHLY
WNCGLESLKN LQQLILDHNQ LINTKGLCDT PTIVYLDCSH NHLTDVEGVE NCGLLQILKL
QGNYLSELPS LENLVLLREL HLDDNSISTV EAFSSYWLPL LQNITISQNS LTKIVPLFHF
VSLEKLDVSH NCLSDLKSAI KWFDACYSLH ELSLTGNPLL QETNWRDSLL KVLPALRILN
GNILNSNSES RTEEHNQLGS AGFLALCQSQ IREFNLLIEN YITGKGDVFT LDTAENLCHY
FKKLMILSTE YRHAHERGDV TITKKDESEA QKNHLAPTNS DSTLQNGVFY SCAREGEPDS
PDIPEKWMDS VSSHSPLSKS ATCENMEGRH QEILVCQKRE DSKASSIPTI RIPFKEVVMT
NSLLRNHQNI EPSEKIMAAV VIQSYWRGYL MRRQTHFSTR LHTAATEGLP NSSIKNQTIL
KKGKRENIVN IRKQREKAAI LIQAVWKGFI LRKKLTTALE AIKNEESDEE YREIDLEDFI
FDEAALEEEW LALDSTRFPS QTLLLSNQLH WPKIPGNLKW DDTSFNLPSN PAQAWLCNDK
ENLSSSEHTQ FNSRSENKTS SWTPESKTSR KSLLKSEKEK KISEEWGFKD ISTAQQMLKR
AQKMKSKKLK KKIDSTVRLA LFKNNENKVS LPKSPKMVQP RRDGYFEGIE EDPIHKDTTA
NEKLERNREY TYQWLHTQVG VHETTSSRNM KCNHFLPELD PDVLNGGRVQ LVARLVSRED
TDLDLFSMTN GSALSVNREK KNQAHRHSAG SSSKLWFPSK LI
//