Full text data of LY6G5B
LY6G5B
(C6orf19, G5B)
[Confidence: low (only semi-automatic identification from reviews)]
Lymphocyte antigen 6 complex locus protein G5b; Flags: Precursor
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Lymphocyte antigen 6 complex locus protein G5b; Flags: Precursor
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q8NDX9
ID LY65B_HUMAN Reviewed; 201 AA.
AC Q8NDX9; B0UXB2; B0UZ65; B0UZP8; B7ZCA3; Q5SQ62; Q5SST3; Q9UKT0;
read moreAC Q9UMQ0;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 22-JAN-2014, entry version 75.
DE RecName: Full=Lymphocyte antigen 6 complex locus protein G5b;
DE Flags: Precursor;
GN Name=LY6G5B; Synonyms=C6orf19, G5B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=8812450; DOI=10.1006/geno.1996.0459;
RA Albertella M.R., Jones H., Thomson W., Olavesen M.G., Campbell R.D.;
RT "Localization of eight additional genes in the human major
RT histocompatibility complex, including the gene encoding the casein
RT kinase II beta subunit (CSNK2B).";
RL Genomics 36:240-251(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=12079290; DOI=10.1006/geno.2002.6794;
RA Mallya M., Campbell R.D., Aguado B.;
RT "Transcriptional analysis of a novel cluster of LY-6 family members in
RT the human and mouse major histocompatibility complex: five genes with
RT many splice forms.";
RL Genomics 80:113-123(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Shiina S., Tamiya G., Oka A., Inoko H.;
RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14656967; DOI=10.1101/gr.1736803;
RA Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S.,
RA Campbell R.D., Hood L.;
RT "Analysis of the gene-dense major histocompatibility complex class III
RT region and its comparison to mouse.";
RL Genome Res. 13:2621-2636(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT CYS-176.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP GLYCOSYLATION, AND SUBUNIT.
RX PubMed=17008713; DOI=10.1110/ps.062242606;
RA Mallya M., Campbell R.D., Aguado B.;
RT "Characterization of the five novel Ly-6 superfamily members encoded
RT in the MHC, and detection of cells expressing their potential
RT ligands.";
RL Protein Sci. 15:2244-2256(2006).
CC -!- SUBUNIT: Forms oligomer.
CC -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NDX9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NDX9-2; Sequence=VSP_031255;
CC -!- PTM: N-glycosylated.
CC -!- SIMILARITY: Contains 1 UPAR/Ly6 domain.
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DR EMBL; AJ245417; CAB52191.1; -; mRNA.
DR EMBL; AJ315545; CAC85543.1; -; mRNA.
DR EMBL; AK289364; BAF82053.1; -; mRNA.
DR EMBL; BA000025; BAB63385.1; -; Genomic_DNA.
DR EMBL; AF129756; AAF04397.1; -; Genomic_DNA.
DR EMBL; AL662899; CAX15050.1; -; Genomic_DNA.
DR EMBL; AL662899; CAI18396.1; -; Genomic_DNA.
DR EMBL; AL670886; CAI17803.1; -; Genomic_DNA.
DR EMBL; AL805934; CAI18526.1; -; Genomic_DNA.
DR EMBL; BX511262; CAM45828.1; -; Genomic_DNA.
DR EMBL; CR354443; CAQ07005.1; -; Genomic_DNA.
DR EMBL; CR753842; CAQ06575.1; -; Genomic_DNA.
DR EMBL; CR759761; CAQ10882.1; -; Genomic_DNA.
DR EMBL; CH471081; EAX03476.1; -; Genomic_DNA.
DR RefSeq; NP_067044.2; NM_021221.2.
DR UniGene; Hs.708719; -.
DR ProteinModelPortal; Q8NDX9; -.
DR PhosphoSite; Q8NDX9; -.
DR DMDM; 74751234; -.
DR PaxDb; Q8NDX9; -.
DR PRIDE; Q8NDX9; -.
DR DNASU; 58496; -.
DR Ensembl; ENST00000375864; ENSP00000365024; ENSG00000240053.
DR Ensembl; ENST00000409525; ENSP00000386365; ENSG00000240053.
DR Ensembl; ENST00000462244; ENSP00000418445; ENSG00000239285.
DR Ensembl; ENST00000471674; ENSP00000417055; ENSG00000241132.
DR Ensembl; ENST00000480515; ENSP00000418119; ENSG00000240433.
DR Ensembl; ENST00000480530; ENSP00000417822; ENSG00000241713.
DR Ensembl; ENST00000484964; ENSP00000420698; ENSG00000244672.
DR Ensembl; ENST00000490011; ENSP00000418217; ENSG00000239497.
DR GeneID; 58496; -.
DR KEGG; hsa:58496; -.
DR UCSC; uc003nvt.1; human.
DR CTD; 58496; -.
DR GeneCards; GC06P031637; -.
DR GeneCards; GC06Pj31624; -.
DR GeneCards; GC06Pk31620; -.
DR GeneCards; GC06Pl31676; -.
DR GeneCards; GC06Pm31713; -.
DR GeneCards; GC06Pn31627; -.
DR GeneCards; GC06Po31626; -.
DR HGNC; HGNC:13931; LY6G5B.
DR HPA; HPA048307; -.
DR MIM; 610433; gene.
DR neXtProt; NX_Q8NDX9; -.
DR PharmGKB; PA37826; -.
DR eggNOG; NOG314201; -.
DR HOVERGEN; HBG108361; -.
DR KO; K06846; -.
DR OrthoDB; EOG7PVWQH; -.
DR PhylomeDB; Q8NDX9; -.
DR GenomeRNAi; 58496; -.
DR NextBio; 64988; -.
DR PRO; PR:Q8NDX9; -.
DR Bgee; Q8NDX9; -.
DR CleanEx; HS_LY6G5B; -.
DR Genevestigator; Q8NDX9; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR PROSITE; PS00983; LY6_UPAR; FALSE_NEG.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein;
KW Polymorphism; Reference proteome; Secreted; Signal.
FT SIGNAL 1 18 Potential.
FT CHAIN 19 201 Lymphocyte antigen 6 complex locus
FT protein G5b.
FT /FTId=PRO_0000318602.
FT DOMAIN 26 118 UPAR/Ly6.
FT COMPBIAS 50 53 Poly-Ser.
FT CARBOHYD 141 141 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 183 183 N-linked (GlcNAc...) (Potential).
FT DISULFID 28 55 By similarity.
FT DISULFID 31 40 By similarity.
FT DISULFID 47 73 By similarity.
FT DISULFID 81 98 By similarity.
FT DISULFID 99 104 By similarity.
FT VAR_SEQ 1 55 Missing (in isoform 2).
FT /FTId=VSP_031255.
FT VARIANT 102 102 D -> N (in dbSNP:rs805267).
FT /FTId=VAR_038842.
FT VARIANT 131 131 S -> Y (in dbSNP:rs11758242).
FT /FTId=VAR_038843.
FT VARIANT 176 176 R -> C (in dbSNP:rs9267532).
FT /FTId=VAR_038844.
SQ SEQUENCE 201 AA; 22572 MW; E2CDFCDD5E166056 CRC64;
MKVHMLVGVL VMVGFTVGKV PVPDIRTCHF CLVEDPSVGC ISGSEKCTIS SSSLCMVITI
YYDVKVRFIV RGCGQYISYR CQEKRNTYFA EYWYQAQCCQ YDYCNSWSSP QLQSSLPEPH
DRPLALPLSD SQIQWFYQAL NLSLPLPNFH AGTEPDGLDP MVTLSLNLGL SFAELRRMYL
FLNSSGLLVL PQAGLLTPHP S
//
ID LY65B_HUMAN Reviewed; 201 AA.
AC Q8NDX9; B0UXB2; B0UZ65; B0UZP8; B7ZCA3; Q5SQ62; Q5SST3; Q9UKT0;
read moreAC Q9UMQ0;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 22-JAN-2014, entry version 75.
DE RecName: Full=Lymphocyte antigen 6 complex locus protein G5b;
DE Flags: Precursor;
GN Name=LY6G5B; Synonyms=C6orf19, G5B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=8812450; DOI=10.1006/geno.1996.0459;
RA Albertella M.R., Jones H., Thomson W., Olavesen M.G., Campbell R.D.;
RT "Localization of eight additional genes in the human major
RT histocompatibility complex, including the gene encoding the casein
RT kinase II beta subunit (CSNK2B).";
RL Genomics 36:240-251(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=12079290; DOI=10.1006/geno.2002.6794;
RA Mallya M., Campbell R.D., Aguado B.;
RT "Transcriptional analysis of a novel cluster of LY-6 family members in
RT the human and mouse major histocompatibility complex: five genes with
RT many splice forms.";
RL Genomics 80:113-123(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Shiina S., Tamiya G., Oka A., Inoko H.;
RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14656967; DOI=10.1101/gr.1736803;
RA Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S.,
RA Campbell R.D., Hood L.;
RT "Analysis of the gene-dense major histocompatibility complex class III
RT region and its comparison to mouse.";
RL Genome Res. 13:2621-2636(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT CYS-176.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP GLYCOSYLATION, AND SUBUNIT.
RX PubMed=17008713; DOI=10.1110/ps.062242606;
RA Mallya M., Campbell R.D., Aguado B.;
RT "Characterization of the five novel Ly-6 superfamily members encoded
RT in the MHC, and detection of cells expressing their potential
RT ligands.";
RL Protein Sci. 15:2244-2256(2006).
CC -!- SUBUNIT: Forms oligomer.
CC -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NDX9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NDX9-2; Sequence=VSP_031255;
CC -!- PTM: N-glycosylated.
CC -!- SIMILARITY: Contains 1 UPAR/Ly6 domain.
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DR EMBL; AJ245417; CAB52191.1; -; mRNA.
DR EMBL; AJ315545; CAC85543.1; -; mRNA.
DR EMBL; AK289364; BAF82053.1; -; mRNA.
DR EMBL; BA000025; BAB63385.1; -; Genomic_DNA.
DR EMBL; AF129756; AAF04397.1; -; Genomic_DNA.
DR EMBL; AL662899; CAX15050.1; -; Genomic_DNA.
DR EMBL; AL662899; CAI18396.1; -; Genomic_DNA.
DR EMBL; AL670886; CAI17803.1; -; Genomic_DNA.
DR EMBL; AL805934; CAI18526.1; -; Genomic_DNA.
DR EMBL; BX511262; CAM45828.1; -; Genomic_DNA.
DR EMBL; CR354443; CAQ07005.1; -; Genomic_DNA.
DR EMBL; CR753842; CAQ06575.1; -; Genomic_DNA.
DR EMBL; CR759761; CAQ10882.1; -; Genomic_DNA.
DR EMBL; CH471081; EAX03476.1; -; Genomic_DNA.
DR RefSeq; NP_067044.2; NM_021221.2.
DR UniGene; Hs.708719; -.
DR ProteinModelPortal; Q8NDX9; -.
DR PhosphoSite; Q8NDX9; -.
DR DMDM; 74751234; -.
DR PaxDb; Q8NDX9; -.
DR PRIDE; Q8NDX9; -.
DR DNASU; 58496; -.
DR Ensembl; ENST00000375864; ENSP00000365024; ENSG00000240053.
DR Ensembl; ENST00000409525; ENSP00000386365; ENSG00000240053.
DR Ensembl; ENST00000462244; ENSP00000418445; ENSG00000239285.
DR Ensembl; ENST00000471674; ENSP00000417055; ENSG00000241132.
DR Ensembl; ENST00000480515; ENSP00000418119; ENSG00000240433.
DR Ensembl; ENST00000480530; ENSP00000417822; ENSG00000241713.
DR Ensembl; ENST00000484964; ENSP00000420698; ENSG00000244672.
DR Ensembl; ENST00000490011; ENSP00000418217; ENSG00000239497.
DR GeneID; 58496; -.
DR KEGG; hsa:58496; -.
DR UCSC; uc003nvt.1; human.
DR CTD; 58496; -.
DR GeneCards; GC06P031637; -.
DR GeneCards; GC06Pj31624; -.
DR GeneCards; GC06Pk31620; -.
DR GeneCards; GC06Pl31676; -.
DR GeneCards; GC06Pm31713; -.
DR GeneCards; GC06Pn31627; -.
DR GeneCards; GC06Po31626; -.
DR HGNC; HGNC:13931; LY6G5B.
DR HPA; HPA048307; -.
DR MIM; 610433; gene.
DR neXtProt; NX_Q8NDX9; -.
DR PharmGKB; PA37826; -.
DR eggNOG; NOG314201; -.
DR HOVERGEN; HBG108361; -.
DR KO; K06846; -.
DR OrthoDB; EOG7PVWQH; -.
DR PhylomeDB; Q8NDX9; -.
DR GenomeRNAi; 58496; -.
DR NextBio; 64988; -.
DR PRO; PR:Q8NDX9; -.
DR Bgee; Q8NDX9; -.
DR CleanEx; HS_LY6G5B; -.
DR Genevestigator; Q8NDX9; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR PROSITE; PS00983; LY6_UPAR; FALSE_NEG.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein;
KW Polymorphism; Reference proteome; Secreted; Signal.
FT SIGNAL 1 18 Potential.
FT CHAIN 19 201 Lymphocyte antigen 6 complex locus
FT protein G5b.
FT /FTId=PRO_0000318602.
FT DOMAIN 26 118 UPAR/Ly6.
FT COMPBIAS 50 53 Poly-Ser.
FT CARBOHYD 141 141 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 183 183 N-linked (GlcNAc...) (Potential).
FT DISULFID 28 55 By similarity.
FT DISULFID 31 40 By similarity.
FT DISULFID 47 73 By similarity.
FT DISULFID 81 98 By similarity.
FT DISULFID 99 104 By similarity.
FT VAR_SEQ 1 55 Missing (in isoform 2).
FT /FTId=VSP_031255.
FT VARIANT 102 102 D -> N (in dbSNP:rs805267).
FT /FTId=VAR_038842.
FT VARIANT 131 131 S -> Y (in dbSNP:rs11758242).
FT /FTId=VAR_038843.
FT VARIANT 176 176 R -> C (in dbSNP:rs9267532).
FT /FTId=VAR_038844.
SQ SEQUENCE 201 AA; 22572 MW; E2CDFCDD5E166056 CRC64;
MKVHMLVGVL VMVGFTVGKV PVPDIRTCHF CLVEDPSVGC ISGSEKCTIS SSSLCMVITI
YYDVKVRFIV RGCGQYISYR CQEKRNTYFA EYWYQAQCCQ YDYCNSWSSP QLQSSLPEPH
DRPLALPLSD SQIQWFYQAL NLSLPLPNFH AGTEPDGLDP MVTLSLNLGL SFAELRRMYL
FLNSSGLLVL PQAGLLTPHP S
//
MIM
610433
*RECORD*
*FIELD* NO
610433
*FIELD* TI
*610433 LYMPHOCYTE ANTIGEN 6 COMPLEX, LOCUS G5B; LY6G5B
;;G5B
*FIELD* TX
DESCRIPTION
read more
LY6G5B belongs to a cluster of leukocyte antigen-6 (LY6) genes located
in the major histocompatibility complex (MHC) class III region on
chromosome 6. Members of the LY6 superfamily typically contain 70 to 80
amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached
to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that
is directly involved in signal transduction (Mallya et al., 2002).
CLONING
By EST database searching and RT-PCR analysis, Mallya et al. (2002)
obtained a full-length LY6G5B cDNA. The predicted protein contains an
N-terminal signal peptide, followed by a cys-rich LY6 domain and a
C-terminal hydrophobic region. RT-PCR detected a 606-bp product in
numerous hematopoietic cell lines and in fetal brain and adult lung.
Faint expression was detected in fetal liver and kidney.
GENE STRUCTURE
Mallya et al. (2002) determined that the LY6G5B gene contains 3 exons
and spans about 1.3 kb.
MAPPING
By genomic sequence analysis, Mallya et al. (2002) mapped the LY6G5B
gene to a LY6 gene cluster within the MHC class III region on chromosome
6p21.3.
*FIELD* RF
1. Mallya, M.; Campbell, R. D.; Aguado, B.: Transcriptional analysis
of a novel cluster of LY-6 family members in the human and mouse major
histocompatibility complex: five genes with many splice forms. Genomics 80:
113-123, 2002.
*FIELD* CD
Paul J. Converse: 9/26/2006
*FIELD* ED
mgross: 09/26/2006
mgross: 9/26/2006
*RECORD*
*FIELD* NO
610433
*FIELD* TI
*610433 LYMPHOCYTE ANTIGEN 6 COMPLEX, LOCUS G5B; LY6G5B
;;G5B
*FIELD* TX
DESCRIPTION
read more
LY6G5B belongs to a cluster of leukocyte antigen-6 (LY6) genes located
in the major histocompatibility complex (MHC) class III region on
chromosome 6. Members of the LY6 superfamily typically contain 70 to 80
amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached
to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that
is directly involved in signal transduction (Mallya et al., 2002).
CLONING
By EST database searching and RT-PCR analysis, Mallya et al. (2002)
obtained a full-length LY6G5B cDNA. The predicted protein contains an
N-terminal signal peptide, followed by a cys-rich LY6 domain and a
C-terminal hydrophobic region. RT-PCR detected a 606-bp product in
numerous hematopoietic cell lines and in fetal brain and adult lung.
Faint expression was detected in fetal liver and kidney.
GENE STRUCTURE
Mallya et al. (2002) determined that the LY6G5B gene contains 3 exons
and spans about 1.3 kb.
MAPPING
By genomic sequence analysis, Mallya et al. (2002) mapped the LY6G5B
gene to a LY6 gene cluster within the MHC class III region on chromosome
6p21.3.
*FIELD* RF
1. Mallya, M.; Campbell, R. D.; Aguado, B.: Transcriptional analysis
of a novel cluster of LY-6 family members in the human and mouse major
histocompatibility complex: five genes with many splice forms. Genomics 80:
113-123, 2002.
*FIELD* CD
Paul J. Converse: 9/26/2006
*FIELD* ED
mgross: 09/26/2006
mgross: 9/26/2006