Full text data of LZIC
LZIC
[Confidence: low (only semi-automatic identification from reviews)]
Protein LZIC (Leucine zipper and CTNNBIP1 domain-containing protein; Leucine zipper and ICAT homologous domain-containing protein)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Protein LZIC (Leucine zipper and CTNNBIP1 domain-containing protein; Leucine zipper and ICAT homologous domain-containing protein)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q8WZA0
ID LZIC_HUMAN Reviewed; 190 AA.
AC Q8WZA0; B2R6F0; Q96IU1;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2002, sequence version 1.
DT 22-JAN-2014, entry version 93.
DE RecName: Full=Protein LZIC;
DE AltName: Full=Leucine zipper and CTNNBIP1 domain-containing protein;
DE AltName: Full=Leucine zipper and ICAT homologous domain-containing protein;
GN Name=LZIC;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Stomach;
RX PubMed=11712074;
RA Katoh M.;
RT "Molecular cloning and characterization of LZIC, a novel gene encoding
RT ICAT homologous protein with leucine zipper domain.";
RL Int. J. Mol. Med. 8:611-615(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SUBUNIT: Does not interact with CTNNB1 (By similarity).
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in
CC kidney. Up-regulated in several cases of gastric cancers.
CC -!- SIMILARITY: Belongs to the CTNNBIP1 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AB060688; BAB72100.1; -; mRNA.
DR EMBL; AK312550; BAG35447.1; -; mRNA.
DR EMBL; AL357140; CAI16887.1; -; Genomic_DNA.
DR EMBL; CH471130; EAW71633.1; -; Genomic_DNA.
DR EMBL; BC007240; AAH07240.2; -; mRNA.
DR EMBL; BC063443; AAH63443.1; -; mRNA.
DR RefSeq; NP_115744.2; NM_032368.3.
DR RefSeq; XP_005263564.1; XM_005263507.1.
DR RefSeq; XP_005263565.1; XM_005263508.1.
DR UniGene; Hs.327252; -.
DR ProteinModelPortal; Q8WZA0; -.
DR SMR; Q8WZA0; 120-165.
DR IntAct; Q8WZA0; 1.
DR STRING; 9606.ENSP00000366418; -.
DR PhosphoSite; Q8WZA0; -.
DR DMDM; 74751644; -.
DR PaxDb; Q8WZA0; -.
DR PeptideAtlas; Q8WZA0; -.
DR PRIDE; Q8WZA0; -.
DR DNASU; 84328; -.
DR Ensembl; ENST00000377213; ENSP00000366418; ENSG00000162441.
DR Ensembl; ENST00000377223; ENSP00000366430; ENSG00000162441.
DR Ensembl; ENST00000400903; ENSP00000383695; ENSG00000162441.
DR GeneID; 84328; -.
DR KEGG; hsa:84328; -.
DR UCSC; uc001aqm.3; human.
DR CTD; 84328; -.
DR GeneCards; GC01M009982; -.
DR HGNC; HGNC:17497; LZIC.
DR HPA; HPA028184; -.
DR MIM; 610458; gene.
DR neXtProt; NX_Q8WZA0; -.
DR PharmGKB; PA30504; -.
DR eggNOG; NOG39638; -.
DR HOVERGEN; HBG080109; -.
DR InParanoid; Q8WZA0; -.
DR PhylomeDB; Q8WZA0; -.
DR GenomeRNAi; 84328; -.
DR NextBio; 74075; -.
DR PRO; PR:Q8WZA0; -.
DR ArrayExpress; Q8WZA0; -.
DR Bgee; Q8WZA0; -.
DR CleanEx; HS_LZIC; -.
DR Genevestigator; Q8WZA0; -.
DR GO; GO:0007417; P:central nervous system development; IBA:RefGenome.
DR GO; GO:0010212; P:response to ionizing radiation; IEA:Ensembl.
DR Gene3D; 1.10.10.490; -; 1.
DR InterPro; IPR009428; ICAT.
DR Pfam; PF06384; ICAT; 1.
DR SUPFAM; SSF81730; SSF81730; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Complete proteome; Polymorphism; Reference proteome.
FT CHAIN 1 190 Protein LZIC.
FT /FTId=PRO_0000263691.
FT COILED 2 63 Potential.
FT VARIANT 104 104 G -> D (in dbSNP:rs2304778).
FT /FTId=VAR_053371.
SQ SEQUENCE 190 AA; 21495 MW; 2DDDD7B788F42DD8 CRC64;
MASRGKTETS KLKQNLEEQL DRLMQQLQDL EECREELDTD EYEETKKETL EQLSEFNDSL
KKIMSGNMTL VDELSGMQLA IQAAISQAFK TPEVIRLFAK KQPGQLRTRL AEMDRDLMVG
KLERDLYTQQ KVEILTALRK LGEKLTADDE AFLSANAGAI LSQFEKVSTD LGSGDKILAL
ASFEVEKTKK
//
ID LZIC_HUMAN Reviewed; 190 AA.
AC Q8WZA0; B2R6F0; Q96IU1;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2002, sequence version 1.
DT 22-JAN-2014, entry version 93.
DE RecName: Full=Protein LZIC;
DE AltName: Full=Leucine zipper and CTNNBIP1 domain-containing protein;
DE AltName: Full=Leucine zipper and ICAT homologous domain-containing protein;
GN Name=LZIC;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Stomach;
RX PubMed=11712074;
RA Katoh M.;
RT "Molecular cloning and characterization of LZIC, a novel gene encoding
RT ICAT homologous protein with leucine zipper domain.";
RL Int. J. Mol. Med. 8:611-615(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SUBUNIT: Does not interact with CTNNB1 (By similarity).
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in
CC kidney. Up-regulated in several cases of gastric cancers.
CC -!- SIMILARITY: Belongs to the CTNNBIP1 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AB060688; BAB72100.1; -; mRNA.
DR EMBL; AK312550; BAG35447.1; -; mRNA.
DR EMBL; AL357140; CAI16887.1; -; Genomic_DNA.
DR EMBL; CH471130; EAW71633.1; -; Genomic_DNA.
DR EMBL; BC007240; AAH07240.2; -; mRNA.
DR EMBL; BC063443; AAH63443.1; -; mRNA.
DR RefSeq; NP_115744.2; NM_032368.3.
DR RefSeq; XP_005263564.1; XM_005263507.1.
DR RefSeq; XP_005263565.1; XM_005263508.1.
DR UniGene; Hs.327252; -.
DR ProteinModelPortal; Q8WZA0; -.
DR SMR; Q8WZA0; 120-165.
DR IntAct; Q8WZA0; 1.
DR STRING; 9606.ENSP00000366418; -.
DR PhosphoSite; Q8WZA0; -.
DR DMDM; 74751644; -.
DR PaxDb; Q8WZA0; -.
DR PeptideAtlas; Q8WZA0; -.
DR PRIDE; Q8WZA0; -.
DR DNASU; 84328; -.
DR Ensembl; ENST00000377213; ENSP00000366418; ENSG00000162441.
DR Ensembl; ENST00000377223; ENSP00000366430; ENSG00000162441.
DR Ensembl; ENST00000400903; ENSP00000383695; ENSG00000162441.
DR GeneID; 84328; -.
DR KEGG; hsa:84328; -.
DR UCSC; uc001aqm.3; human.
DR CTD; 84328; -.
DR GeneCards; GC01M009982; -.
DR HGNC; HGNC:17497; LZIC.
DR HPA; HPA028184; -.
DR MIM; 610458; gene.
DR neXtProt; NX_Q8WZA0; -.
DR PharmGKB; PA30504; -.
DR eggNOG; NOG39638; -.
DR HOVERGEN; HBG080109; -.
DR InParanoid; Q8WZA0; -.
DR PhylomeDB; Q8WZA0; -.
DR GenomeRNAi; 84328; -.
DR NextBio; 74075; -.
DR PRO; PR:Q8WZA0; -.
DR ArrayExpress; Q8WZA0; -.
DR Bgee; Q8WZA0; -.
DR CleanEx; HS_LZIC; -.
DR Genevestigator; Q8WZA0; -.
DR GO; GO:0007417; P:central nervous system development; IBA:RefGenome.
DR GO; GO:0010212; P:response to ionizing radiation; IEA:Ensembl.
DR Gene3D; 1.10.10.490; -; 1.
DR InterPro; IPR009428; ICAT.
DR Pfam; PF06384; ICAT; 1.
DR SUPFAM; SSF81730; SSF81730; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Complete proteome; Polymorphism; Reference proteome.
FT CHAIN 1 190 Protein LZIC.
FT /FTId=PRO_0000263691.
FT COILED 2 63 Potential.
FT VARIANT 104 104 G -> D (in dbSNP:rs2304778).
FT /FTId=VAR_053371.
SQ SEQUENCE 190 AA; 21495 MW; 2DDDD7B788F42DD8 CRC64;
MASRGKTETS KLKQNLEEQL DRLMQQLQDL EECREELDTD EYEETKKETL EQLSEFNDSL
KKIMSGNMTL VDELSGMQLA IQAAISQAFK TPEVIRLFAK KQPGQLRTRL AEMDRDLMVG
KLERDLYTQQ KVEILTALRK LGEKLTADDE AFLSANAGAI LSQFEKVSTD LGSGDKILAL
ASFEVEKTKK
//
MIM
610458
*RECORD*
*FIELD* NO
610458
*FIELD* TI
*610458 LEUCINE ZIPPER AND CTNNBIP1 DOMAINS-CONTAINING PROTEIN; LZIC
*FIELD* TX
CLONING
read more
By database searching for sequences similar to ICAT (CTNNBIP1; 607758),
followed by PCR of a mixed RNA pool from several gastric cancers, Katoh
(2001) cloned LZIC. The deduced 190-amino acid protein contains a
leucine zipper domain and an ICAT-like domain, the latter sharing 38%
amino acid identity with the ICAT gene. Northern blot analysis detected
a major 5.2-kb transcript and minor transcripts of 2.1, 1.6, and 1.0 kb
in almost all fetal and adult tissues examined with highest expression
in adult kidney. Using Northern blot and PCR analysis, Katoh (2001)
demonstrated LZIC expression in all cancer cell lines tested and showed
upregulated expression in a gastric cancer cell line and in 5 of 10
primary gastric cancers tested.
GENE STRUCTURE
Katoh (2001) determined that the LZIC gene contains at least 8 exons.
MAPPING
By genomic sequence analysis, Katoh (2001) mapped the LZIC gene to
chromosome 1pter-p36.32.
*FIELD* RF
1. Katoh, M.: Molecular cloning and characterization of LZIC, a novel
gene encoding ICAT homologous protein with leucine zipper domain. Int.
J. Molec. Med. 8: 611-615, 2001.
*FIELD* CD
Dorothy S. Reilly: 9/28/2006
*FIELD* ED
wwang: 06/18/2007
wwang: 9/29/2006
*RECORD*
*FIELD* NO
610458
*FIELD* TI
*610458 LEUCINE ZIPPER AND CTNNBIP1 DOMAINS-CONTAINING PROTEIN; LZIC
*FIELD* TX
CLONING
read more
By database searching for sequences similar to ICAT (CTNNBIP1; 607758),
followed by PCR of a mixed RNA pool from several gastric cancers, Katoh
(2001) cloned LZIC. The deduced 190-amino acid protein contains a
leucine zipper domain and an ICAT-like domain, the latter sharing 38%
amino acid identity with the ICAT gene. Northern blot analysis detected
a major 5.2-kb transcript and minor transcripts of 2.1, 1.6, and 1.0 kb
in almost all fetal and adult tissues examined with highest expression
in adult kidney. Using Northern blot and PCR analysis, Katoh (2001)
demonstrated LZIC expression in all cancer cell lines tested and showed
upregulated expression in a gastric cancer cell line and in 5 of 10
primary gastric cancers tested.
GENE STRUCTURE
Katoh (2001) determined that the LZIC gene contains at least 8 exons.
MAPPING
By genomic sequence analysis, Katoh (2001) mapped the LZIC gene to
chromosome 1pter-p36.32.
*FIELD* RF
1. Katoh, M.: Molecular cloning and characterization of LZIC, a novel
gene encoding ICAT homologous protein with leucine zipper domain. Int.
J. Molec. Med. 8: 611-615, 2001.
*FIELD* CD
Dorothy S. Reilly: 9/28/2006
*FIELD* ED
wwang: 06/18/2007
wwang: 9/29/2006