Full text data of MBLAC2
MBLAC2
[Confidence: high (present in two of the MS resources)]
Metallo-beta-lactamase domain-containing protein 2; 3.-.-.-
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Metallo-beta-lactamase domain-containing protein 2; 3.-.-.-
Note: presumably soluble (membrane word is not in UniProt keywords or features)
hRBCD
IPI00384742
IPI00384742 Hypothetical protein FLJ39623 Hypothetical protein FLJ39623 membrane n/a n/a n/a n/a n/a n/a n/a n/a 1 n/a n/a n/a 1 n/a n/a n/a n/a n/a n/a n/a not mentioned n/a found at its expected molecular weight found at molecular weight
IPI00384742 Hypothetical protein FLJ39623 Hypothetical protein FLJ39623 membrane n/a n/a n/a n/a n/a n/a n/a n/a 1 n/a n/a n/a 1 n/a n/a n/a n/a n/a n/a n/a not mentioned n/a found at its expected molecular weight found at molecular weight
UniProt
Q68D91
ID MBLC2_HUMAN Reviewed; 279 AA.
AC Q68D91; D6RJI1; Q8IY16; Q8N8D8;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 02-NOV-2010, sequence version 3.
DT 22-JAN-2014, entry version 65.
DE RecName: Full=Metallo-beta-lactamase domain-containing protein 2;
DE EC=3.-.-.-;
GN Name=MBLAC2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP ALA-128.
RC TISSUE=Brain, and Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ALA-128.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
RP ALA-128.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 152-279 (ISOFORM 1).
RC TISSUE=Fetal kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- COFACTOR: Binds 2 zinc ions per subunit (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q68D91-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q68D91-2; Sequence=VSP_032490;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily.
CC Glyoxalase II family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK096942; BAC04908.1; -; mRNA.
DR EMBL; AK289778; BAF82467.1; -; mRNA.
DR EMBL; AC093510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471084; EAW95979.1; -; Genomic_DNA.
DR EMBL; BC038230; AAH38230.1; -; mRNA.
DR EMBL; CR749512; CAH18329.1; -; mRNA.
DR RefSeq; NP_981951.1; NM_203406.1.
DR UniGene; Hs.64004; -.
DR ProteinModelPortal; Q68D91; -.
DR SMR; Q68D91; 31-240.
DR STRING; 9606.ENSP00000314776; -.
DR BindingDB; Q68D91; -.
DR PhosphoSite; Q68D91; -.
DR DMDM; 311033427; -.
DR PaxDb; Q68D91; -.
DR PeptideAtlas; Q68D91; -.
DR PRIDE; Q68D91; -.
DR Ensembl; ENST00000316610; ENSP00000314776; ENSG00000176055.
DR Ensembl; ENST00000514906; ENSP00000425600; ENSG00000176055.
DR GeneID; 153364; -.
DR KEGG; hsa:153364; -.
DR UCSC; uc003kjp.3; human.
DR CTD; 153364; -.
DR GeneCards; GC05M089790; -.
DR H-InvDB; HIX0005023; -.
DR H-InvDB; HIX0005024; -.
DR HGNC; HGNC:33711; MBLAC2.
DR HPA; HPA037757; -.
DR neXtProt; NX_Q68D91; -.
DR PharmGKB; PA164722236; -.
DR eggNOG; COG0491; -.
DR HOGENOM; HOG000247126; -.
DR InParanoid; Q68D91; -.
DR OMA; FDQVAVH; -.
DR OrthoDB; EOG7QRQVC; -.
DR PhylomeDB; Q68D91; -.
DR GenomeRNAi; 153364; -.
DR NextBio; 87105; -.
DR PRO; PR:Q68D91; -.
DR Bgee; Q68D91; -.
DR Genevestigator; Q68D91; -.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.60.15.10; -; 1.
DR InterPro; IPR001279; Beta-lactamas-like.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Hydrolase; Metal-binding;
KW Polymorphism; Reference proteome; Zinc.
FT CHAIN 1 279 Metallo-beta-lactamase domain-containing
FT protein 2.
FT /FTId=PRO_0000325935.
FT METAL 83 83 Zinc 1 (By similarity).
FT METAL 85 85 Zinc 1 (By similarity).
FT METAL 87 87 Zinc 2 (By similarity).
FT METAL 88 88 Zinc 2 (By similarity).
FT METAL 170 170 Zinc 1 (By similarity).
FT METAL 189 189 Zinc 1 (By similarity).
FT METAL 189 189 Zinc 2 (By similarity).
FT METAL 231 231 Zinc 2 (By similarity).
FT VAR_SEQ 153 279 DVINLGDRQLTVMHMPGHSRGSICLHDKDRKILFSGDVVYD
FT GSLIDWLPYSRISDYVGTCERLIELVDRGLVEKVLPGHFNT
FT FGAERLFRLASNYISKAGICHKVSTFAMRSLASLALRVTNS
FT RTSP -> NGPPRARALVKGGYWEETVRVPHVADLRGHKGD
FT YFGTSQSHFCFTLP (in isoform 2).
FT /FTId=VSP_032490.
FT VARIANT 128 128 T -> A (in dbSNP:rs2162986).
FT /FTId=VAR_039956.
FT CONFLICT 25 25 E -> G (in Ref. 1; BAC04908).
SQ SEQUENCE 279 AA; 31372 MW; 14C9C03B62C81867 CRC64;
MSALEWYAHK SLGDGIFWIQ ERFYESGNRA NIWLVRGSEQ DVVIDTGLGL RSLPEYLYSS
GLLQDREAKE DAARRPLLAV ATHVHFDHSG GLYQFDRVAV HHAEAEALAR GDNFETVTWL
SDSEVVRTPS PGWRARQFRV QAVQPTLILQ DGDVINLGDR QLTVMHMPGH SRGSICLHDK
DRKILFSGDV VYDGSLIDWL PYSRISDYVG TCERLIELVD RGLVEKVLPG HFNTFGAERL
FRLASNYISK AGICHKVSTF AMRSLASLAL RVTNSRTSP
//
ID MBLC2_HUMAN Reviewed; 279 AA.
AC Q68D91; D6RJI1; Q8IY16; Q8N8D8;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 02-NOV-2010, sequence version 3.
DT 22-JAN-2014, entry version 65.
DE RecName: Full=Metallo-beta-lactamase domain-containing protein 2;
DE EC=3.-.-.-;
GN Name=MBLAC2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP ALA-128.
RC TISSUE=Brain, and Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ALA-128.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
RP ALA-128.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 152-279 (ISOFORM 1).
RC TISSUE=Fetal kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- COFACTOR: Binds 2 zinc ions per subunit (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q68D91-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q68D91-2; Sequence=VSP_032490;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily.
CC Glyoxalase II family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK096942; BAC04908.1; -; mRNA.
DR EMBL; AK289778; BAF82467.1; -; mRNA.
DR EMBL; AC093510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471084; EAW95979.1; -; Genomic_DNA.
DR EMBL; BC038230; AAH38230.1; -; mRNA.
DR EMBL; CR749512; CAH18329.1; -; mRNA.
DR RefSeq; NP_981951.1; NM_203406.1.
DR UniGene; Hs.64004; -.
DR ProteinModelPortal; Q68D91; -.
DR SMR; Q68D91; 31-240.
DR STRING; 9606.ENSP00000314776; -.
DR BindingDB; Q68D91; -.
DR PhosphoSite; Q68D91; -.
DR DMDM; 311033427; -.
DR PaxDb; Q68D91; -.
DR PeptideAtlas; Q68D91; -.
DR PRIDE; Q68D91; -.
DR Ensembl; ENST00000316610; ENSP00000314776; ENSG00000176055.
DR Ensembl; ENST00000514906; ENSP00000425600; ENSG00000176055.
DR GeneID; 153364; -.
DR KEGG; hsa:153364; -.
DR UCSC; uc003kjp.3; human.
DR CTD; 153364; -.
DR GeneCards; GC05M089790; -.
DR H-InvDB; HIX0005023; -.
DR H-InvDB; HIX0005024; -.
DR HGNC; HGNC:33711; MBLAC2.
DR HPA; HPA037757; -.
DR neXtProt; NX_Q68D91; -.
DR PharmGKB; PA164722236; -.
DR eggNOG; COG0491; -.
DR HOGENOM; HOG000247126; -.
DR InParanoid; Q68D91; -.
DR OMA; FDQVAVH; -.
DR OrthoDB; EOG7QRQVC; -.
DR PhylomeDB; Q68D91; -.
DR GenomeRNAi; 153364; -.
DR NextBio; 87105; -.
DR PRO; PR:Q68D91; -.
DR Bgee; Q68D91; -.
DR Genevestigator; Q68D91; -.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.60.15.10; -; 1.
DR InterPro; IPR001279; Beta-lactamas-like.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Hydrolase; Metal-binding;
KW Polymorphism; Reference proteome; Zinc.
FT CHAIN 1 279 Metallo-beta-lactamase domain-containing
FT protein 2.
FT /FTId=PRO_0000325935.
FT METAL 83 83 Zinc 1 (By similarity).
FT METAL 85 85 Zinc 1 (By similarity).
FT METAL 87 87 Zinc 2 (By similarity).
FT METAL 88 88 Zinc 2 (By similarity).
FT METAL 170 170 Zinc 1 (By similarity).
FT METAL 189 189 Zinc 1 (By similarity).
FT METAL 189 189 Zinc 2 (By similarity).
FT METAL 231 231 Zinc 2 (By similarity).
FT VAR_SEQ 153 279 DVINLGDRQLTVMHMPGHSRGSICLHDKDRKILFSGDVVYD
FT GSLIDWLPYSRISDYVGTCERLIELVDRGLVEKVLPGHFNT
FT FGAERLFRLASNYISKAGICHKVSTFAMRSLASLALRVTNS
FT RTSP -> NGPPRARALVKGGYWEETVRVPHVADLRGHKGD
FT YFGTSQSHFCFTLP (in isoform 2).
FT /FTId=VSP_032490.
FT VARIANT 128 128 T -> A (in dbSNP:rs2162986).
FT /FTId=VAR_039956.
FT CONFLICT 25 25 E -> G (in Ref. 1; BAC04908).
SQ SEQUENCE 279 AA; 31372 MW; 14C9C03B62C81867 CRC64;
MSALEWYAHK SLGDGIFWIQ ERFYESGNRA NIWLVRGSEQ DVVIDTGLGL RSLPEYLYSS
GLLQDREAKE DAARRPLLAV ATHVHFDHSG GLYQFDRVAV HHAEAEALAR GDNFETVTWL
SDSEVVRTPS PGWRARQFRV QAVQPTLILQ DGDVINLGDR QLTVMHMPGH SRGSICLHDK
DRKILFSGDV VYDGSLIDWL PYSRISDYVG TCERLIELVD RGLVEKVLPG HFNTFGAERL
FRLASNYISK AGICHKVSTF AMRSLASLAL RVTNSRTSP
//