Full text data of MFSD2B
MFSD2B
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Major facilitator superfamily domain-containing protein 2B
Major facilitator superfamily domain-containing protein 2B
UniProt
A6NFX1
ID MFS2B_HUMAN Reviewed; 497 AA.
AC A6NFX1; B5MC32;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 15-JUN-2010, sequence version 3.
DT 22-JAN-2014, entry version 42.
DE RecName: Full=Major facilitator superfamily domain-containing protein 2B;
GN Name=MFSD2B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA Waterston R.H., Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2
RT and 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-271.
RC TISSUE=Placenta;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP IDENTIFICATION.
RX PubMed=18694395; DOI=10.1042/BJ20080165;
RA Angers M., Uldry M., Kong D., Gimble J.M., Jetten A.M.;
RT "Mfsd2a encodes a novel major facilitator superfamily domain-
RT containing protein highly induced in brown adipose tissue during
RT fasting and adaptive thermogenesis.";
RL Biochem. J. 416:347-355(2008).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Potential).
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AC104665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX357394; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001073942.1; NM_001080473.1.
DR UniGene; Hs.407482; -.
DR ProteinModelPortal; A6NFX1; -.
DR STRING; 9606.ENSP00000385527; -.
DR PhosphoSite; A6NFX1; -.
DR PaxDb; A6NFX1; -.
DR PRIDE; A6NFX1; -.
DR Ensembl; ENST00000406420; ENSP00000385527; ENSG00000205639.
DR GeneID; 388931; -.
DR KEGG; hsa:388931; -.
DR UCSC; uc002reo.2; human.
DR CTD; 388931; -.
DR GeneCards; GC02P024232; -.
DR HGNC; HGNC:37207; MFSD2B.
DR HPA; HPA044145; -.
DR neXtProt; NX_A6NFX1; -.
DR PharmGKB; PA165696804; -.
DR eggNOG; COG2211; -.
DR HOGENOM; HOG000294186; -.
DR HOVERGEN; HBG080097; -.
DR OrthoDB; EOG7QRQTT; -.
DR GenomeRNAi; 388931; -.
DR NextBio; 102447; -.
DR PRO; PR:A6NFX1; -.
DR ArrayExpress; A6NFX1; -.
DR Bgee; A6NFX1; -.
DR Genevestigator; A6NFX1; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR InterPro; IPR016196; MFS_dom_general_subst_transpt.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; FALSE_NEG.
PE 2: Evidence at transcript level;
KW Complete proteome; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1 497 Major facilitator superfamily domain-
FT containing protein 2B.
FT /FTId=PRO_0000341260.
FT TRANSMEM 113 133 Helical; (Potential).
FT TRANSMEM 150 170 Helical; (Potential).
FT TRANSMEM 185 205 Helical; (Potential).
FT TRANSMEM 233 253 Helical; (Potential).
FT TRANSMEM 287 307 Helical; (Potential).
FT TRANSMEM 320 340 Helical; (Potential).
FT TRANSMEM 350 370 Helical; (Potential).
FT TRANSMEM 373 393 Helical; (Potential).
FT TRANSMEM 412 432 Helical; (Potential).
FT TRANSMEM 459 479 Helical; (Potential).
SQ SEQUENCE 497 AA; 52964 MW; E87AC394084517D9 CRC64;
MAAPPAPAAK GSPQPEPHAP EPGPGSAKRG REDSRAGRLS FCTKVCYGIG GVPNQIASSA
TAFYLQLFLL DIAQIPAAQV SLVLFGGKVS GAAADPVAGF FINRSQRTGS GRLMPWVLGC
TPFIALAYFF LWFLPPFTSL RGLWYTTFYC LFQALATFFQ VPYTALTMLL TPCPRERDSA
TAYRMTVEMA GTLMGATVHG LIVSGAHRPH RCEATATPGP VTVSPNAAHL YCIAAAVVVV
TYPVCISLLC LGVKERPDPS APASGPGLSF LAGLSLTTRH PPYLKLVISF LFISAAVQVE
QSYLVLFCTH ASQLHDHVQG LVLTVLVSAV LSTPLWEWVL QRFGKKTSAF GIFAMVPFAI
LLAAVPTAPV AYVVAFVSGV SIAVSLLLPW SMLPDVVDDF QLQHRHGPGL ETIFYSSYVF
FTKLSGACAL GISTLSLEFS GYKAGVCKQA EEVVVTLKVL IGAVPTCMIL AGLCILMVGS
TPKTPSRDAS SRLSLRR
//
ID MFS2B_HUMAN Reviewed; 497 AA.
AC A6NFX1; B5MC32;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 15-JUN-2010, sequence version 3.
DT 22-JAN-2014, entry version 42.
DE RecName: Full=Major facilitator superfamily domain-containing protein 2B;
GN Name=MFSD2B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA Waterston R.H., Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2
RT and 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-271.
RC TISSUE=Placenta;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP IDENTIFICATION.
RX PubMed=18694395; DOI=10.1042/BJ20080165;
RA Angers M., Uldry M., Kong D., Gimble J.M., Jetten A.M.;
RT "Mfsd2a encodes a novel major facilitator superfamily domain-
RT containing protein highly induced in brown adipose tissue during
RT fasting and adaptive thermogenesis.";
RL Biochem. J. 416:347-355(2008).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Potential).
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AC104665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX357394; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001073942.1; NM_001080473.1.
DR UniGene; Hs.407482; -.
DR ProteinModelPortal; A6NFX1; -.
DR STRING; 9606.ENSP00000385527; -.
DR PhosphoSite; A6NFX1; -.
DR PaxDb; A6NFX1; -.
DR PRIDE; A6NFX1; -.
DR Ensembl; ENST00000406420; ENSP00000385527; ENSG00000205639.
DR GeneID; 388931; -.
DR KEGG; hsa:388931; -.
DR UCSC; uc002reo.2; human.
DR CTD; 388931; -.
DR GeneCards; GC02P024232; -.
DR HGNC; HGNC:37207; MFSD2B.
DR HPA; HPA044145; -.
DR neXtProt; NX_A6NFX1; -.
DR PharmGKB; PA165696804; -.
DR eggNOG; COG2211; -.
DR HOGENOM; HOG000294186; -.
DR HOVERGEN; HBG080097; -.
DR OrthoDB; EOG7QRQTT; -.
DR GenomeRNAi; 388931; -.
DR NextBio; 102447; -.
DR PRO; PR:A6NFX1; -.
DR ArrayExpress; A6NFX1; -.
DR Bgee; A6NFX1; -.
DR Genevestigator; A6NFX1; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR InterPro; IPR016196; MFS_dom_general_subst_transpt.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; FALSE_NEG.
PE 2: Evidence at transcript level;
KW Complete proteome; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1 497 Major facilitator superfamily domain-
FT containing protein 2B.
FT /FTId=PRO_0000341260.
FT TRANSMEM 113 133 Helical; (Potential).
FT TRANSMEM 150 170 Helical; (Potential).
FT TRANSMEM 185 205 Helical; (Potential).
FT TRANSMEM 233 253 Helical; (Potential).
FT TRANSMEM 287 307 Helical; (Potential).
FT TRANSMEM 320 340 Helical; (Potential).
FT TRANSMEM 350 370 Helical; (Potential).
FT TRANSMEM 373 393 Helical; (Potential).
FT TRANSMEM 412 432 Helical; (Potential).
FT TRANSMEM 459 479 Helical; (Potential).
SQ SEQUENCE 497 AA; 52964 MW; E87AC394084517D9 CRC64;
MAAPPAPAAK GSPQPEPHAP EPGPGSAKRG REDSRAGRLS FCTKVCYGIG GVPNQIASSA
TAFYLQLFLL DIAQIPAAQV SLVLFGGKVS GAAADPVAGF FINRSQRTGS GRLMPWVLGC
TPFIALAYFF LWFLPPFTSL RGLWYTTFYC LFQALATFFQ VPYTALTMLL TPCPRERDSA
TAYRMTVEMA GTLMGATVHG LIVSGAHRPH RCEATATPGP VTVSPNAAHL YCIAAAVVVV
TYPVCISLLC LGVKERPDPS APASGPGLSF LAGLSLTTRH PPYLKLVISF LFISAAVQVE
QSYLVLFCTH ASQLHDHVQG LVLTVLVSAV LSTPLWEWVL QRFGKKTSAF GIFAMVPFAI
LLAAVPTAPV AYVVAFVSGV SIAVSLLLPW SMLPDVVDDF QLQHRHGPGL ETIFYSSYVF
FTKLSGACAL GISTLSLEFS GYKAGVCKQA EEVVVTLKVL IGAVPTCMIL AGLCILMVGS
TPKTPSRDAS SRLSLRR
//