Full text data of MPP6
MPP6
(VAM1)
[Confidence: high (present in two of the MS resources)]
MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1; VAM-1)
MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1; VAM-1)
UniProt
Q9NZW5
ID MPP6_HUMAN Reviewed; 540 AA.
AC Q9NZW5; A4D157; Q9H0E1;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 16-FEB-2004, sequence version 2.
DT 22-JAN-2014, entry version 110.
DE RecName: Full=MAGUK p55 subfamily member 6;
DE AltName: Full=Veli-associated MAGUK 1;
DE Short=VAM-1;
GN Name=MPP6; Synonyms=VAM1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11311936; DOI=10.1016/S0167-4781(01)00191-9;
RA Tseng T.-C., Marfatia S.M., Bryant P.J., Pack S., Zhuang Z.,
RA O'Brien J.E., Lin L., Hanada T., Chishti A.H.;
RT "VAM-1: a new member of the MAGUK family binds to human Veli-1 through
RT a conserved domain.";
RL Biochim. Biophys. Acta 1518:249-259(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA Wambutt R., Korn B., Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and
RT analysis of 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S.,
RA Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z.,
RA Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C.,
RA Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J.,
RA Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F.,
RA Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F.,
RA Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H.,
RA Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G.,
RA Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P.,
RA Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J.,
RA Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F.,
RA Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B.,
RA Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W.,
RA Mural R.J., Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA Waterston R.H., Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-500, AND MASS
RP SPECTROMETRY.
RX PubMed=15592455; DOI=10.1038/nbt1046;
RA Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,
RA Zha X.-M., Polakiewicz R.D., Comb M.J.;
RT "Immunoaffinity profiling of tyrosine phosphorylation in cancer
RT cells.";
RL Nat. Biotechnol. 23:94-101(2005).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SUBUNIT: Interacts with CADM1 (By similarity). Interacts with the
CC LIN7 proteins.
CC -!- SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein (By
CC similarity).
CC -!- TISSUE SPECIFICITY: Abundant in testis, brain, and kidney with
CC lower levels detectable in other tissues.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC -!- SIMILARITY: Contains 1 guanylate kinase-like domain.
CC -!- SIMILARITY: Contains 2 L27 domains.
CC -!- SIMILARITY: Contains 1 PDZ (DHR) domain.
CC -!- SIMILARITY: Contains 1 SH3 domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF162130; AAD45919.2; -; mRNA.
DR EMBL; AL136836; CAB66770.1; -; mRNA.
DR EMBL; AC005084; AAQ96847.1; -; Genomic_DNA.
DR EMBL; CH236948; EAL24247.1; -; Genomic_DNA.
DR EMBL; CH471073; EAW93810.1; -; Genomic_DNA.
DR EMBL; BC023638; AAH23638.1; -; mRNA.
DR RefSeq; NP_057531.2; NM_016447.2.
DR RefSeq; XP_005249831.1; XM_005249774.1.
DR UniGene; Hs.533355; -.
DR ProteinModelPortal; Q9NZW5; -.
DR SMR; Q9NZW5; 129-206, 218-535.
DR IntAct; Q9NZW5; 3.
DR STRING; 9606.ENSP00000222644; -.
DR PhosphoSite; Q9NZW5; -.
DR DMDM; 42560556; -.
DR PaxDb; Q9NZW5; -.
DR PeptideAtlas; Q9NZW5; -.
DR PRIDE; Q9NZW5; -.
DR DNASU; 51678; -.
DR Ensembl; ENST00000222644; ENSP00000222644; ENSG00000105926.
DR Ensembl; ENST00000396475; ENSP00000379737; ENSG00000105926.
DR GeneID; 51678; -.
DR KEGG; hsa:51678; -.
DR UCSC; uc003swx.3; human.
DR CTD; 51678; -.
DR GeneCards; GC07P024612; -.
DR HGNC; HGNC:18167; MPP6.
DR HPA; HPA019085; -.
DR HPA; HPA020456; -.
DR MIM; 606959; gene.
DR neXtProt; NX_Q9NZW5; -.
DR PharmGKB; PA38511; -.
DR eggNOG; COG0194; -.
DR HOGENOM; HOG000233034; -.
DR HOVERGEN; HBG001858; -.
DR OMA; DTIIPQQ; -.
DR PhylomeDB; Q9NZW5; -.
DR ChiTaRS; MPP6; human.
DR GeneWiki; MPP6; -.
DR GenomeRNAi; 51678; -.
DR NextBio; 55682; -.
DR PRO; PR:Q9NZW5; -.
DR ArrayExpress; Q9NZW5; -.
DR Bgee; Q9NZW5; -.
DR CleanEx; HS_MPP6; -.
DR Genevestigator; Q9NZW5; -.
DR GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0006461; P:protein complex assembly; NAS:UniProtKB.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR004172; L27.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR011511; SH3_2.
DR InterPro; IPR001452; SH3_domain.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF02828; L27; 2.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00569; L27; 2.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Membrane; Phosphoprotein; Reference proteome;
KW Repeat; SH3 domain.
FT CHAIN 1 540 MAGUK p55 subfamily member 6.
FT /FTId=PRO_0000094584.
FT DOMAIN 1 48 L27 1.
FT DOMAIN 49 107 L27 2.
FT DOMAIN 130 209 PDZ.
FT DOMAIN 215 284 SH3.
FT DOMAIN 338 525 Guanylate kinase-like.
FT MOD_RES 500 500 Phosphotyrosine.
FT CONFLICT 41 41 H -> R (in Ref. 1; AAD45919).
SQ SEQUENCE 540 AA; 61117 MW; 86310E4F6AF632BD CRC64;
MQQVLENLTE LPSSTGAEEI DLIFLKGIME NPIVKSLAKA HERLEDSKLE AVSDNNLELV
NEILEDITPL INVDENVAEL VGILKEPHFQ SLLEAHDIVA SKCYDSPPSS PEMNNSSINN
QLLPVDAIRI LGIHKRAGEP LGVTFRVENN DLVIARILHG GMIDRQGLLH VGDIIKEVNG
HEVGNNPKEL QELLKNISGS VTLKILPSYR DTITPQQVFV KCHFDYNPYN DNLIPCKEAG
LKFSKGEILQ IVNREDPNWW QASHVKEGGS AGLIPSQFLE EKRKAFVRRD WDNSGPFCGT
ISSKKKKKMM YLTTRNAEFD RHEIQIYEEV AKMPPFQRKT LVLIGAQGVG RRSLKNRFIV
LNPTRFGTTV PFTSRKPRED EKDGQAYKFV SRSEMEADIK AGKYLEHGEY EGNLYGTKID
SILEVVQTGR TCILDVNPQA LKVLRTSEFM PYVVFIAAPE LETLRAMHKA VVDAGITTKL
LTDSDLKKTV DESARIQRAY NHYFDLIIIN DNLDKAFEKL QTAIEKLRME PQWVPISWVY
//
ID MPP6_HUMAN Reviewed; 540 AA.
AC Q9NZW5; A4D157; Q9H0E1;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 16-FEB-2004, sequence version 2.
DT 22-JAN-2014, entry version 110.
DE RecName: Full=MAGUK p55 subfamily member 6;
DE AltName: Full=Veli-associated MAGUK 1;
DE Short=VAM-1;
GN Name=MPP6; Synonyms=VAM1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11311936; DOI=10.1016/S0167-4781(01)00191-9;
RA Tseng T.-C., Marfatia S.M., Bryant P.J., Pack S., Zhuang Z.,
RA O'Brien J.E., Lin L., Hanada T., Chishti A.H.;
RT "VAM-1: a new member of the MAGUK family binds to human Veli-1 through
RT a conserved domain.";
RL Biochim. Biophys. Acta 1518:249-259(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA Wambutt R., Korn B., Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and
RT analysis of 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S.,
RA Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z.,
RA Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C.,
RA Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J.,
RA Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F.,
RA Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F.,
RA Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H.,
RA Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G.,
RA Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P.,
RA Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J.,
RA Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F.,
RA Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B.,
RA Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W.,
RA Mural R.J., Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA Waterston R.H., Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-500, AND MASS
RP SPECTROMETRY.
RX PubMed=15592455; DOI=10.1038/nbt1046;
RA Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,
RA Zha X.-M., Polakiewicz R.D., Comb M.J.;
RT "Immunoaffinity profiling of tyrosine phosphorylation in cancer
RT cells.";
RL Nat. Biotechnol. 23:94-101(2005).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SUBUNIT: Interacts with CADM1 (By similarity). Interacts with the
CC LIN7 proteins.
CC -!- SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein (By
CC similarity).
CC -!- TISSUE SPECIFICITY: Abundant in testis, brain, and kidney with
CC lower levels detectable in other tissues.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC -!- SIMILARITY: Contains 1 guanylate kinase-like domain.
CC -!- SIMILARITY: Contains 2 L27 domains.
CC -!- SIMILARITY: Contains 1 PDZ (DHR) domain.
CC -!- SIMILARITY: Contains 1 SH3 domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF162130; AAD45919.2; -; mRNA.
DR EMBL; AL136836; CAB66770.1; -; mRNA.
DR EMBL; AC005084; AAQ96847.1; -; Genomic_DNA.
DR EMBL; CH236948; EAL24247.1; -; Genomic_DNA.
DR EMBL; CH471073; EAW93810.1; -; Genomic_DNA.
DR EMBL; BC023638; AAH23638.1; -; mRNA.
DR RefSeq; NP_057531.2; NM_016447.2.
DR RefSeq; XP_005249831.1; XM_005249774.1.
DR UniGene; Hs.533355; -.
DR ProteinModelPortal; Q9NZW5; -.
DR SMR; Q9NZW5; 129-206, 218-535.
DR IntAct; Q9NZW5; 3.
DR STRING; 9606.ENSP00000222644; -.
DR PhosphoSite; Q9NZW5; -.
DR DMDM; 42560556; -.
DR PaxDb; Q9NZW5; -.
DR PeptideAtlas; Q9NZW5; -.
DR PRIDE; Q9NZW5; -.
DR DNASU; 51678; -.
DR Ensembl; ENST00000222644; ENSP00000222644; ENSG00000105926.
DR Ensembl; ENST00000396475; ENSP00000379737; ENSG00000105926.
DR GeneID; 51678; -.
DR KEGG; hsa:51678; -.
DR UCSC; uc003swx.3; human.
DR CTD; 51678; -.
DR GeneCards; GC07P024612; -.
DR HGNC; HGNC:18167; MPP6.
DR HPA; HPA019085; -.
DR HPA; HPA020456; -.
DR MIM; 606959; gene.
DR neXtProt; NX_Q9NZW5; -.
DR PharmGKB; PA38511; -.
DR eggNOG; COG0194; -.
DR HOGENOM; HOG000233034; -.
DR HOVERGEN; HBG001858; -.
DR OMA; DTIIPQQ; -.
DR PhylomeDB; Q9NZW5; -.
DR ChiTaRS; MPP6; human.
DR GeneWiki; MPP6; -.
DR GenomeRNAi; 51678; -.
DR NextBio; 55682; -.
DR PRO; PR:Q9NZW5; -.
DR ArrayExpress; Q9NZW5; -.
DR Bgee; Q9NZW5; -.
DR CleanEx; HS_MPP6; -.
DR Genevestigator; Q9NZW5; -.
DR GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0006461; P:protein complex assembly; NAS:UniProtKB.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR004172; L27.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR011511; SH3_2.
DR InterPro; IPR001452; SH3_domain.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF02828; L27; 2.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00569; L27; 2.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Membrane; Phosphoprotein; Reference proteome;
KW Repeat; SH3 domain.
FT CHAIN 1 540 MAGUK p55 subfamily member 6.
FT /FTId=PRO_0000094584.
FT DOMAIN 1 48 L27 1.
FT DOMAIN 49 107 L27 2.
FT DOMAIN 130 209 PDZ.
FT DOMAIN 215 284 SH3.
FT DOMAIN 338 525 Guanylate kinase-like.
FT MOD_RES 500 500 Phosphotyrosine.
FT CONFLICT 41 41 H -> R (in Ref. 1; AAD45919).
SQ SEQUENCE 540 AA; 61117 MW; 86310E4F6AF632BD CRC64;
MQQVLENLTE LPSSTGAEEI DLIFLKGIME NPIVKSLAKA HERLEDSKLE AVSDNNLELV
NEILEDITPL INVDENVAEL VGILKEPHFQ SLLEAHDIVA SKCYDSPPSS PEMNNSSINN
QLLPVDAIRI LGIHKRAGEP LGVTFRVENN DLVIARILHG GMIDRQGLLH VGDIIKEVNG
HEVGNNPKEL QELLKNISGS VTLKILPSYR DTITPQQVFV KCHFDYNPYN DNLIPCKEAG
LKFSKGEILQ IVNREDPNWW QASHVKEGGS AGLIPSQFLE EKRKAFVRRD WDNSGPFCGT
ISSKKKKKMM YLTTRNAEFD RHEIQIYEEV AKMPPFQRKT LVLIGAQGVG RRSLKNRFIV
LNPTRFGTTV PFTSRKPRED EKDGQAYKFV SRSEMEADIK AGKYLEHGEY EGNLYGTKID
SILEVVQTGR TCILDVNPQA LKVLRTSEFM PYVVFIAAPE LETLRAMHKA VVDAGITTKL
LTDSDLKKTV DESARIQRAY NHYFDLIIIN DNLDKAFEKL QTAIEKLRME PQWVPISWVY
//
MIM
606959
*RECORD*
*FIELD* NO
606959
*FIELD* TI
*606959 MEMBRANE PROTEIN, PALMITOYLATED 6; MPP6
;;VELI-ASSOCIATED MAGUK 1; VAM1;;
PROTEIN ASSOCIATED WITH LIN7 2, MOUSE, HOMOLOG OF; PALS2
read more*FIELD* TX
DESCRIPTION
Members of the peripheral membrane-associated guanylate kinase (MAGUK)
family function in tumor suppression and receptor clustering by forming
multiprotein complexes containing distinct sets of transmembrane,
cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a
PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1;
601014), ZO1-like (see TJP1; 601009), p55-like (see MPP1; 305360), and
LIN2-like (see CASK; 300172), based on their size and the presence of
additional domains. MPP6 is a member of the p55-like MAGUK subfamily
(Tseng et al., 2001).
CLONING
By searching an EST database with DLG2 (603583) as the probe, followed
by PCR of a brain cDNA library and 5-prime RACE, Tseng et al. (2001)
obtained a cDNA encoding MPP6, which they called VAM1 for VELI
(603380)-associated MAGUK-1. The deduced 540-amino acid protein has a
single PDZ domain, a central SH3 domain, and a C-terminal GUK domain,
resembling other members of the p55 MAGUK subfamily. Like MPP1, MPP6
also contains a protein 4.1 (EPB41; 130500)-binding domain with its
characteristic KKKK sequence, as well as a leucine zipper and 2
phosphorylation sites. Northern blot analysis revealed expression of an
abundant 2.3-kb transcript and a minor 4.2-kb transcript only in testis.
RT-PCR analysis detected predominant expression in testis, with lower
amounts in ovary, prostate, thymus, small intestine, and several other
tissues; VELI has a similar expression pattern. GST pull-down and
mutation analyses indicated that a domain N-terminal of the PDZ region
of VAM1 contains the minimal VELI-binding sequence. No binding between
VAM1 and EPB41 was detected.
Kamberov et al. (2000) cloned and characterized the mouse Mpp5 (606958)
and Mpp6 genes, which they called Pals1 and Pals2, respectively. The
Pals proteins bind to mouse Lin7 (VELI) through a region N-terminal to
their PDZ domains.
GENE STRUCTURE
By genomic sequence analysis, Tseng et al. (2001) determined that the
MPP6 gene contains 12 exons and spans 115 kb.
MAPPING
Using FISH, Tseng et al. (2001) mapped the MPP6 gene to chromosome
7p21-p15. Kamberov et al. (2000) mapped the mouse Pals2 gene to
chromosome 6.
*FIELD* RF
1. Kamberov, E.; Makarova, O.; Roh, M.; Liu, A.; Karnak, D.; Straight,
S.; Margolis, B.: Molecular cloning and characterization of Pals,
proteins associated with mLin-7. J. Biol. Chem. 275: 11425-11431,
2000.
2. Tseng, T.-C.; Marfatia, S. M.; Bryant, P. J.; Pack, S.; Zhuang,
A.; O'Brien, J. E.; Lin, L.; Hanada, T.; Chishti, A. H.: VAM-1: a
new member of the MAGUK family binds to human Veli-1 through a conserved
domain. Biochim. Biophys. Acta 1518: 249-259, 2001.
*FIELD* CD
Paul J. Converse: 5/22/2002
*FIELD* ED
mgross: 05/22/2002
*RECORD*
*FIELD* NO
606959
*FIELD* TI
*606959 MEMBRANE PROTEIN, PALMITOYLATED 6; MPP6
;;VELI-ASSOCIATED MAGUK 1; VAM1;;
PROTEIN ASSOCIATED WITH LIN7 2, MOUSE, HOMOLOG OF; PALS2
read more*FIELD* TX
DESCRIPTION
Members of the peripheral membrane-associated guanylate kinase (MAGUK)
family function in tumor suppression and receptor clustering by forming
multiprotein complexes containing distinct sets of transmembrane,
cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a
PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1;
601014), ZO1-like (see TJP1; 601009), p55-like (see MPP1; 305360), and
LIN2-like (see CASK; 300172), based on their size and the presence of
additional domains. MPP6 is a member of the p55-like MAGUK subfamily
(Tseng et al., 2001).
CLONING
By searching an EST database with DLG2 (603583) as the probe, followed
by PCR of a brain cDNA library and 5-prime RACE, Tseng et al. (2001)
obtained a cDNA encoding MPP6, which they called VAM1 for VELI
(603380)-associated MAGUK-1. The deduced 540-amino acid protein has a
single PDZ domain, a central SH3 domain, and a C-terminal GUK domain,
resembling other members of the p55 MAGUK subfamily. Like MPP1, MPP6
also contains a protein 4.1 (EPB41; 130500)-binding domain with its
characteristic KKKK sequence, as well as a leucine zipper and 2
phosphorylation sites. Northern blot analysis revealed expression of an
abundant 2.3-kb transcript and a minor 4.2-kb transcript only in testis.
RT-PCR analysis detected predominant expression in testis, with lower
amounts in ovary, prostate, thymus, small intestine, and several other
tissues; VELI has a similar expression pattern. GST pull-down and
mutation analyses indicated that a domain N-terminal of the PDZ region
of VAM1 contains the minimal VELI-binding sequence. No binding between
VAM1 and EPB41 was detected.
Kamberov et al. (2000) cloned and characterized the mouse Mpp5 (606958)
and Mpp6 genes, which they called Pals1 and Pals2, respectively. The
Pals proteins bind to mouse Lin7 (VELI) through a region N-terminal to
their PDZ domains.
GENE STRUCTURE
By genomic sequence analysis, Tseng et al. (2001) determined that the
MPP6 gene contains 12 exons and spans 115 kb.
MAPPING
Using FISH, Tseng et al. (2001) mapped the MPP6 gene to chromosome
7p21-p15. Kamberov et al. (2000) mapped the mouse Pals2 gene to
chromosome 6.
*FIELD* RF
1. Kamberov, E.; Makarova, O.; Roh, M.; Liu, A.; Karnak, D.; Straight,
S.; Margolis, B.: Molecular cloning and characterization of Pals,
proteins associated with mLin-7. J. Biol. Chem. 275: 11425-11431,
2000.
2. Tseng, T.-C.; Marfatia, S. M.; Bryant, P. J.; Pack, S.; Zhuang,
A.; O'Brien, J. E.; Lin, L.; Hanada, T.; Chishti, A. H.: VAM-1: a
new member of the MAGUK family binds to human Veli-1 through a conserved
domain. Biochim. Biophys. Acta 1518: 249-259, 2001.
*FIELD* CD
Paul J. Converse: 5/22/2002
*FIELD* ED
mgross: 05/22/2002