Full text data of MSTO1
MSTO1
[Confidence: low (only semi-automatic identification from reviews)]
Protein misato homolog 1
Protein misato homolog 1
UniProt
Q9BUK6
ID MSTO1_HUMAN Reviewed; 570 AA.
AC Q9BUK6; Q53GR8; Q5CZ69; Q5T717; Q68CT6; Q7LBZ8; Q7Z3M7; Q7Z558;
read moreAC Q8TE05; Q9NQX2; Q9NVU4;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 22-JAN-2014, entry version 97.
DE RecName: Full=Protein misato homolog 1;
GN Name=MSTO1; ORFNames=LST005, SLTP005;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
RC TISSUE=Aorta;
RA Hui R.T., Liu B., Zhao B., Wang X.Y.;
RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
RC TISSUE=Testis;
RA Gu A.H., Xu Z.Y., Wang H., Xu M., Yin L.L.;
RT "Identification and characterization of a gene coding an alternative
RT splice of FLJ10504 in testis.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 7).
RC TISSUE=Spleen, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Liver;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
RC TISSUE=Cerebellum, Endometrium, and Hippocampus;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 16-570 (ISOFORM 1).
RC TISSUE=Heart;
RA Fong K.S.K., Fukushima D., de Couet H.G.;
RT "Human homologue of the Drosophila Misato gene.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=17349998; DOI=10.1016/j.yexcr.2007.02.004;
RA Kimura M., Okano Y.;
RT "Human Misato regulates mitochondrial distribution and morphology.";
RL Exp. Cell Res. 313:1393-1404(2007).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Involved in the regulation of mitochondrial distribution
CC and morphology.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=7;
CC Name=1;
CC IsoId=Q9BUK6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BUK6-2; Sequence=VSP_028056;
CC Name=3;
CC IsoId=Q9BUK6-3; Sequence=VSP_028054;
CC Note=No experimental confirmation available;
CC Name=4;
CC IsoId=Q9BUK6-4; Sequence=VSP_028051, VSP_028052;
CC Note=No experimental confirmation available;
CC Name=5;
CC IsoId=Q9BUK6-5; Sequence=VSP_028050, VSP_028056;
CC Name=6;
CC IsoId=Q9BUK6-6; Sequence=VSP_028049;
CC Name=7;
CC IsoId=Q9BUK6-7; Sequence=VSP_028053, VSP_028055;
CC Note=No experimental confirmation available;
CC -!- TISSUE SPECIFICITY: Present in all cell lines tested (at protein
CC level). Widely expressed.
CC -!- SIMILARITY: Belongs to the misato family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM12424.1; Type=Frameshift; Positions=419;
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DR EMBL; AF111708; AAM12424.1; ALT_FRAME; mRNA.
DR EMBL; AY334564; AAP94730.1; -; mRNA.
DR EMBL; AK001366; BAA91651.1; -; mRNA.
DR EMBL; AK092950; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK222863; BAD96583.1; -; mRNA.
DR EMBL; BX537684; CAD97810.1; -; mRNA.
DR EMBL; CR749791; CAH18652.1; -; mRNA.
DR EMBL; CR936872; CAI59784.1; -; Transcribed_RNA.
DR EMBL; AL353807; CAI13215.1; -; Genomic_DNA.
DR EMBL; AL353807; CAI13216.1; -; Genomic_DNA.
DR EMBL; BC002535; AAH02535.1; -; mRNA.
DR EMBL; AF272833; AAF81794.1; -; mRNA.
DR RefSeq; NP_001243461.1; NM_001256532.1.
DR RefSeq; NP_001243462.1; NM_001256533.1.
DR RefSeq; NP_060586.2; NM_018116.3.
DR UniGene; Hs.656547; -.
DR ProteinModelPortal; Q9BUK6; -.
DR IntAct; Q9BUK6; 4.
DR MINT; MINT-4717955; -.
DR PhosphoSite; Q9BUK6; -.
DR DMDM; 74752357; -.
DR PaxDb; Q9BUK6; -.
DR PRIDE; Q9BUK6; -.
DR DNASU; 55154; -.
DR Ensembl; ENST00000245564; ENSP00000245564; ENSG00000125459.
DR Ensembl; ENST00000368341; ENSP00000357325; ENSG00000125459.
DR GeneID; 55154; -.
DR KEGG; hsa:55154; -.
DR UCSC; uc001fky.4; human.
DR CTD; 55154; -.
DR GeneCards; GC01P155580; -.
DR H-InvDB; HIX0001133; -.
DR HGNC; HGNC:29678; MSTO1.
DR neXtProt; NX_Q9BUK6; -.
DR PharmGKB; PA142671313; -.
DR eggNOG; NOG258372; -.
DR HOVERGEN; HBG108151; -.
DR InParanoid; Q9BUK6; -.
DR OMA; GTHWWNL; -.
DR OrthoDB; EOG7HB58T; -.
DR PhylomeDB; Q9BUK6; -.
DR GeneWiki; MSTO1; -.
DR GenomeRNAi; 55154; -.
DR NextBio; 58899; -.
DR PRO; PR:Q9BUK6; -.
DR ArrayExpress; Q9BUK6; -.
DR Bgee; Q9BUK6; -.
DR CleanEx; HS_MSTO1; -.
DR Genevestigator; Q9BUK6; -.
DR GO; GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB.
DR GO; GO:0048311; P:mitochondrion distribution; IMP:UniProtKB.
DR Gene3D; 3.40.50.1440; -; 2.
DR InterPro; IPR019605; Misato_II_tubulin-like.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR Pfam; PF10644; Misat_Tub_SegII; 1.
DR SUPFAM; SSF52490; SSF52490; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Membrane; Mitochondrion;
KW Mitochondrion outer membrane; Phosphoprotein; Polymorphism;
KW Reference proteome.
FT CHAIN 1 570 Protein misato homolog 1.
FT /FTId=PRO_0000304626.
FT MOD_RES 495 495 Phosphoserine.
FT VAR_SEQ 1 388 Missing (in isoform 6).
FT /FTId=VSP_028049.
FT VAR_SEQ 1 178 Missing (in isoform 5).
FT /FTId=VSP_028050.
FT VAR_SEQ 98 99 QG -> EC (in isoform 4).
FT /FTId=VSP_028051.
FT VAR_SEQ 100 570 Missing (in isoform 4).
FT /FTId=VSP_028052.
FT VAR_SEQ 105 139 Missing (in isoform 7).
FT /FTId=VSP_028053.
FT VAR_SEQ 489 500 Missing (in isoform 3).
FT /FTId=VSP_028054.
FT VAR_SEQ 489 499 Missing (in isoform 7).
FT /FTId=VSP_028055.
FT VAR_SEQ 499 499 Missing (in isoform 2 and isoform 5).
FT /FTId=VSP_028056.
FT VARIANT 324 324 T -> I (in dbSNP:rs622288).
FT /FTId=VAR_035046.
FT CONFLICT 389 389 M -> V (in Ref. 3; BAA91651).
FT CONFLICT 482 482 F -> S (in Ref. 3; AK092950).
FT CONFLICT 563 563 Q -> P (in Ref. 5; CAI59784).
SQ SEQUENCE 570 AA; 61835 MW; A139748AF2798619 CRC64;
MAGGAREVLT LQLGHFAGFV GAHWWNQQDA ALGRATDSKE PPGELCPDVL YRTGRTLHGQ
ETYTPRLILM DLKGSLSSLK EEGGLYRDKQ LDAAIAWQGK LTTHKEELYP KNPYLQDFLS
AEGVLSSDGV WRVKSIPNGK GSSPLPTATT PKPLIPTEAS IRVWSDFLRV HLHPRSICMI
QKYNHDGEAG RLEAFGQGES VLKEPKYQEE LEDRLHFYVE ECDYLQGFQI LCDLHDGFSG
VGAKAAELLQ DEYSGRGIIT WGLLPGPYHR GEAQRNIYRL LNTAFGLVHL TAHSSLVCPL
SLGGSLGLRP EPPVSFPYLH YDATLPFHCS AILATALDTV TVPYRLCSSP VSMVHLADML
SFCGKKVVTA GAIIPFPLAP GQSLPDSLMQ FGGATPWTPL SACGEPSGTR CFAQSVVLRG
IDRACHTSQL TPGTPPPSAL HACTTGEEIL AQYLQQQQPG VMSSSHLLLT PCRVAPPYPH
LFSSCSPPGM VLDGSPKGAA VESIPVFGAL CSSSSLHQTL EALARDLTKL DLRRWASFMD
AGVEHDDVAE LLQELQSLAQ CYQGGDSLVD
//
ID MSTO1_HUMAN Reviewed; 570 AA.
AC Q9BUK6; Q53GR8; Q5CZ69; Q5T717; Q68CT6; Q7LBZ8; Q7Z3M7; Q7Z558;
read moreAC Q8TE05; Q9NQX2; Q9NVU4;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 22-JAN-2014, entry version 97.
DE RecName: Full=Protein misato homolog 1;
GN Name=MSTO1; ORFNames=LST005, SLTP005;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
RC TISSUE=Aorta;
RA Hui R.T., Liu B., Zhao B., Wang X.Y.;
RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
RC TISSUE=Testis;
RA Gu A.H., Xu Z.Y., Wang H., Xu M., Yin L.L.;
RT "Identification and characterization of a gene coding an alternative
RT splice of FLJ10504 in testis.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 7).
RC TISSUE=Spleen, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Liver;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
RC TISSUE=Cerebellum, Endometrium, and Hippocampus;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 16-570 (ISOFORM 1).
RC TISSUE=Heart;
RA Fong K.S.K., Fukushima D., de Couet H.G.;
RT "Human homologue of the Drosophila Misato gene.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=17349998; DOI=10.1016/j.yexcr.2007.02.004;
RA Kimura M., Okano Y.;
RT "Human Misato regulates mitochondrial distribution and morphology.";
RL Exp. Cell Res. 313:1393-1404(2007).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Involved in the regulation of mitochondrial distribution
CC and morphology.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=7;
CC Name=1;
CC IsoId=Q9BUK6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BUK6-2; Sequence=VSP_028056;
CC Name=3;
CC IsoId=Q9BUK6-3; Sequence=VSP_028054;
CC Note=No experimental confirmation available;
CC Name=4;
CC IsoId=Q9BUK6-4; Sequence=VSP_028051, VSP_028052;
CC Note=No experimental confirmation available;
CC Name=5;
CC IsoId=Q9BUK6-5; Sequence=VSP_028050, VSP_028056;
CC Name=6;
CC IsoId=Q9BUK6-6; Sequence=VSP_028049;
CC Name=7;
CC IsoId=Q9BUK6-7; Sequence=VSP_028053, VSP_028055;
CC Note=No experimental confirmation available;
CC -!- TISSUE SPECIFICITY: Present in all cell lines tested (at protein
CC level). Widely expressed.
CC -!- SIMILARITY: Belongs to the misato family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM12424.1; Type=Frameshift; Positions=419;
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DR EMBL; AF111708; AAM12424.1; ALT_FRAME; mRNA.
DR EMBL; AY334564; AAP94730.1; -; mRNA.
DR EMBL; AK001366; BAA91651.1; -; mRNA.
DR EMBL; AK092950; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK222863; BAD96583.1; -; mRNA.
DR EMBL; BX537684; CAD97810.1; -; mRNA.
DR EMBL; CR749791; CAH18652.1; -; mRNA.
DR EMBL; CR936872; CAI59784.1; -; Transcribed_RNA.
DR EMBL; AL353807; CAI13215.1; -; Genomic_DNA.
DR EMBL; AL353807; CAI13216.1; -; Genomic_DNA.
DR EMBL; BC002535; AAH02535.1; -; mRNA.
DR EMBL; AF272833; AAF81794.1; -; mRNA.
DR RefSeq; NP_001243461.1; NM_001256532.1.
DR RefSeq; NP_001243462.1; NM_001256533.1.
DR RefSeq; NP_060586.2; NM_018116.3.
DR UniGene; Hs.656547; -.
DR ProteinModelPortal; Q9BUK6; -.
DR IntAct; Q9BUK6; 4.
DR MINT; MINT-4717955; -.
DR PhosphoSite; Q9BUK6; -.
DR DMDM; 74752357; -.
DR PaxDb; Q9BUK6; -.
DR PRIDE; Q9BUK6; -.
DR DNASU; 55154; -.
DR Ensembl; ENST00000245564; ENSP00000245564; ENSG00000125459.
DR Ensembl; ENST00000368341; ENSP00000357325; ENSG00000125459.
DR GeneID; 55154; -.
DR KEGG; hsa:55154; -.
DR UCSC; uc001fky.4; human.
DR CTD; 55154; -.
DR GeneCards; GC01P155580; -.
DR H-InvDB; HIX0001133; -.
DR HGNC; HGNC:29678; MSTO1.
DR neXtProt; NX_Q9BUK6; -.
DR PharmGKB; PA142671313; -.
DR eggNOG; NOG258372; -.
DR HOVERGEN; HBG108151; -.
DR InParanoid; Q9BUK6; -.
DR OMA; GTHWWNL; -.
DR OrthoDB; EOG7HB58T; -.
DR PhylomeDB; Q9BUK6; -.
DR GeneWiki; MSTO1; -.
DR GenomeRNAi; 55154; -.
DR NextBio; 58899; -.
DR PRO; PR:Q9BUK6; -.
DR ArrayExpress; Q9BUK6; -.
DR Bgee; Q9BUK6; -.
DR CleanEx; HS_MSTO1; -.
DR Genevestigator; Q9BUK6; -.
DR GO; GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB.
DR GO; GO:0048311; P:mitochondrion distribution; IMP:UniProtKB.
DR Gene3D; 3.40.50.1440; -; 2.
DR InterPro; IPR019605; Misato_II_tubulin-like.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR Pfam; PF10644; Misat_Tub_SegII; 1.
DR SUPFAM; SSF52490; SSF52490; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Membrane; Mitochondrion;
KW Mitochondrion outer membrane; Phosphoprotein; Polymorphism;
KW Reference proteome.
FT CHAIN 1 570 Protein misato homolog 1.
FT /FTId=PRO_0000304626.
FT MOD_RES 495 495 Phosphoserine.
FT VAR_SEQ 1 388 Missing (in isoform 6).
FT /FTId=VSP_028049.
FT VAR_SEQ 1 178 Missing (in isoform 5).
FT /FTId=VSP_028050.
FT VAR_SEQ 98 99 QG -> EC (in isoform 4).
FT /FTId=VSP_028051.
FT VAR_SEQ 100 570 Missing (in isoform 4).
FT /FTId=VSP_028052.
FT VAR_SEQ 105 139 Missing (in isoform 7).
FT /FTId=VSP_028053.
FT VAR_SEQ 489 500 Missing (in isoform 3).
FT /FTId=VSP_028054.
FT VAR_SEQ 489 499 Missing (in isoform 7).
FT /FTId=VSP_028055.
FT VAR_SEQ 499 499 Missing (in isoform 2 and isoform 5).
FT /FTId=VSP_028056.
FT VARIANT 324 324 T -> I (in dbSNP:rs622288).
FT /FTId=VAR_035046.
FT CONFLICT 389 389 M -> V (in Ref. 3; BAA91651).
FT CONFLICT 482 482 F -> S (in Ref. 3; AK092950).
FT CONFLICT 563 563 Q -> P (in Ref. 5; CAI59784).
SQ SEQUENCE 570 AA; 61835 MW; A139748AF2798619 CRC64;
MAGGAREVLT LQLGHFAGFV GAHWWNQQDA ALGRATDSKE PPGELCPDVL YRTGRTLHGQ
ETYTPRLILM DLKGSLSSLK EEGGLYRDKQ LDAAIAWQGK LTTHKEELYP KNPYLQDFLS
AEGVLSSDGV WRVKSIPNGK GSSPLPTATT PKPLIPTEAS IRVWSDFLRV HLHPRSICMI
QKYNHDGEAG RLEAFGQGES VLKEPKYQEE LEDRLHFYVE ECDYLQGFQI LCDLHDGFSG
VGAKAAELLQ DEYSGRGIIT WGLLPGPYHR GEAQRNIYRL LNTAFGLVHL TAHSSLVCPL
SLGGSLGLRP EPPVSFPYLH YDATLPFHCS AILATALDTV TVPYRLCSSP VSMVHLADML
SFCGKKVVTA GAIIPFPLAP GQSLPDSLMQ FGGATPWTPL SACGEPSGTR CFAQSVVLRG
IDRACHTSQL TPGTPPPSAL HACTTGEEIL AQYLQQQQPG VMSSSHLLLT PCRVAPPYPH
LFSSCSPPGM VLDGSPKGAA VESIPVFGAL CSSSSLHQTL EALARDLTKL DLRRWASFMD
AGVEHDDVAE LLQELQSLAQ CYQGGDSLVD
//