Full text data of MTCH2
MTCH2
(MIMP)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Mitochondrial carrier homolog 2 (Met-induced mitochondrial protein)
Mitochondrial carrier homolog 2 (Met-induced mitochondrial protein)
UniProt
Q9Y6C9
ID MTCH2_HUMAN Reviewed; 303 AA.
AC Q9Y6C9; B2R7L8;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-NOV-1999, sequence version 1.
DT 22-JAN-2014, entry version 102.
DE RecName: Full=Mitochondrial carrier homolog 2;
DE AltName: Full=Met-induced mitochondrial protein;
GN Name=MTCH2; Synonyms=MIMP; ORFNames=HSPC032;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12407445; DOI=10.1038/sj.neo.7900272;
RA Yerushalmi G.M., Leibowitz-Amit R., Shaharabany M., Tsarfaty I.;
RT "Met-HGF/SF signal transduction induces mimp, a novel mitochondrial
RT carrier homologue, which leads to mitochondrial depolarization.";
RL Neoplasia 4:510-522(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Jang J.S., Hahn Y., Park C., Chung J.H.;
RT "Identification of an evolutionary conserved mitochondrial carrier
RT family from various organisms.";
RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Umbilical cord blood;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for
RT 300 previously undefined genes expressed in CD34+ hematopoietic
RT stem/progenitor cells.";
RL Genome Res. 10:1546-1560(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PROTEIN SEQUENCE OF 78-90; 112-122; 132-155 AND 281-287, AND MASS
RP SPECTROMETRY.
RC TISSUE=B-cell lymphoma;
RA Bienvenut W.V.;
RL Submitted (JUN-2005) to UniProtKB.
RN [8]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: The substrate transported is not yet known. Induces
CC mitochondrial depolarization.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC membrane protein (Potential).
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29)
CC family.
CC -!- SIMILARITY: Contains 2 Solcar repeats.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY380792; AAQ88168.1; -; mRNA.
DR EMBL; AF176008; AAD52646.1; -; mRNA.
DR EMBL; AF085361; AAD40196.1; -; mRNA.
DR EMBL; AK313032; BAG35865.1; -; mRNA.
DR EMBL; CH471064; EAW67892.1; -; Genomic_DNA.
DR EMBL; BC000875; AAH00875.1; -; mRNA.
DR RefSeq; NP_055157.1; NM_014342.3.
DR UniGene; Hs.269944; -.
DR ProteinModelPortal; Q9Y6C9; -.
DR IntAct; Q9Y6C9; 1.
DR MINT; MINT-4657883; -.
DR STRING; 9606.ENSP00000303222; -.
DR TCDB; 2.A.29.25.2; the mitochondrial carrier (mc) family.
DR PhosphoSite; Q9Y6C9; -.
DR DMDM; 67461088; -.
DR PaxDb; Q9Y6C9; -.
DR PeptideAtlas; Q9Y6C9; -.
DR PRIDE; Q9Y6C9; -.
DR DNASU; 23788; -.
DR Ensembl; ENST00000302503; ENSP00000303222; ENSG00000109919.
DR GeneID; 23788; -.
DR KEGG; hsa:23788; -.
DR UCSC; uc010rho.2; human.
DR CTD; 23788; -.
DR GeneCards; GC11M048804; -.
DR HGNC; HGNC:17587; MTCH2.
DR HPA; HPA038385; -.
DR HPA; HPA038390; -.
DR MIM; 613221; gene.
DR neXtProt; NX_Q9Y6C9; -.
DR PharmGKB; PA134951260; -.
DR eggNOG; NOG311439; -.
DR HOGENOM; HOG000231394; -.
DR HOVERGEN; HBG058632; -.
DR InParanoid; Q9Y6C9; -.
DR OMA; QHYQECD; -.
DR OrthoDB; EOG7966H6; -.
DR PhylomeDB; Q9Y6C9; -.
DR GeneWiki; MTCH2; -.
DR GenomeRNAi; 23788; -.
DR NextBio; 46797; -.
DR PRO; PR:Q9Y6C9; -.
DR ArrayExpress; Q9Y6C9; -.
DR Bgee; Q9Y6C9; -.
DR CleanEx; HS_MTCH2; -.
DR Genevestigator; Q9Y6C9; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom.
DR Pfam; PF00153; Mito_carr; 1.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 2.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Direct protein sequencing; Membrane;
KW Mitochondrion; Mitochondrion inner membrane; Polymorphism;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW Transport.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 303 Mitochondrial carrier homolog 2.
FT /FTId=PRO_0000090637.
FT TRANSMEM 8 28 Helical; (Potential).
FT TRANSMEM 175 195 Helical; (Potential).
FT TRANSMEM 224 244 Helical; (Potential).
FT REPEAT 2 98 Solcar 1.
FT REPEAT 118 206 Solcar 2.
FT MOD_RES 2 2 N-acetylalanine.
FT VARIANT 68 68 R -> S (in dbSNP:rs34072236).
FT /FTId=VAR_050128.
FT VARIANT 290 290 P -> A (in dbSNP:rs1064608).
FT /FTId=VAR_050129.
SQ SEQUENCE 303 AA; 33331 MW; 339087A8AF4A4508 CRC64;
MADAASQVLL GSGLTILSQP LMYVKVLIQV GYEPLPPTIG RNIFGRQVCQ LPGLFSYAQH
IASIDGRRGL FTGLTPRLCS GVLGTVVHGK VLQHYQESDK GEELGPGNVQ KEVSSSFDHV
IKETTREMIA RSAATLITHP FHVITLRSMV QFIGRESKYC GLCDSIITIY REEGILGFFA
GLVPRLLGDI LSLWLCNSLA YLVNTYALDS GVSTMNEMKS YSQAVTGFFA SMLTYPFVLV
SNLMAVNNCG LAGGCPPYSP IYTSWIDCWC MLQKEGNMSR GNSLFFRKVP FGKTYCCDLK
MLI
//
ID MTCH2_HUMAN Reviewed; 303 AA.
AC Q9Y6C9; B2R7L8;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-NOV-1999, sequence version 1.
DT 22-JAN-2014, entry version 102.
DE RecName: Full=Mitochondrial carrier homolog 2;
DE AltName: Full=Met-induced mitochondrial protein;
GN Name=MTCH2; Synonyms=MIMP; ORFNames=HSPC032;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12407445; DOI=10.1038/sj.neo.7900272;
RA Yerushalmi G.M., Leibowitz-Amit R., Shaharabany M., Tsarfaty I.;
RT "Met-HGF/SF signal transduction induces mimp, a novel mitochondrial
RT carrier homologue, which leads to mitochondrial depolarization.";
RL Neoplasia 4:510-522(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Jang J.S., Hahn Y., Park C., Chung J.H.;
RT "Identification of an evolutionary conserved mitochondrial carrier
RT family from various organisms.";
RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Umbilical cord blood;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for
RT 300 previously undefined genes expressed in CD34+ hematopoietic
RT stem/progenitor cells.";
RL Genome Res. 10:1546-1560(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PROTEIN SEQUENCE OF 78-90; 112-122; 132-155 AND 281-287, AND MASS
RP SPECTROMETRY.
RC TISSUE=B-cell lymphoma;
RA Bienvenut W.V.;
RL Submitted (JUN-2005) to UniProtKB.
RN [8]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: The substrate transported is not yet known. Induces
CC mitochondrial depolarization.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC membrane protein (Potential).
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29)
CC family.
CC -!- SIMILARITY: Contains 2 Solcar repeats.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY380792; AAQ88168.1; -; mRNA.
DR EMBL; AF176008; AAD52646.1; -; mRNA.
DR EMBL; AF085361; AAD40196.1; -; mRNA.
DR EMBL; AK313032; BAG35865.1; -; mRNA.
DR EMBL; CH471064; EAW67892.1; -; Genomic_DNA.
DR EMBL; BC000875; AAH00875.1; -; mRNA.
DR RefSeq; NP_055157.1; NM_014342.3.
DR UniGene; Hs.269944; -.
DR ProteinModelPortal; Q9Y6C9; -.
DR IntAct; Q9Y6C9; 1.
DR MINT; MINT-4657883; -.
DR STRING; 9606.ENSP00000303222; -.
DR TCDB; 2.A.29.25.2; the mitochondrial carrier (mc) family.
DR PhosphoSite; Q9Y6C9; -.
DR DMDM; 67461088; -.
DR PaxDb; Q9Y6C9; -.
DR PeptideAtlas; Q9Y6C9; -.
DR PRIDE; Q9Y6C9; -.
DR DNASU; 23788; -.
DR Ensembl; ENST00000302503; ENSP00000303222; ENSG00000109919.
DR GeneID; 23788; -.
DR KEGG; hsa:23788; -.
DR UCSC; uc010rho.2; human.
DR CTD; 23788; -.
DR GeneCards; GC11M048804; -.
DR HGNC; HGNC:17587; MTCH2.
DR HPA; HPA038385; -.
DR HPA; HPA038390; -.
DR MIM; 613221; gene.
DR neXtProt; NX_Q9Y6C9; -.
DR PharmGKB; PA134951260; -.
DR eggNOG; NOG311439; -.
DR HOGENOM; HOG000231394; -.
DR HOVERGEN; HBG058632; -.
DR InParanoid; Q9Y6C9; -.
DR OMA; QHYQECD; -.
DR OrthoDB; EOG7966H6; -.
DR PhylomeDB; Q9Y6C9; -.
DR GeneWiki; MTCH2; -.
DR GenomeRNAi; 23788; -.
DR NextBio; 46797; -.
DR PRO; PR:Q9Y6C9; -.
DR ArrayExpress; Q9Y6C9; -.
DR Bgee; Q9Y6C9; -.
DR CleanEx; HS_MTCH2; -.
DR Genevestigator; Q9Y6C9; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom.
DR Pfam; PF00153; Mito_carr; 1.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 2.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Direct protein sequencing; Membrane;
KW Mitochondrion; Mitochondrion inner membrane; Polymorphism;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW Transport.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 303 Mitochondrial carrier homolog 2.
FT /FTId=PRO_0000090637.
FT TRANSMEM 8 28 Helical; (Potential).
FT TRANSMEM 175 195 Helical; (Potential).
FT TRANSMEM 224 244 Helical; (Potential).
FT REPEAT 2 98 Solcar 1.
FT REPEAT 118 206 Solcar 2.
FT MOD_RES 2 2 N-acetylalanine.
FT VARIANT 68 68 R -> S (in dbSNP:rs34072236).
FT /FTId=VAR_050128.
FT VARIANT 290 290 P -> A (in dbSNP:rs1064608).
FT /FTId=VAR_050129.
SQ SEQUENCE 303 AA; 33331 MW; 339087A8AF4A4508 CRC64;
MADAASQVLL GSGLTILSQP LMYVKVLIQV GYEPLPPTIG RNIFGRQVCQ LPGLFSYAQH
IASIDGRRGL FTGLTPRLCS GVLGTVVHGK VLQHYQESDK GEELGPGNVQ KEVSSSFDHV
IKETTREMIA RSAATLITHP FHVITLRSMV QFIGRESKYC GLCDSIITIY REEGILGFFA
GLVPRLLGDI LSLWLCNSLA YLVNTYALDS GVSTMNEMKS YSQAVTGFFA SMLTYPFVLV
SNLMAVNNCG LAGGCPPYSP IYTSWIDCWC MLQKEGNMSR GNSLFFRKVP FGKTYCCDLK
MLI
//
MIM
613221
*RECORD*
*FIELD* NO
613221
*FIELD* TI
*613221 MITOCHONDRIAL CARRIER HOMOLOG 2; MTCH2
;;MET-INDUCED MITOCHONDRIAL PROTEIN; MIMP
read more*FIELD* TX
CLONING
Yerushalmi et al. (2002) cloned mouse Mtch2, which they called Mimp, and
they identified human MIMP by database analysis. The mouse and human
MIMP proteins contain 303 amino acids and share 93% identity. Mimp has
characteristics of a mitochondrial carrier protein, including 6
transmembrane domains, weak tandem repeats, and an energy transfer
signature motif. Northern blot and RNA dot-blot analyses of mouse
tissues revealed ubiquitous expression. Expression was highest in testis
and brain and moderate in smooth muscle, thyroid, submaxillary gland,
and epididymis. MIMP was also expressed in a number of human epithelial
cell lines. Transfection of epitope-tagged Mimp followed by
immunohistochemical analysis and subcellular fractionation experiments
confirmed that Mimp is a mitochondrial protein.
GENE FUNCTION
Using differential display, Yerushalmi et al. (2002) showed that
expression of mouse Mimp was upregulated by the Met (167860)-hepatocyte
growth factor (HGF; 142409) signaling pathway. Activation of an
inducible Mimp expression vector in a mouse adenocarcinoma cell line led
to dose-dependent mitochondrial depolarization.
GENE STRUCTURE
Yerushalmi et al. (2002) determined that the MTCH2 gene has 13 exons and
spans at least 29 kb.
Willer et al. (2009) performed a metaanalysis of 15 genomewide
association studies for BMI comprising 32,387 participants and followed
up top signals in 14 additional cohorts comprising 59,082 participants.
Willer et al. (2009) identified dbSNP rs10838738 in the MTCH2 gene as
causing a per-allele change in BMI of 0.07 with an overall P value of
1.9 x 10(-11).
MAPPING
By genomic sequence analysis, Yerushalmi et al. (2002) mapped the MTCH2
gene to chromosome 11q12.1.
*FIELD* RF
1. Willer, C. J.; Speliotes, E. K.; Loos, R. J. F.; Li, S.; Lindgren,
C. M.; Heid, I. M.; Berndt, S. I.; Elliott, A. L.; Jackson, A. U.;
Lamina, C.; Lettre, G.; Lim, N.; and 134 others: Six new loci associated
with body mass index highlight a neuronal influence on body weight
regulation. Nature Genet. 41: 25-34, 2009.
2. Yerushalmi, G. M.; Leibowitz-Amit, R.; Shaharabany, M.; Tsarfaty,
I.: Met-HGF/SF signal transduction induces Mimp, a novel mitochondrial
carrier homologue, which leads to mitochondrial depolarization. Neoplasia 4:
510-522, 2002.
*FIELD* CN
Ada Hamosh - updated: 1/15/2010
*FIELD* CD
Patricia A. Hartz: 1/13/2010
*FIELD* ED
alopez: 01/19/2010
terry: 1/15/2010
mgross: 1/13/2010
*RECORD*
*FIELD* NO
613221
*FIELD* TI
*613221 MITOCHONDRIAL CARRIER HOMOLOG 2; MTCH2
;;MET-INDUCED MITOCHONDRIAL PROTEIN; MIMP
read more*FIELD* TX
CLONING
Yerushalmi et al. (2002) cloned mouse Mtch2, which they called Mimp, and
they identified human MIMP by database analysis. The mouse and human
MIMP proteins contain 303 amino acids and share 93% identity. Mimp has
characteristics of a mitochondrial carrier protein, including 6
transmembrane domains, weak tandem repeats, and an energy transfer
signature motif. Northern blot and RNA dot-blot analyses of mouse
tissues revealed ubiquitous expression. Expression was highest in testis
and brain and moderate in smooth muscle, thyroid, submaxillary gland,
and epididymis. MIMP was also expressed in a number of human epithelial
cell lines. Transfection of epitope-tagged Mimp followed by
immunohistochemical analysis and subcellular fractionation experiments
confirmed that Mimp is a mitochondrial protein.
GENE FUNCTION
Using differential display, Yerushalmi et al. (2002) showed that
expression of mouse Mimp was upregulated by the Met (167860)-hepatocyte
growth factor (HGF; 142409) signaling pathway. Activation of an
inducible Mimp expression vector in a mouse adenocarcinoma cell line led
to dose-dependent mitochondrial depolarization.
GENE STRUCTURE
Yerushalmi et al. (2002) determined that the MTCH2 gene has 13 exons and
spans at least 29 kb.
Willer et al. (2009) performed a metaanalysis of 15 genomewide
association studies for BMI comprising 32,387 participants and followed
up top signals in 14 additional cohorts comprising 59,082 participants.
Willer et al. (2009) identified dbSNP rs10838738 in the MTCH2 gene as
causing a per-allele change in BMI of 0.07 with an overall P value of
1.9 x 10(-11).
MAPPING
By genomic sequence analysis, Yerushalmi et al. (2002) mapped the MTCH2
gene to chromosome 11q12.1.
*FIELD* RF
1. Willer, C. J.; Speliotes, E. K.; Loos, R. J. F.; Li, S.; Lindgren,
C. M.; Heid, I. M.; Berndt, S. I.; Elliott, A. L.; Jackson, A. U.;
Lamina, C.; Lettre, G.; Lim, N.; and 134 others: Six new loci associated
with body mass index highlight a neuronal influence on body weight
regulation. Nature Genet. 41: 25-34, 2009.
2. Yerushalmi, G. M.; Leibowitz-Amit, R.; Shaharabany, M.; Tsarfaty,
I.: Met-HGF/SF signal transduction induces Mimp, a novel mitochondrial
carrier homologue, which leads to mitochondrial depolarization. Neoplasia 4:
510-522, 2002.
*FIELD* CN
Ada Hamosh - updated: 1/15/2010
*FIELD* CD
Patricia A. Hartz: 1/13/2010
*FIELD* ED
alopez: 01/19/2010
terry: 1/15/2010
mgross: 1/13/2010