Full text data of MYADM
MYADM
[Confidence: low (only semi-automatic identification from reviews)]
Myeloid-associated differentiation marker (Protein SB135)
Myeloid-associated differentiation marker (Protein SB135)
UniProt
Q96S97
ID MYADM_HUMAN Reviewed; 322 AA.
AC Q96S97; B2RE58; Q542Z1; Q7Z507; Q8N9R4; Q96CS6; Q96SK9;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2002, sequence version 2.
DT 22-JAN-2014, entry version 97.
DE RecName: Full=Myeloid-associated differentiation marker;
DE AltName: Full=Protein SB135;
GN Name=MYADM; ORFNames=UNQ553/PRO1110;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Bone marrow;
RX PubMed=12075932; DOI=10.1023/A:1015288412047;
RA Cui W., Yu L., He H., Chu Y., Gao J., Wan B., Tang L., Zhao S.;
RT "Cloning of human myeloid-associated differentiation marker (MYADM)
RT gene whose expression was up-regulated in NB4 cells induced by all-
RT trans retinoic acid.";
RL Mol. Biol. Rep. 28:123-138(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Li N., Wan T., Zhang W., Cao X.;
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma, and Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thyroid;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-
RT length human cDNAs encoding secretion or membrane proteins from oligo-
RT capped cDNA libraries.";
RL DNA Res. 12:117-126(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Probable).
CC -!- TISSUE SPECIFICITY: Widely expressed. Not detected in thymus.
CC -!- SIMILARITY: Belongs to the MAL family.
CC -!- SIMILARITY: Contains 2 MARVEL domains.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP97182.1; Type=Frameshift; Positions=228, 277, 278;
CC Sequence=BAB55302.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF087882; AAP97182.1; ALT_FRAME; mRNA.
DR EMBL; AY037147; AAK67628.2; -; mRNA.
DR EMBL; AY358582; AAQ88945.1; -; mRNA.
DR EMBL; AK027693; BAB55302.1; ALT_INIT; mRNA.
DR EMBL; AK093999; BAC04265.1; -; mRNA.
DR EMBL; AK075276; BAC11513.1; -; mRNA.
DR EMBL; AK316566; BAG38155.1; -; mRNA.
DR EMBL; CH471135; EAW72159.1; -; Genomic_DNA.
DR EMBL; BC013995; AAH13995.1; -; mRNA.
DR EMBL; BC095412; AAH95412.1; -; mRNA.
DR RefSeq; NP_001018654.1; NM_001020818.1.
DR RefSeq; NP_001018655.1; NM_001020819.1.
DR RefSeq; NP_001018656.1; NM_001020820.1.
DR RefSeq; NP_001018657.1; NM_001020821.1.
DR RefSeq; NP_612382.1; NM_138373.3.
DR UniGene; Hs.380906; -.
DR ProteinModelPortal; Q96S97; -.
DR TCDB; 1.A.64.3.1; the plasmolipin (plasmolipin) family.
DR PhosphoSite; Q96S97; -.
DR DMDM; 21263793; -.
DR PaxDb; Q96S97; -.
DR PeptideAtlas; Q96S97; -.
DR PRIDE; Q96S97; -.
DR Ensembl; ENST00000336967; ENSP00000337222; ENSG00000179820.
DR Ensembl; ENST00000391768; ENSP00000375648; ENSG00000179820.
DR Ensembl; ENST00000391769; ENSP00000375649; ENSG00000179820.
DR Ensembl; ENST00000391770; ENSP00000375650; ENSG00000179820.
DR Ensembl; ENST00000391771; ENSP00000375651; ENSG00000179820.
DR GeneID; 91663; -.
DR KEGG; hsa:91663; -.
DR UCSC; uc002qcl.3; human.
DR CTD; 91663; -.
DR GeneCards; GC19P054369; -.
DR HGNC; HGNC:7544; MYADM.
DR MIM; 609959; gene.
DR neXtProt; NX_Q96S97; -.
DR PharmGKB; PA31344; -.
DR eggNOG; NOG286453; -.
DR HOVERGEN; HBG052545; -.
DR InParanoid; Q96S97; -.
DR OMA; FPITYAC; -.
DR PhylomeDB; Q96S97; -.
DR ChiTaRS; MYADM; human.
DR GeneWiki; MYADM; -.
DR GenomeRNAi; 91663; -.
DR NextBio; 77374; -.
DR PRO; PR:Q96S97; -.
DR ArrayExpress; Q96S97; -.
DR Bgee; Q96S97; -.
DR CleanEx; HS_MYADM; -.
DR Genevestigator; Q96S97; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 2.
DR PROSITE; PS51225; MARVEL; 2.
PE 1: Evidence at protein level;
KW Complete proteome; Membrane; Phosphoprotein; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1 322 Myeloid-associated differentiation
FT marker.
FT /FTId=PRO_0000156816.
FT TRANSMEM 41 61 Helical; (Potential).
FT TRANSMEM 70 90 Helical; (Potential).
FT TRANSMEM 101 121 Helical; (Potential).
FT TRANSMEM 137 157 Helical; (Potential).
FT TRANSMEM 171 191 Helical; (Potential).
FT TRANSMEM 203 223 Helical; (Potential).
FT TRANSMEM 239 259 Helical; (Potential).
FT TRANSMEM 294 314 Helical; (Potential).
FT DOMAIN 31 163 MARVEL 1.
FT DOMAIN 168 319 MARVEL 2.
FT MOD_RES 22 22 Phosphoserine.
FT CONFLICT 77 94 Missing (in Ref. 4; BAC04265).
FT CONFLICT 279 279 C -> G (in Ref. 1).
SQ SEQUENCE 322 AA; 35274 MW; A92142CC63625A4E CRC64;
MPVTVTRTTI TTTTTSSSGL GSPMIVGSPR ALTQPLGLLR LLQLVSTCVA FSLVASVGAW
TGSMGNWSMF TWCFCFSVTL IILIVELCGL QARFPLSWRN FPITFACYAA LFCLSASIIY
PTTYVQFLSH GRSRDHAIAA TFFSCIACVA YATEVAWTRA RPGEITGYMA TVPGLLKVLE
TFVACIIFAF ISDPNLYQHQ PALEWCVAVY AICFILAAIA ILLNLGECTN VLPIPFPSFL
SGLALLSVLL YATALVLWPL YQFDEKYGGQ PRRSRDVSCS RSHAYYVCAW DRRLAVAILT
AINLLAYVAD LVHSAHLVFV KV
//
ID MYADM_HUMAN Reviewed; 322 AA.
AC Q96S97; B2RE58; Q542Z1; Q7Z507; Q8N9R4; Q96CS6; Q96SK9;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2002, sequence version 2.
DT 22-JAN-2014, entry version 97.
DE RecName: Full=Myeloid-associated differentiation marker;
DE AltName: Full=Protein SB135;
GN Name=MYADM; ORFNames=UNQ553/PRO1110;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Bone marrow;
RX PubMed=12075932; DOI=10.1023/A:1015288412047;
RA Cui W., Yu L., He H., Chu Y., Gao J., Wan B., Tang L., Zhao S.;
RT "Cloning of human myeloid-associated differentiation marker (MYADM)
RT gene whose expression was up-regulated in NB4 cells induced by all-
RT trans retinoic acid.";
RL Mol. Biol. Rep. 28:123-138(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Li N., Wan T., Zhang W., Cao X.;
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma, and Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thyroid;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-
RT length human cDNAs encoding secretion or membrane proteins from oligo-
RT capped cDNA libraries.";
RL DNA Res. 12:117-126(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Probable).
CC -!- TISSUE SPECIFICITY: Widely expressed. Not detected in thymus.
CC -!- SIMILARITY: Belongs to the MAL family.
CC -!- SIMILARITY: Contains 2 MARVEL domains.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP97182.1; Type=Frameshift; Positions=228, 277, 278;
CC Sequence=BAB55302.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF087882; AAP97182.1; ALT_FRAME; mRNA.
DR EMBL; AY037147; AAK67628.2; -; mRNA.
DR EMBL; AY358582; AAQ88945.1; -; mRNA.
DR EMBL; AK027693; BAB55302.1; ALT_INIT; mRNA.
DR EMBL; AK093999; BAC04265.1; -; mRNA.
DR EMBL; AK075276; BAC11513.1; -; mRNA.
DR EMBL; AK316566; BAG38155.1; -; mRNA.
DR EMBL; CH471135; EAW72159.1; -; Genomic_DNA.
DR EMBL; BC013995; AAH13995.1; -; mRNA.
DR EMBL; BC095412; AAH95412.1; -; mRNA.
DR RefSeq; NP_001018654.1; NM_001020818.1.
DR RefSeq; NP_001018655.1; NM_001020819.1.
DR RefSeq; NP_001018656.1; NM_001020820.1.
DR RefSeq; NP_001018657.1; NM_001020821.1.
DR RefSeq; NP_612382.1; NM_138373.3.
DR UniGene; Hs.380906; -.
DR ProteinModelPortal; Q96S97; -.
DR TCDB; 1.A.64.3.1; the plasmolipin (plasmolipin) family.
DR PhosphoSite; Q96S97; -.
DR DMDM; 21263793; -.
DR PaxDb; Q96S97; -.
DR PeptideAtlas; Q96S97; -.
DR PRIDE; Q96S97; -.
DR Ensembl; ENST00000336967; ENSP00000337222; ENSG00000179820.
DR Ensembl; ENST00000391768; ENSP00000375648; ENSG00000179820.
DR Ensembl; ENST00000391769; ENSP00000375649; ENSG00000179820.
DR Ensembl; ENST00000391770; ENSP00000375650; ENSG00000179820.
DR Ensembl; ENST00000391771; ENSP00000375651; ENSG00000179820.
DR GeneID; 91663; -.
DR KEGG; hsa:91663; -.
DR UCSC; uc002qcl.3; human.
DR CTD; 91663; -.
DR GeneCards; GC19P054369; -.
DR HGNC; HGNC:7544; MYADM.
DR MIM; 609959; gene.
DR neXtProt; NX_Q96S97; -.
DR PharmGKB; PA31344; -.
DR eggNOG; NOG286453; -.
DR HOVERGEN; HBG052545; -.
DR InParanoid; Q96S97; -.
DR OMA; FPITYAC; -.
DR PhylomeDB; Q96S97; -.
DR ChiTaRS; MYADM; human.
DR GeneWiki; MYADM; -.
DR GenomeRNAi; 91663; -.
DR NextBio; 77374; -.
DR PRO; PR:Q96S97; -.
DR ArrayExpress; Q96S97; -.
DR Bgee; Q96S97; -.
DR CleanEx; HS_MYADM; -.
DR Genevestigator; Q96S97; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 2.
DR PROSITE; PS51225; MARVEL; 2.
PE 1: Evidence at protein level;
KW Complete proteome; Membrane; Phosphoprotein; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1 322 Myeloid-associated differentiation
FT marker.
FT /FTId=PRO_0000156816.
FT TRANSMEM 41 61 Helical; (Potential).
FT TRANSMEM 70 90 Helical; (Potential).
FT TRANSMEM 101 121 Helical; (Potential).
FT TRANSMEM 137 157 Helical; (Potential).
FT TRANSMEM 171 191 Helical; (Potential).
FT TRANSMEM 203 223 Helical; (Potential).
FT TRANSMEM 239 259 Helical; (Potential).
FT TRANSMEM 294 314 Helical; (Potential).
FT DOMAIN 31 163 MARVEL 1.
FT DOMAIN 168 319 MARVEL 2.
FT MOD_RES 22 22 Phosphoserine.
FT CONFLICT 77 94 Missing (in Ref. 4; BAC04265).
FT CONFLICT 279 279 C -> G (in Ref. 1).
SQ SEQUENCE 322 AA; 35274 MW; A92142CC63625A4E CRC64;
MPVTVTRTTI TTTTTSSSGL GSPMIVGSPR ALTQPLGLLR LLQLVSTCVA FSLVASVGAW
TGSMGNWSMF TWCFCFSVTL IILIVELCGL QARFPLSWRN FPITFACYAA LFCLSASIIY
PTTYVQFLSH GRSRDHAIAA TFFSCIACVA YATEVAWTRA RPGEITGYMA TVPGLLKVLE
TFVACIIFAF ISDPNLYQHQ PALEWCVAVY AICFILAAIA ILLNLGECTN VLPIPFPSFL
SGLALLSVLL YATALVLWPL YQFDEKYGGQ PRRSRDVSCS RSHAYYVCAW DRRLAVAILT
AINLLAYVAD LVHSAHLVFV KV
//
MIM
609959
*RECORD*
*FIELD* NO
609959
*FIELD* TI
*609959 MYELOID-ASSOCIATED DIFFERENTIATION MARKER; MYADM
*FIELD* TX
CLONING
Using differential display analysis, Pettersson et al. (2000) identified
read moremouse myeloid-associated differentiation marker (Myadm) based upon its
varied expression during differentiation of an Il3 (147740)-dependent
myeloid progenitor cell line established from mouse bone marrow. The
deduced protein contains 8 potential transmembrane domains and several
potential phosphorylation sites. Northern blot analysis on hematopoietic
cell lines revealed restricted expression of Myadm to cells belonging to
the myeloid lineage. Expression was also seen in mature granulocytes and
macrophages. Tissue analysis showed high expression of Myadm in lung and
more moderate expression in bone marrow and brain. RT-PCR experiments
demonstrated expression of Myadm in multipotent cells
(c-kit+Sca-1+Lin-), erythroid progenitors, and early lymphoid
progenitors.
By database searching with mouse Myadm as query, Cui et al. (2002)
identified human MYADM and cloned a full-length MYADM sequence from a
human bone marrow cDNA library. The deduced 298-amino acid protein has a
predicted molecular mass of 32 kD. It contains 7 predicted transmembrane
domains and shows sequence homology with the T-cell differentiation
protein MAL (188860) and plasmolipin (PLMP; 600340). MYADM shares 75.8%
overall sequence identity with mouse Myadm, with highest levels of
conservation seen in the predicted transmembrane regions. Northern blot
analysis detected 3.3- and 2.2-kb MYADM transcripts. Expression of the
longer transcript was seen in all tissues tested except thymus;
expression of the shorter transcript was seen in heart, placenta, lung,
pancreas, testis, and peripheral blood leukocytes and was undetectable
in all other tissues. Semiquantitative PCR assays showed that expression
of MYADM was not only significantly higher in peripheral blood
leukocytes than in bone marrow cells, but was also upregulated in NB4
cells (derived from a patient with acute promyelocytic leukemia) that
were treated with the differentiation inducer all-trans retinoic acid
(ATRA).
GENE FUNCTION
Using antisense Myadm oligonucleotides, Pettersson et al. (2000) showed
that downregulation of mouse Myadm expression in pluripotent
hematopoietic progenitor cells inhibited colony formation.
GENE STRUCTURE
Cui et al. (2002) determined that the MYADM gene contains 3 exons and
spans 7.1 kb.
MAPPING
By radiation hybrid analysis, Cui et al. (2002) mapped the MYADM gene to
chromosome 19q13.33-q13.4.
*FIELD* RF
1. Cui, W.; Yu, L.; He, H.; Chu, Y.; Gao, J.; Wan, B.; Tang, L.; Zhao,
S.: Cloning of human myeloid-associated differentiation marker (MYADM)
gene whose expression was up-regulated in NB4 cells induced by all-trans
retinoic acid. Molec. Biol. Rep. 28: 123-138, 2002.
2. Pettersson, M.; Dannaeus, K.; Nilsson, K.; Jonsson, J.-I.: Isolation
of MYADM, a novel hematopoietic-associated marker gene expressed in
multipotent progenitor cells and up-regulated during myeloid differentiation. J.
Leuko. Biol. 67: 423-431, 2000.
*FIELD* CD
Laura L. Baxter: 3/15/2006
*FIELD* ED
carol: 03/15/2006
*RECORD*
*FIELD* NO
609959
*FIELD* TI
*609959 MYELOID-ASSOCIATED DIFFERENTIATION MARKER; MYADM
*FIELD* TX
CLONING
Using differential display analysis, Pettersson et al. (2000) identified
read moremouse myeloid-associated differentiation marker (Myadm) based upon its
varied expression during differentiation of an Il3 (147740)-dependent
myeloid progenitor cell line established from mouse bone marrow. The
deduced protein contains 8 potential transmembrane domains and several
potential phosphorylation sites. Northern blot analysis on hematopoietic
cell lines revealed restricted expression of Myadm to cells belonging to
the myeloid lineage. Expression was also seen in mature granulocytes and
macrophages. Tissue analysis showed high expression of Myadm in lung and
more moderate expression in bone marrow and brain. RT-PCR experiments
demonstrated expression of Myadm in multipotent cells
(c-kit+Sca-1+Lin-), erythroid progenitors, and early lymphoid
progenitors.
By database searching with mouse Myadm as query, Cui et al. (2002)
identified human MYADM and cloned a full-length MYADM sequence from a
human bone marrow cDNA library. The deduced 298-amino acid protein has a
predicted molecular mass of 32 kD. It contains 7 predicted transmembrane
domains and shows sequence homology with the T-cell differentiation
protein MAL (188860) and plasmolipin (PLMP; 600340). MYADM shares 75.8%
overall sequence identity with mouse Myadm, with highest levels of
conservation seen in the predicted transmembrane regions. Northern blot
analysis detected 3.3- and 2.2-kb MYADM transcripts. Expression of the
longer transcript was seen in all tissues tested except thymus;
expression of the shorter transcript was seen in heart, placenta, lung,
pancreas, testis, and peripheral blood leukocytes and was undetectable
in all other tissues. Semiquantitative PCR assays showed that expression
of MYADM was not only significantly higher in peripheral blood
leukocytes than in bone marrow cells, but was also upregulated in NB4
cells (derived from a patient with acute promyelocytic leukemia) that
were treated with the differentiation inducer all-trans retinoic acid
(ATRA).
GENE FUNCTION
Using antisense Myadm oligonucleotides, Pettersson et al. (2000) showed
that downregulation of mouse Myadm expression in pluripotent
hematopoietic progenitor cells inhibited colony formation.
GENE STRUCTURE
Cui et al. (2002) determined that the MYADM gene contains 3 exons and
spans 7.1 kb.
MAPPING
By radiation hybrid analysis, Cui et al. (2002) mapped the MYADM gene to
chromosome 19q13.33-q13.4.
*FIELD* RF
1. Cui, W.; Yu, L.; He, H.; Chu, Y.; Gao, J.; Wan, B.; Tang, L.; Zhao,
S.: Cloning of human myeloid-associated differentiation marker (MYADM)
gene whose expression was up-regulated in NB4 cells induced by all-trans
retinoic acid. Molec. Biol. Rep. 28: 123-138, 2002.
2. Pettersson, M.; Dannaeus, K.; Nilsson, K.; Jonsson, J.-I.: Isolation
of MYADM, a novel hematopoietic-associated marker gene expressed in
multipotent progenitor cells and up-regulated during myeloid differentiation. J.
Leuko. Biol. 67: 423-431, 2000.
*FIELD* CD
Laura L. Baxter: 3/15/2006
*FIELD* ED
carol: 03/15/2006