Full text data of N6AMT2
N6AMT2
[Confidence: low (only semi-automatic identification from reviews)]
N(6)-adenine-specific DNA methyltransferase 2; 2.1.1.-
Note: presumably soluble (membrane word is not in UniProt keywords or features)
N(6)-adenine-specific DNA methyltransferase 2; 2.1.1.-
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q8WVE0
ID N6MT2_HUMAN Reviewed; 214 AA.
AC Q8WVE0; B5G4V1;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2002, sequence version 1.
DT 22-JAN-2014, entry version 92.
DE RecName: Full=N(6)-adenine-specific DNA methyltransferase 2;
DE EC=2.1.1.-;
GN Name=N6AMT2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Epididymis;
RX PubMed=18390568; DOI=10.1093/dnares/dsn005;
RA Li J.Y., Wang H.Y., Liu J., Liu Q., Zhang J.S., Wan F.C., Liu F.J.,
RA Jin S.H., Zhang Y.L.;
RT "Transcriptome analysis of a cDNA library from adult human
RT epididymis.";
RL DNA Res. 15:115-122(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E.,
RA Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.,
RA Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R.,
RA Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S.,
RA Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M.,
RA Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J.,
RA Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E.,
RA Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L.,
RA Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J.,
RA Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S.,
RA Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J.,
RA Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M.,
RA King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A.,
RA Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S.,
RA Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I.,
RA Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S.,
RA Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A.,
RA Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L.,
RA Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M.,
RA Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
CC -!- FUNCTION: Putative DNA methyltransferase (By similarity).
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. AML1
CC family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; DQ823637; ABK41021.1; -; mRNA.
DR EMBL; AL512652; CAH71794.1; -; Genomic_DNA.
DR EMBL; CH471075; EAX08277.1; -; Genomic_DNA.
DR EMBL; BC018091; AAH18091.1; -; mRNA.
DR RefSeq; NP_777588.1; NM_174928.1.
DR RefSeq; XP_005266344.1; XM_005266287.1.
DR UniGene; Hs.26674; -.
DR ProteinModelPortal; Q8WVE0; -.
DR STRING; 9606.ENSP00000372202; -.
DR PhosphoSite; Q8WVE0; -.
DR DMDM; 74751547; -.
DR PaxDb; Q8WVE0; -.
DR PRIDE; Q8WVE0; -.
DR DNASU; 221143; -.
DR Ensembl; ENST00000382754; ENSP00000372202; ENSG00000150456.
DR Ensembl; ENST00000382758; ENSP00000372206; ENSG00000150456.
DR GeneID; 221143; -.
DR KEGG; hsa:221143; -.
DR UCSC; uc001uno.1; human.
DR CTD; 221143; -.
DR GeneCards; GC13M021304; -.
DR H-InvDB; HIX0011161; -.
DR HGNC; HGNC:27351; N6AMT2.
DR HPA; HPA040417; -.
DR HPA; HPA042543; -.
DR neXtProt; NX_Q8WVE0; -.
DR PharmGKB; PA162396671; -.
DR eggNOG; NOG127575; -.
DR HOGENOM; HOG000240418; -.
DR HOVERGEN; HBG059901; -.
DR InParanoid; Q8WVE0; -.
DR OMA; GAIMEEQ; -.
DR OrthoDB; EOG7C2R2J; -.
DR PhylomeDB; Q8WVE0; -.
DR GenomeRNAi; 221143; -.
DR NextBio; 91209; -.
DR PRO; PR:Q8WVE0; -.
DR ArrayExpress; Q8WVE0; -.
DR Bgee; Q8WVE0; -.
DR CleanEx; HS_N6AMT2; -.
DR Genevestigator; Q8WVE0; -.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR019369; N6_adenine_Mtase-rel_euk.
DR Pfam; PF10237; N6-adenineMlase; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Methyltransferase; Polymorphism;
KW Reference proteome; Transferase.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 214 N(6)-adenine-specific DNA
FT methyltransferase 2.
FT /FTId=PRO_0000311294.
FT MOD_RES 2 2 N-acetylserine.
FT VARIANT 193 193 T -> N (in dbSNP:rs11549810).
FT /FTId=VAR_037216.
SQ SEQUENCE 214 AA; 24506 MW; 6E16B4052B696552 CRC64;
MSDLEDDETP QLSAHALAAL QEFYAEQKQQ IEPGEDDKYN IGIIEENWQL SQFWYSQETA
LQLAQEAIAA VGEGGRIACV SAPSVYQKLR ELCRENFSIY IFEYDKRFAM YGEEFIFYDY
NNPLDLPERI AAHSFDIVIA DPPYLSEECL RKTSETVKYL TRGKILLCTG AIMEEQAAEL
LGVKMCTFVP RHTRNLANEF RCYVNYDSGL DCGI
//
ID N6MT2_HUMAN Reviewed; 214 AA.
AC Q8WVE0; B5G4V1;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2002, sequence version 1.
DT 22-JAN-2014, entry version 92.
DE RecName: Full=N(6)-adenine-specific DNA methyltransferase 2;
DE EC=2.1.1.-;
GN Name=N6AMT2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Epididymis;
RX PubMed=18390568; DOI=10.1093/dnares/dsn005;
RA Li J.Y., Wang H.Y., Liu J., Liu Q., Zhang J.S., Wan F.C., Liu F.J.,
RA Jin S.H., Zhang Y.L.;
RT "Transcriptome analysis of a cDNA library from adult human
RT epididymis.";
RL DNA Res. 15:115-122(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E.,
RA Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.,
RA Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R.,
RA Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S.,
RA Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M.,
RA Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J.,
RA Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E.,
RA Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L.,
RA Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J.,
RA Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S.,
RA Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J.,
RA Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M.,
RA King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A.,
RA Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S.,
RA Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I.,
RA Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S.,
RA Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A.,
RA Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L.,
RA Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M.,
RA Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
CC -!- FUNCTION: Putative DNA methyltransferase (By similarity).
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. AML1
CC family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; DQ823637; ABK41021.1; -; mRNA.
DR EMBL; AL512652; CAH71794.1; -; Genomic_DNA.
DR EMBL; CH471075; EAX08277.1; -; Genomic_DNA.
DR EMBL; BC018091; AAH18091.1; -; mRNA.
DR RefSeq; NP_777588.1; NM_174928.1.
DR RefSeq; XP_005266344.1; XM_005266287.1.
DR UniGene; Hs.26674; -.
DR ProteinModelPortal; Q8WVE0; -.
DR STRING; 9606.ENSP00000372202; -.
DR PhosphoSite; Q8WVE0; -.
DR DMDM; 74751547; -.
DR PaxDb; Q8WVE0; -.
DR PRIDE; Q8WVE0; -.
DR DNASU; 221143; -.
DR Ensembl; ENST00000382754; ENSP00000372202; ENSG00000150456.
DR Ensembl; ENST00000382758; ENSP00000372206; ENSG00000150456.
DR GeneID; 221143; -.
DR KEGG; hsa:221143; -.
DR UCSC; uc001uno.1; human.
DR CTD; 221143; -.
DR GeneCards; GC13M021304; -.
DR H-InvDB; HIX0011161; -.
DR HGNC; HGNC:27351; N6AMT2.
DR HPA; HPA040417; -.
DR HPA; HPA042543; -.
DR neXtProt; NX_Q8WVE0; -.
DR PharmGKB; PA162396671; -.
DR eggNOG; NOG127575; -.
DR HOGENOM; HOG000240418; -.
DR HOVERGEN; HBG059901; -.
DR InParanoid; Q8WVE0; -.
DR OMA; GAIMEEQ; -.
DR OrthoDB; EOG7C2R2J; -.
DR PhylomeDB; Q8WVE0; -.
DR GenomeRNAi; 221143; -.
DR NextBio; 91209; -.
DR PRO; PR:Q8WVE0; -.
DR ArrayExpress; Q8WVE0; -.
DR Bgee; Q8WVE0; -.
DR CleanEx; HS_N6AMT2; -.
DR Genevestigator; Q8WVE0; -.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR019369; N6_adenine_Mtase-rel_euk.
DR Pfam; PF10237; N6-adenineMlase; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Methyltransferase; Polymorphism;
KW Reference proteome; Transferase.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 214 N(6)-adenine-specific DNA
FT methyltransferase 2.
FT /FTId=PRO_0000311294.
FT MOD_RES 2 2 N-acetylserine.
FT VARIANT 193 193 T -> N (in dbSNP:rs11549810).
FT /FTId=VAR_037216.
SQ SEQUENCE 214 AA; 24506 MW; 6E16B4052B696552 CRC64;
MSDLEDDETP QLSAHALAAL QEFYAEQKQQ IEPGEDDKYN IGIIEENWQL SQFWYSQETA
LQLAQEAIAA VGEGGRIACV SAPSVYQKLR ELCRENFSIY IFEYDKRFAM YGEEFIFYDY
NNPLDLPERI AAHSFDIVIA DPPYLSEECL RKTSETVKYL TRGKILLCTG AIMEEQAAEL
LGVKMCTFVP RHTRNLANEF RCYVNYDSGL DCGI
//