Full text data of SLC8A2
SLC8A2
(KIAA1087, NCX2)
[Confidence: low (only semi-automatic identification from reviews)]
Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2; Solute carrier family 8 member 2; Flags: Precursor)
Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2; Solute carrier family 8 member 2; Flags: Precursor)
UniProt
Q9UPR5
ID NAC2_HUMAN Reviewed; 921 AA.
AC Q9UPR5; B4DYQ9;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2000, sequence version 2.
DT 22-JAN-2014, entry version 109.
DE RecName: Full=Sodium/calcium exchanger 2;
DE AltName: Full=Na(+)/Ca(2+)-exchange protein 2;
DE AltName: Full=Solute carrier family 8 member 2;
DE Flags: Precursor;
GN Name=SLC8A2; Synonyms=KIAA1087, NCX2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=10470851; DOI=10.1093/dnares/6.3.197;
RA Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N.,
RA Tanaka A., Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIV.
RT The complete sequences of 100 new cDNA clones from brain which code
RT for large proteins in vitro.";
RL DNA Res. 6:197-205(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Rapidly transports Ca(2+) during excitation-contraction
CC coupling. Ca(2+) is extruded from the cell during relaxation so as
CC to prevent overloading of intracellular stores (By similarity).
CC -!- ENZYME REGULATION: By ATP (By similarity).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the sodium/potassium/calcium exchanger
CC family. SLC8 subfamily.
CC -!- SIMILARITY: Contains 2 Calx-beta domains.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA83039.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AB029010; BAA83039.1; ALT_INIT; mRNA.
DR EMBL; AK302552; BAG63821.1; -; mRNA.
DR EMBL; CH471126; EAW57485.1; -; Genomic_DNA.
DR RefSeq; NP_055878.1; NM_015063.2.
DR UniGene; Hs.172884; -.
DR ProteinModelPortal; Q9UPR5; -.
DR SMR; Q9UPR5; 394-674.
DR STRING; 9606.ENSP00000236877; -.
DR TCDB; 2.A.19.3.5; the ca(2+):cation antiporter (caca) family.
DR PhosphoSite; Q9UPR5; -.
DR DMDM; 10720116; -.
DR PaxDb; Q9UPR5; -.
DR PRIDE; Q9UPR5; -.
DR DNASU; 6543; -.
DR Ensembl; ENST00000236877; ENSP00000236877; ENSG00000118160.
DR GeneID; 6543; -.
DR KEGG; hsa:6543; -.
DR UCSC; uc002pgx.3; human.
DR CTD; 6543; -.
DR GeneCards; GC19M047931; -.
DR HGNC; HGNC:11069; SLC8A2.
DR HPA; HPA050818; -.
DR HPA; HPA054671; -.
DR MIM; 601901; gene.
DR neXtProt; NX_Q9UPR5; -.
DR PharmGKB; PA313; -.
DR eggNOG; NOG241889; -.
DR HOGENOM; HOG000266971; -.
DR HOVERGEN; HBG006441; -.
DR InParanoid; Q9UPR5; -.
DR KO; K05849; -.
DR OMA; TMEVTVV; -.
DR OrthoDB; EOG7S4X56; -.
DR PhylomeDB; Q9UPR5; -.
DR Reactome; REACT_15518; Transmembrane transport of small molecules.
DR Reactome; REACT_604; Hemostasis.
DR GenomeRNAi; 6543; -.
DR NextBio; 25461; -.
DR PRO; PR:Q9UPR5; -.
DR ArrayExpress; Q9UPR5; -.
DR Bgee; Q9UPR5; -.
DR CleanEx; HS_SLC8A2; -.
DR Genevestigator; Q9UPR5; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:InterPro.
DR GO; GO:0007596; P:blood coagulation; TAS:Reactome.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; TAS:Reactome.
DR GO; GO:0055085; P:transmembrane transport; TAS:Reactome.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR004836; Na_Ca_Ex.
DR InterPro; IPR004837; NaCa_Exmemb.
DR Pfam; PF03160; Calx-beta; 2.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR PRINTS; PR01259; NACAEXCHNGR.
DR SMART; SM00237; Calx_beta; 2.
DR TIGRFAMs; TIGR00845; caca; 1.
PE 2: Evidence at transcript level;
KW Antiport; Calcium; Calcium transport; Calmodulin-binding;
KW Complete proteome; Glycoprotein; Ion transport; Membrane;
KW Polymorphism; Reference proteome; Repeat; Signal; Sodium;
KW Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1 20 Potential.
FT CHAIN 21 921 Sodium/calcium exchanger 2.
FT /FTId=PRO_0000019382.
FT TOPO_DOM 21 68 Extracellular (Potential).
FT TRANSMEM 69 90 Helical; (Potential).
FT TOPO_DOM 91 130 Cytoplasmic (Potential).
FT TRANSMEM 131 152 Helical; (Potential).
FT TOPO_DOM 153 164 Extracellular (Potential).
FT TRANSMEM 165 185 Helical; (Potential).
FT TOPO_DOM 186 196 Cytoplasmic (Potential).
FT TRANSMEM 197 219 Helical; (Potential).
FT TOPO_DOM 220 222 Extracellular (Potential).
FT TRANSMEM 223 246 Helical; (Potential).
FT TOPO_DOM 247 720 Cytoplasmic (Potential).
FT TRANSMEM 721 740 Helical; (Potential).
FT TOPO_DOM 741 747 Extracellular (Potential).
FT TRANSMEM 748 770 Helical; (Potential).
FT TOPO_DOM 771 772 Cytoplasmic (Potential).
FT TRANSMEM 773 791 Helical; (Potential).
FT TOPO_DOM 792 822 Extracellular (Potential).
FT TRANSMEM 823 843 Helical; (Potential).
FT TOPO_DOM 844 854 Cytoplasmic (Potential).
FT TRANSMEM 855 875 Helical; (Potential).
FT TOPO_DOM 876 892 Extracellular (Potential).
FT TRANSMEM 893 909 Helical; (Potential).
FT TOPO_DOM 910 921 Cytoplasmic (Potential).
FT REPEAT 135 175 Alpha-1.
FT DOMAIN 384 483 Calx-beta 1.
FT DOMAIN 512 612 Calx-beta 2.
FT REPEAT 790 826 Alpha-2.
FT REGION 248 267 Calmodulin-binding (By similarity).
FT COMPBIAS 29 32 Poly-Pro.
FT COMPBIAS 638 641 Poly-Glu.
FT CARBOHYD 34 34 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 817 817 N-linked (GlcNAc...) (Potential).
FT VARIANT 429 429 V -> L (in dbSNP:rs17759929).
FT /FTId=VAR_050226.
SQ SEQUENCE 921 AA; 100368 MW; 798CDF7E32B9410C CRC64;
MAPLALVGVT LLLAAPPCSG AATPTPSLPP PPANDSDTST GGCQGSYRCQ PGVLLPVWEP
DDPSLGDKAA RAVVYFVAMV YMFLGVSIIA DRFMAAIEVI TSKEKEITIT KANGETSVGT
VRIWNETVSN LTLMALGSSA PEILLSVIEV CGHNFQAGEL GPGTIVGSAA FNMFVVIAVC
IYVIPAGESR KIKHLRVFFV TASWSIFAYV WLYLILAVFS PGVVQVWEAL LTLVFFPVCV
VFAWMADKRL LFYKYVYKRY RTDPRSGIII GAEGDPPKSI ELDGTFVGAE APGELGGLGP
GPAEARELDA SRREVIQILK DLKQKHPDKD LEQLVGIANY YALLHQQKSR AFYRIQATRL
MTGAGNVLRR HAADASRRAA PAEGAGEDED DGASRIFFEP SLYHCLENCG SVLLSVTCQG
GEGNSTFYVD YRTEDGSAKA GSDYEYSEGT LVFKPGETQK ELRIGIIDDD IFEEDEHFFV
RLLNLRVGDA QGMFEPDGGG RPKGRLVAPL LATVTILDDD HAGIFSFQDR LLHVSECMGT
VDVRVVRSSG ARGTVRLPYR TVDGTARGGG VHYEDACGEL EFGDDETMKT LQVKIVDDEE
YEKKDNFFIE LGQPQWLKRG ISALLLNQGD GDRKLTAEEE EARRIAEMGK PVLGENCRLE
VIIEESYDFK NTVDKLIKKT NLALVIGTHS WREQFLEAIT VSAGDEEEEE DGSREERLPS
CFDYVMHFLT VFWKVLFACV PPTEYCHGWA CFGVSILVIG LLTALIGDLA SHFGCTVGLK
DSVNAVVFVA LGTSIPDTFA SKVAALQDQC ADASIGNVTG SNAVNVFLGL GVAWSVAAVY
WAVQGRPFEV RTGTLAFSVT LFTVFAFVGI AVLLYRRRPH IGGELGGPRG PKLATTALFL
GLWLLYILFA SLEAYCHIRG F
//
ID NAC2_HUMAN Reviewed; 921 AA.
AC Q9UPR5; B4DYQ9;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2000, sequence version 2.
DT 22-JAN-2014, entry version 109.
DE RecName: Full=Sodium/calcium exchanger 2;
DE AltName: Full=Na(+)/Ca(2+)-exchange protein 2;
DE AltName: Full=Solute carrier family 8 member 2;
DE Flags: Precursor;
GN Name=SLC8A2; Synonyms=KIAA1087, NCX2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=10470851; DOI=10.1093/dnares/6.3.197;
RA Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N.,
RA Tanaka A., Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIV.
RT The complete sequences of 100 new cDNA clones from brain which code
RT for large proteins in vitro.";
RL DNA Res. 6:197-205(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Rapidly transports Ca(2+) during excitation-contraction
CC coupling. Ca(2+) is extruded from the cell during relaxation so as
CC to prevent overloading of intracellular stores (By similarity).
CC -!- ENZYME REGULATION: By ATP (By similarity).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the sodium/potassium/calcium exchanger
CC family. SLC8 subfamily.
CC -!- SIMILARITY: Contains 2 Calx-beta domains.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA83039.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AB029010; BAA83039.1; ALT_INIT; mRNA.
DR EMBL; AK302552; BAG63821.1; -; mRNA.
DR EMBL; CH471126; EAW57485.1; -; Genomic_DNA.
DR RefSeq; NP_055878.1; NM_015063.2.
DR UniGene; Hs.172884; -.
DR ProteinModelPortal; Q9UPR5; -.
DR SMR; Q9UPR5; 394-674.
DR STRING; 9606.ENSP00000236877; -.
DR TCDB; 2.A.19.3.5; the ca(2+):cation antiporter (caca) family.
DR PhosphoSite; Q9UPR5; -.
DR DMDM; 10720116; -.
DR PaxDb; Q9UPR5; -.
DR PRIDE; Q9UPR5; -.
DR DNASU; 6543; -.
DR Ensembl; ENST00000236877; ENSP00000236877; ENSG00000118160.
DR GeneID; 6543; -.
DR KEGG; hsa:6543; -.
DR UCSC; uc002pgx.3; human.
DR CTD; 6543; -.
DR GeneCards; GC19M047931; -.
DR HGNC; HGNC:11069; SLC8A2.
DR HPA; HPA050818; -.
DR HPA; HPA054671; -.
DR MIM; 601901; gene.
DR neXtProt; NX_Q9UPR5; -.
DR PharmGKB; PA313; -.
DR eggNOG; NOG241889; -.
DR HOGENOM; HOG000266971; -.
DR HOVERGEN; HBG006441; -.
DR InParanoid; Q9UPR5; -.
DR KO; K05849; -.
DR OMA; TMEVTVV; -.
DR OrthoDB; EOG7S4X56; -.
DR PhylomeDB; Q9UPR5; -.
DR Reactome; REACT_15518; Transmembrane transport of small molecules.
DR Reactome; REACT_604; Hemostasis.
DR GenomeRNAi; 6543; -.
DR NextBio; 25461; -.
DR PRO; PR:Q9UPR5; -.
DR ArrayExpress; Q9UPR5; -.
DR Bgee; Q9UPR5; -.
DR CleanEx; HS_SLC8A2; -.
DR Genevestigator; Q9UPR5; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:InterPro.
DR GO; GO:0007596; P:blood coagulation; TAS:Reactome.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; TAS:Reactome.
DR GO; GO:0055085; P:transmembrane transport; TAS:Reactome.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR004836; Na_Ca_Ex.
DR InterPro; IPR004837; NaCa_Exmemb.
DR Pfam; PF03160; Calx-beta; 2.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR PRINTS; PR01259; NACAEXCHNGR.
DR SMART; SM00237; Calx_beta; 2.
DR TIGRFAMs; TIGR00845; caca; 1.
PE 2: Evidence at transcript level;
KW Antiport; Calcium; Calcium transport; Calmodulin-binding;
KW Complete proteome; Glycoprotein; Ion transport; Membrane;
KW Polymorphism; Reference proteome; Repeat; Signal; Sodium;
KW Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1 20 Potential.
FT CHAIN 21 921 Sodium/calcium exchanger 2.
FT /FTId=PRO_0000019382.
FT TOPO_DOM 21 68 Extracellular (Potential).
FT TRANSMEM 69 90 Helical; (Potential).
FT TOPO_DOM 91 130 Cytoplasmic (Potential).
FT TRANSMEM 131 152 Helical; (Potential).
FT TOPO_DOM 153 164 Extracellular (Potential).
FT TRANSMEM 165 185 Helical; (Potential).
FT TOPO_DOM 186 196 Cytoplasmic (Potential).
FT TRANSMEM 197 219 Helical; (Potential).
FT TOPO_DOM 220 222 Extracellular (Potential).
FT TRANSMEM 223 246 Helical; (Potential).
FT TOPO_DOM 247 720 Cytoplasmic (Potential).
FT TRANSMEM 721 740 Helical; (Potential).
FT TOPO_DOM 741 747 Extracellular (Potential).
FT TRANSMEM 748 770 Helical; (Potential).
FT TOPO_DOM 771 772 Cytoplasmic (Potential).
FT TRANSMEM 773 791 Helical; (Potential).
FT TOPO_DOM 792 822 Extracellular (Potential).
FT TRANSMEM 823 843 Helical; (Potential).
FT TOPO_DOM 844 854 Cytoplasmic (Potential).
FT TRANSMEM 855 875 Helical; (Potential).
FT TOPO_DOM 876 892 Extracellular (Potential).
FT TRANSMEM 893 909 Helical; (Potential).
FT TOPO_DOM 910 921 Cytoplasmic (Potential).
FT REPEAT 135 175 Alpha-1.
FT DOMAIN 384 483 Calx-beta 1.
FT DOMAIN 512 612 Calx-beta 2.
FT REPEAT 790 826 Alpha-2.
FT REGION 248 267 Calmodulin-binding (By similarity).
FT COMPBIAS 29 32 Poly-Pro.
FT COMPBIAS 638 641 Poly-Glu.
FT CARBOHYD 34 34 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 817 817 N-linked (GlcNAc...) (Potential).
FT VARIANT 429 429 V -> L (in dbSNP:rs17759929).
FT /FTId=VAR_050226.
SQ SEQUENCE 921 AA; 100368 MW; 798CDF7E32B9410C CRC64;
MAPLALVGVT LLLAAPPCSG AATPTPSLPP PPANDSDTST GGCQGSYRCQ PGVLLPVWEP
DDPSLGDKAA RAVVYFVAMV YMFLGVSIIA DRFMAAIEVI TSKEKEITIT KANGETSVGT
VRIWNETVSN LTLMALGSSA PEILLSVIEV CGHNFQAGEL GPGTIVGSAA FNMFVVIAVC
IYVIPAGESR KIKHLRVFFV TASWSIFAYV WLYLILAVFS PGVVQVWEAL LTLVFFPVCV
VFAWMADKRL LFYKYVYKRY RTDPRSGIII GAEGDPPKSI ELDGTFVGAE APGELGGLGP
GPAEARELDA SRREVIQILK DLKQKHPDKD LEQLVGIANY YALLHQQKSR AFYRIQATRL
MTGAGNVLRR HAADASRRAA PAEGAGEDED DGASRIFFEP SLYHCLENCG SVLLSVTCQG
GEGNSTFYVD YRTEDGSAKA GSDYEYSEGT LVFKPGETQK ELRIGIIDDD IFEEDEHFFV
RLLNLRVGDA QGMFEPDGGG RPKGRLVAPL LATVTILDDD HAGIFSFQDR LLHVSECMGT
VDVRVVRSSG ARGTVRLPYR TVDGTARGGG VHYEDACGEL EFGDDETMKT LQVKIVDDEE
YEKKDNFFIE LGQPQWLKRG ISALLLNQGD GDRKLTAEEE EARRIAEMGK PVLGENCRLE
VIIEESYDFK NTVDKLIKKT NLALVIGTHS WREQFLEAIT VSAGDEEEEE DGSREERLPS
CFDYVMHFLT VFWKVLFACV PPTEYCHGWA CFGVSILVIG LLTALIGDLA SHFGCTVGLK
DSVNAVVFVA LGTSIPDTFA SKVAALQDQC ADASIGNVTG SNAVNVFLGL GVAWSVAAVY
WAVQGRPFEV RTGTLAFSVT LFTVFAFVGI AVLLYRRRPH IGGELGGPRG PKLATTALFL
GLWLLYILFA SLEAYCHIRG F
//
MIM
601901
*RECORD*
*FIELD* NO
601901
*FIELD* TI
*601901 SOLUTE CARRIER FAMILY 8 (SODIUM-CALCIUM EXCHANGER), MEMBER 2; SLC8A2
;;SODIUM-CALCIUM EXCHANGER 2; NCX2;;
read moreKIAA1087
*FIELD* TX
CLONING
Li et al. (1994) cloned a partial human cDNA of a novel sodium-calcium
exchanger and, using the partial cDNA, cloned a full-length rat cDNA.
This exchanger was more than 60% similar to NCX1 (182305) and thus was
termed Ncx2. The rat gene predicts a protein of 921 amino acids. The
5-kb transcript was detected in rat brain and skeletal muscle.
By sequencing clones obtained from a size-fractionated brain cDNA
library, Kikuno et al. (1999) cloned SLC8A2, which they designated
KIAA1087. The deduced full-length protein contains 952 amino acids and
shares 97% identity with the rat Ncx2 precursor. RT-PCR ELISA detected
intermediate expression in adult brain, with lower levels in fetal
brain, adult pancreas, testis, and ovary. Little to no expression was
detected in all other organs and tissues examined. Within specific adult
brain regions, expression was highest in amygdala, cerebellum, and
caudate nucleus, with intermediate levels in all other regions examined.
GENE FUNCTION
Li et al. (1994) showed that expression of the rat Ncx2 cDNA produced
functional sodium and calcium exchange.
MAPPING
By radiation hybrid analysis, Kikuno et al. (1999) mapped the SLC8A2
gene to chromosome 19. Li et al. (1994) had originally mapped the NCX2
gene to chromosome 14, a location that corresponds to the NCX3 gene
(607991).
Gross (2011) mapped the SLC8A2 gene to chromosome 19q13.32 based on an
alignment of the SLC8A2 sequence (GenBank GENBANK AK293836) with the
genomic sequence (GRCh37).
Nicoll et al. (1996) mapped the mouse Slc8A2 gene to the proximal region
of mouse chromosome 7, where it is tightly linked to the Apoe gene
(107741).
*FIELD* RF
1. Gross, M. B.: Personal Communication. Baltimore, Md. 2/10/2011.
2. Kikuno, R.; Nagase, T.; Ishikawa, K.; Hirosawa, M.; Miyajima, N.;
Tanaka, A.; Kotani, H.; Nomura, N.; Ohara, O.: Prediction of the
coding sequences of unidentified human genes. XIV. The complete sequences
of 100 new cDNA clones from brain which code for large proteins in
vitro. DNA Res. 6: 197-205, 1999.
3. Li, Z.; Matsuoka, S.; Hryshko, L. V.; Nicoll, D. A.; Bersohn, M.
M.; Burke, E. P.; Lifton, R. P.; Philipson, K. D.: Cloning of the
NCX2 isoform of the plasma membrane Na(+)-Ca(2+) exchanger. J. Biol.
Chem. 269: 17434-17439, 1994.
4. Nicoll, D. A.; Quednau, B. D.; Qui, Z.; Xia, Y.-R.; Lusis, A. J.;
Philipson, K. D.: Cloning of a third mammalian Na(+)-Ca(2+) exchanger,
NCX3. J. Biol. Chem. 271: 24914-24921, 1996.
*FIELD* CN
Matthew B. Gross - updated: 02/10/2011
Patricia A. Hartz - updated: 7/17/2003
*FIELD* CD
Jennifer P. Macke: 6/26/1997
*FIELD* ED
mgross: 02/10/2011
mgross: 7/29/2003
terry: 7/17/2003
alopez: 3/9/1999
carol: 11/12/1998
dholmes: 8/25/1997
alopez: 8/25/1997
terry: 7/28/1997
*RECORD*
*FIELD* NO
601901
*FIELD* TI
*601901 SOLUTE CARRIER FAMILY 8 (SODIUM-CALCIUM EXCHANGER), MEMBER 2; SLC8A2
;;SODIUM-CALCIUM EXCHANGER 2; NCX2;;
read moreKIAA1087
*FIELD* TX
CLONING
Li et al. (1994) cloned a partial human cDNA of a novel sodium-calcium
exchanger and, using the partial cDNA, cloned a full-length rat cDNA.
This exchanger was more than 60% similar to NCX1 (182305) and thus was
termed Ncx2. The rat gene predicts a protein of 921 amino acids. The
5-kb transcript was detected in rat brain and skeletal muscle.
By sequencing clones obtained from a size-fractionated brain cDNA
library, Kikuno et al. (1999) cloned SLC8A2, which they designated
KIAA1087. The deduced full-length protein contains 952 amino acids and
shares 97% identity with the rat Ncx2 precursor. RT-PCR ELISA detected
intermediate expression in adult brain, with lower levels in fetal
brain, adult pancreas, testis, and ovary. Little to no expression was
detected in all other organs and tissues examined. Within specific adult
brain regions, expression was highest in amygdala, cerebellum, and
caudate nucleus, with intermediate levels in all other regions examined.
GENE FUNCTION
Li et al. (1994) showed that expression of the rat Ncx2 cDNA produced
functional sodium and calcium exchange.
MAPPING
By radiation hybrid analysis, Kikuno et al. (1999) mapped the SLC8A2
gene to chromosome 19. Li et al. (1994) had originally mapped the NCX2
gene to chromosome 14, a location that corresponds to the NCX3 gene
(607991).
Gross (2011) mapped the SLC8A2 gene to chromosome 19q13.32 based on an
alignment of the SLC8A2 sequence (GenBank GENBANK AK293836) with the
genomic sequence (GRCh37).
Nicoll et al. (1996) mapped the mouse Slc8A2 gene to the proximal region
of mouse chromosome 7, where it is tightly linked to the Apoe gene
(107741).
*FIELD* RF
1. Gross, M. B.: Personal Communication. Baltimore, Md. 2/10/2011.
2. Kikuno, R.; Nagase, T.; Ishikawa, K.; Hirosawa, M.; Miyajima, N.;
Tanaka, A.; Kotani, H.; Nomura, N.; Ohara, O.: Prediction of the
coding sequences of unidentified human genes. XIV. The complete sequences
of 100 new cDNA clones from brain which code for large proteins in
vitro. DNA Res. 6: 197-205, 1999.
3. Li, Z.; Matsuoka, S.; Hryshko, L. V.; Nicoll, D. A.; Bersohn, M.
M.; Burke, E. P.; Lifton, R. P.; Philipson, K. D.: Cloning of the
NCX2 isoform of the plasma membrane Na(+)-Ca(2+) exchanger. J. Biol.
Chem. 269: 17434-17439, 1994.
4. Nicoll, D. A.; Quednau, B. D.; Qui, Z.; Xia, Y.-R.; Lusis, A. J.;
Philipson, K. D.: Cloning of a third mammalian Na(+)-Ca(2+) exchanger,
NCX3. J. Biol. Chem. 271: 24914-24921, 1996.
*FIELD* CN
Matthew B. Gross - updated: 02/10/2011
Patricia A. Hartz - updated: 7/17/2003
*FIELD* CD
Jennifer P. Macke: 6/26/1997
*FIELD* ED
mgross: 02/10/2011
mgross: 7/29/2003
terry: 7/17/2003
alopez: 3/9/1999
carol: 11/12/1998
dholmes: 8/25/1997
alopez: 8/25/1997
terry: 7/28/1997