Full text data of NLRP14
NLRP14
(NALP14, NOD5)
[Confidence: low (only semi-automatic identification from reviews)]
NACHT, LRR and PYD domains-containing protein 14 (Nucleotide-binding oligomerization domain protein 5)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
NACHT, LRR and PYD domains-containing protein 14 (Nucleotide-binding oligomerization domain protein 5)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q86W24
ID NAL14_HUMAN Reviewed; 1093 AA.
AC Q86W24; Q7RTR6;
DT 14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-2003, sequence version 1.
DT 22-JAN-2014, entry version 95.
DE RecName: Full=NACHT, LRR and PYD domains-containing protein 14;
DE AltName: Full=Nucleotide-binding oligomerization domain protein 5;
GN Name=NLRP14; Synonyms=NALP14, NOD5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12563287; DOI=10.1038/nrm1019;
RA Tschopp J., Martinon F., Burns K.;
RT "NALPs: a novel protein family involved in inflammation.";
RL Nat. Rev. Mol. Cell Biol. 4:95-104(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12766759; DOI=10.1038/nri1086;
RA Inohara N., Nunez G.;
RT "NODs: intracellular proteins involved in inflammation and
RT apoptosis.";
RL Nat. Rev. Immunol. 3:371-382(2003).
RN [3]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND VARIANTS THR-48; GLU-55;
RP VAL-86; ARG-92; LEU-98; THR-375; ILE-397; MET-441; GLN-522; LYS-808;
RP THR-951; SER-954; PHE-1010 AND ILE-1019.
RX PubMed=16931801; DOI=10.1093/humrep/del293;
RA Westerveld G.H., Korver C.M., van Pelt A.M.M., Leschot N.J.,
RA van der Veen F., Repping S., Lombardi M.P.;
RT "Mutations in the testis-specific NALP14 gene in men suffering from
RT spermatogenic failure.";
RL Hum. Reprod. 21:3178-3184(2006).
RN [4]
RP VARIANT [LARGE SCALE ANALYSIS] CYS-779.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
RA Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
RA Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
RA Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
RA Vogelstein B., Kinzler K.W., Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal
RT cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: May be involved in inflammation and spermatogenesis.
CC -!- TISSUE SPECIFICITY: Testis-specific.
CC -!- DEVELOPMENTAL STAGE: In the testis, expressed mainly in A dark
CC spermatogonia, mid and late spermatocytes and spermatids but not
CC in mitotically active A pale and B spermatogonia.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC -!- SIMILARITY: Contains 1 DAPIN domain.
CC -!- SIMILARITY: Contains 11 LRR (leucine-rich) repeats.
CC -!- SIMILARITY: Contains 1 NACHT domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY154469; AAO18165.1; -; mRNA.
DR EMBL; BK001107; DAA01240.1; -; mRNA.
DR RefSeq; NP_789792.1; NM_176822.3.
DR UniGene; Hs.449637; -.
DR ProteinModelPortal; Q86W24; -.
DR SMR; Q86W24; 9-94, 174-199, 653-1075.
DR STRING; 9606.ENSP00000299481; -.
DR PhosphoSite; Q86W24; -.
DR DMDM; 38372322; -.
DR PaxDb; Q86W24; -.
DR PRIDE; Q86W24; -.
DR DNASU; 338323; -.
DR Ensembl; ENST00000299481; ENSP00000299481; ENSG00000158077.
DR GeneID; 338323; -.
DR KEGG; hsa:338323; -.
DR UCSC; uc001mfb.1; human.
DR CTD; 338323; -.
DR GeneCards; GC11P007017; -.
DR HGNC; HGNC:22939; NLRP14.
DR HPA; HPA039477; -.
DR MIM; 609665; gene.
DR neXtProt; NX_Q86W24; -.
DR PharmGKB; PA162397917; -.
DR eggNOG; NOG82860; -.
DR HOGENOM; HOG000294064; -.
DR HOVERGEN; HBG063656; -.
DR InParanoid; Q86W24; -.
DR OMA; NIIQKDA; -.
DR OrthoDB; EOG7P5T07; -.
DR PhylomeDB; Q86W24; -.
DR GeneWiki; NLRP14; -.
DR GenomeRNAi; 338323; -.
DR NextBio; 96933; -.
DR PRO; PR:Q86W24; -.
DR Bgee; Q86W24; -.
DR CleanEx; HS_NLRP14; -.
DR Genevestigator; Q86W24; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IMP:UniProtKB.
DR Gene3D; 1.10.533.10; -; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF02758; PYRIN; 1.
DR SUPFAM; SSF47986; SSF47986; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Complete proteome; Developmental protein;
KW Differentiation; Leucine-rich repeat; Nucleotide-binding;
KW Polymorphism; Reference proteome; Repeat; Spermatogenesis.
FT CHAIN 1 1093 NACHT, LRR and PYD domains-containing
FT protein 14.
FT /FTId=PRO_0000080901.
FT DOMAIN 1 97 DAPIN.
FT DOMAIN 177 499 NACHT.
FT REPEAT 730 750 LRR 1.
FT REPEAT 759 780 LRR 2.
FT REPEAT 787 807 LRR 3.
FT REPEAT 816 836 LRR 4.
FT REPEAT 844 864 LRR 5.
FT REPEAT 873 894 LRR 6.
FT REPEAT 901 921 LRR 7.
FT REPEAT 930 951 LRR 8.
FT REPEAT 958 978 LRR 9.
FT REPEAT 987 1008 LRR 10.
FT REPEAT 1015 1035 LRR 11.
FT NP_BIND 183 190 ATP (Potential).
FT VARIANT 21 21 E -> K (in dbSNP:rs11041150).
FT /FTId=VAR_053622.
FT VARIANT 48 48 N -> T (in dbSNP:rs12801277).
FT /FTId=VAR_031932.
FT VARIANT 55 55 R -> E (requires 2 nucleotide
FT substitutions).
FT /FTId=VAR_031933.
FT VARIANT 86 86 D -> V (associated with spermatogenic
FT failure).
FT /FTId=VAR_031934.
FT VARIANT 92 92 K -> R (in dbSNP:rs16921697).
FT /FTId=VAR_031935.
FT VARIANT 98 98 S -> L (in dbSNP:rs117823353).
FT /FTId=VAR_031936.
FT VARIANT 375 375 A -> T (associated with spermatogenic
FT failure).
FT /FTId=VAR_031937.
FT VARIANT 397 397 T -> I (in dbSNP:rs76670455).
FT /FTId=VAR_031938.
FT VARIANT 441 441 V -> M (in dbSNP:rs147389856).
FT /FTId=VAR_031939.
FT VARIANT 511 511 L -> F (in dbSNP:rs11041151).
FT /FTId=VAR_053623.
FT VARIANT 522 522 D -> Q (associated with spermatogenic
FT failure; requires 2 nucleotide
FT substitutions).
FT /FTId=VAR_031940.
FT VARIANT 779 779 S -> C (in a breast cancer sample;
FT somatic mutation).
FT /FTId=VAR_036387.
FT VARIANT 808 808 E -> K (in dbSNP:rs10839708).
FT /FTId=VAR_024180.
FT VARIANT 951 951 S -> T (in dbSNP:rs117124176).
FT /FTId=VAR_031941.
FT VARIANT 954 954 L -> S (in dbSNP:rs117583918).
FT /FTId=VAR_031942.
FT VARIANT 1010 1010 L -> F (in dbSNP:rs17280682).
FT /FTId=VAR_031943.
FT VARIANT 1019 1019 M -> I (associated with spermatogenic
FT failure; dbSNP:rs115776642).
FT /FTId=VAR_031944.
SQ SEQUENCE 1093 AA; 124733 MW; 124EEACE22A11D6F CRC64;
MADSSSSSFF PDFGLLLYLE ELNKEELNTF KLFLKETMEP EHGLTPWNEV KKARREDLAN
LMKKYYPGEK AWSVSLKIFG KMNLKDLCER AKEEINWSAQ TIGPDDAKAG ETQEDQEAVL
GDGTEYRNRI KEKFCITWDK KSLAGKPEDF HHGIAEKDRK LLEHLFDVDV KTGAQPQIVV
LQGAAGVGKT TLVRKAMLDW AEGSLYQQRF KYVFYLNGRE INQLKERSFA QLISKDWPST
EGPIEEIMYQ PSSLLFIIDS FDELNFAFEE PEFALCEDWT QEHPVSFLMS SLLRKVMLPE
ASLLVTTRLT TSKRLKQLLK NHHYVELLGM SEDAREEYIY QFFEDKRWAM KVFSSLKSNE
MLFSMCQVPL VCWAACTCLK QQMEKGGDVT LTCQTTTALF TCYISSLFTP VDGGSPSLPN
QAQLRRLCQV AAKGIWTMTY VFYRENLRRL GLTQSDVSSF MDSNIIQKDA EYENCYVFTH
LHVQEFFAAM FYMLKGSWEA GNPSCQPFED LKSLLQSTSY KDPHLTQMKC FLFGLLNEDR
VKQLERTFNC KMSLKIKSKL LQCMEVLGNS DYSPSQLGFL ELFHCLYETQ DKAFISQAMR
CFPKVAINIC EKIHLLVSSF CLKHCRCLRT IRLSVTVVFE KKILKTSLPT NTWDGDRITH
CWQDLCSVLH TNEHLRELDL YHSNLDKSAM NILHHELRHP NCKLQKLLLK FITFPDGCQD
ISTSLIHNKN LMHLDLKGSD IGDNGVKSLC EALKHPECKL QTLRLESCNL TVFCCLNISN
ALIRSQSLIF LNLSTNNLLD DGVQLLCEAL RHPKCYLERL SLESCGLTEA GCEYLSLALI
SNKRLTHLCL ADNVLGDGGV KLMSDALQHA QCTLKSLVLR RCHFTSLSSE YLSTSLLHNK
SLTHLDLGSN WLQDNGVKLL CDVFRHPSCN LQDLELMGCV LTNACCLDLA SVILNNPNLR
SLDLGNNDLQ DDGVKILCDA LRYPNCNIQR LGLEYCGLTS LCCQDLSSAL ICNKRLIKMN
LTQNTLGYEG IVKLYKVLKS PKCKLQVLGL CKEAFDEEAQ KLLEAVGVSN PHLIIKPDCN
YHNEEDVSWW WCF
//
ID NAL14_HUMAN Reviewed; 1093 AA.
AC Q86W24; Q7RTR6;
DT 14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-2003, sequence version 1.
DT 22-JAN-2014, entry version 95.
DE RecName: Full=NACHT, LRR and PYD domains-containing protein 14;
DE AltName: Full=Nucleotide-binding oligomerization domain protein 5;
GN Name=NLRP14; Synonyms=NALP14, NOD5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12563287; DOI=10.1038/nrm1019;
RA Tschopp J., Martinon F., Burns K.;
RT "NALPs: a novel protein family involved in inflammation.";
RL Nat. Rev. Mol. Cell Biol. 4:95-104(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12766759; DOI=10.1038/nri1086;
RA Inohara N., Nunez G.;
RT "NODs: intracellular proteins involved in inflammation and
RT apoptosis.";
RL Nat. Rev. Immunol. 3:371-382(2003).
RN [3]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND VARIANTS THR-48; GLU-55;
RP VAL-86; ARG-92; LEU-98; THR-375; ILE-397; MET-441; GLN-522; LYS-808;
RP THR-951; SER-954; PHE-1010 AND ILE-1019.
RX PubMed=16931801; DOI=10.1093/humrep/del293;
RA Westerveld G.H., Korver C.M., van Pelt A.M.M., Leschot N.J.,
RA van der Veen F., Repping S., Lombardi M.P.;
RT "Mutations in the testis-specific NALP14 gene in men suffering from
RT spermatogenic failure.";
RL Hum. Reprod. 21:3178-3184(2006).
RN [4]
RP VARIANT [LARGE SCALE ANALYSIS] CYS-779.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
RA Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
RA Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
RA Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
RA Vogelstein B., Kinzler K.W., Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal
RT cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: May be involved in inflammation and spermatogenesis.
CC -!- TISSUE SPECIFICITY: Testis-specific.
CC -!- DEVELOPMENTAL STAGE: In the testis, expressed mainly in A dark
CC spermatogonia, mid and late spermatocytes and spermatids but not
CC in mitotically active A pale and B spermatogonia.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC -!- SIMILARITY: Contains 1 DAPIN domain.
CC -!- SIMILARITY: Contains 11 LRR (leucine-rich) repeats.
CC -!- SIMILARITY: Contains 1 NACHT domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY154469; AAO18165.1; -; mRNA.
DR EMBL; BK001107; DAA01240.1; -; mRNA.
DR RefSeq; NP_789792.1; NM_176822.3.
DR UniGene; Hs.449637; -.
DR ProteinModelPortal; Q86W24; -.
DR SMR; Q86W24; 9-94, 174-199, 653-1075.
DR STRING; 9606.ENSP00000299481; -.
DR PhosphoSite; Q86W24; -.
DR DMDM; 38372322; -.
DR PaxDb; Q86W24; -.
DR PRIDE; Q86W24; -.
DR DNASU; 338323; -.
DR Ensembl; ENST00000299481; ENSP00000299481; ENSG00000158077.
DR GeneID; 338323; -.
DR KEGG; hsa:338323; -.
DR UCSC; uc001mfb.1; human.
DR CTD; 338323; -.
DR GeneCards; GC11P007017; -.
DR HGNC; HGNC:22939; NLRP14.
DR HPA; HPA039477; -.
DR MIM; 609665; gene.
DR neXtProt; NX_Q86W24; -.
DR PharmGKB; PA162397917; -.
DR eggNOG; NOG82860; -.
DR HOGENOM; HOG000294064; -.
DR HOVERGEN; HBG063656; -.
DR InParanoid; Q86W24; -.
DR OMA; NIIQKDA; -.
DR OrthoDB; EOG7P5T07; -.
DR PhylomeDB; Q86W24; -.
DR GeneWiki; NLRP14; -.
DR GenomeRNAi; 338323; -.
DR NextBio; 96933; -.
DR PRO; PR:Q86W24; -.
DR Bgee; Q86W24; -.
DR CleanEx; HS_NLRP14; -.
DR Genevestigator; Q86W24; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IMP:UniProtKB.
DR Gene3D; 1.10.533.10; -; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF02758; PYRIN; 1.
DR SUPFAM; SSF47986; SSF47986; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Complete proteome; Developmental protein;
KW Differentiation; Leucine-rich repeat; Nucleotide-binding;
KW Polymorphism; Reference proteome; Repeat; Spermatogenesis.
FT CHAIN 1 1093 NACHT, LRR and PYD domains-containing
FT protein 14.
FT /FTId=PRO_0000080901.
FT DOMAIN 1 97 DAPIN.
FT DOMAIN 177 499 NACHT.
FT REPEAT 730 750 LRR 1.
FT REPEAT 759 780 LRR 2.
FT REPEAT 787 807 LRR 3.
FT REPEAT 816 836 LRR 4.
FT REPEAT 844 864 LRR 5.
FT REPEAT 873 894 LRR 6.
FT REPEAT 901 921 LRR 7.
FT REPEAT 930 951 LRR 8.
FT REPEAT 958 978 LRR 9.
FT REPEAT 987 1008 LRR 10.
FT REPEAT 1015 1035 LRR 11.
FT NP_BIND 183 190 ATP (Potential).
FT VARIANT 21 21 E -> K (in dbSNP:rs11041150).
FT /FTId=VAR_053622.
FT VARIANT 48 48 N -> T (in dbSNP:rs12801277).
FT /FTId=VAR_031932.
FT VARIANT 55 55 R -> E (requires 2 nucleotide
FT substitutions).
FT /FTId=VAR_031933.
FT VARIANT 86 86 D -> V (associated with spermatogenic
FT failure).
FT /FTId=VAR_031934.
FT VARIANT 92 92 K -> R (in dbSNP:rs16921697).
FT /FTId=VAR_031935.
FT VARIANT 98 98 S -> L (in dbSNP:rs117823353).
FT /FTId=VAR_031936.
FT VARIANT 375 375 A -> T (associated with spermatogenic
FT failure).
FT /FTId=VAR_031937.
FT VARIANT 397 397 T -> I (in dbSNP:rs76670455).
FT /FTId=VAR_031938.
FT VARIANT 441 441 V -> M (in dbSNP:rs147389856).
FT /FTId=VAR_031939.
FT VARIANT 511 511 L -> F (in dbSNP:rs11041151).
FT /FTId=VAR_053623.
FT VARIANT 522 522 D -> Q (associated with spermatogenic
FT failure; requires 2 nucleotide
FT substitutions).
FT /FTId=VAR_031940.
FT VARIANT 779 779 S -> C (in a breast cancer sample;
FT somatic mutation).
FT /FTId=VAR_036387.
FT VARIANT 808 808 E -> K (in dbSNP:rs10839708).
FT /FTId=VAR_024180.
FT VARIANT 951 951 S -> T (in dbSNP:rs117124176).
FT /FTId=VAR_031941.
FT VARIANT 954 954 L -> S (in dbSNP:rs117583918).
FT /FTId=VAR_031942.
FT VARIANT 1010 1010 L -> F (in dbSNP:rs17280682).
FT /FTId=VAR_031943.
FT VARIANT 1019 1019 M -> I (associated with spermatogenic
FT failure; dbSNP:rs115776642).
FT /FTId=VAR_031944.
SQ SEQUENCE 1093 AA; 124733 MW; 124EEACE22A11D6F CRC64;
MADSSSSSFF PDFGLLLYLE ELNKEELNTF KLFLKETMEP EHGLTPWNEV KKARREDLAN
LMKKYYPGEK AWSVSLKIFG KMNLKDLCER AKEEINWSAQ TIGPDDAKAG ETQEDQEAVL
GDGTEYRNRI KEKFCITWDK KSLAGKPEDF HHGIAEKDRK LLEHLFDVDV KTGAQPQIVV
LQGAAGVGKT TLVRKAMLDW AEGSLYQQRF KYVFYLNGRE INQLKERSFA QLISKDWPST
EGPIEEIMYQ PSSLLFIIDS FDELNFAFEE PEFALCEDWT QEHPVSFLMS SLLRKVMLPE
ASLLVTTRLT TSKRLKQLLK NHHYVELLGM SEDAREEYIY QFFEDKRWAM KVFSSLKSNE
MLFSMCQVPL VCWAACTCLK QQMEKGGDVT LTCQTTTALF TCYISSLFTP VDGGSPSLPN
QAQLRRLCQV AAKGIWTMTY VFYRENLRRL GLTQSDVSSF MDSNIIQKDA EYENCYVFTH
LHVQEFFAAM FYMLKGSWEA GNPSCQPFED LKSLLQSTSY KDPHLTQMKC FLFGLLNEDR
VKQLERTFNC KMSLKIKSKL LQCMEVLGNS DYSPSQLGFL ELFHCLYETQ DKAFISQAMR
CFPKVAINIC EKIHLLVSSF CLKHCRCLRT IRLSVTVVFE KKILKTSLPT NTWDGDRITH
CWQDLCSVLH TNEHLRELDL YHSNLDKSAM NILHHELRHP NCKLQKLLLK FITFPDGCQD
ISTSLIHNKN LMHLDLKGSD IGDNGVKSLC EALKHPECKL QTLRLESCNL TVFCCLNISN
ALIRSQSLIF LNLSTNNLLD DGVQLLCEAL RHPKCYLERL SLESCGLTEA GCEYLSLALI
SNKRLTHLCL ADNVLGDGGV KLMSDALQHA QCTLKSLVLR RCHFTSLSSE YLSTSLLHNK
SLTHLDLGSN WLQDNGVKLL CDVFRHPSCN LQDLELMGCV LTNACCLDLA SVILNNPNLR
SLDLGNNDLQ DDGVKILCDA LRYPNCNIQR LGLEYCGLTS LCCQDLSSAL ICNKRLIKMN
LTQNTLGYEG IVKLYKVLKS PKCKLQVLGL CKEAFDEEAQ KLLEAVGVSN PHLIIKPDCN
YHNEEDVSWW WCF
//
MIM
609665
*RECORD*
*FIELD* NO
609665
*FIELD* TI
*609665 NLR FAMILY, PYRIN DOMAIN-CONTAINING 14; NLRP14
;;NACHT DOMAIN-, LEUCINE-RICH REPEAT-, AND PYD-CONTAINING PROTEIN 14;
read moreNALP14;;
NOD5
*FIELD* TX
DESCRIPTION
NALPs are cytoplasmic proteins that form a subfamily within the larger
CATERPILLER protein family. Most short NALPs, such as NALP14, have an
N-terminal pyrin (MEFV; 608107) domain (PYD), followed by a NACHT
domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich
repeat (LRR) region. The long NALP, NALP1 (606636), also has a
C-terminal extension containing a function to find domain (FIIND) and a
caspase recruitment domain (CARD). NALPs are implicated in the
activation of proinflammatory caspases (e.g., CASP1; 147678) via their
involvement in multiprotein complexes called inflammasomes (Tschopp et
al., 2003).
CLONING
Tschopp et al. (2003) stated that the 993-amino acid NALP14 protein has
the typical PYD-NACHT-LRR domain structure found in the NALP family.
Inohara and Nunez (2003) also reported the NALP14 gene, which they
called NOD5.
MAPPING
Tschopp et al. (2003) stated that the NALP14 gene maps to chromosome
11p15.4.
*FIELD* RF
1. Inohara, N.; Nunez, G.: NODs: intracellular proteins involved
in inflammation and apoptosis. Nature Rev. Immun. 3: 371-382, 2003.
2. Tschopp, J.; Martinon, F.; Burns, K.: NALPs: a novel protein family
involved in inflammation. Nature Rev. Molec. Cell Biol. 4: 95-104,
2003.
*FIELD* CD
Paul J. Converse: 10/19/2005
*FIELD* ED
alopez: 06/16/2009
carol: 6/3/2009
alopez: 12/4/2008
carol: 6/27/2007
mgross: 10/19/2005
*RECORD*
*FIELD* NO
609665
*FIELD* TI
*609665 NLR FAMILY, PYRIN DOMAIN-CONTAINING 14; NLRP14
;;NACHT DOMAIN-, LEUCINE-RICH REPEAT-, AND PYD-CONTAINING PROTEIN 14;
read moreNALP14;;
NOD5
*FIELD* TX
DESCRIPTION
NALPs are cytoplasmic proteins that form a subfamily within the larger
CATERPILLER protein family. Most short NALPs, such as NALP14, have an
N-terminal pyrin (MEFV; 608107) domain (PYD), followed by a NACHT
domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich
repeat (LRR) region. The long NALP, NALP1 (606636), also has a
C-terminal extension containing a function to find domain (FIIND) and a
caspase recruitment domain (CARD). NALPs are implicated in the
activation of proinflammatory caspases (e.g., CASP1; 147678) via their
involvement in multiprotein complexes called inflammasomes (Tschopp et
al., 2003).
CLONING
Tschopp et al. (2003) stated that the 993-amino acid NALP14 protein has
the typical PYD-NACHT-LRR domain structure found in the NALP family.
Inohara and Nunez (2003) also reported the NALP14 gene, which they
called NOD5.
MAPPING
Tschopp et al. (2003) stated that the NALP14 gene maps to chromosome
11p15.4.
*FIELD* RF
1. Inohara, N.; Nunez, G.: NODs: intracellular proteins involved
in inflammation and apoptosis. Nature Rev. Immun. 3: 371-382, 2003.
2. Tschopp, J.; Martinon, F.; Burns, K.: NALPs: a novel protein family
involved in inflammation. Nature Rev. Molec. Cell Biol. 4: 95-104,
2003.
*FIELD* CD
Paul J. Converse: 10/19/2005
*FIELD* ED
alopez: 06/16/2009
carol: 6/3/2009
alopez: 12/4/2008
carol: 6/27/2007
mgross: 10/19/2005