Full text data of NHLRC2
NHLRC2
[Confidence: low (only semi-automatic identification from reviews)]
NHL repeat-containing protein 2
Note: presumably soluble (membrane word is not in UniProt keywords or features)
NHL repeat-containing protein 2
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q8NBF2
ID NHLC2_HUMAN Reviewed; 726 AA.
AC Q8NBF2; Q8N1H1; Q8N5A6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-2002, sequence version 1.
DT 22-JAN-2014, entry version 108.
DE RecName: Full=NHL repeat-containing protein 2;
GN Name=NHLRC2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Gastric mucosa;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NBF2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NBF2-2; Sequence=VSP_030153;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Contains 6 NHL repeats.
CC -!- SIMILARITY: Contains 1 thioredoxin domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05316.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK090631; BAC03493.1; -; mRNA.
DR EMBL; AK098487; BAC05316.1; ALT_INIT; mRNA.
DR EMBL; AL627429; CAH73013.1; -; Genomic_DNA.
DR EMBL; AL162407; CAH73013.1; JOINED; Genomic_DNA.
DR EMBL; AL592546; CAH73013.1; JOINED; Genomic_DNA.
DR EMBL; AL162407; CAH73301.1; -; Genomic_DNA.
DR EMBL; AL592546; CAH73301.1; JOINED; Genomic_DNA.
DR EMBL; AL627429; CAH73301.1; JOINED; Genomic_DNA.
DR EMBL; AL592546; CAI12636.1; -; Genomic_DNA.
DR EMBL; AL162407; CAI12636.1; JOINED; Genomic_DNA.
DR EMBL; AL627429; CAI12636.1; JOINED; Genomic_DNA.
DR EMBL; BC032598; AAH32598.1; -; mRNA.
DR RefSeq; NP_940916.2; NM_198514.3.
DR UniGene; Hs.369924; -.
DR UniGene; Hs.594372; -.
DR ProteinModelPortal; Q8NBF2; -.
DR SMR; Q8NBF2; 53-226, 287-312, 477-507.
DR STRING; 9606.ENSP00000358307; -.
DR PhosphoSite; Q8NBF2; -.
DR DMDM; 74762548; -.
DR PaxDb; Q8NBF2; -.
DR PRIDE; Q8NBF2; -.
DR DNASU; 374354; -.
DR Ensembl; ENST00000369301; ENSP00000358307; ENSG00000196865.
DR GeneID; 374354; -.
DR KEGG; hsa:374354; -.
DR UCSC; uc001lax.2; human.
DR CTD; 374354; -.
DR GeneCards; GC10P115604; -.
DR HGNC; HGNC:24731; NHLRC2.
DR HPA; HPA038493; -.
DR neXtProt; NX_Q8NBF2; -.
DR PharmGKB; PA134883896; -.
DR eggNOG; COG0526; -.
DR HOGENOM; HOG000229147; -.
DR HOVERGEN; HBG059736; -.
DR InParanoid; Q8NBF2; -.
DR OMA; PWSCLFV; -.
DR OrthoDB; EOG718KDF; -.
DR PhylomeDB; Q8NBF2; -.
DR GenomeRNAi; 374354; -.
DR NextBio; 100154; -.
DR PRO; PR:Q8NBF2; -.
DR Bgee; Q8NBF2; -.
DR CleanEx; HS_NHLRC2; -.
DR Genevestigator; Q8NBF2; -.
DR Gene3D; 2.120.10.30; -; 1.
DR Gene3D; 3.40.30.10; -; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001258; NHL_repeat.
DR InterPro; IPR013017; NHL_repeat_subgr.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR Pfam; PF01436; NHL; 4.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS51125; NHL; 4.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Polymorphism;
KW Reference proteome; Repeat.
FT CHAIN 1 726 NHL repeat-containing protein 2.
FT /FTId=PRO_0000313808.
FT DOMAIN 43 200 Thioredoxin.
FT REPEAT 212 254 NHL 1.
FT REPEAT 265 307 NHL 2.
FT REPEAT 335 369 NHL 3.
FT REPEAT 409 439 NHL 4.
FT REPEAT 461 505 NHL 5.
FT REPEAT 518 562 NHL 6.
FT VAR_SEQ 1 359 Missing (in isoform 2).
FT /FTId=VSP_030153.
FT VARIANT 314 314 V -> I (in dbSNP:rs7913176).
FT /FTId=VAR_037749.
FT CONFLICT 216 216 D -> N (in Ref. 1; BAC05316).
SQ SEQUENCE 726 AA; 79444 MW; FB0EF710BBB2E3B6 CRC64;
MAAPGGRGRS LSGLLPAQTS LEYALLDAVT QQEKDSLVYQ YLQKVDGWEQ DLSVPEFPEG
LEWLNTEEPI SVYKDLCGKI VVLDFFTYCC INCIHLLPDL HALEHTYSDK DGLLIIGVHS
AKFPNEKVLD NIKSAVLRYN ITHPMVNDAD ASLWQELEVS CWPTLVILGP RGNMLFSLIG
EGHKDKLFLY TSIALKYYKD RGQIRDNKIG IKLYKDSLPP SPLLFPGKVT VDQVTDRLVI
ADTGHHRILV VWKNGQIQYS IGGPNPGRKD GIFSESTFNS PQGVAIMNNI IYVADTENHL
IRKIDLEAEK VSTVAGIGIQ GTDKEGGAKG EQQPISSPWD VVFGTSGSEV QRGDILWIAM
AGTHQIWALL LDSGKLPKKN ELTKGTCLRF AGSGNEENRN NAYPHKAGFA QPSGLSLASE
DPWSCLFVAD SESSTVRTVS LKDGAVKHLV GGERDPMNLF AFGDVDGVGI NAKLQHPLGV
TWDKKRNLLY VADSYNHKIK VVDPKTKNCT TLAGTGDTNN VTSSSFTEST FNEPGGLCIG
ENGELLYVAD TNNHQIKVMD LETKMVSVLP IFRSENAVVD GPFLVEKQKT LPKLPKSAPS
IRLSPVTACA GQTLQFKLRL DLPSGSKLTE GVSSCWFLTA EGNEWLLQGQ IAAGDIENIS
SQPTISLQIP DDCLSLEAIV SVSVFLYYCS ADSSACMMKA ILFSQPLQIT DTQQGCIAPV
ELRYVF
//
ID NHLC2_HUMAN Reviewed; 726 AA.
AC Q8NBF2; Q8N1H1; Q8N5A6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-2002, sequence version 1.
DT 22-JAN-2014, entry version 108.
DE RecName: Full=NHL repeat-containing protein 2;
GN Name=NHLRC2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Gastric mucosa;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NBF2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NBF2-2; Sequence=VSP_030153;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Contains 6 NHL repeats.
CC -!- SIMILARITY: Contains 1 thioredoxin domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05316.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK090631; BAC03493.1; -; mRNA.
DR EMBL; AK098487; BAC05316.1; ALT_INIT; mRNA.
DR EMBL; AL627429; CAH73013.1; -; Genomic_DNA.
DR EMBL; AL162407; CAH73013.1; JOINED; Genomic_DNA.
DR EMBL; AL592546; CAH73013.1; JOINED; Genomic_DNA.
DR EMBL; AL162407; CAH73301.1; -; Genomic_DNA.
DR EMBL; AL592546; CAH73301.1; JOINED; Genomic_DNA.
DR EMBL; AL627429; CAH73301.1; JOINED; Genomic_DNA.
DR EMBL; AL592546; CAI12636.1; -; Genomic_DNA.
DR EMBL; AL162407; CAI12636.1; JOINED; Genomic_DNA.
DR EMBL; AL627429; CAI12636.1; JOINED; Genomic_DNA.
DR EMBL; BC032598; AAH32598.1; -; mRNA.
DR RefSeq; NP_940916.2; NM_198514.3.
DR UniGene; Hs.369924; -.
DR UniGene; Hs.594372; -.
DR ProteinModelPortal; Q8NBF2; -.
DR SMR; Q8NBF2; 53-226, 287-312, 477-507.
DR STRING; 9606.ENSP00000358307; -.
DR PhosphoSite; Q8NBF2; -.
DR DMDM; 74762548; -.
DR PaxDb; Q8NBF2; -.
DR PRIDE; Q8NBF2; -.
DR DNASU; 374354; -.
DR Ensembl; ENST00000369301; ENSP00000358307; ENSG00000196865.
DR GeneID; 374354; -.
DR KEGG; hsa:374354; -.
DR UCSC; uc001lax.2; human.
DR CTD; 374354; -.
DR GeneCards; GC10P115604; -.
DR HGNC; HGNC:24731; NHLRC2.
DR HPA; HPA038493; -.
DR neXtProt; NX_Q8NBF2; -.
DR PharmGKB; PA134883896; -.
DR eggNOG; COG0526; -.
DR HOGENOM; HOG000229147; -.
DR HOVERGEN; HBG059736; -.
DR InParanoid; Q8NBF2; -.
DR OMA; PWSCLFV; -.
DR OrthoDB; EOG718KDF; -.
DR PhylomeDB; Q8NBF2; -.
DR GenomeRNAi; 374354; -.
DR NextBio; 100154; -.
DR PRO; PR:Q8NBF2; -.
DR Bgee; Q8NBF2; -.
DR CleanEx; HS_NHLRC2; -.
DR Genevestigator; Q8NBF2; -.
DR Gene3D; 2.120.10.30; -; 1.
DR Gene3D; 3.40.30.10; -; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001258; NHL_repeat.
DR InterPro; IPR013017; NHL_repeat_subgr.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR Pfam; PF01436; NHL; 4.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS51125; NHL; 4.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Polymorphism;
KW Reference proteome; Repeat.
FT CHAIN 1 726 NHL repeat-containing protein 2.
FT /FTId=PRO_0000313808.
FT DOMAIN 43 200 Thioredoxin.
FT REPEAT 212 254 NHL 1.
FT REPEAT 265 307 NHL 2.
FT REPEAT 335 369 NHL 3.
FT REPEAT 409 439 NHL 4.
FT REPEAT 461 505 NHL 5.
FT REPEAT 518 562 NHL 6.
FT VAR_SEQ 1 359 Missing (in isoform 2).
FT /FTId=VSP_030153.
FT VARIANT 314 314 V -> I (in dbSNP:rs7913176).
FT /FTId=VAR_037749.
FT CONFLICT 216 216 D -> N (in Ref. 1; BAC05316).
SQ SEQUENCE 726 AA; 79444 MW; FB0EF710BBB2E3B6 CRC64;
MAAPGGRGRS LSGLLPAQTS LEYALLDAVT QQEKDSLVYQ YLQKVDGWEQ DLSVPEFPEG
LEWLNTEEPI SVYKDLCGKI VVLDFFTYCC INCIHLLPDL HALEHTYSDK DGLLIIGVHS
AKFPNEKVLD NIKSAVLRYN ITHPMVNDAD ASLWQELEVS CWPTLVILGP RGNMLFSLIG
EGHKDKLFLY TSIALKYYKD RGQIRDNKIG IKLYKDSLPP SPLLFPGKVT VDQVTDRLVI
ADTGHHRILV VWKNGQIQYS IGGPNPGRKD GIFSESTFNS PQGVAIMNNI IYVADTENHL
IRKIDLEAEK VSTVAGIGIQ GTDKEGGAKG EQQPISSPWD VVFGTSGSEV QRGDILWIAM
AGTHQIWALL LDSGKLPKKN ELTKGTCLRF AGSGNEENRN NAYPHKAGFA QPSGLSLASE
DPWSCLFVAD SESSTVRTVS LKDGAVKHLV GGERDPMNLF AFGDVDGVGI NAKLQHPLGV
TWDKKRNLLY VADSYNHKIK VVDPKTKNCT TLAGTGDTNN VTSSSFTEST FNEPGGLCIG
ENGELLYVAD TNNHQIKVMD LETKMVSVLP IFRSENAVVD GPFLVEKQKT LPKLPKSAPS
IRLSPVTACA GQTLQFKLRL DLPSGSKLTE GVSSCWFLTA EGNEWLLQGQ IAAGDIENIS
SQPTISLQIP DDCLSLEAIV SVSVFLYYCS ADSSACMMKA ILFSQPLQIT DTQQGCIAPV
ELRYVF
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