Full text data of NAP1L5
NAP1L5
(DRLM)
[Confidence: low (only semi-automatic identification from reviews)]
Nucleosome assembly protein 1-like 5 (Down-regulated in liver malignancy)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Nucleosome assembly protein 1-like 5 (Down-regulated in liver malignancy)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q96NT1
ID NP1L5_HUMAN Reviewed; 182 AA.
AC Q96NT1;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2001, sequence version 1.
DT 22-JAN-2014, entry version 85.
DE RecName: Full=Nucleosome assembly protein 1-like 5;
DE AltName: Full=Down-regulated in liver malignancy;
GN Name=NAP1L5; Synonyms=DRLM;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=12383514; DOI=10.1016/S0378-1119(02)00855-7;
RA Harada H., Nagai H., Ezura Y., Yokota T., Ohsawa I., Yamaguchi K.,
RA Ohue C., Tsuneizumi M., Mikami I., Terada Y., Yabe A., Emi M.;
RT "Down-regulation of a novel gene, DRLM, in human liver malignancy from
RT 4q22 that encodes a NAP-like protein.";
RL Gene 296:171-177(2002).
CC -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC -!- TISSUE SPECIFICITY: Predominantly expressed in brain.
CC -!- SIMILARITY: Belongs to the nucleosome assembly protein (NAP)
CC family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK054689; BAB70793.1; -; mRNA.
DR EMBL; CH471057; EAX06025.1; -; Genomic_DNA.
DR EMBL; BC104883; AAI04884.1; -; mRNA.
DR RefSeq; NP_715638.1; NM_153757.2.
DR UniGene; Hs.12554; -.
DR ProteinModelPortal; Q96NT1; -.
DR SMR; Q96NT1; 68-178.
DR IntAct; Q96NT1; 8.
DR MINT; MINT-1369088; -.
DR STRING; 9606.ENSP00000320488; -.
DR PhosphoSite; Q96NT1; -.
DR DMDM; 74732635; -.
DR PaxDb; Q96NT1; -.
DR PRIDE; Q96NT1; -.
DR Ensembl; ENST00000323061; ENSP00000320488; ENSG00000177432.
DR GeneID; 266812; -.
DR KEGG; hsa:266812; -.
DR UCSC; uc003hrx.3; human.
DR CTD; 266812; -.
DR GeneCards; GC04M089617; -.
DR HGNC; HGNC:19968; NAP1L5.
DR HPA; HPA038615; -.
DR MIM; 612203; gene.
DR neXtProt; NX_Q96NT1; -.
DR PharmGKB; PA134921404; -.
DR eggNOG; NOG251009; -.
DR HOGENOM; HOG000113834; -.
DR HOVERGEN; HBG056984; -.
DR InParanoid; Q96NT1; -.
DR KO; K11283; -.
DR OMA; CAWTLEG; -.
DR OrthoDB; EOG7BKCX2; -.
DR PhylomeDB; Q96NT1; -.
DR GenomeRNAi; 266812; -.
DR NextBio; 93352; -.
DR PRO; PR:Q96NT1; -.
DR Bgee; Q96NT1; -.
DR CleanEx; HS_NAP1L5; -.
DR Genevestigator; Q96NT1; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR InterPro; IPR002164; NAP_family.
DR PANTHER; PTHR11875; PTHR11875; 1.
DR Pfam; PF00956; NAP; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Complete proteome; Nucleus; Polymorphism;
KW Reference proteome.
FT CHAIN 1 182 Nucleosome assembly protein 1-like 5.
FT /FTId=PRO_0000317142.
FT COILED 81 107 Potential.
FT COMPBIAS 15 23 Poly-Ala.
FT COMPBIAS 122 162 Glu-rich.
FT VARIANT 154 154 E -> Q (in dbSNP:rs13109442).
FT /FTId=VAR_050227.
SQ SEQUENCE 182 AA; 19593 MW; 8774791B37F99986 CRC64;
MADSENQGPA EPSQAAAAAE AAAEEVMAEG GAQGGDCDSA AGDPDSAAGQ MAEEPQTPAE
NAPKPKNDFI ESLPNSVKCR VLALKKLQKR CDKIEAKFDK EFQALEKKYN DIYKPLLAKI
QELTGEMEGC AWTLEGEEEE EEEYEDDEEE GEDEEEEEAA AEAAAGAKHD DAHAEMPDDA
KK
//
ID NP1L5_HUMAN Reviewed; 182 AA.
AC Q96NT1;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2001, sequence version 1.
DT 22-JAN-2014, entry version 85.
DE RecName: Full=Nucleosome assembly protein 1-like 5;
DE AltName: Full=Down-regulated in liver malignancy;
GN Name=NAP1L5; Synonyms=DRLM;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=12383514; DOI=10.1016/S0378-1119(02)00855-7;
RA Harada H., Nagai H., Ezura Y., Yokota T., Ohsawa I., Yamaguchi K.,
RA Ohue C., Tsuneizumi M., Mikami I., Terada Y., Yabe A., Emi M.;
RT "Down-regulation of a novel gene, DRLM, in human liver malignancy from
RT 4q22 that encodes a NAP-like protein.";
RL Gene 296:171-177(2002).
CC -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC -!- TISSUE SPECIFICITY: Predominantly expressed in brain.
CC -!- SIMILARITY: Belongs to the nucleosome assembly protein (NAP)
CC family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK054689; BAB70793.1; -; mRNA.
DR EMBL; CH471057; EAX06025.1; -; Genomic_DNA.
DR EMBL; BC104883; AAI04884.1; -; mRNA.
DR RefSeq; NP_715638.1; NM_153757.2.
DR UniGene; Hs.12554; -.
DR ProteinModelPortal; Q96NT1; -.
DR SMR; Q96NT1; 68-178.
DR IntAct; Q96NT1; 8.
DR MINT; MINT-1369088; -.
DR STRING; 9606.ENSP00000320488; -.
DR PhosphoSite; Q96NT1; -.
DR DMDM; 74732635; -.
DR PaxDb; Q96NT1; -.
DR PRIDE; Q96NT1; -.
DR Ensembl; ENST00000323061; ENSP00000320488; ENSG00000177432.
DR GeneID; 266812; -.
DR KEGG; hsa:266812; -.
DR UCSC; uc003hrx.3; human.
DR CTD; 266812; -.
DR GeneCards; GC04M089617; -.
DR HGNC; HGNC:19968; NAP1L5.
DR HPA; HPA038615; -.
DR MIM; 612203; gene.
DR neXtProt; NX_Q96NT1; -.
DR PharmGKB; PA134921404; -.
DR eggNOG; NOG251009; -.
DR HOGENOM; HOG000113834; -.
DR HOVERGEN; HBG056984; -.
DR InParanoid; Q96NT1; -.
DR KO; K11283; -.
DR OMA; CAWTLEG; -.
DR OrthoDB; EOG7BKCX2; -.
DR PhylomeDB; Q96NT1; -.
DR GenomeRNAi; 266812; -.
DR NextBio; 93352; -.
DR PRO; PR:Q96NT1; -.
DR Bgee; Q96NT1; -.
DR CleanEx; HS_NAP1L5; -.
DR Genevestigator; Q96NT1; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR InterPro; IPR002164; NAP_family.
DR PANTHER; PTHR11875; PTHR11875; 1.
DR Pfam; PF00956; NAP; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Complete proteome; Nucleus; Polymorphism;
KW Reference proteome.
FT CHAIN 1 182 Nucleosome assembly protein 1-like 5.
FT /FTId=PRO_0000317142.
FT COILED 81 107 Potential.
FT COMPBIAS 15 23 Poly-Ala.
FT COMPBIAS 122 162 Glu-rich.
FT VARIANT 154 154 E -> Q (in dbSNP:rs13109442).
FT /FTId=VAR_050227.
SQ SEQUENCE 182 AA; 19593 MW; 8774791B37F99986 CRC64;
MADSENQGPA EPSQAAAAAE AAAEEVMAEG GAQGGDCDSA AGDPDSAAGQ MAEEPQTPAE
NAPKPKNDFI ESLPNSVKCR VLALKKLQKR CDKIEAKFDK EFQALEKKYN DIYKPLLAKI
QELTGEMEGC AWTLEGEEEE EEEYEDDEEE GEDEEEEEAA AEAAAGAKHD DAHAEMPDDA
KK
//
MIM
612203
*RECORD*
*FIELD* NO
612203
*FIELD* TI
*612203 NUCLEOSOME ASSEMBLY PROTEIN 1-LIKE 5; NAP1L5
;;DOWNREGULATED IN LIVER MALIGNANCY; DRLM
read more*FIELD* TX
CLONING
By searching for genes in a region of chromosome 4 that is commonly
deleted in hepatocellular carcinomas (HCC), followed by 5-prime and
3-prime RACE of normal human breast cDNA, Harada et al. (2002) cloned
NAP1L5, which they called DRLM. The deduced 182-amino acid protein has
an N-terminal half similar to HSPD1 (118190) and a C-terminal half
similar to the yeast nucleosome assembly protein (see NAP1L1; 164060).
The authors also identified mouse Nap1l5, which shares 75% identity with
human NAP1L5. Northern blot analysis of human tissues detected a major
NAP1L5 transcript between 2- and 2.3-kb, with highest expression in
brain, followed by liver, kidney, heart, and skeletal muscle. Weak
expression was detected in all other tissues, and a minor 5-kb
transcript was also observed. Fluorescence-tagged NAP1L5 was expressed
in the cytosol of transfected HeLa cells.
GENE FUNCTION
Harada et al. (2002) found that expression of DRLM was downregulated in
5 of 13 HCC cell lines and in 7 of 16 primary HCCs in comparison with
normal tissue.
GENE STRUCTURE
Harada et al. (2002) determined that the coding region of the NAP1L5
gene is contained within a single exon.
MAPPING
Harada et al. (2002) identified NAP1L5 in a region of chromosome
4q21-q22 that is frequently deleted in HCCs and hepatoblastomas.
*FIELD* RF
1. Harada, H.; Nagai, H.; Ezura, Y.; Yokota, T.; Ohsawa, I.; Yamaguchi,
K.; Ohue, C.; Tsuneizumi, M.; Mikami, I.; Terada, Y.; Yabe, A.; Emi,
M.: Down-regulation of a novel gene, DRLM, in human liver malignancy
from 4q22 that encodes a NAP-like protein. Gene 296: 171-177, 2002.
*FIELD* CD
Patricia A. Hartz: 7/30/2008
*FIELD* ED
wwang: 07/30/2008
*RECORD*
*FIELD* NO
612203
*FIELD* TI
*612203 NUCLEOSOME ASSEMBLY PROTEIN 1-LIKE 5; NAP1L5
;;DOWNREGULATED IN LIVER MALIGNANCY; DRLM
read more*FIELD* TX
CLONING
By searching for genes in a region of chromosome 4 that is commonly
deleted in hepatocellular carcinomas (HCC), followed by 5-prime and
3-prime RACE of normal human breast cDNA, Harada et al. (2002) cloned
NAP1L5, which they called DRLM. The deduced 182-amino acid protein has
an N-terminal half similar to HSPD1 (118190) and a C-terminal half
similar to the yeast nucleosome assembly protein (see NAP1L1; 164060).
The authors also identified mouse Nap1l5, which shares 75% identity with
human NAP1L5. Northern blot analysis of human tissues detected a major
NAP1L5 transcript between 2- and 2.3-kb, with highest expression in
brain, followed by liver, kidney, heart, and skeletal muscle. Weak
expression was detected in all other tissues, and a minor 5-kb
transcript was also observed. Fluorescence-tagged NAP1L5 was expressed
in the cytosol of transfected HeLa cells.
GENE FUNCTION
Harada et al. (2002) found that expression of DRLM was downregulated in
5 of 13 HCC cell lines and in 7 of 16 primary HCCs in comparison with
normal tissue.
GENE STRUCTURE
Harada et al. (2002) determined that the coding region of the NAP1L5
gene is contained within a single exon.
MAPPING
Harada et al. (2002) identified NAP1L5 in a region of chromosome
4q21-q22 that is frequently deleted in HCCs and hepatoblastomas.
*FIELD* RF
1. Harada, H.; Nagai, H.; Ezura, Y.; Yokota, T.; Ohsawa, I.; Yamaguchi,
K.; Ohue, C.; Tsuneizumi, M.; Mikami, I.; Terada, Y.; Yabe, A.; Emi,
M.: Down-regulation of a novel gene, DRLM, in human liver malignancy
from 4q22 that encodes a NAP-like protein. Gene 296: 171-177, 2002.
*FIELD* CD
Patricia A. Hartz: 7/30/2008
*FIELD* ED
wwang: 07/30/2008