Full text data of NRBF2
NRBF2
(COPR)
[Confidence: low (only semi-automatic identification from reviews)]
Nuclear receptor-binding factor 2; NRBF-2 (Comodulator of PPAR and RXR)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Nuclear receptor-binding factor 2; NRBF-2 (Comodulator of PPAR and RXR)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q96F24
ID NRBF2_HUMAN Reviewed; 287 AA.
AC Q96F24; A6PW36; Q86UR2; Q96NP6; Q9H0S9; Q9H2I2;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2001, sequence version 1.
DT 22-JAN-2014, entry version 98.
DE RecName: Full=Nuclear receptor-binding factor 2;
DE Short=NRBF-2;
DE AltName: Full=Comodulator of PPAR and RXR;
GN Name=NRBF2; Synonyms=COPR;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, MUTAGENESIS
RP OF 144-LEU-LEU-145, INTERACTION WITH PPARA; PPARD; PPARG; RARA; RARG
RP AND RXRA, AND TISSUE SPECIFICITY.
RC TISSUE=Keratinocyte;
RX PubMed=15610520; DOI=10.1111/j.0022-202X.2004.23424.x;
RA Flores A.M., Li L., Aneskievich B.J.;
RT "Isolation and functional analysis of a keratinocyte-derived, ligand-
RT regulated nuclear receptor comodulator.";
RL J. Invest. Dermatol. 123:1092-1101(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Dendritic cell;
RA Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.;
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA Wambutt R., Korn B., Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and
RT analysis of 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of
RT the kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268, AND MASS
RP SPECTROMETRY.
RX PubMed=19369195; DOI=10.1074/mcp.M800588-MCP200;
RA Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,
RA Mann M., Daub H.;
RT "Large-scale proteomics analysis of the human kinome.";
RL Mol. Cell. Proteomics 8:1751-1764(2009).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA Blagoev B.;
RT "System-wide temporal characterization of the proteome and
RT phosphoproteome of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [12]
RP INTERACTION WITH SCOC.
RX PubMed=22354037; DOI=10.1038/emboj.2012.36;
RA McKnight N.C., Jefferies H.B., Alemu E.A., Saunders R.E., Howell M.,
RA Johansen T., Tooze S.A.;
RT "Genome-wide siRNA screen reveals amino acid starvation-induced
RT autophagy requires SCOC and WAC.";
RL EMBO J. 31:1931-1946(2012).
CC -!- FUNCTION: May modulate transcriptional activation by target
CC nuclear receptors. Can act as transcriptional activator (in
CC vitro).
CC -!- SUBUNIT: Interacts with PPARA, PPARD and PPARG. Interacts with
CC RARA, RARG and RXRA in the presence of bound ligand. Interacts
CC with SCOC.
CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By
CC similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=COPR2, Comodulator of PPAR and RXR 2;
CC IsoId=Q96F24-1; Sequence=Displayed;
CC Name=2; Synonyms=COPR1, Comodulator of PPAR and RXR 1;
CC IsoId=Q96F24-2; Sequence=VSP_018488;
CC -!- TISSUE SPECIFICITY: Detected in keratinocytes, liver and placenta.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG44735.1; Type=Frameshift; Positions=234, 251, 278;
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DR EMBL; AY267839; AAP03081.1; -; mRNA.
DR EMBL; AY267840; AAP03082.1; -; mRNA.
DR EMBL; AF267866; AAG44735.1; ALT_FRAME; mRNA.
DR EMBL; AL136656; CAB66591.1; -; mRNA.
DR EMBL; AK054957; BAB70833.1; -; mRNA.
DR EMBL; AL590502; CAO03491.1; -; Genomic_DNA.
DR EMBL; CH471083; EAW54241.1; -; Genomic_DNA.
DR EMBL; BC011707; AAH11707.1; -; mRNA.
DR RefSeq; NP_110386.2; NM_030759.4.
DR RefSeq; XP_005269780.1; XM_005269723.1.
DR UniGene; Hs.449628; -.
DR ProteinModelPortal; Q96F24; -.
DR SMR; Q96F24; 4-87.
DR IntAct; Q96F24; 10.
DR MINT; MINT-4715689; -.
DR STRING; 9606.ENSP00000277746; -.
DR DMDM; 74731648; -.
DR PaxDb; Q96F24; -.
DR PRIDE; Q96F24; -.
DR DNASU; 29982; -.
DR Ensembl; ENST00000277746; ENSP00000277746; ENSG00000148572.
DR GeneID; 29982; -.
DR KEGG; hsa:29982; -.
DR UCSC; uc001jmj.4; human.
DR CTD; 29982; -.
DR GeneCards; GC10P064893; -.
DR H-InvDB; HIX0008862; -.
DR H-InvDB; HIX0170466; -.
DR HGNC; HGNC:19692; NRBF2.
DR neXtProt; NX_Q96F24; -.
DR PharmGKB; PA134946285; -.
DR eggNOG; NOG26343; -.
DR HOGENOM; HOG000293418; -.
DR HOVERGEN; HBG056976; -.
DR InParanoid; Q96F24; -.
DR OMA; AASSTWQ; -.
DR OrthoDB; EOG7XDBH8; -.
DR PhylomeDB; Q96F24; -.
DR Reactome; REACT_71; Gene Expression.
DR GeneWiki; NRBF2; -.
DR GenomeRNAi; 29982; -.
DR NextBio; 52742; -.
DR PRO; PR:Q96F24; -.
DR ArrayExpress; Q96F24; -.
DR Bgee; Q96F24; -.
DR CleanEx; HS_NRBF2; -.
DR Genevestigator; Q96F24; -.
DR GO; GO:0005737; C:cytoplasm; IDA:LIFEdb.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
DR InterPro; IPR015056; DUF1875.
DR Pfam; PF08961; DUF1875; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Complete proteome; Cytoplasm;
KW Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1 287 Nuclear receptor-binding factor 2.
FT /FTId=PRO_0000235816.
FT COILED 168 209 Potential.
FT MOTIF 141 145 Nuclear receptor interaction motif.
FT MOD_RES 268 268 Phosphoserine.
FT VAR_SEQ 90 139 Missing (in isoform 2).
FT /FTId=VSP_018488.
FT MUTAGEN 144 145 LL->AA: Decreased interaction with
FT nuclear receptors.
FT CONFLICT 150 150 E -> G (in Ref. 4; BAB70833).
FT CONFLICT 284 284 F -> L (in Ref. 3; CAB66591).
SQ SEQUENCE 287 AA; 32378 MW; 91EC0407F5108806 CRC64;
MEVMEGPLNL AHQQSRRADR LLAAGKYEEA ISCHKKAAAY LSEAMKLTQS EQAHLSLELQ
RDSHMKQLLL IQERWKRAQR EERLKAQQNT DKDAAAHLQT SHKPSAEDAE GQSPLSQKYS
PSTEKCLPEI QGIFDRDPDT LLYLLQQKSE PAEPCIGSKA PKDDKTIIEE QATKIADLKR
HVEFLVAENE RLRKENKQLK AEKARLLKGP IEKELDVDAD FVETSELWSL PPHAETATAS
STWQKFAANT GKAKDIPIPN LPPLDFPSPE LPLMELSEDI LKGFMNN
//
ID NRBF2_HUMAN Reviewed; 287 AA.
AC Q96F24; A6PW36; Q86UR2; Q96NP6; Q9H0S9; Q9H2I2;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2001, sequence version 1.
DT 22-JAN-2014, entry version 98.
DE RecName: Full=Nuclear receptor-binding factor 2;
DE Short=NRBF-2;
DE AltName: Full=Comodulator of PPAR and RXR;
GN Name=NRBF2; Synonyms=COPR;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, MUTAGENESIS
RP OF 144-LEU-LEU-145, INTERACTION WITH PPARA; PPARD; PPARG; RARA; RARG
RP AND RXRA, AND TISSUE SPECIFICITY.
RC TISSUE=Keratinocyte;
RX PubMed=15610520; DOI=10.1111/j.0022-202X.2004.23424.x;
RA Flores A.M., Li L., Aneskievich B.J.;
RT "Isolation and functional analysis of a keratinocyte-derived, ligand-
RT regulated nuclear receptor comodulator.";
RL J. Invest. Dermatol. 123:1092-1101(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Dendritic cell;
RA Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.;
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA Wambutt R., Korn B., Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and
RT analysis of 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of
RT the kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268, AND MASS
RP SPECTROMETRY.
RX PubMed=19369195; DOI=10.1074/mcp.M800588-MCP200;
RA Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,
RA Mann M., Daub H.;
RT "Large-scale proteomics analysis of the human kinome.";
RL Mol. Cell. Proteomics 8:1751-1764(2009).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA Blagoev B.;
RT "System-wide temporal characterization of the proteome and
RT phosphoproteome of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [12]
RP INTERACTION WITH SCOC.
RX PubMed=22354037; DOI=10.1038/emboj.2012.36;
RA McKnight N.C., Jefferies H.B., Alemu E.A., Saunders R.E., Howell M.,
RA Johansen T., Tooze S.A.;
RT "Genome-wide siRNA screen reveals amino acid starvation-induced
RT autophagy requires SCOC and WAC.";
RL EMBO J. 31:1931-1946(2012).
CC -!- FUNCTION: May modulate transcriptional activation by target
CC nuclear receptors. Can act as transcriptional activator (in
CC vitro).
CC -!- SUBUNIT: Interacts with PPARA, PPARD and PPARG. Interacts with
CC RARA, RARG and RXRA in the presence of bound ligand. Interacts
CC with SCOC.
CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By
CC similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=COPR2, Comodulator of PPAR and RXR 2;
CC IsoId=Q96F24-1; Sequence=Displayed;
CC Name=2; Synonyms=COPR1, Comodulator of PPAR and RXR 1;
CC IsoId=Q96F24-2; Sequence=VSP_018488;
CC -!- TISSUE SPECIFICITY: Detected in keratinocytes, liver and placenta.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG44735.1; Type=Frameshift; Positions=234, 251, 278;
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DR EMBL; AY267839; AAP03081.1; -; mRNA.
DR EMBL; AY267840; AAP03082.1; -; mRNA.
DR EMBL; AF267866; AAG44735.1; ALT_FRAME; mRNA.
DR EMBL; AL136656; CAB66591.1; -; mRNA.
DR EMBL; AK054957; BAB70833.1; -; mRNA.
DR EMBL; AL590502; CAO03491.1; -; Genomic_DNA.
DR EMBL; CH471083; EAW54241.1; -; Genomic_DNA.
DR EMBL; BC011707; AAH11707.1; -; mRNA.
DR RefSeq; NP_110386.2; NM_030759.4.
DR RefSeq; XP_005269780.1; XM_005269723.1.
DR UniGene; Hs.449628; -.
DR ProteinModelPortal; Q96F24; -.
DR SMR; Q96F24; 4-87.
DR IntAct; Q96F24; 10.
DR MINT; MINT-4715689; -.
DR STRING; 9606.ENSP00000277746; -.
DR DMDM; 74731648; -.
DR PaxDb; Q96F24; -.
DR PRIDE; Q96F24; -.
DR DNASU; 29982; -.
DR Ensembl; ENST00000277746; ENSP00000277746; ENSG00000148572.
DR GeneID; 29982; -.
DR KEGG; hsa:29982; -.
DR UCSC; uc001jmj.4; human.
DR CTD; 29982; -.
DR GeneCards; GC10P064893; -.
DR H-InvDB; HIX0008862; -.
DR H-InvDB; HIX0170466; -.
DR HGNC; HGNC:19692; NRBF2.
DR neXtProt; NX_Q96F24; -.
DR PharmGKB; PA134946285; -.
DR eggNOG; NOG26343; -.
DR HOGENOM; HOG000293418; -.
DR HOVERGEN; HBG056976; -.
DR InParanoid; Q96F24; -.
DR OMA; AASSTWQ; -.
DR OrthoDB; EOG7XDBH8; -.
DR PhylomeDB; Q96F24; -.
DR Reactome; REACT_71; Gene Expression.
DR GeneWiki; NRBF2; -.
DR GenomeRNAi; 29982; -.
DR NextBio; 52742; -.
DR PRO; PR:Q96F24; -.
DR ArrayExpress; Q96F24; -.
DR Bgee; Q96F24; -.
DR CleanEx; HS_NRBF2; -.
DR Genevestigator; Q96F24; -.
DR GO; GO:0005737; C:cytoplasm; IDA:LIFEdb.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
DR InterPro; IPR015056; DUF1875.
DR Pfam; PF08961; DUF1875; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Complete proteome; Cytoplasm;
KW Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1 287 Nuclear receptor-binding factor 2.
FT /FTId=PRO_0000235816.
FT COILED 168 209 Potential.
FT MOTIF 141 145 Nuclear receptor interaction motif.
FT MOD_RES 268 268 Phosphoserine.
FT VAR_SEQ 90 139 Missing (in isoform 2).
FT /FTId=VSP_018488.
FT MUTAGEN 144 145 LL->AA: Decreased interaction with
FT nuclear receptors.
FT CONFLICT 150 150 E -> G (in Ref. 4; BAB70833).
FT CONFLICT 284 284 F -> L (in Ref. 3; CAB66591).
SQ SEQUENCE 287 AA; 32378 MW; 91EC0407F5108806 CRC64;
MEVMEGPLNL AHQQSRRADR LLAAGKYEEA ISCHKKAAAY LSEAMKLTQS EQAHLSLELQ
RDSHMKQLLL IQERWKRAQR EERLKAQQNT DKDAAAHLQT SHKPSAEDAE GQSPLSQKYS
PSTEKCLPEI QGIFDRDPDT LLYLLQQKSE PAEPCIGSKA PKDDKTIIEE QATKIADLKR
HVEFLVAENE RLRKENKQLK AEKARLLKGP IEKELDVDAD FVETSELWSL PPHAETATAS
STWQKFAANT GKAKDIPIPN LPPLDFPSPE LPLMELSEDI LKGFMNN
//