Full text data of NRD1
NRD1
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
B1AKJ5
ID B1AKJ5_HUMAN Unreviewed; 1219 AA.
AC B1AKJ5;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
read moreDT 22-JAN-2014, entry version 54.
DE SubName: Full=Nardilysin;
DE SubName: Full=Nardilysin (N-arginine dibasic convertase), isoform CRA_d;
GN Name=NRD1; ORFNames=hCG_40292;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11181995; DOI=10.1126/science.1058040;
RA Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
RA Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D.,
RA Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q.,
RA Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G.,
RA Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S.,
RA Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J.,
RA Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R.,
RA Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A.,
RA Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K.,
RA Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V.,
RA Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
RA Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
RA Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z.,
RA Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A.,
RA Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V.,
RA Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B.,
RA Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J.,
RA Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C.,
RA Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L.,
RA Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S.,
RA Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A.,
RA Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D.,
RA Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L.,
RA Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N.,
RA Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S.,
RA Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F.,
RA Kline L., Koduru S., Love A., Mann F., May D., McCawley S.,
RA McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K.,
RA Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
RA Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
RA Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N.,
RA Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M.,
RA Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F.,
RA Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A.,
RA Mi H., Lazareva B., Hatton T., Narechania A., Diemer K.,
RA Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R.,
RA Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J.,
RA Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H.,
RA Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D.,
RA Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A.,
RA Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S.,
RA Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L.,
RA Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W.,
RA McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M.,
RA Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
RA Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
RA Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
RT "The sequence of the human genome.";
RL Science 291:1304-1351(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA Porter K.M., Prigmore E.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AL050343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL589663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471059; EAX06807.1; -; Genomic_DNA.
DR RefSeq; NP_002516.2; NM_002525.2.
DR UniGene; Hs.584782; -.
DR ProteinModelPortal; B1AKJ5; -.
DR SMR; B1AKJ5; 279-1157.
DR MEROPS; M16.005; -.
DR PRIDE; B1AKJ5; -.
DR Ensembl; ENST00000354831; ENSP00000346890; ENSG00000078618.
DR GeneID; 4898; -.
DR KEGG; hsa:4898; -.
DR UCSC; uc001ctc.4; human.
DR CTD; 4898; -.
DR HGNC; HGNC:7995; NRD1.
DR PharmGKB; PA31774; -.
DR HOGENOM; HOG000231160; -.
DR HOVERGEN; HBG006530; -.
DR KO; K01411; -.
DR OMA; RSLKEYT; -.
DR PhylomeDB; B1AKJ5; -.
DR ChiTaRS; NRD1; human.
DR GenomeRNAi; 4898; -.
DR NextBio; 18847; -.
DR ArrayExpress; B1AKJ5; -.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.30.830.10; -; 5.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011237; Pept_M16_dom.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR SUPFAM; SSF63411; SSF63411; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Reference proteome.
SQ SEQUENCE 1219 AA; 139413 MW; 4E41D50112DB4070 CRC64;
MLRRVTVAAV CATRRKLCEA GRELAALWGI ETRGRCEDSA AARPFPILAM PGRNKAKSTC
SCPDLQPNGQ DLGENSRVAR LGADESEEEG RRGSLSNAGD PEIVKSPSDP KQYRYIKLQN
GLQALLISDL SNMEGKTGNT TDDEEEEEVE EEEEDDDEDS GAEIEDDDEE GFDDEDEFDD
EHDDDLDTED NELEELEERA EARKKTTEKQ QLQSLFLLWS KLTDRLWFKS TYSKMSSTLL
VETRNLYGVV GAESRSAPVQ HLAGWQAEEQ QGETDTVLSA AALCVGVGSF ADPDDLPGLA
HFLEHMVFMG SLKYPDENGF DAFLKKHGGS DNASTDCERT VFQFDVQRKY FKEALDRWAQ
FFIHPLMIRD AIDREVEAVD SEYQLARPSD ANRKEMLFGS LARPGHPMGK FFWGNAETLK
HEPRKNNIDT HARLREFWMR YYSSHYMTLV VQSKETLDTL EKWVTEIFSQ IPNNGLPRPN
FGHLTDPFDT PAFNKLYRVV PIRKIHALTI TWALPPQQQH YRVKPLHYIS WLVGHEGKGS
ILSFLRKKCW ALALFGGNGE TGFEQNSTYS VFSISITLTD EGYEHFYEVA YTVFQYLKML
QKLGPEKRIF EEIRKIEDNE FHYQEQTDPV EYVENMCENM QLYPLQDILT GDQLLFEYKP
EVIGEALNQL VPQKANLVLL SGANEGKCDL KEKWFGTQYS IEDIENSWAE LWNSNFELNP
DLHLPAENKY IATDFTLKAF DCPETEYPVK IVNTPQGCLW YKKDNKFKIP KAYIRFHLIS
PLIQKSAANV VLFDIFVNIL THNLAEPAYE ADVAQLEYKL VAGEHGLIIR VKGFNHKLPL
LFQLIIDYLA EFNSTPAVFT MITEQLKKTY FNILIKPETL AKDVRLLILE YARWSMIDKY
QALMDGLSLE SLLSFVKEFK SQLFVEGLVQ GNVTSTESMD FLKYVVDKLN FKPLEQEMPV
QFQVVELPSG HHLCKVKALN KGDANSEVTV YYQSGTRSLR EYTLMELLVM HMEEPCFDFL
RTKQTLGYHV YPTCRNTSGI LGFSVTVGTQ ATKYNSEVVD KKIEEFLSSF EEKIENLTEE
AFNTQVTALI KLKECEDTHL GEEVDRNWNE VVTQQYLFDR LAHEIEALKS FSKSDLVNWF
KAHRGPGSKM LSVHVVGYGK YELEEDGTPS SEDSNSSCEV MQLTYLPTSP LLADCIIPIT
DIRAFTTTLN LLPYHKIVK
//
ID B1AKJ5_HUMAN Unreviewed; 1219 AA.
AC B1AKJ5;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
read moreDT 22-JAN-2014, entry version 54.
DE SubName: Full=Nardilysin;
DE SubName: Full=Nardilysin (N-arginine dibasic convertase), isoform CRA_d;
GN Name=NRD1; ORFNames=hCG_40292;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11181995; DOI=10.1126/science.1058040;
RA Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
RA Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D.,
RA Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q.,
RA Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G.,
RA Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S.,
RA Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J.,
RA Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R.,
RA Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A.,
RA Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K.,
RA Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V.,
RA Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
RA Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
RA Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z.,
RA Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A.,
RA Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V.,
RA Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B.,
RA Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J.,
RA Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C.,
RA Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L.,
RA Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S.,
RA Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A.,
RA Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D.,
RA Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L.,
RA Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N.,
RA Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S.,
RA Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F.,
RA Kline L., Koduru S., Love A., Mann F., May D., McCawley S.,
RA McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K.,
RA Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
RA Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
RA Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N.,
RA Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M.,
RA Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F.,
RA Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A.,
RA Mi H., Lazareva B., Hatton T., Narechania A., Diemer K.,
RA Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R.,
RA Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J.,
RA Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H.,
RA Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D.,
RA Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A.,
RA Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S.,
RA Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L.,
RA Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W.,
RA McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M.,
RA Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
RA Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
RA Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
RT "The sequence of the human genome.";
RL Science 291:1304-1351(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA Porter K.M., Prigmore E.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AL050343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL589663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471059; EAX06807.1; -; Genomic_DNA.
DR RefSeq; NP_002516.2; NM_002525.2.
DR UniGene; Hs.584782; -.
DR ProteinModelPortal; B1AKJ5; -.
DR SMR; B1AKJ5; 279-1157.
DR MEROPS; M16.005; -.
DR PRIDE; B1AKJ5; -.
DR Ensembl; ENST00000354831; ENSP00000346890; ENSG00000078618.
DR GeneID; 4898; -.
DR KEGG; hsa:4898; -.
DR UCSC; uc001ctc.4; human.
DR CTD; 4898; -.
DR HGNC; HGNC:7995; NRD1.
DR PharmGKB; PA31774; -.
DR HOGENOM; HOG000231160; -.
DR HOVERGEN; HBG006530; -.
DR KO; K01411; -.
DR OMA; RSLKEYT; -.
DR PhylomeDB; B1AKJ5; -.
DR ChiTaRS; NRD1; human.
DR GenomeRNAi; 4898; -.
DR NextBio; 18847; -.
DR ArrayExpress; B1AKJ5; -.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.30.830.10; -; 5.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011237; Pept_M16_dom.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR SUPFAM; SSF63411; SSF63411; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Reference proteome.
SQ SEQUENCE 1219 AA; 139413 MW; 4E41D50112DB4070 CRC64;
MLRRVTVAAV CATRRKLCEA GRELAALWGI ETRGRCEDSA AARPFPILAM PGRNKAKSTC
SCPDLQPNGQ DLGENSRVAR LGADESEEEG RRGSLSNAGD PEIVKSPSDP KQYRYIKLQN
GLQALLISDL SNMEGKTGNT TDDEEEEEVE EEEEDDDEDS GAEIEDDDEE GFDDEDEFDD
EHDDDLDTED NELEELEERA EARKKTTEKQ QLQSLFLLWS KLTDRLWFKS TYSKMSSTLL
VETRNLYGVV GAESRSAPVQ HLAGWQAEEQ QGETDTVLSA AALCVGVGSF ADPDDLPGLA
HFLEHMVFMG SLKYPDENGF DAFLKKHGGS DNASTDCERT VFQFDVQRKY FKEALDRWAQ
FFIHPLMIRD AIDREVEAVD SEYQLARPSD ANRKEMLFGS LARPGHPMGK FFWGNAETLK
HEPRKNNIDT HARLREFWMR YYSSHYMTLV VQSKETLDTL EKWVTEIFSQ IPNNGLPRPN
FGHLTDPFDT PAFNKLYRVV PIRKIHALTI TWALPPQQQH YRVKPLHYIS WLVGHEGKGS
ILSFLRKKCW ALALFGGNGE TGFEQNSTYS VFSISITLTD EGYEHFYEVA YTVFQYLKML
QKLGPEKRIF EEIRKIEDNE FHYQEQTDPV EYVENMCENM QLYPLQDILT GDQLLFEYKP
EVIGEALNQL VPQKANLVLL SGANEGKCDL KEKWFGTQYS IEDIENSWAE LWNSNFELNP
DLHLPAENKY IATDFTLKAF DCPETEYPVK IVNTPQGCLW YKKDNKFKIP KAYIRFHLIS
PLIQKSAANV VLFDIFVNIL THNLAEPAYE ADVAQLEYKL VAGEHGLIIR VKGFNHKLPL
LFQLIIDYLA EFNSTPAVFT MITEQLKKTY FNILIKPETL AKDVRLLILE YARWSMIDKY
QALMDGLSLE SLLSFVKEFK SQLFVEGLVQ GNVTSTESMD FLKYVVDKLN FKPLEQEMPV
QFQVVELPSG HHLCKVKALN KGDANSEVTV YYQSGTRSLR EYTLMELLVM HMEEPCFDFL
RTKQTLGYHV YPTCRNTSGI LGFSVTVGTQ ATKYNSEVVD KKIEEFLSSF EEKIENLTEE
AFNTQVTALI KLKECEDTHL GEEVDRNWNE VVTQQYLFDR LAHEIEALKS FSKSDLVNWF
KAHRGPGSKM LSVHVVGYGK YELEEDGTPS SEDSNSSCEV MQLTYLPTSP LLADCIIPIT
DIRAFTTTLN LLPYHKIVK
//