Full text data of NUPL1
NUPL1
(KIAA0410)
[Confidence: low (only semi-automatic identification from reviews)]
Nucleoporin p58/p45 (Nucleoporin-like protein 1)
Nucleoporin p58/p45 (Nucleoporin-like protein 1)
UniProt
Q9BVL2
ID NUPL1_HUMAN Reviewed; 599 AA.
AC Q9BVL2; A6NI12; B4DZJ1; O43160; Q5JRG2; Q5JRG5;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-2001, sequence version 1.
DT 22-JAN-2014, entry version 108.
DE RecName: Full=Nucleoporin p58/p45;
DE AltName: Full=Nucleoporin-like protein 1;
GN Name=NUPL1; Synonyms=KIAA0410;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=9455477; DOI=10.1093/dnares/4.5.307;
RA Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N.,
RA Tanaka A., Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. VIII.
RT 78 new cDNA clones from brain which code for large proteins in
RT vitro.";
RL DNA Res. 4:307-313(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT
RP THR-34.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E.,
RA Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.,
RA Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R.,
RA Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S.,
RA Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M.,
RA Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J.,
RA Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E.,
RA Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L.,
RA Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J.,
RA Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S.,
RA Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J.,
RA Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M.,
RA King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A.,
RA Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S.,
RA Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I.,
RA Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S.,
RA Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A.,
RA Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L.,
RA Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M.,
RA Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-331, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Component of the nuclear pore complex, a complex
CC required for the trafficking across the nuclear membrane (By
CC similarity).
CC -!- SUBUNIT: Component of the p62 complex, a complex at least composed
CC of NUP62, NUP54, and NUPL1. Interacts with NUTF2. Interacts with
CC SRP1-alpha and Importin p97 proteins when they are together, but
CC not with SRP1-alpha protein alone (By similarity).
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex (By
CC similarity). Nucleus membrane; Peripheral membrane protein;
CC Cytoplasmic side (By similarity). Nucleus membrane; Peripheral
CC membrane protein; Nucleoplasmic side (By similarity). Note=Biased
CC towards cytoplasmic side. Central region of the nuclear pore
CC complex, within the transporter (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=p58;
CC IsoId=Q9BVL2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BVL2-2; Sequence=VSP_007946, VSP_007947;
CC Name=3;
CC IsoId=Q9BVL2-3; Sequence=VSP_045658;
CC Note=No experimental confirmation available;
CC -!- DOMAIN: Contains FG repeats.
CC -!- PTM: O-glycosylated (By similarity).
CC -!- MISCELLANEOUS: In rat, the p62 complex contains two different
CC isoforms of NUPL1. Isoform p45 has however not been isolated in
CC human so far.
CC -!- SIMILARITY: Belongs to the NUPL1 family.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA23706.2; Type=Erroneous initiation;
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DR EMBL; AB007870; BAA23706.2; ALT_INIT; mRNA.
DR EMBL; AK302946; BAG64103.1; -; mRNA.
DR EMBL; AL138958; CAH71290.1; -; Genomic_DNA.
DR EMBL; AL590787; CAH71290.1; JOINED; Genomic_DNA.
DR EMBL; AL646102; CAH71290.1; JOINED; Genomic_DNA.
DR EMBL; AL590787; CAI39898.1; -; Genomic_DNA.
DR EMBL; AL138958; CAI39898.1; JOINED; Genomic_DNA.
DR EMBL; AL646102; CAI39898.1; JOINED; Genomic_DNA.
DR EMBL; AL590787; CAI39901.1; -; Genomic_DNA.
DR EMBL; AL646102; CAH72184.1; -; Genomic_DNA.
DR EMBL; AL138958; CAH72184.1; JOINED; Genomic_DNA.
DR EMBL; AL590787; CAH72184.1; JOINED; Genomic_DNA.
DR EMBL; BC001104; AAH01104.1; -; mRNA.
DR RefSeq; NP_001008564.1; NM_001008564.1.
DR RefSeq; NP_054808.1; NM_014089.3.
DR UniGene; Hs.507537; -.
DR UniGene; Hs.718943; -.
DR UniGene; Hs.732064; -.
DR ProteinModelPortal; Q9BVL2; -.
DR SMR; Q9BVL2; 341-426.
DR IntAct; Q9BVL2; 6.
DR STRING; 9606.ENSP00000371155; -.
DR PhosphoSite; Q9BVL2; -.
DR DMDM; 44888845; -.
DR PaxDb; Q9BVL2; -.
DR PRIDE; Q9BVL2; -.
DR Ensembl; ENST00000381718; ENSP00000371137; ENSG00000139496.
DR Ensembl; ENST00000381736; ENSP00000371155; ENSG00000139496.
DR Ensembl; ENST00000463407; ENSP00000418555; ENSG00000139496.
DR GeneID; 9818; -.
DR KEGG; hsa:9818; -.
DR UCSC; uc001uqj.3; human.
DR CTD; 9818; -.
DR GeneCards; GC13P025875; -.
DR HGNC; HGNC:20261; NUPL1.
DR HPA; HPA039360; -.
DR MIM; 607615; gene.
DR neXtProt; NX_Q9BVL2; -.
DR PharmGKB; PA134981903; -.
DR eggNOG; NOG148149; -.
DR HOGENOM; HOG000273874; -.
DR HOVERGEN; HBG052703; -.
DR InParanoid; Q9BVL2; -.
DR KO; K14307; -.
DR OMA; HENVKML; -.
DR OrthoDB; EOG7H1JN7; -.
DR PhylomeDB; Q9BVL2; -.
DR Reactome; REACT_111217; Metabolism.
DR Reactome; REACT_115566; Cell Cycle.
DR Reactome; REACT_116125; Disease.
DR Reactome; REACT_15518; Transmembrane transport of small molecules.
DR Reactome; REACT_21300; Mitotic M-M/G1 phases.
DR Reactome; REACT_6900; Immune System.
DR ChiTaRS; NUPL1; human.
DR GeneWiki; NUPL1; -.
DR GenomeRNAi; 9818; -.
DR NextBio; 35476494; -.
DR PRO; PR:Q9BVL2; -.
DR ArrayExpress; Q9BVL2; -.
DR Bgee; Q9BVL2; -.
DR CleanEx; HS_NUPL1; -.
DR Genevestigator; Q9BVL2; -.
DR GO; GO:0005635; C:nuclear envelope; TAS:Reactome.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR GO; GO:0005487; F:nucleocytoplasmic transporter activity; IEA:Ensembl.
DR GO; GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.
DR GO; GO:0015758; P:glucose transport; TAS:Reactome.
DR GO; GO:0007077; P:mitotic nuclear envelope disassembly; TAS:Reactome.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0010827; P:regulation of glucose transport; TAS:Reactome.
DR GO; GO:0044281; P:small molecule metabolic process; TAS:Reactome.
DR GO; GO:0055085; P:transmembrane transport; TAS:Reactome.
DR GO; GO:0016032; P:viral process; TAS:Reactome.
DR InterPro; IPR024882; Nucleoporin_p58/p45.
DR PANTHER; PTHR13437; PTHR13437; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Complete proteome; Glycoprotein;
KW Membrane; mRNA transport; Nuclear pore complex; Nucleus;
KW Phosphoprotein; Polymorphism; Protein transport; Reference proteome;
KW Repeat; Translocation; Transport.
FT CHAIN 1 599 Nucleoporin p58/p45.
FT /FTId=PRO_0000204892.
FT REPEAT 7 8 1.
FT REPEAT 30 31 2.
FT REPEAT 44 45 3.
FT REPEAT 63 64 4.
FT REPEAT 68 69 5.
FT REPEAT 488 489 6.
FT REPEAT 492 493 7.
FT REPEAT 513 514 8.
FT REPEAT 519 520 9.
FT REPEAT 529 530 10.
FT REPEAT 531 532 11.
FT REPEAT 545 546 12.
FT REPEAT 568 569 13.
FT REPEAT 578 579 14.
FT REGION 7 579 14 X 2 AA repeats of F-G.
FT COILED 256 276 Potential.
FT COILED 314 381 Potential.
FT MOD_RES 331 331 Phosphothreonine.
FT VAR_SEQ 84 95 Missing (in isoform 3).
FT /FTId=VSP_045658.
FT VAR_SEQ 480 485 PQPSLG -> LNAFKL (in isoform 2).
FT /FTId=VSP_007946.
FT VAR_SEQ 486 599 Missing (in isoform 2).
FT /FTId=VSP_007947.
FT VARIANT 34 34 A -> T (in dbSNP:rs12871898).
FT /FTId=VAR_050570.
FT VARIANT 166 166 S -> P (in dbSNP:rs12871608).
FT /FTId=VAR_050571.
SQ SEQUENCE 599 AA; 60897 MW; 2CC32E2A1B9E5132 CRC64;
MSTGFSFGSG TLGSTTVAAG GTSTGGVFSF GTGASSNPSV GLNFGNLGST STPATTSAPS
SGFGTGLFGS KPATGFTLGG TNTGIATTIT TGLTLGTPAT TSAATTGFSL GFNKPAASAT
PFALPITSTS ASGLTLSSAL TSTPAASTGF TLNNLGGTTA TTTTASTGLS LGGALAGLGG
SLFQSTNTGT SGLGQNALGL TLGTTAATST AGNEGLGGID FSSSSDKKSD KTGTRPEDSK
ALKDENLPPV ICQDVENLQK FVKEQKQVQE EISRMSSKAM LKVQEDIKAL KQLLSLAANG
IQRNTLNIDK LKIETAQELK NAEIALRTQK TPPGLQHEYA APADYFRILV QQFEVQLQQY
RQQIEELENH LATQANNSHI TPQDLSMAMQ KIYQTFVALA AQLQSIHENV KVLKEQYLGY
RKMFLGDAVD VFETRRAEAK KWQNTPRVTT GPTPFSTMPN AAAVAMAATL TQQQQPATGP
QPSLGVSFGT PFGSGIGTGL QSSGLGSSNL GGFGTSSGFG CSTTGASTFG FGTTNKPSGS
LSAGFGSSST SGFNFSNPGI TASAGLTFGV SNPASAGFGT GGQLLQLKKP PAGNKRGKR
//
ID NUPL1_HUMAN Reviewed; 599 AA.
AC Q9BVL2; A6NI12; B4DZJ1; O43160; Q5JRG2; Q5JRG5;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-2001, sequence version 1.
DT 22-JAN-2014, entry version 108.
DE RecName: Full=Nucleoporin p58/p45;
DE AltName: Full=Nucleoporin-like protein 1;
GN Name=NUPL1; Synonyms=KIAA0410;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=9455477; DOI=10.1093/dnares/4.5.307;
RA Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N.,
RA Tanaka A., Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. VIII.
RT 78 new cDNA clones from brain which code for large proteins in
RT vitro.";
RL DNA Res. 4:307-313(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT
RP THR-34.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E.,
RA Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.,
RA Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R.,
RA Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S.,
RA Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M.,
RA Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J.,
RA Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E.,
RA Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L.,
RA Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J.,
RA Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S.,
RA Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J.,
RA Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M.,
RA King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A.,
RA Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S.,
RA Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I.,
RA Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S.,
RA Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A.,
RA Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L.,
RA Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M.,
RA Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-331, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Component of the nuclear pore complex, a complex
CC required for the trafficking across the nuclear membrane (By
CC similarity).
CC -!- SUBUNIT: Component of the p62 complex, a complex at least composed
CC of NUP62, NUP54, and NUPL1. Interacts with NUTF2. Interacts with
CC SRP1-alpha and Importin p97 proteins when they are together, but
CC not with SRP1-alpha protein alone (By similarity).
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex (By
CC similarity). Nucleus membrane; Peripheral membrane protein;
CC Cytoplasmic side (By similarity). Nucleus membrane; Peripheral
CC membrane protein; Nucleoplasmic side (By similarity). Note=Biased
CC towards cytoplasmic side. Central region of the nuclear pore
CC complex, within the transporter (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=p58;
CC IsoId=Q9BVL2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BVL2-2; Sequence=VSP_007946, VSP_007947;
CC Name=3;
CC IsoId=Q9BVL2-3; Sequence=VSP_045658;
CC Note=No experimental confirmation available;
CC -!- DOMAIN: Contains FG repeats.
CC -!- PTM: O-glycosylated (By similarity).
CC -!- MISCELLANEOUS: In rat, the p62 complex contains two different
CC isoforms of NUPL1. Isoform p45 has however not been isolated in
CC human so far.
CC -!- SIMILARITY: Belongs to the NUPL1 family.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA23706.2; Type=Erroneous initiation;
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DR EMBL; AB007870; BAA23706.2; ALT_INIT; mRNA.
DR EMBL; AK302946; BAG64103.1; -; mRNA.
DR EMBL; AL138958; CAH71290.1; -; Genomic_DNA.
DR EMBL; AL590787; CAH71290.1; JOINED; Genomic_DNA.
DR EMBL; AL646102; CAH71290.1; JOINED; Genomic_DNA.
DR EMBL; AL590787; CAI39898.1; -; Genomic_DNA.
DR EMBL; AL138958; CAI39898.1; JOINED; Genomic_DNA.
DR EMBL; AL646102; CAI39898.1; JOINED; Genomic_DNA.
DR EMBL; AL590787; CAI39901.1; -; Genomic_DNA.
DR EMBL; AL646102; CAH72184.1; -; Genomic_DNA.
DR EMBL; AL138958; CAH72184.1; JOINED; Genomic_DNA.
DR EMBL; AL590787; CAH72184.1; JOINED; Genomic_DNA.
DR EMBL; BC001104; AAH01104.1; -; mRNA.
DR RefSeq; NP_001008564.1; NM_001008564.1.
DR RefSeq; NP_054808.1; NM_014089.3.
DR UniGene; Hs.507537; -.
DR UniGene; Hs.718943; -.
DR UniGene; Hs.732064; -.
DR ProteinModelPortal; Q9BVL2; -.
DR SMR; Q9BVL2; 341-426.
DR IntAct; Q9BVL2; 6.
DR STRING; 9606.ENSP00000371155; -.
DR PhosphoSite; Q9BVL2; -.
DR DMDM; 44888845; -.
DR PaxDb; Q9BVL2; -.
DR PRIDE; Q9BVL2; -.
DR Ensembl; ENST00000381718; ENSP00000371137; ENSG00000139496.
DR Ensembl; ENST00000381736; ENSP00000371155; ENSG00000139496.
DR Ensembl; ENST00000463407; ENSP00000418555; ENSG00000139496.
DR GeneID; 9818; -.
DR KEGG; hsa:9818; -.
DR UCSC; uc001uqj.3; human.
DR CTD; 9818; -.
DR GeneCards; GC13P025875; -.
DR HGNC; HGNC:20261; NUPL1.
DR HPA; HPA039360; -.
DR MIM; 607615; gene.
DR neXtProt; NX_Q9BVL2; -.
DR PharmGKB; PA134981903; -.
DR eggNOG; NOG148149; -.
DR HOGENOM; HOG000273874; -.
DR HOVERGEN; HBG052703; -.
DR InParanoid; Q9BVL2; -.
DR KO; K14307; -.
DR OMA; HENVKML; -.
DR OrthoDB; EOG7H1JN7; -.
DR PhylomeDB; Q9BVL2; -.
DR Reactome; REACT_111217; Metabolism.
DR Reactome; REACT_115566; Cell Cycle.
DR Reactome; REACT_116125; Disease.
DR Reactome; REACT_15518; Transmembrane transport of small molecules.
DR Reactome; REACT_21300; Mitotic M-M/G1 phases.
DR Reactome; REACT_6900; Immune System.
DR ChiTaRS; NUPL1; human.
DR GeneWiki; NUPL1; -.
DR GenomeRNAi; 9818; -.
DR NextBio; 35476494; -.
DR PRO; PR:Q9BVL2; -.
DR ArrayExpress; Q9BVL2; -.
DR Bgee; Q9BVL2; -.
DR CleanEx; HS_NUPL1; -.
DR Genevestigator; Q9BVL2; -.
DR GO; GO:0005635; C:nuclear envelope; TAS:Reactome.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR GO; GO:0005487; F:nucleocytoplasmic transporter activity; IEA:Ensembl.
DR GO; GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.
DR GO; GO:0015758; P:glucose transport; TAS:Reactome.
DR GO; GO:0007077; P:mitotic nuclear envelope disassembly; TAS:Reactome.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0010827; P:regulation of glucose transport; TAS:Reactome.
DR GO; GO:0044281; P:small molecule metabolic process; TAS:Reactome.
DR GO; GO:0055085; P:transmembrane transport; TAS:Reactome.
DR GO; GO:0016032; P:viral process; TAS:Reactome.
DR InterPro; IPR024882; Nucleoporin_p58/p45.
DR PANTHER; PTHR13437; PTHR13437; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Complete proteome; Glycoprotein;
KW Membrane; mRNA transport; Nuclear pore complex; Nucleus;
KW Phosphoprotein; Polymorphism; Protein transport; Reference proteome;
KW Repeat; Translocation; Transport.
FT CHAIN 1 599 Nucleoporin p58/p45.
FT /FTId=PRO_0000204892.
FT REPEAT 7 8 1.
FT REPEAT 30 31 2.
FT REPEAT 44 45 3.
FT REPEAT 63 64 4.
FT REPEAT 68 69 5.
FT REPEAT 488 489 6.
FT REPEAT 492 493 7.
FT REPEAT 513 514 8.
FT REPEAT 519 520 9.
FT REPEAT 529 530 10.
FT REPEAT 531 532 11.
FT REPEAT 545 546 12.
FT REPEAT 568 569 13.
FT REPEAT 578 579 14.
FT REGION 7 579 14 X 2 AA repeats of F-G.
FT COILED 256 276 Potential.
FT COILED 314 381 Potential.
FT MOD_RES 331 331 Phosphothreonine.
FT VAR_SEQ 84 95 Missing (in isoform 3).
FT /FTId=VSP_045658.
FT VAR_SEQ 480 485 PQPSLG -> LNAFKL (in isoform 2).
FT /FTId=VSP_007946.
FT VAR_SEQ 486 599 Missing (in isoform 2).
FT /FTId=VSP_007947.
FT VARIANT 34 34 A -> T (in dbSNP:rs12871898).
FT /FTId=VAR_050570.
FT VARIANT 166 166 S -> P (in dbSNP:rs12871608).
FT /FTId=VAR_050571.
SQ SEQUENCE 599 AA; 60897 MW; 2CC32E2A1B9E5132 CRC64;
MSTGFSFGSG TLGSTTVAAG GTSTGGVFSF GTGASSNPSV GLNFGNLGST STPATTSAPS
SGFGTGLFGS KPATGFTLGG TNTGIATTIT TGLTLGTPAT TSAATTGFSL GFNKPAASAT
PFALPITSTS ASGLTLSSAL TSTPAASTGF TLNNLGGTTA TTTTASTGLS LGGALAGLGG
SLFQSTNTGT SGLGQNALGL TLGTTAATST AGNEGLGGID FSSSSDKKSD KTGTRPEDSK
ALKDENLPPV ICQDVENLQK FVKEQKQVQE EISRMSSKAM LKVQEDIKAL KQLLSLAANG
IQRNTLNIDK LKIETAQELK NAEIALRTQK TPPGLQHEYA APADYFRILV QQFEVQLQQY
RQQIEELENH LATQANNSHI TPQDLSMAMQ KIYQTFVALA AQLQSIHENV KVLKEQYLGY
RKMFLGDAVD VFETRRAEAK KWQNTPRVTT GPTPFSTMPN AAAVAMAATL TQQQQPATGP
QPSLGVSFGT PFGSGIGTGL QSSGLGSSNL GGFGTSSGFG CSTTGASTFG FGTTNKPSGS
LSAGFGSSST SGFNFSNPGI TASAGLTFGV SNPASAGFGT GGQLLQLKKP PAGNKRGKR
//
MIM
607615
*RECORD*
*FIELD* NO
607615
*FIELD* TI
*607615 NUCLEOPORIN-LIKE 1; NUPL1
;;KIAA0410
*FIELD* TX
CLONING
By sequencing clones obtained from a size-fractionated brain cDNA
read morelibrary, Ishikawa et al. (1997) cloned NUPL1, which they designated
KIAA0410. The deduced 485-amino acid protein has a calculated molecular
mass of about 53 kD. NUPL1 shares 87% sequence identity with rat
nucleoporin p58. RT-PCR detected low-level NUPL1 expression in all
tissues examined.
MAPPING
By radiation hybrid analysis, Ishikawa et al. (1997) mapped the NUPL1
gene to chromosome 13.
*FIELD* RF
1. Ishikawa, K.; Nagase, T.; Nakajima, D.; Seki, N.; Ohira, M.; Miyajima,
N.; Tanaka, A.; Kotani, H.; Nomura, N.; Ohara, O.: Prediction of
the coding sequences of unidentified human genes. VIII. 78 new cDNA
clones from brain which code for large proteins in vitro. DNA Res. 4:
307-313, 1997.
*FIELD* CD
Patricia A. Hartz: 3/7/2003
*FIELD* ED
mgross: 03/07/2003
*RECORD*
*FIELD* NO
607615
*FIELD* TI
*607615 NUCLEOPORIN-LIKE 1; NUPL1
;;KIAA0410
*FIELD* TX
CLONING
By sequencing clones obtained from a size-fractionated brain cDNA
read morelibrary, Ishikawa et al. (1997) cloned NUPL1, which they designated
KIAA0410. The deduced 485-amino acid protein has a calculated molecular
mass of about 53 kD. NUPL1 shares 87% sequence identity with rat
nucleoporin p58. RT-PCR detected low-level NUPL1 expression in all
tissues examined.
MAPPING
By radiation hybrid analysis, Ishikawa et al. (1997) mapped the NUPL1
gene to chromosome 13.
*FIELD* RF
1. Ishikawa, K.; Nagase, T.; Nakajima, D.; Seki, N.; Ohira, M.; Miyajima,
N.; Tanaka, A.; Kotani, H.; Nomura, N.; Ohara, O.: Prediction of
the coding sequences of unidentified human genes. VIII. 78 new cDNA
clones from brain which code for large proteins in vitro. DNA Res. 4:
307-313, 1997.
*FIELD* CD
Patricia A. Hartz: 3/7/2003
*FIELD* ED
mgross: 03/07/2003