Full text data of PDDC1
PDDC1
[Confidence: low (only semi-automatic identification from reviews)]
Parkinson disease 7 domain-containing protein 1; Flags: Precursor
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Parkinson disease 7 domain-containing protein 1; Flags: Precursor
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q8NB37
ID PDDC1_HUMAN Reviewed; 220 AA.
AC Q8NB37; B7ZKW5; Q2NL76; Q6ZQY0; Q8NAE0;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-2002, sequence version 1.
DT 22-JAN-2014, entry version 75.
DE RecName: Full=Parkinson disease 7 domain-containing protein 1;
DE Flags: Precursor;
GN Name=PDDC1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
RC TISSUE=Brain, Small intestine, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8NB37-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NB37-2; Sequence=VSP_028233;
CC Note=No experimental confirmation available;
CC Name=3;
CC IsoId=Q8NB37-3; Sequence=VSP_028231;
CC Name=4;
CC IsoId=Q8NB37-4; Sequence=VSP_028231, VSP_028232;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the peptidase C56 family.
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DR EMBL; AK091602; BAC03706.1; -; mRNA.
DR EMBL; AK092816; BAC03983.1; -; mRNA.
DR EMBL; AK128653; BAC87551.1; -; mRNA.
DR EMBL; BC110868; AAI10869.1; -; mRNA.
DR EMBL; BC112145; AAI12146.1; -; mRNA.
DR EMBL; BC143420; AAI43421.1; -; mRNA.
DR RefSeq; NP_872418.1; NM_182612.2.
DR RefSeq; XP_005252953.1; XM_005252896.1.
DR UniGene; Hs.218362; -.
DR ProteinModelPortal; Q8NB37; -.
DR IntAct; Q8NB37; 1.
DR MINT; MINT-1397454; -.
DR STRING; 9606.ENSP00000321691; -.
DR MEROPS; C56.974; -.
DR DMDM; 74730065; -.
DR PaxDb; Q8NB37; -.
DR PRIDE; Q8NB37; -.
DR Ensembl; ENST00000319863; ENSP00000321691; ENSG00000177225.
DR Ensembl; ENST00000354286; ENSP00000346239; ENSG00000177225.
DR Ensembl; ENST00000397472; ENSP00000380612; ENSG00000177225.
DR Ensembl; ENST00000524550; ENSP00000431183; ENSG00000177225.
DR GeneID; 347862; -.
DR KEGG; hsa:347862; -.
DR UCSC; uc001lrc.3; human.
DR CTD; 347862; -.
DR GeneCards; GC11M000759; -.
DR HGNC; HGNC:26616; PDDC1.
DR HPA; HPA008812; -.
DR neXtProt; NX_Q8NB37; -.
DR PharmGKB; PA142671193; -.
DR eggNOG; COG0693; -.
DR HOGENOM; HOG000067792; -.
DR HOVERGEN; HBG106581; -.
DR OMA; FLCGSRK; -.
DR PhylomeDB; Q8NB37; -.
DR GenomeRNAi; 347862; -.
DR NextBio; 99299; -.
DR PRO; PR:Q8NB37; -.
DR ArrayExpress; Q8NB37; -.
DR Bgee; Q8NB37; -.
DR CleanEx; HS_PDDC1; -.
DR Genevestigator; Q8NB37; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR002818; ThiJ/PfpI.
DR Pfam; PF01965; DJ-1_PfpI; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1 38 Potential.
FT CHAIN 39 220 Parkinson disease 7 domain-containing
FT protein 1.
FT /FTId=PRO_0000305094.
FT CARBOHYD 201 201 N-linked (GlcNAc...) (Potential).
FT VAR_SEQ 83 119 GARYHALLIPSCPGALTDLASSGSLARILQHFHSESK ->
FT E (in isoform 3 and isoform 4).
FT /FTId=VSP_028231.
FT VAR_SEQ 151 220 PSVCELVRAPGFARLPLVVEDFVKDSGACFSASEPDAVHVV
FT LDRHLVTGQNASSTVPAVQNLLFLCGSRK -> GLGLSQEP
FT PPRSRSPLCVSSSGPPASPACRSWWRTS (in isoform
FT 4).
FT /FTId=VSP_028232.
FT VAR_SEQ 182 220 ASEPDAVHVVLDRHLVTGQNASSTVPAVQNLLFLCGSRK
FT -> GAAASCPKADRHWQHFPVEEIFLACGFKVAGLGAAPGW
FT GRGGKQEDRPPEEQRRAGEDFPIYQCVFIYP (in
FT isoform 2).
FT /FTId=VSP_028233.
SQ SEQUENCE 220 AA; 23298 MW; 73A49DD9C551D6BD CRC64;
MASERLPNRP ACLLVASGAA EGVSAQSFLH CFTMASTAFN LQVATPGGKA MEFVDVTESN
ARWVQDFRLK AYASPAKLES IDGARYHALL IPSCPGALTD LASSGSLARI LQHFHSESKP
ICAVGHGVAA LCCATNEDRS WVFDSYSLTG PSVCELVRAP GFARLPLVVE DFVKDSGACF
SASEPDAVHV VLDRHLVTGQ NASSTVPAVQ NLLFLCGSRK
//
ID PDDC1_HUMAN Reviewed; 220 AA.
AC Q8NB37; B7ZKW5; Q2NL76; Q6ZQY0; Q8NAE0;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-2002, sequence version 1.
DT 22-JAN-2014, entry version 75.
DE RecName: Full=Parkinson disease 7 domain-containing protein 1;
DE Flags: Precursor;
GN Name=PDDC1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
RC TISSUE=Brain, Small intestine, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8NB37-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NB37-2; Sequence=VSP_028233;
CC Note=No experimental confirmation available;
CC Name=3;
CC IsoId=Q8NB37-3; Sequence=VSP_028231;
CC Name=4;
CC IsoId=Q8NB37-4; Sequence=VSP_028231, VSP_028232;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the peptidase C56 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK091602; BAC03706.1; -; mRNA.
DR EMBL; AK092816; BAC03983.1; -; mRNA.
DR EMBL; AK128653; BAC87551.1; -; mRNA.
DR EMBL; BC110868; AAI10869.1; -; mRNA.
DR EMBL; BC112145; AAI12146.1; -; mRNA.
DR EMBL; BC143420; AAI43421.1; -; mRNA.
DR RefSeq; NP_872418.1; NM_182612.2.
DR RefSeq; XP_005252953.1; XM_005252896.1.
DR UniGene; Hs.218362; -.
DR ProteinModelPortal; Q8NB37; -.
DR IntAct; Q8NB37; 1.
DR MINT; MINT-1397454; -.
DR STRING; 9606.ENSP00000321691; -.
DR MEROPS; C56.974; -.
DR DMDM; 74730065; -.
DR PaxDb; Q8NB37; -.
DR PRIDE; Q8NB37; -.
DR Ensembl; ENST00000319863; ENSP00000321691; ENSG00000177225.
DR Ensembl; ENST00000354286; ENSP00000346239; ENSG00000177225.
DR Ensembl; ENST00000397472; ENSP00000380612; ENSG00000177225.
DR Ensembl; ENST00000524550; ENSP00000431183; ENSG00000177225.
DR GeneID; 347862; -.
DR KEGG; hsa:347862; -.
DR UCSC; uc001lrc.3; human.
DR CTD; 347862; -.
DR GeneCards; GC11M000759; -.
DR HGNC; HGNC:26616; PDDC1.
DR HPA; HPA008812; -.
DR neXtProt; NX_Q8NB37; -.
DR PharmGKB; PA142671193; -.
DR eggNOG; COG0693; -.
DR HOGENOM; HOG000067792; -.
DR HOVERGEN; HBG106581; -.
DR OMA; FLCGSRK; -.
DR PhylomeDB; Q8NB37; -.
DR GenomeRNAi; 347862; -.
DR NextBio; 99299; -.
DR PRO; PR:Q8NB37; -.
DR ArrayExpress; Q8NB37; -.
DR Bgee; Q8NB37; -.
DR CleanEx; HS_PDDC1; -.
DR Genevestigator; Q8NB37; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR002818; ThiJ/PfpI.
DR Pfam; PF01965; DJ-1_PfpI; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1 38 Potential.
FT CHAIN 39 220 Parkinson disease 7 domain-containing
FT protein 1.
FT /FTId=PRO_0000305094.
FT CARBOHYD 201 201 N-linked (GlcNAc...) (Potential).
FT VAR_SEQ 83 119 GARYHALLIPSCPGALTDLASSGSLARILQHFHSESK ->
FT E (in isoform 3 and isoform 4).
FT /FTId=VSP_028231.
FT VAR_SEQ 151 220 PSVCELVRAPGFARLPLVVEDFVKDSGACFSASEPDAVHVV
FT LDRHLVTGQNASSTVPAVQNLLFLCGSRK -> GLGLSQEP
FT PPRSRSPLCVSSSGPPASPACRSWWRTS (in isoform
FT 4).
FT /FTId=VSP_028232.
FT VAR_SEQ 182 220 ASEPDAVHVVLDRHLVTGQNASSTVPAVQNLLFLCGSRK
FT -> GAAASCPKADRHWQHFPVEEIFLACGFKVAGLGAAPGW
FT GRGGKQEDRPPEEQRRAGEDFPIYQCVFIYP (in
FT isoform 2).
FT /FTId=VSP_028233.
SQ SEQUENCE 220 AA; 23298 MW; 73A49DD9C551D6BD CRC64;
MASERLPNRP ACLLVASGAA EGVSAQSFLH CFTMASTAFN LQVATPGGKA MEFVDVTESN
ARWVQDFRLK AYASPAKLES IDGARYHALL IPSCPGALTD LASSGSLARI LQHFHSESKP
ICAVGHGVAA LCCATNEDRS WVFDSYSLTG PSVCELVRAP GFARLPLVVE DFVKDSGACF
SASEPDAVHV VLDRHLVTGQ NASSTVPAVQ NLLFLCGSRK
//