Full text data of PIPSL
PIPSL
(PSMD4P2)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Putative PIP5K1A and PSMD4-like protein; PIP5K1A-PSMD4
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Putative PIP5K1A and PSMD4-like protein; PIP5K1A-PSMD4
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
A2A3N6
ID PIPSL_HUMAN Reviewed; 862 AA.
AC A2A3N6; Q6NUK8;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 20-FEB-2007, sequence version 1.
DT 22-JAN-2014, entry version 55.
DE RecName: Full=Putative PIP5K1A and PSMD4-like protein;
DE Short=PIP5K1A-PSMD4;
GN Name=PIPSL; Synonyms=PSMD4P2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND GENE EVOLUTION.
RX PubMed=17623810; DOI=10.1101/gr.6252107;
RA Babushok D.V., Ohshima K., Ostertag E.M., Chen X., Wang Y.,
RA Mandal P.K., Okada N., Abrams C.S., Kazazian H.H. Jr.;
RT "A novel testis ubiquitin-binding protein gene arose by exon shuffling
RT in hominoids.";
RL Genome Res. 17:1129-1138(2007).
CC -!- FUNCTION: Has negligeable PIP5 kinase activity. Binds to
CC ubiquitinated proteins.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- TISSUE SPECIFICITY: Testis-specific.
CC -!- MISCELLANEOUS: PIPSL gene appeared in hominoids by L1-mediated
CC retrotransposition in a hominoid ancestor of a readthrough,
CC intergenically spliced transcript between the PIP5K1A and PSMD4
CC genes.
CC -!- SIMILARITY: Contains 1 PIPK domain.
CC -!- SIMILARITY: Contains 2 UIM (ubiquitin-interacting motif) repeats.
CC -!- SIMILARITY: Contains 1 VWFA domain.
CC -!- CAUTION: Could be the product of a pseudogene. Although
CC transcribed, the gene is poorly translated probably due to a
CC deletion in the regulatory region. PubMed:17623810 could not
CC detect the protein by Western blot.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AL365510; CAM19360.1; -; Genomic_DNA.
DR UniGene; Hs.149255; -.
DR ProteinModelPortal; A2A3N6; -.
DR SMR; A2A3N6; 29-314, 488-678, 681-791.
DR STRING; 9606.ENSP00000375503; -.
DR PaxDb; A2A3N6; -.
DR PRIDE; A2A3N6; -.
DR UCSC; uc009xuj.2; human.
DR GeneCards; GC10M095707; -.
DR HGNC; HGNC:23733; PIPSL.
DR neXtProt; NX_A2A3N6; -.
DR eggNOG; COG5148; -.
DR InParanoid; A2A3N6; -.
DR PRO; PR:A2A3N6; -.
DR Genevestigator; A2A3N6; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016307; F:phosphatidylinositol phosphate kinase activity; IEA:InterPro.
DR GO; GO:0046854; P:phosphatidylinositol phosphorylation; IEA:GOC.
DR Gene3D; 3.30.800.10; -; 1.
DR Gene3D; 3.30.810.10; -; 1.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR023610; PInositol-4-P-5-kinase.
DR InterPro; IPR027483; PInositol-4-P-5-kinase_C.
DR InterPro; IPR002498; PInositol-4-P-5-kinase_core.
DR InterPro; IPR027484; PInositol-4-P-5-kinase_N.
DR InterPro; IPR016034; PInositol-4P-5-kinase_core_sub.
DR InterPro; IPR002035; VWF_A.
DR PANTHER; PTHR23086; PTHR23086; 1.
DR Pfam; PF01504; PIP5K; 1.
DR SMART; SM00330; PIPKc; 1.
DR SMART; SM00327; VWA; 1.
DR PROSITE; PS51455; PIPK; 1.
DR PROSITE; PS50330; UIM; FALSE_NEG.
DR PROSITE; PS50234; VWFA; 1.
PE 5: Uncertain;
KW Complete proteome; Cytoplasm; Reference proteome; Repeat.
FT CHAIN 1 862 Putative PIP5K1A and PSMD4-like protein.
FT /FTId=PRO_0000347057.
FT DOMAIN 28 396 PIPK.
FT DOMAIN 490 673 VWFA.
FT REPEAT 696 715 UIM 1.
FT REPEAT 766 783 UIM 2.
FT COMPBIAS 723 731 Poly-Ala.
SQ SEQUENCE 862 AA; 95048 MW; 3F1F11EC0AB0D704 CRC64;
MASEVPYASG MPIKKIGHRS VDSSGGTTSS ALKGAIQLGI THTVGSLSTK PESDVLMQDF
HMVESIFFPS EGSNLTPAHH YNAFRFKTYA PVAFRYFWEL FGIRPDDYLY SLCSEPLIEL
CSSGASGSLF YVSSDDEFIV KTVRHKEAEF LQKLLPGYYI NLNQNPRTLL PKFYGLYCVQ
TGGKNIRIVV MNNLLPRSVK MHIKYDLKGS TYRRRASQKE REKPLPTFKD LDFLQDIPDG
LFLDADVHNA LCKTLQRDCL VLQSFKIMDY SLLMSIHNID HAQREPLSSE TQYSVDTRRP
APQKALYSTA MESIQGEARR GGTMETDDHM GGIPARNSKG ERLLLYIGII DILQSYRFVK
KLEHSWKALI HDGDTVSVHR PGFYAEWFQR FMCNTVFKKI PLKPSPSKKL RSGSSFSQRA
GSSGNSCITY QPLVSGEHKA QVTTKAEVEP GVHLGCPDVL PQTPPLEEIS EGSPTPDPSF
SPLVEETLQM LTTSVDNSEY MGNGDFLPTR LQAQQDAVNT VCHSKTRSNP ENNVGLITLD
NDCEVLTTLT PDTGRILSKL HTVQPKGKIT FCMGIHVAHL ALKHRQGNNH KIRIIAFVGN
PVEDNEKNLV KLAKCLKKEK VNVDIINFGE EEVNTEKLTA FVNTLNGKDG TGSHLVTVPP
GPSLADALIS FPILAGEGGA MMGLGASDFE FGVDPSADPE LALVLRVFME EQRQRQEEEA
RQAAAASAAE AGIATTGTED SDDALLKMTI SQQEFGHTGL PDLSSMTEEE KIVCAMQMSL
QGAEFGLAES ADIDASSAMD TSEPAKEEDD YDVMQDPEFL QSVLENLPGV DPNNEAIRNA
VGSLASQATK DSKKDKKEED KK
//
ID PIPSL_HUMAN Reviewed; 862 AA.
AC A2A3N6; Q6NUK8;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 20-FEB-2007, sequence version 1.
DT 22-JAN-2014, entry version 55.
DE RecName: Full=Putative PIP5K1A and PSMD4-like protein;
DE Short=PIP5K1A-PSMD4;
GN Name=PIPSL; Synonyms=PSMD4P2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND GENE EVOLUTION.
RX PubMed=17623810; DOI=10.1101/gr.6252107;
RA Babushok D.V., Ohshima K., Ostertag E.M., Chen X., Wang Y.,
RA Mandal P.K., Okada N., Abrams C.S., Kazazian H.H. Jr.;
RT "A novel testis ubiquitin-binding protein gene arose by exon shuffling
RT in hominoids.";
RL Genome Res. 17:1129-1138(2007).
CC -!- FUNCTION: Has negligeable PIP5 kinase activity. Binds to
CC ubiquitinated proteins.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- TISSUE SPECIFICITY: Testis-specific.
CC -!- MISCELLANEOUS: PIPSL gene appeared in hominoids by L1-mediated
CC retrotransposition in a hominoid ancestor of a readthrough,
CC intergenically spliced transcript between the PIP5K1A and PSMD4
CC genes.
CC -!- SIMILARITY: Contains 1 PIPK domain.
CC -!- SIMILARITY: Contains 2 UIM (ubiquitin-interacting motif) repeats.
CC -!- SIMILARITY: Contains 1 VWFA domain.
CC -!- CAUTION: Could be the product of a pseudogene. Although
CC transcribed, the gene is poorly translated probably due to a
CC deletion in the regulatory region. PubMed:17623810 could not
CC detect the protein by Western blot.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AL365510; CAM19360.1; -; Genomic_DNA.
DR UniGene; Hs.149255; -.
DR ProteinModelPortal; A2A3N6; -.
DR SMR; A2A3N6; 29-314, 488-678, 681-791.
DR STRING; 9606.ENSP00000375503; -.
DR PaxDb; A2A3N6; -.
DR PRIDE; A2A3N6; -.
DR UCSC; uc009xuj.2; human.
DR GeneCards; GC10M095707; -.
DR HGNC; HGNC:23733; PIPSL.
DR neXtProt; NX_A2A3N6; -.
DR eggNOG; COG5148; -.
DR InParanoid; A2A3N6; -.
DR PRO; PR:A2A3N6; -.
DR Genevestigator; A2A3N6; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016307; F:phosphatidylinositol phosphate kinase activity; IEA:InterPro.
DR GO; GO:0046854; P:phosphatidylinositol phosphorylation; IEA:GOC.
DR Gene3D; 3.30.800.10; -; 1.
DR Gene3D; 3.30.810.10; -; 1.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR023610; PInositol-4-P-5-kinase.
DR InterPro; IPR027483; PInositol-4-P-5-kinase_C.
DR InterPro; IPR002498; PInositol-4-P-5-kinase_core.
DR InterPro; IPR027484; PInositol-4-P-5-kinase_N.
DR InterPro; IPR016034; PInositol-4P-5-kinase_core_sub.
DR InterPro; IPR002035; VWF_A.
DR PANTHER; PTHR23086; PTHR23086; 1.
DR Pfam; PF01504; PIP5K; 1.
DR SMART; SM00330; PIPKc; 1.
DR SMART; SM00327; VWA; 1.
DR PROSITE; PS51455; PIPK; 1.
DR PROSITE; PS50330; UIM; FALSE_NEG.
DR PROSITE; PS50234; VWFA; 1.
PE 5: Uncertain;
KW Complete proteome; Cytoplasm; Reference proteome; Repeat.
FT CHAIN 1 862 Putative PIP5K1A and PSMD4-like protein.
FT /FTId=PRO_0000347057.
FT DOMAIN 28 396 PIPK.
FT DOMAIN 490 673 VWFA.
FT REPEAT 696 715 UIM 1.
FT REPEAT 766 783 UIM 2.
FT COMPBIAS 723 731 Poly-Ala.
SQ SEQUENCE 862 AA; 95048 MW; 3F1F11EC0AB0D704 CRC64;
MASEVPYASG MPIKKIGHRS VDSSGGTTSS ALKGAIQLGI THTVGSLSTK PESDVLMQDF
HMVESIFFPS EGSNLTPAHH YNAFRFKTYA PVAFRYFWEL FGIRPDDYLY SLCSEPLIEL
CSSGASGSLF YVSSDDEFIV KTVRHKEAEF LQKLLPGYYI NLNQNPRTLL PKFYGLYCVQ
TGGKNIRIVV MNNLLPRSVK MHIKYDLKGS TYRRRASQKE REKPLPTFKD LDFLQDIPDG
LFLDADVHNA LCKTLQRDCL VLQSFKIMDY SLLMSIHNID HAQREPLSSE TQYSVDTRRP
APQKALYSTA MESIQGEARR GGTMETDDHM GGIPARNSKG ERLLLYIGII DILQSYRFVK
KLEHSWKALI HDGDTVSVHR PGFYAEWFQR FMCNTVFKKI PLKPSPSKKL RSGSSFSQRA
GSSGNSCITY QPLVSGEHKA QVTTKAEVEP GVHLGCPDVL PQTPPLEEIS EGSPTPDPSF
SPLVEETLQM LTTSVDNSEY MGNGDFLPTR LQAQQDAVNT VCHSKTRSNP ENNVGLITLD
NDCEVLTTLT PDTGRILSKL HTVQPKGKIT FCMGIHVAHL ALKHRQGNNH KIRIIAFVGN
PVEDNEKNLV KLAKCLKKEK VNVDIINFGE EEVNTEKLTA FVNTLNGKDG TGSHLVTVPP
GPSLADALIS FPILAGEGGA MMGLGASDFE FGVDPSADPE LALVLRVFME EQRQRQEEEA
RQAAAASAAE AGIATTGTED SDDALLKMTI SQQEFGHTGL PDLSSMTEEE KIVCAMQMSL
QGAEFGLAES ADIDASSAMD TSEPAKEEDD YDVMQDPEFL QSVLENLPGV DPNNEAIRNA
VGSLASQATK DSKKDKKEED KK
//