Full text data of PLP2
PLP2
(A4)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Proteolipid protein 2 (Differentiation-dependent protein A4; Intestinal membrane A4 protein)
Proteolipid protein 2 (Differentiation-dependent protein A4; Intestinal membrane A4 protein)
UniProt
Q04941
ID PLP2_HUMAN Reviewed; 152 AA.
AC Q04941; A6NDT7; Q32MM8;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-1993, sequence version 1.
DT 22-JAN-2014, entry version 112.
DE RecName: Full=Proteolipid protein 2;
DE AltName: Full=Differentiation-dependent protein A4;
DE AltName: Full=Intestinal membrane A4 protein;
GN Name=PLP2; Synonyms=A4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8470895; DOI=10.1006/abbi.1993.1197;
RA Oliva M.M., Wu T.-C., Yang V.W.;
RT "Isolation and characterization of a differentiation-dependent gene in
RT the human colonic cell line HT29-18.";
RL Arch. Biochem. Biophys. 302:183-192(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9344658; DOI=10.1006/geno.1997.4941;
RA Fisher S.E., Ciccodicola A., Tanaka K., Curci A., Desicato S.,
RA D'Urso M., Craig I.W.;
RT "Sequence-based exon prediction around the synaptophysin locus reveals
RT a gene-rich area containing novel genes in human proximal Xp.";
RL Genomics 45:340-347(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Thymus;
RX PubMed=16344560; DOI=10.1101/gr.4039406;
RA Kimura K., Wakamatsu A., Suzuki Y., Ota T., Nishikawa T.,
RA Yamashita R., Yamamoto J., Sekine M., Tsuritani K., Wakaguri H.,
RA Ishii S., Sugiyama T., Saito K., Isono Y., Irie R., Kushida N.,
RA Yoneyama T., Otsuka R., Kanda K., Yokoi T., Kondo H., Wagatsuma M.,
RA Murakawa K., Ishida S., Ishibashi T., Takahashi-Fujii A., Tanase T.,
RA Nagai K., Kikuchi H., Nakai K., Isogai T., Sugano S.;
RT "Diversification of transcriptional modulation: large-scale
RT identification and characterization of putative alternative promoters
RT of human genes.";
RL Genome Res. 16:55-65(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A.,
RA Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G.,
RA Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S.,
RA Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R.,
RA Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L.,
RA Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A.,
RA Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S.,
RA Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R.,
RA Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M.,
RA Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N.,
RA Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D.,
RA Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W.,
RA Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C.,
RA Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C.,
RA Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J.,
RA Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S.,
RA Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I.,
RA Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L.,
RA Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P.,
RA Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S.,
RA Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A.,
RA Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J.,
RA Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J.,
RA Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S.,
RA de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z.,
RA Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C.,
RA Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W.,
RA Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T.,
RA Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I.,
RA Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N.,
RA Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J.,
RA Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E.,
RA Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S.,
RA Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T.,
RA Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S.,
RA Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L.,
RA Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A.,
RA Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L.,
RA Williams G., Williams L., Williamson A., Williamson H., Wilming L.,
RA Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H.,
RA Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A.,
RA Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A.,
RA Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T.,
RA Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May play a role in cell differentiation in the
CC intestinal epithelium.
CC -!- INTERACTION:
CC P32246:CCR1; NbExp=3; IntAct=EBI-608347, EBI-608322;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q04941-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q04941-2; Sequence=VSP_041602;
CC -!- TISSUE SPECIFICITY: Enriched in colonic mucosa. The expression of
CC A4 follows a gradient along the crypto-villus axis with the most
CC abundant message occurring in the lower half of the crypt.
CC -!- SIMILARITY: Contains 1 MARVEL domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; L09604; AAA35499.1; -; mRNA.
DR EMBL; U93305; AAB92356.1; -; Genomic_DNA.
DR EMBL; DB102321; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AF196779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC109066; AAI09067.1; -; mRNA.
DR PIR; S32567; S32567.
DR RefSeq; NP_002659.1; NM_002668.2.
DR UniGene; Hs.77422; -.
DR ProteinModelPortal; Q04941; -.
DR IntAct; Q04941; 3.
DR MINT; MINT-1394473; -.
DR STRING; 9606.ENSP00000365505; -.
DR TCDB; 1.A.64.5.2; the plasmolipin (plasmolipin) family.
DR PhosphoSite; Q04941; -.
DR DMDM; 416563; -.
DR PaxDb; Q04941; -.
DR PRIDE; Q04941; -.
DR Ensembl; ENST00000376322; ENSP00000365500; ENSG00000102007.
DR Ensembl; ENST00000376327; ENSP00000365505; ENSG00000102007.
DR Ensembl; ENST00000595824; ENSP00000470766; ENSG00000269034.
DR Ensembl; ENST00000597997; ENSP00000472888; ENSG00000269034.
DR GeneID; 5355; -.
DR KEGG; hsa:5355; -.
DR UCSC; uc004dmx.3; human.
DR CTD; 5355; -.
DR GeneCards; GC0XP049037; -.
DR HGNC; HGNC:9087; PLP2.
DR HPA; HPA042415; -.
DR MIM; 300112; gene.
DR neXtProt; NX_Q04941; -.
DR PharmGKB; PA33415; -.
DR eggNOG; NOG296424; -.
DR HOGENOM; HOG000293179; -.
DR HOVERGEN; HBG099247; -.
DR InParanoid; Q04941; -.
DR OMA; IYMCDLH; -.
DR OrthoDB; EOG7DNNXK; -.
DR PhylomeDB; Q04941; -.
DR ChiTaRS; PLP2; human.
DR GeneWiki; PLP2; -.
DR GenomeRNAi; 5355; -.
DR NextBio; 20758; -.
DR PRO; PR:Q04941; -.
DR Bgee; Q04941; -.
DR CleanEx; HS_PLP2; -.
DR Genevestigator; Q04941; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:ProtInc.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0015075; F:ion transmembrane transporter activity; TAS:ProtInc.
DR GO; GO:0006935; P:chemotaxis; NAS:UniProtKB.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; NAS:UniProtKB.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 1.
DR PROSITE; PS51225; MARVEL; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Glycoprotein; Membrane;
KW Polymorphism; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1 152 Proteolipid protein 2.
FT /FTId=PRO_0000156819.
FT TRANSMEM 25 45 Helical; (Potential).
FT TRANSMEM 48 68 Helical; (Potential).
FT TRANSMEM 85 105 Helical; (Potential).
FT TRANSMEM 112 132 Helical; (Potential).
FT DOMAIN 19 137 MARVEL.
FT CARBOHYD 18 18 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 108 108 N-linked (GlcNAc...) (Potential).
FT VAR_SEQ 117 152 LGLIATCLFGYDAYVTFPVRQPRHTAAPTDPADGPV -> K
FT AMGAALKHRAKGLRSQGPFLPLLLAEIV (in isoform
FT 2).
FT /FTId=VSP_041602.
FT VARIANT 91 91 A -> S (in dbSNP:rs1802969).
FT /FTId=VAR_011924.
SQ SEQUENCE 152 AA; 16691 MW; 689378A8C326206C CRC64;
MADSERLSAP GCWAACTNFS RTRKGILLFA EIILCLVILI CFSASTPGYS SLSVIEMILA
AIFFVVYMCD LHTKIPFINW PWSDFFRTLI AAILYLITSI VVLVERGNHS KIVAGVLGLI
ATCLFGYDAY VTFPVRQPRH TAAPTDPADG PV
//
ID PLP2_HUMAN Reviewed; 152 AA.
AC Q04941; A6NDT7; Q32MM8;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-1993, sequence version 1.
DT 22-JAN-2014, entry version 112.
DE RecName: Full=Proteolipid protein 2;
DE AltName: Full=Differentiation-dependent protein A4;
DE AltName: Full=Intestinal membrane A4 protein;
GN Name=PLP2; Synonyms=A4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8470895; DOI=10.1006/abbi.1993.1197;
RA Oliva M.M., Wu T.-C., Yang V.W.;
RT "Isolation and characterization of a differentiation-dependent gene in
RT the human colonic cell line HT29-18.";
RL Arch. Biochem. Biophys. 302:183-192(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9344658; DOI=10.1006/geno.1997.4941;
RA Fisher S.E., Ciccodicola A., Tanaka K., Curci A., Desicato S.,
RA D'Urso M., Craig I.W.;
RT "Sequence-based exon prediction around the synaptophysin locus reveals
RT a gene-rich area containing novel genes in human proximal Xp.";
RL Genomics 45:340-347(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Thymus;
RX PubMed=16344560; DOI=10.1101/gr.4039406;
RA Kimura K., Wakamatsu A., Suzuki Y., Ota T., Nishikawa T.,
RA Yamashita R., Yamamoto J., Sekine M., Tsuritani K., Wakaguri H.,
RA Ishii S., Sugiyama T., Saito K., Isono Y., Irie R., Kushida N.,
RA Yoneyama T., Otsuka R., Kanda K., Yokoi T., Kondo H., Wagatsuma M.,
RA Murakawa K., Ishida S., Ishibashi T., Takahashi-Fujii A., Tanase T.,
RA Nagai K., Kikuchi H., Nakai K., Isogai T., Sugano S.;
RT "Diversification of transcriptional modulation: large-scale
RT identification and characterization of putative alternative promoters
RT of human genes.";
RL Genome Res. 16:55-65(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A.,
RA Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G.,
RA Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S.,
RA Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R.,
RA Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L.,
RA Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A.,
RA Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S.,
RA Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R.,
RA Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M.,
RA Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N.,
RA Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D.,
RA Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W.,
RA Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C.,
RA Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C.,
RA Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J.,
RA Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S.,
RA Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I.,
RA Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L.,
RA Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P.,
RA Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S.,
RA Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A.,
RA Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J.,
RA Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J.,
RA Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S.,
RA de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z.,
RA Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C.,
RA Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W.,
RA Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T.,
RA Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I.,
RA Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N.,
RA Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J.,
RA Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E.,
RA Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S.,
RA Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T.,
RA Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S.,
RA Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L.,
RA Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A.,
RA Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L.,
RA Williams G., Williams L., Williamson A., Williamson H., Wilming L.,
RA Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H.,
RA Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A.,
RA Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A.,
RA Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T.,
RA Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May play a role in cell differentiation in the
CC intestinal epithelium.
CC -!- INTERACTION:
CC P32246:CCR1; NbExp=3; IntAct=EBI-608347, EBI-608322;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q04941-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q04941-2; Sequence=VSP_041602;
CC -!- TISSUE SPECIFICITY: Enriched in colonic mucosa. The expression of
CC A4 follows a gradient along the crypto-villus axis with the most
CC abundant message occurring in the lower half of the crypt.
CC -!- SIMILARITY: Contains 1 MARVEL domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; L09604; AAA35499.1; -; mRNA.
DR EMBL; U93305; AAB92356.1; -; Genomic_DNA.
DR EMBL; DB102321; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AF196779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC109066; AAI09067.1; -; mRNA.
DR PIR; S32567; S32567.
DR RefSeq; NP_002659.1; NM_002668.2.
DR UniGene; Hs.77422; -.
DR ProteinModelPortal; Q04941; -.
DR IntAct; Q04941; 3.
DR MINT; MINT-1394473; -.
DR STRING; 9606.ENSP00000365505; -.
DR TCDB; 1.A.64.5.2; the plasmolipin (plasmolipin) family.
DR PhosphoSite; Q04941; -.
DR DMDM; 416563; -.
DR PaxDb; Q04941; -.
DR PRIDE; Q04941; -.
DR Ensembl; ENST00000376322; ENSP00000365500; ENSG00000102007.
DR Ensembl; ENST00000376327; ENSP00000365505; ENSG00000102007.
DR Ensembl; ENST00000595824; ENSP00000470766; ENSG00000269034.
DR Ensembl; ENST00000597997; ENSP00000472888; ENSG00000269034.
DR GeneID; 5355; -.
DR KEGG; hsa:5355; -.
DR UCSC; uc004dmx.3; human.
DR CTD; 5355; -.
DR GeneCards; GC0XP049037; -.
DR HGNC; HGNC:9087; PLP2.
DR HPA; HPA042415; -.
DR MIM; 300112; gene.
DR neXtProt; NX_Q04941; -.
DR PharmGKB; PA33415; -.
DR eggNOG; NOG296424; -.
DR HOGENOM; HOG000293179; -.
DR HOVERGEN; HBG099247; -.
DR InParanoid; Q04941; -.
DR OMA; IYMCDLH; -.
DR OrthoDB; EOG7DNNXK; -.
DR PhylomeDB; Q04941; -.
DR ChiTaRS; PLP2; human.
DR GeneWiki; PLP2; -.
DR GenomeRNAi; 5355; -.
DR NextBio; 20758; -.
DR PRO; PR:Q04941; -.
DR Bgee; Q04941; -.
DR CleanEx; HS_PLP2; -.
DR Genevestigator; Q04941; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:ProtInc.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0015075; F:ion transmembrane transporter activity; TAS:ProtInc.
DR GO; GO:0006935; P:chemotaxis; NAS:UniProtKB.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; NAS:UniProtKB.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 1.
DR PROSITE; PS51225; MARVEL; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Glycoprotein; Membrane;
KW Polymorphism; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1 152 Proteolipid protein 2.
FT /FTId=PRO_0000156819.
FT TRANSMEM 25 45 Helical; (Potential).
FT TRANSMEM 48 68 Helical; (Potential).
FT TRANSMEM 85 105 Helical; (Potential).
FT TRANSMEM 112 132 Helical; (Potential).
FT DOMAIN 19 137 MARVEL.
FT CARBOHYD 18 18 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 108 108 N-linked (GlcNAc...) (Potential).
FT VAR_SEQ 117 152 LGLIATCLFGYDAYVTFPVRQPRHTAAPTDPADGPV -> K
FT AMGAALKHRAKGLRSQGPFLPLLLAEIV (in isoform
FT 2).
FT /FTId=VSP_041602.
FT VARIANT 91 91 A -> S (in dbSNP:rs1802969).
FT /FTId=VAR_011924.
SQ SEQUENCE 152 AA; 16691 MW; 689378A8C326206C CRC64;
MADSERLSAP GCWAACTNFS RTRKGILLFA EIILCLVILI CFSASTPGYS SLSVIEMILA
AIFFVVYMCD LHTKIPFINW PWSDFFRTLI AAILYLITSI VVLVERGNHS KIVAGVLGLI
ATCLFGYDAY VTFPVRQPRH TAAPTDPADG PV
//
MIM
300112
*RECORD*
*FIELD* NO
300112
*FIELD* TI
*300112 PROTEOLIPID PROTEIN 2; PLP2
;;PROTEOLIPID PROTEIN, COLONIC EPITHELIUM-ENRICHED;;
read moreDIFFERENTIATION-DEPENDENT PROTEIN A4
*FIELD* TX
CLONING
Oliva et al. (1993) cloned a cDNA encoding the A4
differentiation-dependent protein from a human colon cell line.
Fisher et al. (1997) determined that the product of the A4 gene is an
integral membrane protein, containing 4 putative transmembrane domains.
The protein may play a role in cell differentiation in the intestinal
epithelium.
GENE STRUCTURE
In a study of the gene-rich region Xp11.23-p11.22, Fisher et al. (1997)
identified the promoter and complete coding sequence of the A4 gene,
which is organized into 5 exons spanning approximately 3.5 kb of DNA.
MAPPING
Fisher et al. (1997) identified the A4 gene on chromosome
Xp11.23-p11.22.
*FIELD* RF
1. Fisher, S. E.; Ciccodicola, A.; Tanaka, K.; Curci, A.; Desicato,
S.; D'Urso, M.; Craig, I. W.: Sequence-based exon prediction around
the synaptophysin locus reveals a gene-rich area containing novel
genes in human proximal Xp. Genomics 45: 340-347, 1997.
2. Oliva, M. M.; Wu, T. C.; Yang, V. W.: Isolation and characterization
of a differentiation-dependent gene in the human colonic cell line
HT29-18. Arch. Biochem. Biophys. 302: 183-192, 1993.
*FIELD* CD
Victor A. McKusick: 12/11/1997
*FIELD* ED
carol: 08/20/2012
alopez: 9/30/1999
mark: 12/11/1997
*RECORD*
*FIELD* NO
300112
*FIELD* TI
*300112 PROTEOLIPID PROTEIN 2; PLP2
;;PROTEOLIPID PROTEIN, COLONIC EPITHELIUM-ENRICHED;;
read moreDIFFERENTIATION-DEPENDENT PROTEIN A4
*FIELD* TX
CLONING
Oliva et al. (1993) cloned a cDNA encoding the A4
differentiation-dependent protein from a human colon cell line.
Fisher et al. (1997) determined that the product of the A4 gene is an
integral membrane protein, containing 4 putative transmembrane domains.
The protein may play a role in cell differentiation in the intestinal
epithelium.
GENE STRUCTURE
In a study of the gene-rich region Xp11.23-p11.22, Fisher et al. (1997)
identified the promoter and complete coding sequence of the A4 gene,
which is organized into 5 exons spanning approximately 3.5 kb of DNA.
MAPPING
Fisher et al. (1997) identified the A4 gene on chromosome
Xp11.23-p11.22.
*FIELD* RF
1. Fisher, S. E.; Ciccodicola, A.; Tanaka, K.; Curci, A.; Desicato,
S.; D'Urso, M.; Craig, I. W.: Sequence-based exon prediction around
the synaptophysin locus reveals a gene-rich area containing novel
genes in human proximal Xp. Genomics 45: 340-347, 1997.
2. Oliva, M. M.; Wu, T. C.; Yang, V. W.: Isolation and characterization
of a differentiation-dependent gene in the human colonic cell line
HT29-18. Arch. Biochem. Biophys. 302: 183-192, 1993.
*FIELD* CD
Victor A. McKusick: 12/11/1997
*FIELD* ED
carol: 08/20/2012
alopez: 9/30/1999
mark: 12/11/1997