Full text data of PPP1R11
PPP1R11
(HCGV, TCTE5)
[Confidence: low (only semi-automatic identification from reviews)]
Protein phosphatase 1 regulatory subunit 11 (Hemochromatosis candidate gene V protein; HCG V; Protein phosphatase inhibitor 3)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Protein phosphatase 1 regulatory subunit 11 (Hemochromatosis candidate gene V protein; HCG V; Protein phosphatase inhibitor 3)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
O60927
ID PP1RB_HUMAN Reviewed; 126 AA.
AC O60927;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-AUG-1998, sequence version 1.
DT 22-JAN-2014, entry version 102.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 11;
DE AltName: Full=Hemochromatosis candidate gene V protein;
DE Short=HCG V;
DE AltName: Full=Protein phosphatase inhibitor 3;
GN Name=PPP1R11; Synonyms=HCGV, TCTE5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Duodenal mucosa;
RX PubMed=8781118; DOI=10.1007/s002510050134;
RA Giffon T., Lepourcelet M., Pichon L., Jezequel P., Bouric P., Carn G.,
RA Pontarotti P., Gall J.-Y., David V.;
RT "Cloning of a human homologue of the mouse Tctex-5 gene within the MHC
RT class I region.";
RL Immunogenetics 44:331-339(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8938444; DOI=10.1006/geno.1996.0566;
RA Lepourcelet M., Andrieux N., Giffon T., Pichon L., Hampe A.,
RA Galibert F., Mosser J.;
RT "Systematic sequencing of the human HLA-A/HLA-F region: establishment
RT of a cosmid contig and identification of a new gene cluster within 37
RT kb of sequence.";
RL Genomics 37:316-326(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Shiina S., Tamiya G., Oka A., Inoko H.;
RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Peripheral blood leukocyte;
RA Shiina T., Ota M., Takasu M., Katsuyama Y., Hashimoto N., Tokunaga K.,
RA Inoko H.;
RT "Genome diversity in HLA: a new strategy for detection of genetic
RT polymorphisms in expressed genes within the HLA class III and class I
RT regions.";
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 14-126, AND FUNCTION.
RC TISSUE=Brain;
RX PubMed=9843442; DOI=10.1021/bi981169g;
RA Zhang J., Zhang L., Zhao S., Lee E.Y.C.;
RT "Identification and characterization of the human HCG V gene product
RT as a novel inhibitor of protein phosphatase-1.";
RL Biochemistry 37:16728-16734(1998).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73; SER-74; THR-75;
RP SER-77 AND THR-109, AND MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [10]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Inhibitor of protein phosphatase 1.
CC -!- INTERACTION:
CC P62139:PPP1CA (xeno); NbExp=2; IntAct=EBI-1048104, EBI-2008988;
CC -!- TISSUE SPECIFICITY: Widely expressed.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; X81003; CAC16920.1; -; mRNA.
DR EMBL; X89902; CAC16919.1; -; Genomic_DNA.
DR EMBL; U53588; AAC52082.1; -; Genomic_DNA.
DR EMBL; BA000025; BAB63334.1; -; Genomic_DNA.
DR EMBL; AB088087; BAC54919.1; -; Genomic_DNA.
DR EMBL; AB202082; BAE78601.1; -; Genomic_DNA.
DR EMBL; AL669914; CAI18177.1; -; Genomic_DNA.
DR EMBL; AL671859; CAI17578.1; -; Genomic_DNA.
DR EMBL; AL845439; CAI18539.1; -; Genomic_DNA.
DR EMBL; BC102010; AAI02011.1; -; mRNA.
DR EMBL; BC102011; AAI02012.1; -; mRNA.
DR EMBL; BC104750; AAI04751.1; -; mRNA.
DR RefSeq; NP_068778.1; NM_021959.2.
DR UniGene; Hs.82887; -.
DR DisProt; DP00219; -.
DR ProteinModelPortal; O60927; -.
DR IntAct; O60927; 1.
DR MINT; MINT-3000724; -.
DR PhosphoSite; O60927; -.
DR PaxDb; O60927; -.
DR PeptideAtlas; O60927; -.
DR PRIDE; O60927; -.
DR Ensembl; ENST00000376772; ENSP00000365963; ENSG00000204619.
DR Ensembl; ENST00000383612; ENSP00000373107; ENSG00000206501.
DR Ensembl; ENST00000431424; ENSP00000411038; ENSG00000236560.
DR Ensembl; ENST00000431977; ENSP00000407981; ENSG00000237829.
DR Ensembl; ENST00000436591; ENSP00000414808; ENSG00000234058.
DR Ensembl; ENST00000437937; ENSP00000394056; ENSG00000233314.
DR Ensembl; ENST00000448378; ENSP00000403557; ENSG00000237403.
DR Ensembl; ENST00000452679; ENSP00000412297; ENSG00000227720.
DR GeneID; 6992; -.
DR KEGG; hsa:6992; -.
DR UCSC; uc003npb.3; human.
DR CTD; 6992; -.
DR GeneCards; GC06P030047; -.
DR GeneCards; GC06Pi29971; -.
DR GeneCards; GC06Pj30024; -.
DR GeneCards; GC06Pk30024; -.
DR GeneCards; GC06Pl30029; -.
DR GeneCards; GC06Pm30112; -.
DR GeneCards; GC06Pn30024; -.
DR GeneCards; GC06Po30024; -.
DR HGNC; HGNC:9285; PPP1R11.
DR HPA; HPA043266; -.
DR MIM; 606670; gene.
DR neXtProt; NX_O60927; -.
DR PharmGKB; PA33614; -.
DR eggNOG; NOG77393; -.
DR HOGENOM; HOG000232107; -.
DR HOVERGEN; HBG080560; -.
DR InParanoid; O60927; -.
DR KO; K17553; -.
DR OMA; YEKPRQF; -.
DR PhylomeDB; O60927; -.
DR ChiTaRS; PPP1R11; human.
DR GeneWiki; PPP1R11; -.
DR GenomeRNAi; 6992; -.
DR NextBio; 27317; -.
DR PMAP-CutDB; O60927; -.
DR PRO; PR:O60927; -.
DR ArrayExpress; O60927; -.
DR Bgee; O60927; -.
DR CleanEx; HS_PPP1R11; -.
DR Genevestigator; O60927; -.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR InterPro; IPR011107; PPI_Ypi1.
DR PANTHER; PTHR20835; PTHR20835; 1.
DR Pfam; PF07491; PPI_Ypi1; 1.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Phosphoprotein;
KW Protein phosphatase inhibitor; Reference proteome.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 126 Protein phosphatase 1 regulatory subunit
FT 11.
FT /FTId=PRO_0000239619.
FT COMPBIAS 105 123 Pro-rich.
FT MOD_RES 2 2 N-acetylalanine.
FT MOD_RES 73 73 Phosphoserine.
FT MOD_RES 74 74 Phosphoserine.
FT MOD_RES 75 75 Phosphothreonine.
FT MOD_RES 77 77 Phosphoserine.
FT MOD_RES 109 109 Phosphothreonine.
SQ SEQUENCE 126 AA; 13953 MW; D6788A5AAC073549 CRC64;
MAEAGAGLSE TVTETTVTVT TEPENRSLTI KLRKRKPEKK VEWTSDTVDN EHMGRRSSKC
CCIYEKPRAF GESSTESDEE EEEGCGHTHC VRGHRKGRRR ATLGPTPTTP PQPPDPSQPP
PGPMQH
//
ID PP1RB_HUMAN Reviewed; 126 AA.
AC O60927;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-AUG-1998, sequence version 1.
DT 22-JAN-2014, entry version 102.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 11;
DE AltName: Full=Hemochromatosis candidate gene V protein;
DE Short=HCG V;
DE AltName: Full=Protein phosphatase inhibitor 3;
GN Name=PPP1R11; Synonyms=HCGV, TCTE5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Duodenal mucosa;
RX PubMed=8781118; DOI=10.1007/s002510050134;
RA Giffon T., Lepourcelet M., Pichon L., Jezequel P., Bouric P., Carn G.,
RA Pontarotti P., Gall J.-Y., David V.;
RT "Cloning of a human homologue of the mouse Tctex-5 gene within the MHC
RT class I region.";
RL Immunogenetics 44:331-339(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8938444; DOI=10.1006/geno.1996.0566;
RA Lepourcelet M., Andrieux N., Giffon T., Pichon L., Hampe A.,
RA Galibert F., Mosser J.;
RT "Systematic sequencing of the human HLA-A/HLA-F region: establishment
RT of a cosmid contig and identification of a new gene cluster within 37
RT kb of sequence.";
RL Genomics 37:316-326(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Shiina S., Tamiya G., Oka A., Inoko H.;
RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Peripheral blood leukocyte;
RA Shiina T., Ota M., Takasu M., Katsuyama Y., Hashimoto N., Tokunaga K.,
RA Inoko H.;
RT "Genome diversity in HLA: a new strategy for detection of genetic
RT polymorphisms in expressed genes within the HLA class III and class I
RT regions.";
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 14-126, AND FUNCTION.
RC TISSUE=Brain;
RX PubMed=9843442; DOI=10.1021/bi981169g;
RA Zhang J., Zhang L., Zhao S., Lee E.Y.C.;
RT "Identification and characterization of the human HCG V gene product
RT as a novel inhibitor of protein phosphatase-1.";
RL Biochemistry 37:16728-16734(1998).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73; SER-74; THR-75;
RP SER-77 AND THR-109, AND MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [10]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Inhibitor of protein phosphatase 1.
CC -!- INTERACTION:
CC P62139:PPP1CA (xeno); NbExp=2; IntAct=EBI-1048104, EBI-2008988;
CC -!- TISSUE SPECIFICITY: Widely expressed.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; X81003; CAC16920.1; -; mRNA.
DR EMBL; X89902; CAC16919.1; -; Genomic_DNA.
DR EMBL; U53588; AAC52082.1; -; Genomic_DNA.
DR EMBL; BA000025; BAB63334.1; -; Genomic_DNA.
DR EMBL; AB088087; BAC54919.1; -; Genomic_DNA.
DR EMBL; AB202082; BAE78601.1; -; Genomic_DNA.
DR EMBL; AL669914; CAI18177.1; -; Genomic_DNA.
DR EMBL; AL671859; CAI17578.1; -; Genomic_DNA.
DR EMBL; AL845439; CAI18539.1; -; Genomic_DNA.
DR EMBL; BC102010; AAI02011.1; -; mRNA.
DR EMBL; BC102011; AAI02012.1; -; mRNA.
DR EMBL; BC104750; AAI04751.1; -; mRNA.
DR RefSeq; NP_068778.1; NM_021959.2.
DR UniGene; Hs.82887; -.
DR DisProt; DP00219; -.
DR ProteinModelPortal; O60927; -.
DR IntAct; O60927; 1.
DR MINT; MINT-3000724; -.
DR PhosphoSite; O60927; -.
DR PaxDb; O60927; -.
DR PeptideAtlas; O60927; -.
DR PRIDE; O60927; -.
DR Ensembl; ENST00000376772; ENSP00000365963; ENSG00000204619.
DR Ensembl; ENST00000383612; ENSP00000373107; ENSG00000206501.
DR Ensembl; ENST00000431424; ENSP00000411038; ENSG00000236560.
DR Ensembl; ENST00000431977; ENSP00000407981; ENSG00000237829.
DR Ensembl; ENST00000436591; ENSP00000414808; ENSG00000234058.
DR Ensembl; ENST00000437937; ENSP00000394056; ENSG00000233314.
DR Ensembl; ENST00000448378; ENSP00000403557; ENSG00000237403.
DR Ensembl; ENST00000452679; ENSP00000412297; ENSG00000227720.
DR GeneID; 6992; -.
DR KEGG; hsa:6992; -.
DR UCSC; uc003npb.3; human.
DR CTD; 6992; -.
DR GeneCards; GC06P030047; -.
DR GeneCards; GC06Pi29971; -.
DR GeneCards; GC06Pj30024; -.
DR GeneCards; GC06Pk30024; -.
DR GeneCards; GC06Pl30029; -.
DR GeneCards; GC06Pm30112; -.
DR GeneCards; GC06Pn30024; -.
DR GeneCards; GC06Po30024; -.
DR HGNC; HGNC:9285; PPP1R11.
DR HPA; HPA043266; -.
DR MIM; 606670; gene.
DR neXtProt; NX_O60927; -.
DR PharmGKB; PA33614; -.
DR eggNOG; NOG77393; -.
DR HOGENOM; HOG000232107; -.
DR HOVERGEN; HBG080560; -.
DR InParanoid; O60927; -.
DR KO; K17553; -.
DR OMA; YEKPRQF; -.
DR PhylomeDB; O60927; -.
DR ChiTaRS; PPP1R11; human.
DR GeneWiki; PPP1R11; -.
DR GenomeRNAi; 6992; -.
DR NextBio; 27317; -.
DR PMAP-CutDB; O60927; -.
DR PRO; PR:O60927; -.
DR ArrayExpress; O60927; -.
DR Bgee; O60927; -.
DR CleanEx; HS_PPP1R11; -.
DR Genevestigator; O60927; -.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR InterPro; IPR011107; PPI_Ypi1.
DR PANTHER; PTHR20835; PTHR20835; 1.
DR Pfam; PF07491; PPI_Ypi1; 1.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Phosphoprotein;
KW Protein phosphatase inhibitor; Reference proteome.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 126 Protein phosphatase 1 regulatory subunit
FT 11.
FT /FTId=PRO_0000239619.
FT COMPBIAS 105 123 Pro-rich.
FT MOD_RES 2 2 N-acetylalanine.
FT MOD_RES 73 73 Phosphoserine.
FT MOD_RES 74 74 Phosphoserine.
FT MOD_RES 75 75 Phosphothreonine.
FT MOD_RES 77 77 Phosphoserine.
FT MOD_RES 109 109 Phosphothreonine.
SQ SEQUENCE 126 AA; 13953 MW; D6788A5AAC073549 CRC64;
MAEAGAGLSE TVTETTVTVT TEPENRSLTI KLRKRKPEKK VEWTSDTVDN EHMGRRSSKC
CCIYEKPRAF GESSTESDEE EEEGCGHTHC VRGHRKGRRR ATLGPTPTTP PQPPDPSQPP
PGPMQH
//
MIM
606670
*RECORD*
*FIELD* NO
606670
*FIELD* TI
*606670 PROTEIN PHOSPHATASE 1, REGULATORY SUBUNIT 11; PPP1R11
;;PROTEIN PHOSPHATASE 1 INHIBITOR 3; IPP3;;
read moreTCTEX5, MOUSE, HOMOLOG OF; TCTEX5
*FIELD* TX
CLONING
Using a cDNA selection technique to identify genes in the
hemochromatosis (235200) locus region on 6p21.3, El Kahloun et al.
(1993) cloned PPP1R11, which they called HCGV (hemochromatosis candidate
gene V). By screening cDNA libraries and using PCR techniques, Giffon et
al. (1996) obtained a full-length cDNA encoding PPP1R11. The predicted
126-amino acid PPP1R11 protein contains 8 potential phosphorylation
sites and a C-terminal PEST pattern that is characteristic of proteins
with short half-lives. PPP1R11 shares 89.7% amino acid identity with its
mouse homolog, Tctex5. Northern blot analysis detected a 1.8-kb PPP1R11
transcript in all fetal and adult tissues tested. The PPP1R11 gene
appeared to be widely preserved throughout animal evolution, and Giffon
et al. (1996) detected fragments on the DNAs of primates, rat, dog, cow,
and rabbit.
By screening sequence databases, Lepourcelet et al. (1996) identified a
cDNA clone that suggested the existence of at least 1 spliced isoform of
PPP1R11.
Using a yeast 2-hybrid screen to identify putative protein phosphatase-1
(PP1; see 176875)-binding proteins, Zhang et al. (1998) obtained a cDNA
encoding PPP1R11, which they called inhibitor-3. They reported that
PPP1R11 is hydrophilic, heat stable, and behaves anomalously on
SDS-PAGE, with an apparent molecular mass of 23 kD compared with its
calculated molecular mass of 14 kD, and on gel filtration, with a
relative molecular weight of 55,000. Zhang et al. (1998) showed that
PPP1R11 is a specific inhibitor of PP1 with a differential sensitivity
toward the metal-independent and metal-dependent forms of PP1. They
hypothesized that the PP1-binding ability of PPP1R11 is due at least in
part to the possession of a VxW motif. PPP1R11 is well conserved in
evolution, with related genes in S. cerevisiae, S. pombe, and C.
elegans.
GENE STRUCTURE
Giffon et al. (1996) determined that the PPP1R11 gene spans 3.1 kb and
contains 3 exons.
MAPPING
Using mouse Tctex5 gene probes that cross-hybridize to human, Amadou et
al. (1995) placed the PPP1R11 gene on a physical map of the major
histocompatibility complex (MHC) genomic region of chromosome 6p21.3. By
YAC and genomic sequence analyses, Giffon et al. (1996) mapped the
PPP1R11 gene 150 kb centromeric to the HLA-A gene (142800) on 6p21.3.
*FIELD* RF
1. Amadou, C.; Ribouchon, M. T.; Mattei, M. G.; Jenkins, N. A.; Gilbert,
D. J.; Copeland, N. G.; Avoustin, P.; Pontarotti, P.: Localization
of new genes and markers to the distal part of the human major histocompatibility
complex (MHC) region and comparison with the mouse: new insights into
the evolution of mammalian genomes. Genomics 26: 9-20, 1995.
2. el Kahloun, A.; Chauvel, B.; Mauvieux, V.; Dorval, I.; Jouanolle,
A.-M.; Gicquel, I.; Le Gall, J.-Y.; David, V.: Localization of seven
new genes around the HLA-A locus. Hum. Molec. Genet. 2: 55-60, 1993.
3. Giffon, T.; Lepourcelet, M.; Pichon, L.; Jezequel, P.; Bouric,
P.; Carn, G.; Pontarotti, P.; Le Gall, J.-Y.; David, V.: Cloning
of a human homologue of the mouse Tctex-5 gene within the MHC class
I region. Immunogenetics 44: 331-339, 1996.
4. Lepourcelet, M.; Andrieux, N.; Giffon, T.; Pichon, L.; Hampe, A.;
Galibert, F.; Mosser, J.: Systematic sequencing of the human HLA-A/HLA-F
region: establishment of a cosmid contig and identification of a new
gene cluster within 37 kb of sequence. Genomics 37: 316-326, 1996.
5. Zhang, J.; Zhang, L.; Zhao, S.; Lee, E. Y. C.: Identification
and characterization of the human HCG V gene product as a novel inhibitor
of protein phosphatase-1. Biochemistry 37: 16728-16734, 1998.
*FIELD* CD
Dawn Watkins-Chow: 1/31/2002
*FIELD* ED
carol: 10/21/2010
mgross: 1/29/2010
mgross: 1/31/2002
*RECORD*
*FIELD* NO
606670
*FIELD* TI
*606670 PROTEIN PHOSPHATASE 1, REGULATORY SUBUNIT 11; PPP1R11
;;PROTEIN PHOSPHATASE 1 INHIBITOR 3; IPP3;;
read moreTCTEX5, MOUSE, HOMOLOG OF; TCTEX5
*FIELD* TX
CLONING
Using a cDNA selection technique to identify genes in the
hemochromatosis (235200) locus region on 6p21.3, El Kahloun et al.
(1993) cloned PPP1R11, which they called HCGV (hemochromatosis candidate
gene V). By screening cDNA libraries and using PCR techniques, Giffon et
al. (1996) obtained a full-length cDNA encoding PPP1R11. The predicted
126-amino acid PPP1R11 protein contains 8 potential phosphorylation
sites and a C-terminal PEST pattern that is characteristic of proteins
with short half-lives. PPP1R11 shares 89.7% amino acid identity with its
mouse homolog, Tctex5. Northern blot analysis detected a 1.8-kb PPP1R11
transcript in all fetal and adult tissues tested. The PPP1R11 gene
appeared to be widely preserved throughout animal evolution, and Giffon
et al. (1996) detected fragments on the DNAs of primates, rat, dog, cow,
and rabbit.
By screening sequence databases, Lepourcelet et al. (1996) identified a
cDNA clone that suggested the existence of at least 1 spliced isoform of
PPP1R11.
Using a yeast 2-hybrid screen to identify putative protein phosphatase-1
(PP1; see 176875)-binding proteins, Zhang et al. (1998) obtained a cDNA
encoding PPP1R11, which they called inhibitor-3. They reported that
PPP1R11 is hydrophilic, heat stable, and behaves anomalously on
SDS-PAGE, with an apparent molecular mass of 23 kD compared with its
calculated molecular mass of 14 kD, and on gel filtration, with a
relative molecular weight of 55,000. Zhang et al. (1998) showed that
PPP1R11 is a specific inhibitor of PP1 with a differential sensitivity
toward the metal-independent and metal-dependent forms of PP1. They
hypothesized that the PP1-binding ability of PPP1R11 is due at least in
part to the possession of a VxW motif. PPP1R11 is well conserved in
evolution, with related genes in S. cerevisiae, S. pombe, and C.
elegans.
GENE STRUCTURE
Giffon et al. (1996) determined that the PPP1R11 gene spans 3.1 kb and
contains 3 exons.
MAPPING
Using mouse Tctex5 gene probes that cross-hybridize to human, Amadou et
al. (1995) placed the PPP1R11 gene on a physical map of the major
histocompatibility complex (MHC) genomic region of chromosome 6p21.3. By
YAC and genomic sequence analyses, Giffon et al. (1996) mapped the
PPP1R11 gene 150 kb centromeric to the HLA-A gene (142800) on 6p21.3.
*FIELD* RF
1. Amadou, C.; Ribouchon, M. T.; Mattei, M. G.; Jenkins, N. A.; Gilbert,
D. J.; Copeland, N. G.; Avoustin, P.; Pontarotti, P.: Localization
of new genes and markers to the distal part of the human major histocompatibility
complex (MHC) region and comparison with the mouse: new insights into
the evolution of mammalian genomes. Genomics 26: 9-20, 1995.
2. el Kahloun, A.; Chauvel, B.; Mauvieux, V.; Dorval, I.; Jouanolle,
A.-M.; Gicquel, I.; Le Gall, J.-Y.; David, V.: Localization of seven
new genes around the HLA-A locus. Hum. Molec. Genet. 2: 55-60, 1993.
3. Giffon, T.; Lepourcelet, M.; Pichon, L.; Jezequel, P.; Bouric,
P.; Carn, G.; Pontarotti, P.; Le Gall, J.-Y.; David, V.: Cloning
of a human homologue of the mouse Tctex-5 gene within the MHC class
I region. Immunogenetics 44: 331-339, 1996.
4. Lepourcelet, M.; Andrieux, N.; Giffon, T.; Pichon, L.; Hampe, A.;
Galibert, F.; Mosser, J.: Systematic sequencing of the human HLA-A/HLA-F
region: establishment of a cosmid contig and identification of a new
gene cluster within 37 kb of sequence. Genomics 37: 316-326, 1996.
5. Zhang, J.; Zhang, L.; Zhao, S.; Lee, E. Y. C.: Identification
and characterization of the human HCG V gene product as a novel inhibitor
of protein phosphatase-1. Biochemistry 37: 16728-16734, 1998.
*FIELD* CD
Dawn Watkins-Chow: 1/31/2002
*FIELD* ED
carol: 10/21/2010
mgross: 1/29/2010
mgross: 1/31/2002