Full text data of PPP4R1
PPP4R1
(MEG1, PP4R1)
[Confidence: low (only semi-automatic identification from reviews)]
Serine/threonine-protein phosphatase 4 regulatory subunit 1
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Serine/threonine-protein phosphatase 4 regulatory subunit 1
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q8TF05
ID PP4R1_HUMAN Reviewed; 950 AA.
AC Q8TF05; Q99774; Q9UNQ7;
DT 01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-2002, sequence version 1.
DT 22-JAN-2014, entry version 108.
DE RecName: Full=Serine/threonine-protein phosphatase 4 regulatory subunit 1;
GN Name=PPP4R1; Synonyms=MEG1, PP4R1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND SUBUNIT.
RC TISSUE=Neuroepithelium;
RX PubMed=10026142; DOI=10.1074/jbc.274.9.5339;
RA Kloeker S., Wadzinski B.E.;
RT "Purification and identification of a novel subunit of protein
RT serine/threonine phosphatase 4.";
RL J. Biol. Chem. 274:5339-5347(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBUNIT, AND TISSUE
RP SPECIFICITY.
RX PubMed=11729228;
RA Wada T., Miyata T., Inagi R., Nangaku M., Wagatsuma M., Suzuki D.,
RA Wadzinski B.E., Okubo K., Kurokawa K.;
RT "Cloning and characterization of a novel subunit of protein
RT serine/threonine phosphatase 4 from mesangial cells.";
RL J. Am. Soc. Nephrol. 12:2601-2608(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D.,
RA Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S.,
RA Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R.,
RA Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T.,
RA Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E.,
RA Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H.,
RA O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 571-950 (ISOFORMS 1/2).
RC TISSUE=Pituitary;
RA Song H., Peng Y., Dai M., Huang Q., Mao Y., Zhang Q., Mao M., Fu G.,
RA Luo M., Chen J., Hu R.;
RT "Human hypothetical 19.5 kDa protein gene.";
RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 778-950 (ISOFORMS 1/2).
RC TISSUE=Brain;
RX PubMed=9110174;
RA Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W.,
RA Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.;
RT "Large-scale concatenation cDNA sequencing.";
RL Genome Res. 7:353-358(1997).
RN [7]
RP INTERACTION WITH HDAC3, AND FUNCTION OF THE PPP4C-PPP4R1 COMPLEX.
RX PubMed=15805470; DOI=10.1101/gad.1286005;
RA Zhang X., Ozawa Y., Lee H., Wen Y.D., Tan T.H., Wadzinski B.E.,
RA Seto E.;
RT "Histone deacetylase 3 (HDAC3) activity is regulated by interaction
RT with protein serine/threonine phosphatase 4.";
RL Genes Dev. 19:827-839(2005).
RN [8]
RP IDENTIFICATION IN THE PPP4C-PPP4R1 COMPLEX.
RX PubMed=18614045; DOI=10.1016/j.molcel.2008.05.016;
RA Chowdhury D., Xu X., Zhong X., Ahmed F., Zhong J., Liao J.,
RA Dykxhoorn D.M., Weinstock D.M., Pfeifer G.P., Lieberman J.;
RT "A PP4-phosphatase complex dephosphorylates gamma-H2AX generated
RT during DNA replication.";
RL Mol. Cell 31:33-46(2008).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Regulatory subunit of serine/threonine-protein
CC phosphatase 4. May play a role in regulation of cell division in
CC renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in
CC dephosphorylation and regulation of HDAC3.
CC -!- SUBUNIT: Serine/threonine-protein phosphatase 4 (PP4) occurs in
CC different assemblies of the catalytic and one or more regulatory
CC subunits. Component of the PP4 complex PPP4C-PPP4R1. Interacts
CC with HDAC3.
CC -!- INTERACTION:
CC P60510:PPP4C; NbExp=5; IntAct=EBI-1056262, EBI-1046072;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=PP4Rmeg;
CC IsoId=Q8TF05-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TF05-2; Sequence=VSP_009469;
CC -!- TISSUE SPECIFICITY: Widely expressed with high expression in
CC cultured mesangial cells. Isoform 1 and isoform 2 are expressed in
CC renal tissues.
CC -!- SIMILARITY: Contains 14 HEAT repeats.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD43008.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF111106; AAD09818.1; -; mRNA.
DR EMBL; AF200478; AAL78298.1; -; mRNA.
DR EMBL; AP000902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP001381; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC060829; AAH60829.1; -; mRNA.
DR EMBL; AF100744; AAD43008.1; ALT_INIT; mRNA.
DR EMBL; U79267; AAB50211.1; -; mRNA.
DR RefSeq; NP_001035847.1; NM_001042388.2.
DR RefSeq; NP_005125.1; NM_005134.3.
DR UniGene; Hs.743236; -.
DR ProteinModelPortal; Q8TF05; -.
DR SMR; Q8TF05; 169-323, 497-929.
DR IntAct; Q8TF05; 4.
DR MINT; MINT-8215714; -.
DR STRING; 9606.ENSP00000383402; -.
DR PhosphoSite; Q8TF05; -.
DR DMDM; 44888283; -.
DR PaxDb; Q8TF05; -.
DR PRIDE; Q8TF05; -.
DR Ensembl; ENST00000400555; ENSP00000383401; ENSG00000154845.
DR Ensembl; ENST00000400556; ENSP00000383402; ENSG00000154845.
DR GeneID; 9989; -.
DR KEGG; hsa:9989; -.
DR UCSC; uc002koe.2; human.
DR CTD; 9989; -.
DR GeneCards; GC18M009546; -.
DR HGNC; HGNC:9320; PPP4R1.
DR HPA; HPA040905; -.
DR HPA; HPA041089; -.
DR MIM; 604908; gene.
DR neXtProt; NX_Q8TF05; -.
DR PharmGKB; PA33684; -.
DR eggNOG; NOG256584; -.
DR HOGENOM; HOG000115650; -.
DR HOVERGEN; HBG053649; -.
DR InParanoid; Q8TF05; -.
DR KO; K15424; -.
DR OMA; FAVHLMP; -.
DR OrthoDB; EOG7RRF6D; -.
DR GeneWiki; PPP4R1; -.
DR GenomeRNAi; 9989; -.
DR NextBio; 37723; -.
DR PRO; PR:Q8TF05; -.
DR ArrayExpress; Q8TF05; -.
DR Bgee; Q8TF05; -.
DR CleanEx; HS_PPP4R1; -.
DR Genevestigator; Q8TF05; -.
DR GO; GO:0030289; C:protein phosphatase 4 complex; ISS:UniProtKB.
DR GO; GO:0030362; F:protein phosphatase type 4 regulator activity; NAS:UniProtKB.
DR GO; GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; NAS:UniProtKB.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR Pfam; PF02985; HEAT; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Polymorphism;
KW Reference proteome; Repeat.
FT CHAIN 1 950 Serine/threonine-protein phosphatase 4
FT regulatory subunit 1.
FT /FTId=PRO_0000071527.
FT REPEAT 1 25 HEAT 1.
FT REPEAT 26 63 HEAT 2.
FT REPEAT 65 81 HEAT 3.
FT REPEAT 82 119 HEAT 4.
FT REPEAT 127 164 HEAT 5.
FT REPEAT 168 206 HEAT 6.
FT REPEAT 208 246 HEAT 7.
FT REPEAT 248 285 HEAT 8.
FT REPEAT 287 324 HEAT 9.
FT REPEAT 505 542 HEAT 10.
FT REPEAT 568 606 HEAT 11.
FT REPEAT 698 734 HEAT 12.
FT REPEAT 799 837 HEAT 13.
FT REPEAT 861 898 HEAT 14.
FT VAR_SEQ 18 35 FGVDDYSSESDVIIIPSA -> S (in isoform 2).
FT /FTId=VSP_009469.
FT VARIANT 43 43 E -> K (in dbSNP:rs1056191).
FT /FTId=VAR_017807.
FT VARIANT 470 470 I -> V (in dbSNP:rs329003).
FT /FTId=VAR_017808.
FT VARIANT 593 593 S -> N (in dbSNP:rs2306134).
FT /FTId=VAR_051748.
FT VARIANT 595 595 S -> N (in dbSNP:rs2306134).
FT /FTId=VAR_017809.
SQ SEQUENCE 950 AA; 107004 MW; E1392E6BAD3B58CB CRC64;
MADLSLLQED LQEDADGFGV DDYSSESDVI IIPSALDFVS QDEMLTPLGR LDKYAASENI
FNRQMVARSL LDTLREVCDD ERDCIAVLER ISRLADDSEP TVRAELMEQV PHIALFCQEN
RPSIPYAFSK FLLPIVVRYL ADQNNQVRKT SQAALLALLE QELIERFDVE TKVCPVLIEL
TAPDSNDDVK TEAVAIMCKM APMVGKDITE RLILPRFCEM CCDCRMFHVR KVCAANFGDI
CSVVGQQATE EMLLPRFFQL CSDNVWGVRK ACAECFMAVS CATCQEIRRT KLSALFINLI
SDPSRWVRQA AFQSLGPFIS TFANPSSSGQ YFKEESKSSE EMSVENKNRT RDQEAPEDVQ
VRPEDTPSDL SVSNSSVILE NTMEDHAAEA SGKPLGEISV PLDSSLLCTL SSESHQEAAS
NENDKKPGNY KSMLRPEVGT TSQDSALLDQ ELYNSFHFWR TPLPEIDLDI ELEQNSGGKP
SPEGPEEESE GPVPSSPNIT MATRKELEEM IENLEPHIDD PDVKAQVEVL SAALRASSLD
AHEETISIEK RSDLQDELDI NELPNCKINQ EDSVPLISDA VENMDSTLHY IHSDSDLSNN
SSFSPDEERR TKVQDVVPQA LLDQYLSMTD PSRAQTVDTE IAKHCAYSLP GVALTLGRQN
WHCLRETYET LASDMQWKVR RTLAFSIHEL AVILGDQLTA ADLVPIFNGF LKDLDEVRIG
VLKHLHDFLK LLHIDKRREY LYQLQEFLVT DNSRNWRFRA ELAEQLILLL ELYSPRDVYD
YLRPIALNLC ADKVSSVRWI SYKLVSEMVK KLHAATPPTF GVDLINELVE NFGRCPKWSG
RQAFVFVCQT VIEDDCLPMD QFAVHLMPHL LTLANDRVPN VRVLLAKTLR QTLLEKDYFL
ASASCHQEAV EQTIMALQMD RDSDVKYFAS IHPASTKISE DAMSTASSTY
//
ID PP4R1_HUMAN Reviewed; 950 AA.
AC Q8TF05; Q99774; Q9UNQ7;
DT 01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-2002, sequence version 1.
DT 22-JAN-2014, entry version 108.
DE RecName: Full=Serine/threonine-protein phosphatase 4 regulatory subunit 1;
GN Name=PPP4R1; Synonyms=MEG1, PP4R1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND SUBUNIT.
RC TISSUE=Neuroepithelium;
RX PubMed=10026142; DOI=10.1074/jbc.274.9.5339;
RA Kloeker S., Wadzinski B.E.;
RT "Purification and identification of a novel subunit of protein
RT serine/threonine phosphatase 4.";
RL J. Biol. Chem. 274:5339-5347(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBUNIT, AND TISSUE
RP SPECIFICITY.
RX PubMed=11729228;
RA Wada T., Miyata T., Inagi R., Nangaku M., Wagatsuma M., Suzuki D.,
RA Wadzinski B.E., Okubo K., Kurokawa K.;
RT "Cloning and characterization of a novel subunit of protein
RT serine/threonine phosphatase 4 from mesangial cells.";
RL J. Am. Soc. Nephrol. 12:2601-2608(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D.,
RA Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S.,
RA Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R.,
RA Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T.,
RA Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E.,
RA Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H.,
RA O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 571-950 (ISOFORMS 1/2).
RC TISSUE=Pituitary;
RA Song H., Peng Y., Dai M., Huang Q., Mao Y., Zhang Q., Mao M., Fu G.,
RA Luo M., Chen J., Hu R.;
RT "Human hypothetical 19.5 kDa protein gene.";
RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 778-950 (ISOFORMS 1/2).
RC TISSUE=Brain;
RX PubMed=9110174;
RA Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W.,
RA Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.;
RT "Large-scale concatenation cDNA sequencing.";
RL Genome Res. 7:353-358(1997).
RN [7]
RP INTERACTION WITH HDAC3, AND FUNCTION OF THE PPP4C-PPP4R1 COMPLEX.
RX PubMed=15805470; DOI=10.1101/gad.1286005;
RA Zhang X., Ozawa Y., Lee H., Wen Y.D., Tan T.H., Wadzinski B.E.,
RA Seto E.;
RT "Histone deacetylase 3 (HDAC3) activity is regulated by interaction
RT with protein serine/threonine phosphatase 4.";
RL Genes Dev. 19:827-839(2005).
RN [8]
RP IDENTIFICATION IN THE PPP4C-PPP4R1 COMPLEX.
RX PubMed=18614045; DOI=10.1016/j.molcel.2008.05.016;
RA Chowdhury D., Xu X., Zhong X., Ahmed F., Zhong J., Liao J.,
RA Dykxhoorn D.M., Weinstock D.M., Pfeifer G.P., Lieberman J.;
RT "A PP4-phosphatase complex dephosphorylates gamma-H2AX generated
RT during DNA replication.";
RL Mol. Cell 31:33-46(2008).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Regulatory subunit of serine/threonine-protein
CC phosphatase 4. May play a role in regulation of cell division in
CC renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in
CC dephosphorylation and regulation of HDAC3.
CC -!- SUBUNIT: Serine/threonine-protein phosphatase 4 (PP4) occurs in
CC different assemblies of the catalytic and one or more regulatory
CC subunits. Component of the PP4 complex PPP4C-PPP4R1. Interacts
CC with HDAC3.
CC -!- INTERACTION:
CC P60510:PPP4C; NbExp=5; IntAct=EBI-1056262, EBI-1046072;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=PP4Rmeg;
CC IsoId=Q8TF05-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TF05-2; Sequence=VSP_009469;
CC -!- TISSUE SPECIFICITY: Widely expressed with high expression in
CC cultured mesangial cells. Isoform 1 and isoform 2 are expressed in
CC renal tissues.
CC -!- SIMILARITY: Contains 14 HEAT repeats.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD43008.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF111106; AAD09818.1; -; mRNA.
DR EMBL; AF200478; AAL78298.1; -; mRNA.
DR EMBL; AP000902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP001381; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC060829; AAH60829.1; -; mRNA.
DR EMBL; AF100744; AAD43008.1; ALT_INIT; mRNA.
DR EMBL; U79267; AAB50211.1; -; mRNA.
DR RefSeq; NP_001035847.1; NM_001042388.2.
DR RefSeq; NP_005125.1; NM_005134.3.
DR UniGene; Hs.743236; -.
DR ProteinModelPortal; Q8TF05; -.
DR SMR; Q8TF05; 169-323, 497-929.
DR IntAct; Q8TF05; 4.
DR MINT; MINT-8215714; -.
DR STRING; 9606.ENSP00000383402; -.
DR PhosphoSite; Q8TF05; -.
DR DMDM; 44888283; -.
DR PaxDb; Q8TF05; -.
DR PRIDE; Q8TF05; -.
DR Ensembl; ENST00000400555; ENSP00000383401; ENSG00000154845.
DR Ensembl; ENST00000400556; ENSP00000383402; ENSG00000154845.
DR GeneID; 9989; -.
DR KEGG; hsa:9989; -.
DR UCSC; uc002koe.2; human.
DR CTD; 9989; -.
DR GeneCards; GC18M009546; -.
DR HGNC; HGNC:9320; PPP4R1.
DR HPA; HPA040905; -.
DR HPA; HPA041089; -.
DR MIM; 604908; gene.
DR neXtProt; NX_Q8TF05; -.
DR PharmGKB; PA33684; -.
DR eggNOG; NOG256584; -.
DR HOGENOM; HOG000115650; -.
DR HOVERGEN; HBG053649; -.
DR InParanoid; Q8TF05; -.
DR KO; K15424; -.
DR OMA; FAVHLMP; -.
DR OrthoDB; EOG7RRF6D; -.
DR GeneWiki; PPP4R1; -.
DR GenomeRNAi; 9989; -.
DR NextBio; 37723; -.
DR PRO; PR:Q8TF05; -.
DR ArrayExpress; Q8TF05; -.
DR Bgee; Q8TF05; -.
DR CleanEx; HS_PPP4R1; -.
DR Genevestigator; Q8TF05; -.
DR GO; GO:0030289; C:protein phosphatase 4 complex; ISS:UniProtKB.
DR GO; GO:0030362; F:protein phosphatase type 4 regulator activity; NAS:UniProtKB.
DR GO; GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; NAS:UniProtKB.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR Pfam; PF02985; HEAT; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Polymorphism;
KW Reference proteome; Repeat.
FT CHAIN 1 950 Serine/threonine-protein phosphatase 4
FT regulatory subunit 1.
FT /FTId=PRO_0000071527.
FT REPEAT 1 25 HEAT 1.
FT REPEAT 26 63 HEAT 2.
FT REPEAT 65 81 HEAT 3.
FT REPEAT 82 119 HEAT 4.
FT REPEAT 127 164 HEAT 5.
FT REPEAT 168 206 HEAT 6.
FT REPEAT 208 246 HEAT 7.
FT REPEAT 248 285 HEAT 8.
FT REPEAT 287 324 HEAT 9.
FT REPEAT 505 542 HEAT 10.
FT REPEAT 568 606 HEAT 11.
FT REPEAT 698 734 HEAT 12.
FT REPEAT 799 837 HEAT 13.
FT REPEAT 861 898 HEAT 14.
FT VAR_SEQ 18 35 FGVDDYSSESDVIIIPSA -> S (in isoform 2).
FT /FTId=VSP_009469.
FT VARIANT 43 43 E -> K (in dbSNP:rs1056191).
FT /FTId=VAR_017807.
FT VARIANT 470 470 I -> V (in dbSNP:rs329003).
FT /FTId=VAR_017808.
FT VARIANT 593 593 S -> N (in dbSNP:rs2306134).
FT /FTId=VAR_051748.
FT VARIANT 595 595 S -> N (in dbSNP:rs2306134).
FT /FTId=VAR_017809.
SQ SEQUENCE 950 AA; 107004 MW; E1392E6BAD3B58CB CRC64;
MADLSLLQED LQEDADGFGV DDYSSESDVI IIPSALDFVS QDEMLTPLGR LDKYAASENI
FNRQMVARSL LDTLREVCDD ERDCIAVLER ISRLADDSEP TVRAELMEQV PHIALFCQEN
RPSIPYAFSK FLLPIVVRYL ADQNNQVRKT SQAALLALLE QELIERFDVE TKVCPVLIEL
TAPDSNDDVK TEAVAIMCKM APMVGKDITE RLILPRFCEM CCDCRMFHVR KVCAANFGDI
CSVVGQQATE EMLLPRFFQL CSDNVWGVRK ACAECFMAVS CATCQEIRRT KLSALFINLI
SDPSRWVRQA AFQSLGPFIS TFANPSSSGQ YFKEESKSSE EMSVENKNRT RDQEAPEDVQ
VRPEDTPSDL SVSNSSVILE NTMEDHAAEA SGKPLGEISV PLDSSLLCTL SSESHQEAAS
NENDKKPGNY KSMLRPEVGT TSQDSALLDQ ELYNSFHFWR TPLPEIDLDI ELEQNSGGKP
SPEGPEEESE GPVPSSPNIT MATRKELEEM IENLEPHIDD PDVKAQVEVL SAALRASSLD
AHEETISIEK RSDLQDELDI NELPNCKINQ EDSVPLISDA VENMDSTLHY IHSDSDLSNN
SSFSPDEERR TKVQDVVPQA LLDQYLSMTD PSRAQTVDTE IAKHCAYSLP GVALTLGRQN
WHCLRETYET LASDMQWKVR RTLAFSIHEL AVILGDQLTA ADLVPIFNGF LKDLDEVRIG
VLKHLHDFLK LLHIDKRREY LYQLQEFLVT DNSRNWRFRA ELAEQLILLL ELYSPRDVYD
YLRPIALNLC ADKVSSVRWI SYKLVSEMVK KLHAATPPTF GVDLINELVE NFGRCPKWSG
RQAFVFVCQT VIEDDCLPMD QFAVHLMPHL LTLANDRVPN VRVLLAKTLR QTLLEKDYFL
ASASCHQEAV EQTIMALQMD RDSDVKYFAS IHPASTKISE DAMSTASSTY
//
MIM
604908
*RECORD*
*FIELD* NO
604908
*FIELD* TI
*604908 PROTEIN PHOSPHATASE 4, REGULATORY SUBUNIT 1; PPP4R1
;;PP4R1
*FIELD* TX
Protein phosphorylation on serine and threonine residues by protein
read morekinases is responsible for the communication of many intracellular
signals. Equally important is the dephosphorylation of proteins by
ser/thr phosphatases; see, for example, PPP2R1B (603113) and PPP2CA
(176915).
By peptide microsequencing of bovine PP4R1 and EST database searching,
Kloeker and Wadzinski (1999) identified a human PPP4R1 cDNA clone
encoding a 933-amino acid protein. Sequence analysis identified 13
'heat' repeats that are similar to those in the regulatory component
PP2A-A of PPP2R1B but are not contiguous. Mass spectrometry analysis
indicated that PPP4R1 is a 105-kD protein, whereas SDS-PAGE analysis
showed a doublet migrating at 120 to 125 kD. Immunoblot analysis
revealed that PPP4R1 copurifies with PPP4C (602035), suggesting that the
PPP4 complex contains at least 1 catalytic and 1 regulatory subunit.
The International Radiation Hybrid Mapping consortium mapped the PPP4R1
gene to chromosome 18 (TMAP WI-13171).
*FIELD* RF
1. Kloeker, S.; Wadzinski, B. E.: Purification and identification
of a novel subunit of protein serine/threonine phosphatase 4. J.
Biol. Chem. 274: 5339-5347, 1999.
*FIELD* CD
Paul J. Converse: 5/2/2000
*FIELD* ED
carol: 05/03/2000
carol: 5/3/2000
*RECORD*
*FIELD* NO
604908
*FIELD* TI
*604908 PROTEIN PHOSPHATASE 4, REGULATORY SUBUNIT 1; PPP4R1
;;PP4R1
*FIELD* TX
Protein phosphorylation on serine and threonine residues by protein
read morekinases is responsible for the communication of many intracellular
signals. Equally important is the dephosphorylation of proteins by
ser/thr phosphatases; see, for example, PPP2R1B (603113) and PPP2CA
(176915).
By peptide microsequencing of bovine PP4R1 and EST database searching,
Kloeker and Wadzinski (1999) identified a human PPP4R1 cDNA clone
encoding a 933-amino acid protein. Sequence analysis identified 13
'heat' repeats that are similar to those in the regulatory component
PP2A-A of PPP2R1B but are not contiguous. Mass spectrometry analysis
indicated that PPP4R1 is a 105-kD protein, whereas SDS-PAGE analysis
showed a doublet migrating at 120 to 125 kD. Immunoblot analysis
revealed that PPP4R1 copurifies with PPP4C (602035), suggesting that the
PPP4 complex contains at least 1 catalytic and 1 regulatory subunit.
The International Radiation Hybrid Mapping consortium mapped the PPP4R1
gene to chromosome 18 (TMAP WI-13171).
*FIELD* RF
1. Kloeker, S.; Wadzinski, B. E.: Purification and identification
of a novel subunit of protein serine/threonine phosphatase 4. J.
Biol. Chem. 274: 5339-5347, 1999.
*FIELD* CD
Paul J. Converse: 5/2/2000
*FIELD* ED
carol: 05/03/2000
carol: 5/3/2000