Full text data of PROSC
PROSC
[Confidence: low (only semi-automatic identification from reviews)]
Proline synthase co-transcribed bacterial homolog protein
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Proline synthase co-transcribed bacterial homolog protein
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
O94903
ID PROSC_HUMAN Reviewed; 275 AA.
AC O94903; Q6FI94;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAY-1999, sequence version 1.
DT 22-JAN-2014, entry version 116.
DE RecName: Full=Proline synthase co-transcribed bacterial homolog protein;
GN Name=PROSC;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10496079; DOI=10.1007/s100380050172;
RA Ikegawa S., Isomura M., Koshizuka Y., Nakamura Y.;
RT "Cloning and characterization of human and mouse PROSC (proline
RT synthetase co-transcribed) genes.";
RL J. Hum. Genet. 44:337-342(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA Wambutt R., Korn B., Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and
RT analysis of 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- COFACTOR: Pyridoxal phosphate (By similarity).
CC -!- TISSUE SPECIFICITY: Ubiquitous.
CC -!- SIMILARITY: Belongs to the UPF0001 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AB018566; BAA36842.1; -; Genomic_DNA.
DR EMBL; AL136616; CAB66551.1; -; mRNA.
DR EMBL; CR533532; CAG38563.1; -; mRNA.
DR EMBL; BC012334; AAH12334.1; -; mRNA.
DR RefSeq; NP_009129.1; NM_007198.3.
DR UniGene; Hs.304792; -.
DR UniGene; Hs.608177; -.
DR ProteinModelPortal; O94903; -.
DR SMR; O94903; 42-248.
DR IntAct; O94903; 1.
DR MINT; MINT-3002521; -.
DR STRING; 9606.ENSP00000333551; -.
DR DrugBank; DB00172; L-Proline.
DR DrugBank; DB00114; Pyridoxal Phosphate.
DR PhosphoSite; O94903; -.
DR UCD-2DPAGE; O94903; -.
DR PaxDb; O94903; -.
DR PeptideAtlas; O94903; -.
DR PRIDE; O94903; -.
DR DNASU; 11212; -.
DR Ensembl; ENST00000328195; ENSP00000333551; ENSG00000147471.
DR GeneID; 11212; -.
DR KEGG; hsa:11212; -.
DR UCSC; uc003xkh.3; human.
DR CTD; 11212; -.
DR GeneCards; GC08P037620; -.
DR HGNC; HGNC:9457; PROSC.
DR HPA; CAB017033; -.
DR HPA; HPA023646; -.
DR HPA; HPA023733; -.
DR MIM; 604436; gene.
DR neXtProt; NX_O94903; -.
DR PharmGKB; PA33810; -.
DR eggNOG; COG0325; -.
DR HOVERGEN; HBG053692; -.
DR InParanoid; O94903; -.
DR KO; K06997; -.
DR OMA; NVCIQVN; -.
DR OrthoDB; EOG712TX0; -.
DR PhylomeDB; O94903; -.
DR ChiTaRS; PROSC; human.
DR GeneWiki; PROSC; -.
DR GenomeRNAi; 11212; -.
DR NextBio; 42671; -.
DR PRO; PR:O94903; -.
DR ArrayExpress; O94903; -.
DR Bgee; O94903; -.
DR CleanEx; HS_PROSC; -.
DR Genevestigator; O94903; -.
DR GO; GO:0005737; C:cytoplasm; NAS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IBA:RefGenome.
DR InterPro; IPR001608; Ala_racemase_N.
DR InterPro; IPR011078; UPF0001.
DR PANTHER; PTHR10146; PTHR10146; 1.
DR Pfam; PF01168; Ala_racemase_N; 1.
DR PIRSF; PIRSF004848; YBL036c_PLPDEIII; 1.
DR TIGRFAMs; TIGR00044; TIGR00044; 1.
DR PROSITE; PS01211; UPF0001; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Phosphoprotein; Polymorphism; Pyridoxal phosphate;
KW Reference proteome.
FT CHAIN 1 275 Proline synthase co-transcribed bacterial
FT homolog protein.
FT /FTId=PRO_0000163210.
FT MOD_RES 47 47 N6-(pyridoxal phosphate)lysine (By
FT similarity).
FT MOD_RES 69 69 Phosphotyrosine (By similarity).
FT VARIANT 24 24 V -> M (in dbSNP:rs35423325).
FT /FTId=VAR_052476.
SQ SEQUENCE 275 AA; 30344 MW; A81049432B1A8732 CRC64;
MWRAGSMSAE LGVGCALRAV NERVQQAVAR RPRDLPAIQP RLVAVSKTKP ADMVIEAYGH
GQRTFGENYV QELLEKASNP KILSLCPEIK WHFIGHLQKQ NVNKLMAVPN LFMLETVDSV
KLADKVNSSW QRKGSPERLK VMVQINTSGE ESKHGLPPSE TIAIVEHINA KCPNLEFVGL
MTIGSFGHDL SQGPNPDFQL LLSLREELCK KLNIPADQVE LSMGMSADFQ HAVEVGSTNV
RIGSTIFGER DYSKKPTPDK CAADVKAPLE VAQEH
//
ID PROSC_HUMAN Reviewed; 275 AA.
AC O94903; Q6FI94;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAY-1999, sequence version 1.
DT 22-JAN-2014, entry version 116.
DE RecName: Full=Proline synthase co-transcribed bacterial homolog protein;
GN Name=PROSC;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10496079; DOI=10.1007/s100380050172;
RA Ikegawa S., Isomura M., Koshizuka Y., Nakamura Y.;
RT "Cloning and characterization of human and mouse PROSC (proline
RT synthetase co-transcribed) genes.";
RL J. Hum. Genet. 44:337-342(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA Wambutt R., Korn B., Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and
RT analysis of 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- COFACTOR: Pyridoxal phosphate (By similarity).
CC -!- TISSUE SPECIFICITY: Ubiquitous.
CC -!- SIMILARITY: Belongs to the UPF0001 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AB018566; BAA36842.1; -; Genomic_DNA.
DR EMBL; AL136616; CAB66551.1; -; mRNA.
DR EMBL; CR533532; CAG38563.1; -; mRNA.
DR EMBL; BC012334; AAH12334.1; -; mRNA.
DR RefSeq; NP_009129.1; NM_007198.3.
DR UniGene; Hs.304792; -.
DR UniGene; Hs.608177; -.
DR ProteinModelPortal; O94903; -.
DR SMR; O94903; 42-248.
DR IntAct; O94903; 1.
DR MINT; MINT-3002521; -.
DR STRING; 9606.ENSP00000333551; -.
DR DrugBank; DB00172; L-Proline.
DR DrugBank; DB00114; Pyridoxal Phosphate.
DR PhosphoSite; O94903; -.
DR UCD-2DPAGE; O94903; -.
DR PaxDb; O94903; -.
DR PeptideAtlas; O94903; -.
DR PRIDE; O94903; -.
DR DNASU; 11212; -.
DR Ensembl; ENST00000328195; ENSP00000333551; ENSG00000147471.
DR GeneID; 11212; -.
DR KEGG; hsa:11212; -.
DR UCSC; uc003xkh.3; human.
DR CTD; 11212; -.
DR GeneCards; GC08P037620; -.
DR HGNC; HGNC:9457; PROSC.
DR HPA; CAB017033; -.
DR HPA; HPA023646; -.
DR HPA; HPA023733; -.
DR MIM; 604436; gene.
DR neXtProt; NX_O94903; -.
DR PharmGKB; PA33810; -.
DR eggNOG; COG0325; -.
DR HOVERGEN; HBG053692; -.
DR InParanoid; O94903; -.
DR KO; K06997; -.
DR OMA; NVCIQVN; -.
DR OrthoDB; EOG712TX0; -.
DR PhylomeDB; O94903; -.
DR ChiTaRS; PROSC; human.
DR GeneWiki; PROSC; -.
DR GenomeRNAi; 11212; -.
DR NextBio; 42671; -.
DR PRO; PR:O94903; -.
DR ArrayExpress; O94903; -.
DR Bgee; O94903; -.
DR CleanEx; HS_PROSC; -.
DR Genevestigator; O94903; -.
DR GO; GO:0005737; C:cytoplasm; NAS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IBA:RefGenome.
DR InterPro; IPR001608; Ala_racemase_N.
DR InterPro; IPR011078; UPF0001.
DR PANTHER; PTHR10146; PTHR10146; 1.
DR Pfam; PF01168; Ala_racemase_N; 1.
DR PIRSF; PIRSF004848; YBL036c_PLPDEIII; 1.
DR TIGRFAMs; TIGR00044; TIGR00044; 1.
DR PROSITE; PS01211; UPF0001; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Phosphoprotein; Polymorphism; Pyridoxal phosphate;
KW Reference proteome.
FT CHAIN 1 275 Proline synthase co-transcribed bacterial
FT homolog protein.
FT /FTId=PRO_0000163210.
FT MOD_RES 47 47 N6-(pyridoxal phosphate)lysine (By
FT similarity).
FT MOD_RES 69 69 Phosphotyrosine (By similarity).
FT VARIANT 24 24 V -> M (in dbSNP:rs35423325).
FT /FTId=VAR_052476.
SQ SEQUENCE 275 AA; 30344 MW; A81049432B1A8732 CRC64;
MWRAGSMSAE LGVGCALRAV NERVQQAVAR RPRDLPAIQP RLVAVSKTKP ADMVIEAYGH
GQRTFGENYV QELLEKASNP KILSLCPEIK WHFIGHLQKQ NVNKLMAVPN LFMLETVDSV
KLADKVNSSW QRKGSPERLK VMVQINTSGE ESKHGLPPSE TIAIVEHINA KCPNLEFVGL
MTIGSFGHDL SQGPNPDFQL LLSLREELCK KLNIPADQVE LSMGMSADFQ HAVEVGSTNV
RIGSTIFGER DYSKKPTPDK CAADVKAPLE VAQEH
//
MIM
604436
*RECORD*
*FIELD* NO
604436
*FIELD* TI
*604436 PROLINE SYNTHETASE COTRANSCRIBED, BACTERIA, HOMOLOG OF; PROSC
*FIELD* TX
By sequencing a 1.8-Mb segment of human 8p11.2, coupled with
read morebioinformatics analyses, Ikegawa et al. (1999) identified a novel gene.
Since the P. aeruginosa homolog of this novel gene is located upstream
of and may be cotranscribed with a known proline biosynthetic gene, the
authors called the human gene PROSC, for 'proline synthetase
cotranscribed, bacterial homolog.' The PROSC gene spans 17.2 kb and
contains 8 exons. It is oriented in a 5-prime to 3-prime direction from
telomere to centromere. Northern blot analysis detected a 2.6-kb PROSC
transcript that was expressed in all human adult and fetal tissues
tested. Ikegawa et al. (1999) isolated cDNAs corresponding to the
full-length PROSC transcript. The deduced 275-amino acid PROSC protein
shares 86.5% sequence identity with mouse Prosc and 28% identity with
its P. aeruginosa homolog. PROSC is predicted to be a soluble,
cytoplasmic protein. It contains a putative N-linked glycosylation site
and a putative cAMP- and cGMP-dependent protein kinase phosphorylation
site.
Ikegawa et al. (1999) determined that the PROSC gene is located between
the proximal STS marker NIB1979 and the distal STS marker AFMA295ZD5 on
8p11.2.
*FIELD* RF
1. Ikegawa, S.; Isomura, M.; Koshizuka, Y.; Nakamura, Y.: Cloning
and characterization of human and mouse PROSC (proline synthetase
co-transcribed) genes. J. Hum. Genet. 44: 337-342, 1999.
*FIELD* CD
Patti M. Sherman: 1/18/2000
*FIELD* ED
mgross: 01/20/2000
psherman: 1/18/2000
*RECORD*
*FIELD* NO
604436
*FIELD* TI
*604436 PROLINE SYNTHETASE COTRANSCRIBED, BACTERIA, HOMOLOG OF; PROSC
*FIELD* TX
By sequencing a 1.8-Mb segment of human 8p11.2, coupled with
read morebioinformatics analyses, Ikegawa et al. (1999) identified a novel gene.
Since the P. aeruginosa homolog of this novel gene is located upstream
of and may be cotranscribed with a known proline biosynthetic gene, the
authors called the human gene PROSC, for 'proline synthetase
cotranscribed, bacterial homolog.' The PROSC gene spans 17.2 kb and
contains 8 exons. It is oriented in a 5-prime to 3-prime direction from
telomere to centromere. Northern blot analysis detected a 2.6-kb PROSC
transcript that was expressed in all human adult and fetal tissues
tested. Ikegawa et al. (1999) isolated cDNAs corresponding to the
full-length PROSC transcript. The deduced 275-amino acid PROSC protein
shares 86.5% sequence identity with mouse Prosc and 28% identity with
its P. aeruginosa homolog. PROSC is predicted to be a soluble,
cytoplasmic protein. It contains a putative N-linked glycosylation site
and a putative cAMP- and cGMP-dependent protein kinase phosphorylation
site.
Ikegawa et al. (1999) determined that the PROSC gene is located between
the proximal STS marker NIB1979 and the distal STS marker AFMA295ZD5 on
8p11.2.
*FIELD* RF
1. Ikegawa, S.; Isomura, M.; Koshizuka, Y.; Nakamura, Y.: Cloning
and characterization of human and mouse PROSC (proline synthetase
co-transcribed) genes. J. Hum. Genet. 44: 337-342, 1999.
*FIELD* CD
Patti M. Sherman: 1/18/2000
*FIELD* ED
mgross: 01/20/2000
psherman: 1/18/2000