Full text data of PSMG4
PSMG4
(C6orf86, PAC4)
[Confidence: low (only semi-automatic identification from reviews)]
Proteasome assembly chaperone 4; PAC-4; hPAC4
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Proteasome assembly chaperone 4; PAC-4; hPAC4
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q5JS54
ID PSMG4_HUMAN Reviewed; 123 AA.
AC Q5JS54; C9J2F8; F8WBZ2; Q5JS53; Q5JS56;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 10-JUN-2008, sequence version 2.
DT 22-JAN-2014, entry version 55.
DE RecName: Full=Proteasome assembly chaperone 4;
DE Short=PAC-4;
DE Short=hPAC4;
GN Name=PSMG4; Synonyms=C6orf86, PAC4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Embryonic stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=17707236; DOI=10.1016/j.molcel.2007.06.025;
RA Le Tallec B., Barrault M.-B., Courbeyrette R., Guerois R.,
RA Marsolier-Kergoat M.-C., Peyroche A.;
RT "20S proteasome assembly is orchestrated by two distinct pairs of
RT chaperones in yeast and in mammals.";
RL Mol. Cell 27:660-674(2007).
CC -!- FUNCTION: Chaperone protein which promotes assembly of the 20S
CC proteasome.
CC -!- SUBUNIT: Interacts with PSMG3. Associates with alpha subunits of
CC the 20S proteasome (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5JS54-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5JS54-2; Sequence=VSP_046635;
CC Note=No experimental confirmation available;
CC Name=3;
CC IsoId=Q5JS54-3; Sequence=VSP_046636;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the PSMG4 family.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAI40954.1; Type=Erroneous gene model prediction;
CC Sequence=CAI40955.1; Type=Erroneous gene model prediction;
CC Sequence=CAI40957.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AL445309; CAI40954.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL445309; CAI40955.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL445309; CAI40957.1; ALT_INIT; Genomic_DNA.
DR EMBL; CH471087; EAW55130.1; -; Genomic_DNA.
DR EMBL; CD173424; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001122063.1; NM_001128591.1.
DR RefSeq; NP_001122064.1; NM_001128592.1.
DR RefSeq; NP_001129222.1; NM_001135750.1.
DR UniGene; Hs.207069; -.
DR UniGene; Hs.731726; -.
DR ProteinModelPortal; Q5JS54; -.
DR STRING; 9606.ENSP00000392353; -.
DR DMDM; 190360085; -.
DR PaxDb; Q5JS54; -.
DR PRIDE; Q5JS54; -.
DR Ensembl; ENST00000419065; ENSP00000392353; ENSG00000180822.
DR Ensembl; ENST00000438998; ENSP00000413353; ENSG00000180822.
DR Ensembl; ENST00000473000; ENSP00000418241; ENSG00000180822.
DR GeneID; 389362; -.
DR KEGG; hsa:389362; -.
DR UCSC; uc010jnl.1; human.
DR CTD; 389362; -.
DR GeneCards; GC06P003231; -.
DR HGNC; HGNC:21108; PSMG4.
DR neXtProt; NX_Q5JS54; -.
DR PharmGKB; PA162400256; -.
DR eggNOG; NOG69142; -.
DR HOGENOM; HOG000060342; -.
DR HOVERGEN; HBG089938; -.
DR InParanoid; Q5JS54; -.
DR KO; K11878; -.
DR OMA; FVSYNLP; -.
DR GenomeRNAi; 389362; -.
DR NextBio; 102804; -.
DR PRO; PR:Q5JS54; -.
DR ArrayExpress; Q5JS54; -.
DR Bgee; Q5JS54; -.
DR CleanEx; HS_PSMG4; -.
DR Genevestigator; Q5JS54; -.
PE 2: Evidence at transcript level;
KW Alternative splicing; Chaperone; Complete proteome;
KW Reference proteome.
FT CHAIN 1 123 Proteasome assembly chaperone 4.
FT /FTId=PRO_0000341397.
FT VAR_SEQ 83 83 L -> LGLGGKTGLACECGVEWGLSKGHEAECSTLPTPQHT
FT SCGP (in isoform 2).
FT /FTId=VSP_046635.
FT VAR_SEQ 84 123 ARKTNKQVFVSYNLQNTDSNFALLVENRIKEEMEAFPEKF
FT -> GMYPQLALHGQPGGAHSLMEP (in isoform 3).
FT /FTId=VSP_046636.
FT CONFLICT 47 47 L -> Q (in Ref. 3; CD173424).
SQ SEQUENCE 123 AA; 13775 MW; 44F98C0CC00B937F CRC64;
MEGLVVAAGG DVSLHNFSAR LWEQLVHFHV MRLTDSLFLW VGATPHLRNL AVAMCSRYDS
IPVSTSLLGD TSDTTSTGLA QRLARKTNKQ VFVSYNLQNT DSNFALLVEN RIKEEMEAFP
EKF
//
ID PSMG4_HUMAN Reviewed; 123 AA.
AC Q5JS54; C9J2F8; F8WBZ2; Q5JS53; Q5JS56;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 10-JUN-2008, sequence version 2.
DT 22-JAN-2014, entry version 55.
DE RecName: Full=Proteasome assembly chaperone 4;
DE Short=PAC-4;
DE Short=hPAC4;
GN Name=PSMG4; Synonyms=C6orf86, PAC4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Embryonic stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=17707236; DOI=10.1016/j.molcel.2007.06.025;
RA Le Tallec B., Barrault M.-B., Courbeyrette R., Guerois R.,
RA Marsolier-Kergoat M.-C., Peyroche A.;
RT "20S proteasome assembly is orchestrated by two distinct pairs of
RT chaperones in yeast and in mammals.";
RL Mol. Cell 27:660-674(2007).
CC -!- FUNCTION: Chaperone protein which promotes assembly of the 20S
CC proteasome.
CC -!- SUBUNIT: Interacts with PSMG3. Associates with alpha subunits of
CC the 20S proteasome (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5JS54-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5JS54-2; Sequence=VSP_046635;
CC Note=No experimental confirmation available;
CC Name=3;
CC IsoId=Q5JS54-3; Sequence=VSP_046636;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the PSMG4 family.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAI40954.1; Type=Erroneous gene model prediction;
CC Sequence=CAI40955.1; Type=Erroneous gene model prediction;
CC Sequence=CAI40957.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AL445309; CAI40954.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL445309; CAI40955.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL445309; CAI40957.1; ALT_INIT; Genomic_DNA.
DR EMBL; CH471087; EAW55130.1; -; Genomic_DNA.
DR EMBL; CD173424; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001122063.1; NM_001128591.1.
DR RefSeq; NP_001122064.1; NM_001128592.1.
DR RefSeq; NP_001129222.1; NM_001135750.1.
DR UniGene; Hs.207069; -.
DR UniGene; Hs.731726; -.
DR ProteinModelPortal; Q5JS54; -.
DR STRING; 9606.ENSP00000392353; -.
DR DMDM; 190360085; -.
DR PaxDb; Q5JS54; -.
DR PRIDE; Q5JS54; -.
DR Ensembl; ENST00000419065; ENSP00000392353; ENSG00000180822.
DR Ensembl; ENST00000438998; ENSP00000413353; ENSG00000180822.
DR Ensembl; ENST00000473000; ENSP00000418241; ENSG00000180822.
DR GeneID; 389362; -.
DR KEGG; hsa:389362; -.
DR UCSC; uc010jnl.1; human.
DR CTD; 389362; -.
DR GeneCards; GC06P003231; -.
DR HGNC; HGNC:21108; PSMG4.
DR neXtProt; NX_Q5JS54; -.
DR PharmGKB; PA162400256; -.
DR eggNOG; NOG69142; -.
DR HOGENOM; HOG000060342; -.
DR HOVERGEN; HBG089938; -.
DR InParanoid; Q5JS54; -.
DR KO; K11878; -.
DR OMA; FVSYNLP; -.
DR GenomeRNAi; 389362; -.
DR NextBio; 102804; -.
DR PRO; PR:Q5JS54; -.
DR ArrayExpress; Q5JS54; -.
DR Bgee; Q5JS54; -.
DR CleanEx; HS_PSMG4; -.
DR Genevestigator; Q5JS54; -.
PE 2: Evidence at transcript level;
KW Alternative splicing; Chaperone; Complete proteome;
KW Reference proteome.
FT CHAIN 1 123 Proteasome assembly chaperone 4.
FT /FTId=PRO_0000341397.
FT VAR_SEQ 83 83 L -> LGLGGKTGLACECGVEWGLSKGHEAECSTLPTPQHT
FT SCGP (in isoform 2).
FT /FTId=VSP_046635.
FT VAR_SEQ 84 123 ARKTNKQVFVSYNLQNTDSNFALLVENRIKEEMEAFPEKF
FT -> GMYPQLALHGQPGGAHSLMEP (in isoform 3).
FT /FTId=VSP_046636.
FT CONFLICT 47 47 L -> Q (in Ref. 3; CD173424).
SQ SEQUENCE 123 AA; 13775 MW; 44F98C0CC00B937F CRC64;
MEGLVVAAGG DVSLHNFSAR LWEQLVHFHV MRLTDSLFLW VGATPHLRNL AVAMCSRYDS
IPVSTSLLGD TSDTTSTGLA QRLARKTNKQ VFVSYNLQNT DSNFALLVEN RIKEEMEAFP
EKF
//