Full text data of UBA1
UBA1
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
hRBCD
IPI00026119
IPI00026119 Ubiquitin-activating enzyme E1 lymph, found in the other proteome also, UBQ conjugation 1st step yielding an ubiquitin-E1 thiolester and free AMP soluble n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a cytoplasmic n/a found at its expected molecular weight found at molecular weight
IPI00026119 Ubiquitin-activating enzyme E1 lymph, found in the other proteome also, UBQ conjugation 1st step yielding an ubiquitin-E1 thiolester and free AMP soluble n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a cytoplasmic n/a found at its expected molecular weight found at molecular weight
UniProt
Q5JRR6
ID Q5JRR6_HUMAN Unreviewed; 506 AA.
AC Q5JRR6;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
read moreDT 22-JAN-2014, entry version 59.
DE SubName: Full=Ubiquitin-like modifier-activating enzyme 1;
GN Name=UBA1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A.,
RA Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G.,
RA Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S.,
RA Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R.,
RA Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L.,
RA Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A.,
RA Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S.,
RA Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R.,
RA Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M.,
RA Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N.,
RA Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D.,
RA Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W.,
RA Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C.,
RA Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C.,
RA Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J.,
RA Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S.,
RA Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I.,
RA Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L.,
RA Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P.,
RA Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S.,
RA Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A.,
RA Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J.,
RA Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J.,
RA Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S.,
RA de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z.,
RA Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C.,
RA Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W.,
RA Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T.,
RA Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I.,
RA Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N.,
RA Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J.,
RA Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E.,
RA Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S.,
RA Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T.,
RA Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S.,
RA Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L.,
RA Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A.,
RA Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L.,
RA Williams G., Williams L., Williamson A., Williamson H., Wilming L.,
RA Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H.,
RA Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A.,
RA Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A.,
RA Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T.,
RA Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AL513366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR ProteinModelPortal; Q5JRR6; -.
DR SMR; Q5JRR6; 79-501.
DR PRIDE; Q5JRR6; -.
DR Ensembl; ENST00000377269; ENSP00000366481; ENSG00000130985.
DR UCSC; uc004dhm.3; human.
DR HGNC; HGNC:12469; UBA1.
DR HOVERGEN; HBG056231; -.
DR ChiTaRS; UBA1; human.
DR ArrayExpress; Q5JRR6; -.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0008641; F:small protein activating enzyme activity; IEA:InterPro.
DR GO; GO:0006464; P:cellular protein modification process; IEA:InterPro.
DR Gene3D; 1.10.3240.10; -; 1.
DR Gene3D; 3.40.50.720; -; 1.
DR InterPro; IPR009036; Molybdenum_cofac_synth_MoeB.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR018965; Ub-activating_enz_e1_C.
DR InterPro; IPR023280; Ub-like_act_enz_cat_cys_dom.
DR InterPro; IPR000127; UBact_repeat.
DR Pfam; PF09358; UBA_e1_C; 1.
DR Pfam; PF02134; UBACT; 2.
DR SMART; SM00985; UBA_e1_C; 1.
DR SUPFAM; SSF69572; SSF69572; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Reference proteome.
SQ SEQUENCE 506 AA; 56852 MW; 41BDBD28B48D92A6 CRC64;
MGFHHVGQAG LEPLTSGDPS ALASQSAGIT GVSYCAWPGF SIEVGEWGRL EGFPTSRVAV
RLVLALFTDG PSNNACGNPF CQLWPHVICL LCLQWARDEF EGLFKQPAEN VNQYLTDPKF
VERTLRLAGT QPLEVLEAVQ RSLVLQRPQT WADCVTWACH HWHTQYSNNI RQLLHNFPPD
QLTSSGAPFW SGPKRCPHPL TFDVNNPLHL DYVMAAANLF AQTYGLTGSQ DRAAVATFLQ
SVQVPEFTPK SGVKIHVSDQ ELQSANASVD DSRLEELKAT LPSPDKLPGF KMYPIDFEKD
DDSNFHMDFI VAASNLRAEN YDIPSADRHK SKLIAGKIIP AIATTTAAVV GLVCLELYKV
VQGHRQLDSY KNGFLNLALP FFGFSEPLAA PRHQYYNQEW TLWDRFEVQG LQPNGEEMTL
KQFLDYFKTE HKLEITMLSQ GVSMLYSFFM PAAKLKERLD QPMTEIVSRV SKRKLGRHVR
ALVLELCCND ESGEDVEVPY VRYTIR
//
ID Q5JRR6_HUMAN Unreviewed; 506 AA.
AC Q5JRR6;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
read moreDT 22-JAN-2014, entry version 59.
DE SubName: Full=Ubiquitin-like modifier-activating enzyme 1;
GN Name=UBA1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A.,
RA Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G.,
RA Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S.,
RA Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R.,
RA Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L.,
RA Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A.,
RA Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S.,
RA Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R.,
RA Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M.,
RA Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N.,
RA Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D.,
RA Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W.,
RA Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C.,
RA Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C.,
RA Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J.,
RA Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S.,
RA Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I.,
RA Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L.,
RA Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P.,
RA Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S.,
RA Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A.,
RA Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J.,
RA Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J.,
RA Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S.,
RA de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z.,
RA Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C.,
RA Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W.,
RA Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T.,
RA Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I.,
RA Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N.,
RA Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J.,
RA Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E.,
RA Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S.,
RA Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T.,
RA Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S.,
RA Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L.,
RA Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A.,
RA Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L.,
RA Williams G., Williams L., Williamson A., Williamson H., Wilming L.,
RA Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H.,
RA Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A.,
RA Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A.,
RA Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T.,
RA Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AL513366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR ProteinModelPortal; Q5JRR6; -.
DR SMR; Q5JRR6; 79-501.
DR PRIDE; Q5JRR6; -.
DR Ensembl; ENST00000377269; ENSP00000366481; ENSG00000130985.
DR UCSC; uc004dhm.3; human.
DR HGNC; HGNC:12469; UBA1.
DR HOVERGEN; HBG056231; -.
DR ChiTaRS; UBA1; human.
DR ArrayExpress; Q5JRR6; -.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0008641; F:small protein activating enzyme activity; IEA:InterPro.
DR GO; GO:0006464; P:cellular protein modification process; IEA:InterPro.
DR Gene3D; 1.10.3240.10; -; 1.
DR Gene3D; 3.40.50.720; -; 1.
DR InterPro; IPR009036; Molybdenum_cofac_synth_MoeB.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR018965; Ub-activating_enz_e1_C.
DR InterPro; IPR023280; Ub-like_act_enz_cat_cys_dom.
DR InterPro; IPR000127; UBact_repeat.
DR Pfam; PF09358; UBA_e1_C; 1.
DR Pfam; PF02134; UBACT; 2.
DR SMART; SM00985; UBA_e1_C; 1.
DR SUPFAM; SSF69572; SSF69572; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Reference proteome.
SQ SEQUENCE 506 AA; 56852 MW; 41BDBD28B48D92A6 CRC64;
MGFHHVGQAG LEPLTSGDPS ALASQSAGIT GVSYCAWPGF SIEVGEWGRL EGFPTSRVAV
RLVLALFTDG PSNNACGNPF CQLWPHVICL LCLQWARDEF EGLFKQPAEN VNQYLTDPKF
VERTLRLAGT QPLEVLEAVQ RSLVLQRPQT WADCVTWACH HWHTQYSNNI RQLLHNFPPD
QLTSSGAPFW SGPKRCPHPL TFDVNNPLHL DYVMAAANLF AQTYGLTGSQ DRAAVATFLQ
SVQVPEFTPK SGVKIHVSDQ ELQSANASVD DSRLEELKAT LPSPDKLPGF KMYPIDFEKD
DDSNFHMDFI VAASNLRAEN YDIPSADRHK SKLIAGKIIP AIATTTAAVV GLVCLELYKV
VQGHRQLDSY KNGFLNLALP FFGFSEPLAA PRHQYYNQEW TLWDRFEVQG LQPNGEEMTL
KQFLDYFKTE HKLEITMLSQ GVSMLYSFFM PAAKLKERLD QPMTEIVSRV SKRKLGRHVR
ALVLELCCND ESGEDVEVPY VRYTIR
//