Full text data of ZZZZ
Q7Z3Y4
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
hRBCD
IPI00385058
IPI00385058 Ig kappa chain C region Ig kappa chain C region membrane n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 2 extracellular binds RBC n/a found at its expected molecular weight found at molecular weight
IPI00385058 Ig kappa chain C region Ig kappa chain C region membrane n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 2 extracellular binds RBC n/a found at its expected molecular weight found at molecular weight
UniProt
Q7Z3Y4
ID Q7Z3Y4_HUMAN Unreviewed; 236 AA.
AC Q7Z3Y4;
DT 01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2003, sequence version 1.
read moreDT 22-JAN-2014, entry version 89.
DE SubName: Full=Uncharacterized protein;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 27-233.
RX PubMed=9305839; DOI=10.1038/38470;
RA Ulrich H.D., Mundorff E., Santarsiero B.D., Driggers E.M.,
RA Stevens R.C., Schultz P.G.;
RT "The interplay between binding energy and catalysis in the evolution
RT of a catalytic antibody.";
RL Nature 389:271-275(1997).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 23-236.
RX PubMed=12079396; DOI=10.1016/S0022-2836(02)00264-4;
RA Vajdos F.F., Adams C.W., Breece T.N., Presta L.G., de Vos A.M.,
RA Sidhu S.S.;
RT "Comprehensive functional maps of the antigen-binding site of an anti-
RT ErbB2 antibody obtained with shotgun scanning mutagenesis.";
RL J. Mol. Biol. 320:415-428(2002).
RN [3]
RP X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 23-235.
RX PubMed=12888350; DOI=10.1016/S0022-2836(03)00735-6;
RA Eigenbrot C., Meng Y.G., Krishnamurthy R., Lipari M.T., Presta L.,
RA Devaux B., Wong T., Moran P., Bullens S., Kirchhofer D.;
RT "Structural insight into how an anti-idiotypic antibody against D3H44
RT (anti-tissue factor antibody) restores normal coagulation.";
RL J. Mol. Biol. 331:433-446(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skeletal Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
RA Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) OF 23-236.
RX PubMed=17620453; DOI=10.1182/blood-2007-04-083998;
RA Liu Z., Stoll V.S., Devries P.J., Jakob C.G., Xie N., Simmer R.L.,
RA Lacy S.E., Egan D.A., Harlan J.E., Lesniewski R.R., Reilly E.B.;
RT "A potent erythropoietin-mimicking human antibody interacts through a
RT novel binding site.";
RL Blood 110:2408-2413(2007).
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; BC005332; AAH05332.1; -; mRNA.
DR PDB; 1AXS; X-ray; 2.60 A; A/L=27-233.
DR PDB; 1L7I; X-ray; 1.80 A; L=23-236.
DR PDB; 1PG7; X-ray; 2.50 A; L/M=23-235.
DR PDB; 2JIX; X-ray; 3.20 A; A/G/L=23-236.
DR PDBsum; 1AXS; -.
DR PDBsum; 1L7I; -.
DR PDBsum; 1PG7; -.
DR PDBsum; 2JIX; -.
DR ProteinModelPortal; Q7Z3Y4; -.
DR SMR; Q7Z3Y4; 23-236.
DR IntAct; Q7Z3Y4; 1.
DR PeptideAtlas; Q7Z3Y4; -.
DR PRIDE; Q7Z3Y4; -.
DR HOGENOM; HOG000059537; -.
DR HOVERGEN; HBG018013; -.
DR EvolutionaryTrace; Q7Z3Y4; -.
DR NextBio; 35540917; -.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR003596; Ig_V-set_subgr.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00406; IGv; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW 3D-structure.
SQ SEQUENCE 236 AA; 25702 MW; 7FBFE4ED23084BC6 CRC64;
MDMRVLAQLL GLLLLCFPGA RCDIQMTQSP SSLSASVGDT VTITCRASQD ISNYLAWFQQ
KPGKAPKSLI YGASSLQSGV QSKFSGSGSG TDFTLTISSL QPEDFATYYC QQYKSYPVTF
GQGTKLEIKR TVAAPSVFIF PPSDEQLKSG TASVVCLLNN FYPREAKVQW KVDNALQSGN
SQESVTEQDS KDSTYSLSST LTLSKADYEK HKVYACEVTH QGLSSPVTKS FNRGEC
//
ID Q7Z3Y4_HUMAN Unreviewed; 236 AA.
AC Q7Z3Y4;
DT 01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2003, sequence version 1.
read moreDT 22-JAN-2014, entry version 89.
DE SubName: Full=Uncharacterized protein;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 27-233.
RX PubMed=9305839; DOI=10.1038/38470;
RA Ulrich H.D., Mundorff E., Santarsiero B.D., Driggers E.M.,
RA Stevens R.C., Schultz P.G.;
RT "The interplay between binding energy and catalysis in the evolution
RT of a catalytic antibody.";
RL Nature 389:271-275(1997).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 23-236.
RX PubMed=12079396; DOI=10.1016/S0022-2836(02)00264-4;
RA Vajdos F.F., Adams C.W., Breece T.N., Presta L.G., de Vos A.M.,
RA Sidhu S.S.;
RT "Comprehensive functional maps of the antigen-binding site of an anti-
RT ErbB2 antibody obtained with shotgun scanning mutagenesis.";
RL J. Mol. Biol. 320:415-428(2002).
RN [3]
RP X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 23-235.
RX PubMed=12888350; DOI=10.1016/S0022-2836(03)00735-6;
RA Eigenbrot C., Meng Y.G., Krishnamurthy R., Lipari M.T., Presta L.,
RA Devaux B., Wong T., Moran P., Bullens S., Kirchhofer D.;
RT "Structural insight into how an anti-idiotypic antibody against D3H44
RT (anti-tissue factor antibody) restores normal coagulation.";
RL J. Mol. Biol. 331:433-446(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skeletal Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
RA Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) OF 23-236.
RX PubMed=17620453; DOI=10.1182/blood-2007-04-083998;
RA Liu Z., Stoll V.S., Devries P.J., Jakob C.G., Xie N., Simmer R.L.,
RA Lacy S.E., Egan D.A., Harlan J.E., Lesniewski R.R., Reilly E.B.;
RT "A potent erythropoietin-mimicking human antibody interacts through a
RT novel binding site.";
RL Blood 110:2408-2413(2007).
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; BC005332; AAH05332.1; -; mRNA.
DR PDB; 1AXS; X-ray; 2.60 A; A/L=27-233.
DR PDB; 1L7I; X-ray; 1.80 A; L=23-236.
DR PDB; 1PG7; X-ray; 2.50 A; L/M=23-235.
DR PDB; 2JIX; X-ray; 3.20 A; A/G/L=23-236.
DR PDBsum; 1AXS; -.
DR PDBsum; 1L7I; -.
DR PDBsum; 1PG7; -.
DR PDBsum; 2JIX; -.
DR ProteinModelPortal; Q7Z3Y4; -.
DR SMR; Q7Z3Y4; 23-236.
DR IntAct; Q7Z3Y4; 1.
DR PeptideAtlas; Q7Z3Y4; -.
DR PRIDE; Q7Z3Y4; -.
DR HOGENOM; HOG000059537; -.
DR HOVERGEN; HBG018013; -.
DR EvolutionaryTrace; Q7Z3Y4; -.
DR NextBio; 35540917; -.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR003596; Ig_V-set_subgr.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00406; IGv; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW 3D-structure.
SQ SEQUENCE 236 AA; 25702 MW; 7FBFE4ED23084BC6 CRC64;
MDMRVLAQLL GLLLLCFPGA RCDIQMTQSP SSLSASVGDT VTITCRASQD ISNYLAWFQQ
KPGKAPKSLI YGASSLQSGV QSKFSGSGSG TDFTLTISSL QPEDFATYYC QQYKSYPVTF
GQGTKLEIKR TVAAPSVFIF PPSDEQLKSG TASVVCLLNN FYPREAKVQW KVDNALQSGN
SQESVTEQDS KDSTYSLSST LTLSKADYEK HKVYACEVTH QGLSSPVTKS FNRGEC
//