Full text data of PRKAR2A
PRKAR2A
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
hRBCD
IPI00063234
IPI00063234 PRKAR2A protein AMP-dependent protein kinase complex,cAMP-dependent protein kinase regulator activity,kinase activity, protein amino acid phosphorylation, signal transduction soluble n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a cytoplasmic n/a found at its expected molecular weight found at molecular weight
IPI00063234 PRKAR2A protein AMP-dependent protein kinase complex,cAMP-dependent protein kinase regulator activity,kinase activity, protein amino acid phosphorylation, signal transduction soluble n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a cytoplasmic n/a found at its expected molecular weight found at molecular weight
UniProt
Q9BUB1
ID Q9BUB1_HUMAN Unreviewed; 382 AA.
AC Q9BUB1;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
read moreDT 22-JAN-2014, entry version 87.
DE SubName: Full=PRKAR2A protein;
DE SubName: Full=Protein kinase, cAMP-dependent, regulatory, type II, alpha;
DE SubName: Full=Protein kinase, cAMP-dependent, regulatory, type II, alpha, isoform CRA_b;
DE SubName: Full=cAMP-dependent protein kinase type II-alpha regulatory subunit;
GN Name=PRKAR2A; ORFNames=hCG_1779456;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11181995; DOI=10.1126/science.1058040;
RA Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
RA Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D.,
RA Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q.,
RA Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G.,
RA Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S.,
RA Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J.,
RA Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R.,
RA Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A.,
RA Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K.,
RA Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V.,
RA Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
RA Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
RA Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z.,
RA Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A.,
RA Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V.,
RA Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B.,
RA Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J.,
RA Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C.,
RA Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L.,
RA Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S.,
RA Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A.,
RA Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D.,
RA Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L.,
RA Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N.,
RA Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S.,
RA Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F.,
RA Kline L., Koduru S., Love A., Mann F., May D., McCawley S.,
RA McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K.,
RA Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
RA Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
RA Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N.,
RA Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M.,
RA Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F.,
RA Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A.,
RA Mi H., Lazareva B., Hatton T., Narechania A., Diemer K.,
RA Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R.,
RA Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J.,
RA Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H.,
RA Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D.,
RA Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A.,
RA Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S.,
RA Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L.,
RA Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W.,
RA McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M.,
RA Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
RA Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
RA Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
RT "The sequence of the human genome.";
RL Science 291:1304-1351(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) System Donor
RT vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
RA Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE.
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [6]
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AC141002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC144546; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC002763; AAH02763.1; -; mRNA.
DR EMBL; BT007225; AAP35889.1; -; mRNA.
DR EMBL; CH471055; EAW64926.1; -; Genomic_DNA.
DR RefSeq; NP_004148.1; NM_004157.2.
DR RefSeq; XP_005265371.1; XM_005265314.1.
DR UniGene; Hs.631923; -.
DR SMR; Q9BUB1; 4-44, 96-374.
DR DNASU; 5576; -.
DR Ensembl; ENST00000296446; ENSP00000296446; ENSG00000114302.
DR GeneID; 5576; -.
DR KEGG; hsa:5576; -.
DR UCSC; uc003cuy.1; human.
DR CTD; 5576; -.
DR HGNC; HGNC:9391; PRKAR2A.
DR PharmGKB; PA33757; -.
DR HOGENOM; HOG000196668; -.
DR HOVERGEN; HBG002025; -.
DR KO; K04739; -.
DR ChiTaRS; PRKAR2A; human.
DR GenomeRNAi; 5576; -.
DR NextBio; 21620; -.
DR ArrayExpress; Q9BUB1; -.
DR GO; GO:0005952; C:cAMP-dependent protein kinase complex; IEA:InterPro.
DR GO; GO:0008603; F:cAMP-dependent protein kinase regulator activity; IEA:InterPro.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.10; -; 2.
DR InterPro; IPR002373; cAMP/cGMP_kin.
DR InterPro; IPR012198; cAMP_dep_PK_reg_su.
DR InterPro; IPR003117; cAMP_dep_PK_reg_su_I/II_a/b.
DR InterPro; IPR018490; cNMP-bd-like.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR Pfam; PF00027; cNMP_binding; 2.
DR Pfam; PF02197; RIIa; 1.
DR PIRSF; PIRSF000548; PK_regulatory; 1.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00394; RIIa; 1.
DR SUPFAM; SSF47391; SSF47391; 1.
DR SUPFAM; SSF51206; SSF51206; 2.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 2.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
PE 2: Evidence at transcript level;
KW Complete proteome; Kinase; Reference proteome; Transferase.
SQ SEQUENCE 382 AA; 43067 MW; 87D6AC1A5CE9E300 CRC64;
MSHIQIPPGL TELLQGYTVE VLRQQPPDLV EFAVEYFTRL REARAPASVL PAATPRQSLG
HPPPEPGPDR VADAKGDSES EEDEDLEVPV PSRFNRRVSV CAETYNPDEE EEDTDPRVIH
PKTDEQRCRL QEACKDILLF KNLDQEQLSQ VLDAMFERIV KADEHVIDQG DDGDNFYVIE
RGTYDILVTK DNQTRSVGQY DNRGSFGELA LMYNTPRAAT IVATSEGSLW GLDRVTFRRI
IVKNNAKKRK MFESFIESVP LLKSLEVSER MKIVDVIGEK IYKDGERIIT QTKSNKDGGN
QEVEIARCHK GQYFGELALV TNKPRAASAY AVGDVKCLVM DVQAFERLLG PCMDIMKRNI
SHYEEQLVKM FGSSVDLGNL GQ
//
ID Q9BUB1_HUMAN Unreviewed; 382 AA.
AC Q9BUB1;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
read moreDT 22-JAN-2014, entry version 87.
DE SubName: Full=PRKAR2A protein;
DE SubName: Full=Protein kinase, cAMP-dependent, regulatory, type II, alpha;
DE SubName: Full=Protein kinase, cAMP-dependent, regulatory, type II, alpha, isoform CRA_b;
DE SubName: Full=cAMP-dependent protein kinase type II-alpha regulatory subunit;
GN Name=PRKAR2A; ORFNames=hCG_1779456;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11181995; DOI=10.1126/science.1058040;
RA Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
RA Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D.,
RA Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q.,
RA Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G.,
RA Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S.,
RA Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J.,
RA Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R.,
RA Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A.,
RA Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K.,
RA Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V.,
RA Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
RA Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
RA Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z.,
RA Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A.,
RA Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V.,
RA Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B.,
RA Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J.,
RA Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C.,
RA Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L.,
RA Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S.,
RA Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A.,
RA Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D.,
RA Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L.,
RA Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N.,
RA Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S.,
RA Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F.,
RA Kline L., Koduru S., Love A., Mann F., May D., McCawley S.,
RA McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K.,
RA Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
RA Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
RA Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N.,
RA Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M.,
RA Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F.,
RA Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A.,
RA Mi H., Lazareva B., Hatton T., Narechania A., Diemer K.,
RA Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R.,
RA Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J.,
RA Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H.,
RA Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D.,
RA Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A.,
RA Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S.,
RA Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L.,
RA Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W.,
RA McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M.,
RA Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
RA Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
RA Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
RT "The sequence of the human genome.";
RL Science 291:1304-1351(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) System Donor
RT vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
RA Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE.
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [6]
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AC141002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC144546; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC002763; AAH02763.1; -; mRNA.
DR EMBL; BT007225; AAP35889.1; -; mRNA.
DR EMBL; CH471055; EAW64926.1; -; Genomic_DNA.
DR RefSeq; NP_004148.1; NM_004157.2.
DR RefSeq; XP_005265371.1; XM_005265314.1.
DR UniGene; Hs.631923; -.
DR SMR; Q9BUB1; 4-44, 96-374.
DR DNASU; 5576; -.
DR Ensembl; ENST00000296446; ENSP00000296446; ENSG00000114302.
DR GeneID; 5576; -.
DR KEGG; hsa:5576; -.
DR UCSC; uc003cuy.1; human.
DR CTD; 5576; -.
DR HGNC; HGNC:9391; PRKAR2A.
DR PharmGKB; PA33757; -.
DR HOGENOM; HOG000196668; -.
DR HOVERGEN; HBG002025; -.
DR KO; K04739; -.
DR ChiTaRS; PRKAR2A; human.
DR GenomeRNAi; 5576; -.
DR NextBio; 21620; -.
DR ArrayExpress; Q9BUB1; -.
DR GO; GO:0005952; C:cAMP-dependent protein kinase complex; IEA:InterPro.
DR GO; GO:0008603; F:cAMP-dependent protein kinase regulator activity; IEA:InterPro.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.10; -; 2.
DR InterPro; IPR002373; cAMP/cGMP_kin.
DR InterPro; IPR012198; cAMP_dep_PK_reg_su.
DR InterPro; IPR003117; cAMP_dep_PK_reg_su_I/II_a/b.
DR InterPro; IPR018490; cNMP-bd-like.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR Pfam; PF00027; cNMP_binding; 2.
DR Pfam; PF02197; RIIa; 1.
DR PIRSF; PIRSF000548; PK_regulatory; 1.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00394; RIIa; 1.
DR SUPFAM; SSF47391; SSF47391; 1.
DR SUPFAM; SSF51206; SSF51206; 2.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 2.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
PE 2: Evidence at transcript level;
KW Complete proteome; Kinase; Reference proteome; Transferase.
SQ SEQUENCE 382 AA; 43067 MW; 87D6AC1A5CE9E300 CRC64;
MSHIQIPPGL TELLQGYTVE VLRQQPPDLV EFAVEYFTRL REARAPASVL PAATPRQSLG
HPPPEPGPDR VADAKGDSES EEDEDLEVPV PSRFNRRVSV CAETYNPDEE EEDTDPRVIH
PKTDEQRCRL QEACKDILLF KNLDQEQLSQ VLDAMFERIV KADEHVIDQG DDGDNFYVIE
RGTYDILVTK DNQTRSVGQY DNRGSFGELA LMYNTPRAAT IVATSEGSLW GLDRVTFRRI
IVKNNAKKRK MFESFIESVP LLKSLEVSER MKIVDVIGEK IYKDGERIIT QTKSNKDGGN
QEVEIARCHK GQYFGELALV TNKPRAASAY AVGDVKCLVM DVQAFERLLG PCMDIMKRNI
SHYEEQLVKM FGSSVDLGNL GQ
//