Full text data of CRYZL1
CRYZL1
(4P11)
[Confidence: low (only semi-automatic identification from reviews)]
Quinone oxidoreductase-like protein 1; 1.-.-.- (Protein 4P11; Quinone oxidoreductase homolog 1; QOH-1; Zeta-crystallin homolog)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Quinone oxidoreductase-like protein 1; 1.-.-.- (Protein 4P11; Quinone oxidoreductase homolog 1; QOH-1; Zeta-crystallin homolog)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
O95825
ID QORL1_HUMAN Reviewed; 349 AA.
AC O95825; B2RDX1; Q96DY0; Q9NVY7;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
read moreDT 03-OCT-2006, sequence version 2.
DT 22-JAN-2014, entry version 125.
DE RecName: Full=Quinone oxidoreductase-like protein 1;
DE EC=1.-.-.-;
DE AltName: Full=Protein 4P11;
DE AltName: Full=Quinone oxidoreductase homolog 1;
DE Short=QOH-1;
DE AltName: Full=Zeta-crystallin homolog;
GN Name=CRYZL1; Synonyms=4P11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Cook J.R., Bradshaw G., Donnelly R.J., Soh J., Pestka S.;
RT "Identification of a novel gene, 4P11, which maps to the D142H8 region
RT of chromosome 21q22.1 and is closely linked to the IFN-gamma receptor-
RT 2 (AF-1) gene.";
RL Eur. Cytokine Netw. 9:504-504(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=10191096; DOI=10.1006/geno.1998.5714;
RA Kim M.-Y., Lee H.-K., Park J.-S., Park S.-H., Kwon H.-B., Soh J.;
RT "Identification of a zeta-crystallin (quinone reductase)-like 1 gene
RT (CRYZL1) mapped to human chromosome 21q22.1.";
RL Genomics 57:156-159(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O95825-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O95825-2; Sequence=Not described;
CC Note=No experimental confirmation available;
CC -!- TISSUE SPECIFICITY: Ubiquitous.
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. Quinone oxidoreductase subfamily.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH13155.1; Type=Miscellaneous discrepancy;
CC Sequence=BAA91605.1; Type=Frameshift; Positions=302;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF098798; AAD20219.1; -; mRNA.
DR EMBL; AF029689; AAD22381.1; -; mRNA.
DR EMBL; AK001293; BAA91605.1; ALT_FRAME; mRNA.
DR EMBL; AK315707; BAG38068.1; -; mRNA.
DR EMBL; BC013155; AAH13155.1; ALT_SEQ; mRNA.
DR EMBL; BC033023; AAH33023.1; -; mRNA.
DR RefSeq; NP_665857.2; NM_145858.2.
DR UniGene; Hs.352671; -.
DR ProteinModelPortal; O95825; -.
DR SMR; O95825; 19-272.
DR STRING; 9606.ENSP00000370966; -.
DR PhosphoSite; O95825; -.
DR PaxDb; O95825; -.
DR PRIDE; O95825; -.
DR DNASU; 9946; -.
DR Ensembl; ENST00000381554; ENSP00000370966; ENSG00000205758.
DR Ensembl; ENST00000413017; ENSP00000389209; ENSG00000205758.
DR GeneID; 9946; -.
DR KEGG; hsa:9946; -.
DR UCSC; uc021wio.1; human.
DR CTD; 9946; -.
DR GeneCards; GC21M034961; -.
DR HGNC; HGNC:2420; CRYZL1.
DR HPA; CAB034129; -.
DR HPA; HPA019120; -.
DR HPA; HPA029399; -.
DR MIM; 603920; gene.
DR neXtProt; NX_O95825; -.
DR PharmGKB; PA26926; -.
DR eggNOG; COG0604; -.
DR HOGENOM; HOG000293267; -.
DR HOVERGEN; HBG009484; -.
DR InParanoid; O95825; -.
DR KO; K00540; -.
DR OMA; SNGKAHV; -.
DR OrthoDB; EOG7K0ZDM; -.
DR GeneWiki; CRYZL1; -.
DR GenomeRNAi; 9946; -.
DR NextBio; 37524; -.
DR PRO; PR:O95825; -.
DR ArrayExpress; O95825; -.
DR Bgee; O95825; -.
DR CleanEx; HS_CRYZL1; -.
DR Genevestigator; O95825; -.
DR GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR GO; GO:0050661; F:NADP binding; NAS:UniProtKB.
DR GO; GO:0003960; F:NADPH:quinone reductase activity; NAS:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:1901661; P:quinone metabolic process; NAS:UniProtKB.
DR Gene3D; 3.40.50.720; -; 1.
DR Gene3D; 3.90.180.10; -; 1.
DR InterPro; IPR013149; ADH_C.
DR InterPro; IPR013154; ADH_GroES-like.
DR InterPro; IPR002085; ADH_SF_Zn-type.
DR InterPro; IPR011032; GroES-like.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR PANTHER; PTHR11695; PTHR11695; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; SSF50129; 1.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; FALSE_NEG.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; NADP; Oxidoreductase;
KW Polymorphism; Reference proteome.
FT CHAIN 1 349 Quinone oxidoreductase-like protein 1.
FT /FTId=PRO_0000160913.
FT VARIANT 39 39 A -> T (in dbSNP:rs13050238).
FT /FTId=VAR_027835.
FT CONFLICT 78 78 S -> P (in Ref. 3; BAA91605).
FT CONFLICT 89 89 I -> T (in Ref. 3; BAA91605).
FT CONFLICT 276 276 F -> L (in Ref. 1; AAD20219, 2; AAD22381
FT and 4; AAH13155).
FT CONFLICT 299 299 K -> E (in Ref. 3; BAA91605).
SQ SEQUENCE 349 AA; 38697 MW; 7EC26B8852A5BD31 CRC64;
MKGLYFQQSS TDEEITFVFQ EKEDLPVTED NFVKLQVKAC ALSQINTKLL AEMKMKKDLF
PVGREIAGIV LDVGSKVSFF QPDDEVVGIL PLDSEDPGLC EVVRVHEHYL VHKPEKVTWT
EAAGSIRDGV RAYTALHYLS HLSPGKSVLI MDGASAFGTI AIQLAHHRGA KVISTACSLE
DKQCLERFRP PIARVIDVSN GKVHVAESCL EETGGLGVDI VLDAGVRLYS KDDEPAVKLQ
LLPHKHDIIT LLGVGGHWVT TEENLQLDPP DSHCLFLKGA TLAFLNDEVW NLSNVQQGKY
LCILKDVMEK LSTGVFRPQL DEPIPLYEAK VSMEAVQKNQ GRKKQVVQF
//
ID QORL1_HUMAN Reviewed; 349 AA.
AC O95825; B2RDX1; Q96DY0; Q9NVY7;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
read moreDT 03-OCT-2006, sequence version 2.
DT 22-JAN-2014, entry version 125.
DE RecName: Full=Quinone oxidoreductase-like protein 1;
DE EC=1.-.-.-;
DE AltName: Full=Protein 4P11;
DE AltName: Full=Quinone oxidoreductase homolog 1;
DE Short=QOH-1;
DE AltName: Full=Zeta-crystallin homolog;
GN Name=CRYZL1; Synonyms=4P11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Cook J.R., Bradshaw G., Donnelly R.J., Soh J., Pestka S.;
RT "Identification of a novel gene, 4P11, which maps to the D142H8 region
RT of chromosome 21q22.1 and is closely linked to the IFN-gamma receptor-
RT 2 (AF-1) gene.";
RL Eur. Cytokine Netw. 9:504-504(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=10191096; DOI=10.1006/geno.1998.5714;
RA Kim M.-Y., Lee H.-K., Park J.-S., Park S.-H., Kwon H.-B., Soh J.;
RT "Identification of a zeta-crystallin (quinone reductase)-like 1 gene
RT (CRYZL1) mapped to human chromosome 21q22.1.";
RL Genomics 57:156-159(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O95825-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O95825-2; Sequence=Not described;
CC Note=No experimental confirmation available;
CC -!- TISSUE SPECIFICITY: Ubiquitous.
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. Quinone oxidoreductase subfamily.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH13155.1; Type=Miscellaneous discrepancy;
CC Sequence=BAA91605.1; Type=Frameshift; Positions=302;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF098798; AAD20219.1; -; mRNA.
DR EMBL; AF029689; AAD22381.1; -; mRNA.
DR EMBL; AK001293; BAA91605.1; ALT_FRAME; mRNA.
DR EMBL; AK315707; BAG38068.1; -; mRNA.
DR EMBL; BC013155; AAH13155.1; ALT_SEQ; mRNA.
DR EMBL; BC033023; AAH33023.1; -; mRNA.
DR RefSeq; NP_665857.2; NM_145858.2.
DR UniGene; Hs.352671; -.
DR ProteinModelPortal; O95825; -.
DR SMR; O95825; 19-272.
DR STRING; 9606.ENSP00000370966; -.
DR PhosphoSite; O95825; -.
DR PaxDb; O95825; -.
DR PRIDE; O95825; -.
DR DNASU; 9946; -.
DR Ensembl; ENST00000381554; ENSP00000370966; ENSG00000205758.
DR Ensembl; ENST00000413017; ENSP00000389209; ENSG00000205758.
DR GeneID; 9946; -.
DR KEGG; hsa:9946; -.
DR UCSC; uc021wio.1; human.
DR CTD; 9946; -.
DR GeneCards; GC21M034961; -.
DR HGNC; HGNC:2420; CRYZL1.
DR HPA; CAB034129; -.
DR HPA; HPA019120; -.
DR HPA; HPA029399; -.
DR MIM; 603920; gene.
DR neXtProt; NX_O95825; -.
DR PharmGKB; PA26926; -.
DR eggNOG; COG0604; -.
DR HOGENOM; HOG000293267; -.
DR HOVERGEN; HBG009484; -.
DR InParanoid; O95825; -.
DR KO; K00540; -.
DR OMA; SNGKAHV; -.
DR OrthoDB; EOG7K0ZDM; -.
DR GeneWiki; CRYZL1; -.
DR GenomeRNAi; 9946; -.
DR NextBio; 37524; -.
DR PRO; PR:O95825; -.
DR ArrayExpress; O95825; -.
DR Bgee; O95825; -.
DR CleanEx; HS_CRYZL1; -.
DR Genevestigator; O95825; -.
DR GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR GO; GO:0050661; F:NADP binding; NAS:UniProtKB.
DR GO; GO:0003960; F:NADPH:quinone reductase activity; NAS:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:1901661; P:quinone metabolic process; NAS:UniProtKB.
DR Gene3D; 3.40.50.720; -; 1.
DR Gene3D; 3.90.180.10; -; 1.
DR InterPro; IPR013149; ADH_C.
DR InterPro; IPR013154; ADH_GroES-like.
DR InterPro; IPR002085; ADH_SF_Zn-type.
DR InterPro; IPR011032; GroES-like.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR PANTHER; PTHR11695; PTHR11695; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; SSF50129; 1.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; FALSE_NEG.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; NADP; Oxidoreductase;
KW Polymorphism; Reference proteome.
FT CHAIN 1 349 Quinone oxidoreductase-like protein 1.
FT /FTId=PRO_0000160913.
FT VARIANT 39 39 A -> T (in dbSNP:rs13050238).
FT /FTId=VAR_027835.
FT CONFLICT 78 78 S -> P (in Ref. 3; BAA91605).
FT CONFLICT 89 89 I -> T (in Ref. 3; BAA91605).
FT CONFLICT 276 276 F -> L (in Ref. 1; AAD20219, 2; AAD22381
FT and 4; AAH13155).
FT CONFLICT 299 299 K -> E (in Ref. 3; BAA91605).
SQ SEQUENCE 349 AA; 38697 MW; 7EC26B8852A5BD31 CRC64;
MKGLYFQQSS TDEEITFVFQ EKEDLPVTED NFVKLQVKAC ALSQINTKLL AEMKMKKDLF
PVGREIAGIV LDVGSKVSFF QPDDEVVGIL PLDSEDPGLC EVVRVHEHYL VHKPEKVTWT
EAAGSIRDGV RAYTALHYLS HLSPGKSVLI MDGASAFGTI AIQLAHHRGA KVISTACSLE
DKQCLERFRP PIARVIDVSN GKVHVAESCL EETGGLGVDI VLDAGVRLYS KDDEPAVKLQ
LLPHKHDIIT LLGVGGHWVT TEENLQLDPP DSHCLFLKGA TLAFLNDEVW NLSNVQQGKY
LCILKDVMEK LSTGVFRPQL DEPIPLYEAK VSMEAVQKNQ GRKKQVVQF
//
MIM
603920
*RECORD*
*FIELD* NO
603920
*FIELD* TI
*603920 CRYSTALLIN, ZETA-LIKE 1; CRYZL1
;;QUINONE OXIDOREDUCTASE-LIKE 1
*FIELD* TX
read moreTo search for novel genes located within a specific YAC that was mapped
to 21q22.1, Kim et al. (1999) screened a human brain cDNA library with
the YAC. They isolated a cDNA encoding a protein with high sequence
similarity to human zeta-crystallin (123691), and thus named the gene
zeta-crystallin-like-1 (CRYZL1). The open reading frame of the CRYZL1
cDNA predicts a 349-amino acid protein with a conserved NAD(P)H-binding
site. Northern blot analysis showed that the CRYZL1 gene is ubiquitously
expressed as a 1.4-kb transcript in human tissues. The CRYZL1 gene
contains at least 12 exons and spans more than 35 kb.
Kim et al. (1999) mapped the CRYZL1 gene to 21q22.1 by FISH.
*FIELD* RF
1. Kim, M.-Y.; Lee, H.-K.; Park, J.-S.; Park, S.-H.; Kwon, H.-B.;
Soh, J.: Identification of a zeta-crystallin (quinone reductase)-like
1 gene (CRYZL1) mapped to human chromosome 21q22.1. Genomics 57:
156-159, 1999.
*FIELD* CD
Barbara J. Biery: 6/17/1999
*FIELD* ED
psherman: 06/17/1999
*RECORD*
*FIELD* NO
603920
*FIELD* TI
*603920 CRYSTALLIN, ZETA-LIKE 1; CRYZL1
;;QUINONE OXIDOREDUCTASE-LIKE 1
*FIELD* TX
read moreTo search for novel genes located within a specific YAC that was mapped
to 21q22.1, Kim et al. (1999) screened a human brain cDNA library with
the YAC. They isolated a cDNA encoding a protein with high sequence
similarity to human zeta-crystallin (123691), and thus named the gene
zeta-crystallin-like-1 (CRYZL1). The open reading frame of the CRYZL1
cDNA predicts a 349-amino acid protein with a conserved NAD(P)H-binding
site. Northern blot analysis showed that the CRYZL1 gene is ubiquitously
expressed as a 1.4-kb transcript in human tissues. The CRYZL1 gene
contains at least 12 exons and spans more than 35 kb.
Kim et al. (1999) mapped the CRYZL1 gene to 21q22.1 by FISH.
*FIELD* RF
1. Kim, M.-Y.; Lee, H.-K.; Park, J.-S.; Park, S.-H.; Kwon, H.-B.;
Soh, J.: Identification of a zeta-crystallin (quinone reductase)-like
1 gene (CRYZL1) mapped to human chromosome 21q22.1. Genomics 57:
156-159, 1999.
*FIELD* CD
Barbara J. Biery: 6/17/1999
*FIELD* ED
psherman: 06/17/1999