Full text data of RAB15
RAB15
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Ras-related protein Rab-15
Ras-related protein Rab-15
hRBCD
IPI00394882
IPI00394882 Splice isoform 1 of P59190 Ras-related protein Rab-15 Splice isoform 1 of P59190 Ras-related protein Rab-15 membrane n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 2 2 n/a n/a cytoplasmic and membrane associated n/a found at its expected molecular weight found at molecular weight
IPI00394882 Splice isoform 1 of P59190 Ras-related protein Rab-15 Splice isoform 1 of P59190 Ras-related protein Rab-15 membrane n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 2 2 n/a n/a cytoplasmic and membrane associated n/a found at its expected molecular weight found at molecular weight
UniProt
P59190
ID RAB15_HUMAN Reviewed; 212 AA.
AC P59190; Q86TX7; Q8IW89;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 10-JAN-2003, sequence version 1.
DT 22-JAN-2014, entry version 109.
DE RecName: Full=Ras-related protein Rab-15;
GN Name=RAB15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA Quetier F., Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 42-212 (ISOFORM 2).
RC TISSUE=Placenta;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP INTERACTION WITH REP15.
RX PubMed=16195351; DOI=10.1091/mbc.E05-03-0204;
RA Strick D.J., Elferink L.A.;
RT "Rab15 effector protein: a novel protein for receptor recycling from
RT the endocytic recycling compartment.";
RL Mol. Biol. Cell 16:5699-5709(2005).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May act in concert with RAB3A in regulating aspects of
CC synaptic vesicle membrane flow within the nerve terminal (By
CC similarity).
CC -!- SUBUNIT: The GTP bound form of RAB15 interacts with REP15.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic
CC side (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P59190-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P59190-2; Sequence=VSP_010420;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AL139022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC040679; AAH40679.2; -; mRNA.
DR EMBL; BX248046; CAD62353.1; -; mRNA.
DR RefSeq; NP_941959.1; NM_198686.2.
DR RefSeq; XP_005267654.1; XM_005267597.1.
DR UniGene; Hs.512492; -.
DR ProteinModelPortal; P59190; -.
DR SMR; P59190; 6-197.
DR IntAct; P59190; 1.
DR STRING; 9606.ENSP00000267512; -.
DR PhosphoSite; P59190; -.
DR DMDM; 27734452; -.
DR PaxDb; P59190; -.
DR PRIDE; P59190; -.
DR DNASU; 376267; -.
DR Ensembl; ENST00000267512; ENSP00000267512; ENSG00000139998.
DR Ensembl; ENST00000533601; ENSP00000434103; ENSG00000139998.
DR GeneID; 376267; -.
DR KEGG; hsa:376267; -.
DR UCSC; uc021rut.1; human.
DR CTD; 376267; -.
DR GeneCards; GC14M065412; -.
DR HGNC; HGNC:20150; RAB15.
DR HPA; HPA041177; -.
DR neXtProt; NX_P59190; -.
DR PharmGKB; PA134901572; -.
DR eggNOG; COG1100; -.
DR HOGENOM; HOG000233968; -.
DR HOVERGEN; HBG009351; -.
DR KO; K07908; -.
DR OMA; ITETFTR; -.
DR OrthoDB; EOG7V4B0R; -.
DR GeneWiki; RAB15; -.
DR GenomeRNAi; 376267; -.
DR NextBio; 100634; -.
DR PRO; PR:P59190; -.
DR ArrayExpress; P59190; -.
DR Bgee; P59190; -.
DR CleanEx; HS_RAB15; -.
DR Genevestigator; P59190; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR003579; Small_GTPase_Rab_type.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Complete proteome; GTP-binding;
KW Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1 212 Ras-related protein Rab-15.
FT /FTId=PRO_0000121188.
FT NP_BIND 15 22 GTP (By similarity).
FT NP_BIND 63 67 GTP (By similarity).
FT NP_BIND 121 124 GTP (By similarity).
FT MOD_RES 212 212 Cysteine methyl ester (By similarity).
FT LIPID 210 210 S-geranylgeranyl cysteine (By
FT similarity).
FT LIPID 212 212 S-geranylgeranyl cysteine (By
FT similarity).
FT VAR_SEQ 109 212 YAPEGVQKILIGNKADEEQKRQVGREQGQQLAKEYGMDFYE
FT TSACTNLNIKESFTRLTELVLQAHRKELEGLRMRASNELAL
FT AELEEEEGKPEGPANSSKTCWC -> VGDATSLPGCGEGAS
FT PGKARRGPDGKANASRKLCLPQPWMKTSGTHQKASRRSLLG
FT IRLMRSRNGRWEESKGSSWRRSMAWTSMKQVPAPTSTLKSH
FT SRV (in isoform 2).
FT /FTId=VSP_010420.
SQ SEQUENCE 212 AA; 24391 MW; D16A0C71797ED782 CRC64;
MAKQYDVLFR LLLIGDSGVG KTCLLCRFTD NEFHSSHIST IGVDFKMKTI EVDGIKVRIQ
IWDTAGQERY QTITKQYYRR AQGIFLVYDI SSERSYQHIM KWVSDVDEYA PEGVQKILIG
NKADEEQKRQ VGREQGQQLA KEYGMDFYET SACTNLNIKE SFTRLTELVL QAHRKELEGL
RMRASNELAL AELEEEEGKP EGPANSSKTC WC
//
ID RAB15_HUMAN Reviewed; 212 AA.
AC P59190; Q86TX7; Q8IW89;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 10-JAN-2003, sequence version 1.
DT 22-JAN-2014, entry version 109.
DE RecName: Full=Ras-related protein Rab-15;
GN Name=RAB15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA Quetier F., Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 42-212 (ISOFORM 2).
RC TISSUE=Placenta;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP INTERACTION WITH REP15.
RX PubMed=16195351; DOI=10.1091/mbc.E05-03-0204;
RA Strick D.J., Elferink L.A.;
RT "Rab15 effector protein: a novel protein for receptor recycling from
RT the endocytic recycling compartment.";
RL Mol. Biol. Cell 16:5699-5709(2005).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May act in concert with RAB3A in regulating aspects of
CC synaptic vesicle membrane flow within the nerve terminal (By
CC similarity).
CC -!- SUBUNIT: The GTP bound form of RAB15 interacts with REP15.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic
CC side (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P59190-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P59190-2; Sequence=VSP_010420;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AL139022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC040679; AAH40679.2; -; mRNA.
DR EMBL; BX248046; CAD62353.1; -; mRNA.
DR RefSeq; NP_941959.1; NM_198686.2.
DR RefSeq; XP_005267654.1; XM_005267597.1.
DR UniGene; Hs.512492; -.
DR ProteinModelPortal; P59190; -.
DR SMR; P59190; 6-197.
DR IntAct; P59190; 1.
DR STRING; 9606.ENSP00000267512; -.
DR PhosphoSite; P59190; -.
DR DMDM; 27734452; -.
DR PaxDb; P59190; -.
DR PRIDE; P59190; -.
DR DNASU; 376267; -.
DR Ensembl; ENST00000267512; ENSP00000267512; ENSG00000139998.
DR Ensembl; ENST00000533601; ENSP00000434103; ENSG00000139998.
DR GeneID; 376267; -.
DR KEGG; hsa:376267; -.
DR UCSC; uc021rut.1; human.
DR CTD; 376267; -.
DR GeneCards; GC14M065412; -.
DR HGNC; HGNC:20150; RAB15.
DR HPA; HPA041177; -.
DR neXtProt; NX_P59190; -.
DR PharmGKB; PA134901572; -.
DR eggNOG; COG1100; -.
DR HOGENOM; HOG000233968; -.
DR HOVERGEN; HBG009351; -.
DR KO; K07908; -.
DR OMA; ITETFTR; -.
DR OrthoDB; EOG7V4B0R; -.
DR GeneWiki; RAB15; -.
DR GenomeRNAi; 376267; -.
DR NextBio; 100634; -.
DR PRO; PR:P59190; -.
DR ArrayExpress; P59190; -.
DR Bgee; P59190; -.
DR CleanEx; HS_RAB15; -.
DR Genevestigator; P59190; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR003579; Small_GTPase_Rab_type.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Complete proteome; GTP-binding;
KW Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1 212 Ras-related protein Rab-15.
FT /FTId=PRO_0000121188.
FT NP_BIND 15 22 GTP (By similarity).
FT NP_BIND 63 67 GTP (By similarity).
FT NP_BIND 121 124 GTP (By similarity).
FT MOD_RES 212 212 Cysteine methyl ester (By similarity).
FT LIPID 210 210 S-geranylgeranyl cysteine (By
FT similarity).
FT LIPID 212 212 S-geranylgeranyl cysteine (By
FT similarity).
FT VAR_SEQ 109 212 YAPEGVQKILIGNKADEEQKRQVGREQGQQLAKEYGMDFYE
FT TSACTNLNIKESFTRLTELVLQAHRKELEGLRMRASNELAL
FT AELEEEEGKPEGPANSSKTCWC -> VGDATSLPGCGEGAS
FT PGKARRGPDGKANASRKLCLPQPWMKTSGTHQKASRRSLLG
FT IRLMRSRNGRWEESKGSSWRRSMAWTSMKQVPAPTSTLKSH
FT SRV (in isoform 2).
FT /FTId=VSP_010420.
SQ SEQUENCE 212 AA; 24391 MW; D16A0C71797ED782 CRC64;
MAKQYDVLFR LLLIGDSGVG KTCLLCRFTD NEFHSSHIST IGVDFKMKTI EVDGIKVRIQ
IWDTAGQERY QTITKQYYRR AQGIFLVYDI SSERSYQHIM KWVSDVDEYA PEGVQKILIG
NKADEEQKRQ VGREQGQQLA KEYGMDFYET SACTNLNIKE SFTRLTELVL QAHRKELEGL
RMRASNELAL AELEEEEGKP EGPANSSKTC WC
//