Full text data of RAB2B
RAB2B
[Confidence: high (present in two of the MS resources)]
Ras-related protein Rab-2B
Ras-related protein Rab-2B
UniProt
Q8WUD1
ID RAB2B_HUMAN Reviewed; 216 AA.
AC Q8WUD1; B2RD03; D3DS24;
DT 12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2002, sequence version 1.
DT 22-JAN-2014, entry version 113.
DE RecName: Full=Ras-related protein Rab-2B;
GN Name=RAB2B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12376746; DOI=10.1007/s100380200083;
RA Ni X., Ma Y., Cheng H., Jiang M., Guo L., Ji C., Gu S., Cao Y.,
RA Xie Y., Mao Y.;
RT "Molecular cloning and characterization of a novel human Rab (Rab2B)
RT gene.";
RL J. Hum. Genet. 47:548-551(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6]
RP X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 5-176 IN COMPLEX WITH GDP.
RG Structural genomics consortium (SGC);
RT "Crystal structure of human RAB2B.";
RL Submitted (FEB-2009) to the PDB data bank.
CC -!- FUNCTION: Required for protein transport from the endoplasmic
CC reticulum to the Golgi complex (Potential).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic
CC side (Potential). Endoplasmic reticulum membrane (Potential).
CC Golgi apparatus membrane (Potential).
CC -!- TISSUE SPECIFICITY: Expressed in kidney, prostate, lung, liver,
CC thymus, colon, pancreas, and skeletal muscle, and low levels in
CC placenta. Not detected in heart, brain, spleen, testis, ovary,
CC small intestine and leukocyte.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF468652; AAN86142.1; -; mRNA.
DR EMBL; AK315354; BAG37750.1; -; mRNA.
DR EMBL; CH471078; EAW66382.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66383.1; -; Genomic_DNA.
DR EMBL; BC020839; AAH20839.1; -; mRNA.
DR RefSeq; NP_116235.2; NM_032846.3.
DR UniGene; Hs.22399; -.
DR PDB; 2A5J; X-ray; 1.50 A; A=5-176.
DR PDBsum; 2A5J; -.
DR ProteinModelPortal; Q8WUD1; -.
DR SMR; Q8WUD1; 4-176.
DR IntAct; Q8WUD1; 1.
DR STRING; 9606.ENSP00000302005; -.
DR PhosphoSite; Q8WUD1; -.
DR DMDM; 28436385; -.
DR PaxDb; Q8WUD1; -.
DR PRIDE; Q8WUD1; -.
DR DNASU; 84932; -.
DR Ensembl; ENST00000397762; ENSP00000380869; ENSG00000129472.
DR GeneID; 84932; -.
DR KEGG; hsa:84932; -.
DR UCSC; uc010tls.2; human.
DR CTD; 84932; -.
DR GeneCards; GC14M021927; -.
DR H-InvDB; HIX0011509; -.
DR HGNC; HGNC:20246; RAB2B.
DR HPA; HPA050292; -.
DR MIM; 607466; gene.
DR neXtProt; NX_Q8WUD1; -.
DR PharmGKB; PA134865942; -.
DR eggNOG; COG1100; -.
DR HOGENOM; HOG000233968; -.
DR HOVERGEN; HBG009351; -.
DR InParanoid; Q8WUD1; -.
DR KO; K07878; -.
DR OMA; EAYINTA; -.
DR OrthoDB; EOG7QK0CV; -.
DR PhylomeDB; Q8WUD1; -.
DR EvolutionaryTrace; Q8WUD1; -.
DR GenomeRNAi; 84932; -.
DR NextBio; 75368; -.
DR PRO; PR:Q8WUD1; -.
DR ArrayExpress; Q8WUD1; -.
DR Bgee; Q8WUD1; -.
DR CleanEx; HS_RAB2B; -.
DR Genevestigator; Q8WUD1; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0045921; P:positive regulation of exocytosis; IMP:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR003579; Small_GTPase_Rab_type.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Complete proteome; Endoplasmic reticulum;
KW ER-Golgi transport; Golgi apparatus; GTP-binding; Lipoprotein;
KW Membrane; Nucleotide-binding; Polymorphism; Prenylation;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1 216 Ras-related protein Rab-2B.
FT /FTId=PRO_0000121071.
FT NP_BIND 13 21 GTP.
FT NP_BIND 61 65 GTP (By similarity).
FT NP_BIND 119 122 GTP.
FT NP_BIND 149 151 GTP.
FT MOTIF 35 43 Effector region (By similarity).
FT LIPID 215 215 S-geranylgeranyl cysteine (By
FT similarity).
FT LIPID 216 216 S-geranylgeranyl cysteine (By
FT similarity).
FT VARIANT 212 212 N -> T (in dbSNP:rs17106411).
FT /FTId=VAR_051709.
FT CONFLICT 168 168 Y -> H (in Ref. 1; AAN86142).
FT STRAND 5 14
FT HELIX 19 28
FT STRAND 41 50
FT STRAND 53 60
FT HELIX 65 67
FT HELIX 73 76
FT STRAND 80 87
FT HELIX 91 95
FT HELIX 97 107
FT STRAND 113 119
FT HELIX 124 126
FT HELIX 131 141
FT STRAND 144 148
FT TURN 150 152
FT HELIX 156 172
SQ SEQUENCE 216 AA; 24214 MW; 80A73F6D259701D8 CRC64;
MTYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMVNI DGKQIKLQIW
DTAGQESFRS ITRSYYRGAA GALLVYDITR RETFNHLTSW LEDARQHSSS NMVIMLIGNK
SDLESRRDVK REEGEAFARE HGLIFMETSA KTACNVEEAF INTAKEIYRK IQQGLFDVHN
EANGIKIGPQ QSISTSVGPS ASQRNSRDIG SNSGCC
//
ID RAB2B_HUMAN Reviewed; 216 AA.
AC Q8WUD1; B2RD03; D3DS24;
DT 12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2002, sequence version 1.
DT 22-JAN-2014, entry version 113.
DE RecName: Full=Ras-related protein Rab-2B;
GN Name=RAB2B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12376746; DOI=10.1007/s100380200083;
RA Ni X., Ma Y., Cheng H., Jiang M., Guo L., Ji C., Gu S., Cao Y.,
RA Xie Y., Mao Y.;
RT "Molecular cloning and characterization of a novel human Rab (Rab2B)
RT gene.";
RL J. Hum. Genet. 47:548-551(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6]
RP X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 5-176 IN COMPLEX WITH GDP.
RG Structural genomics consortium (SGC);
RT "Crystal structure of human RAB2B.";
RL Submitted (FEB-2009) to the PDB data bank.
CC -!- FUNCTION: Required for protein transport from the endoplasmic
CC reticulum to the Golgi complex (Potential).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic
CC side (Potential). Endoplasmic reticulum membrane (Potential).
CC Golgi apparatus membrane (Potential).
CC -!- TISSUE SPECIFICITY: Expressed in kidney, prostate, lung, liver,
CC thymus, colon, pancreas, and skeletal muscle, and low levels in
CC placenta. Not detected in heart, brain, spleen, testis, ovary,
CC small intestine and leukocyte.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF468652; AAN86142.1; -; mRNA.
DR EMBL; AK315354; BAG37750.1; -; mRNA.
DR EMBL; CH471078; EAW66382.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66383.1; -; Genomic_DNA.
DR EMBL; BC020839; AAH20839.1; -; mRNA.
DR RefSeq; NP_116235.2; NM_032846.3.
DR UniGene; Hs.22399; -.
DR PDB; 2A5J; X-ray; 1.50 A; A=5-176.
DR PDBsum; 2A5J; -.
DR ProteinModelPortal; Q8WUD1; -.
DR SMR; Q8WUD1; 4-176.
DR IntAct; Q8WUD1; 1.
DR STRING; 9606.ENSP00000302005; -.
DR PhosphoSite; Q8WUD1; -.
DR DMDM; 28436385; -.
DR PaxDb; Q8WUD1; -.
DR PRIDE; Q8WUD1; -.
DR DNASU; 84932; -.
DR Ensembl; ENST00000397762; ENSP00000380869; ENSG00000129472.
DR GeneID; 84932; -.
DR KEGG; hsa:84932; -.
DR UCSC; uc010tls.2; human.
DR CTD; 84932; -.
DR GeneCards; GC14M021927; -.
DR H-InvDB; HIX0011509; -.
DR HGNC; HGNC:20246; RAB2B.
DR HPA; HPA050292; -.
DR MIM; 607466; gene.
DR neXtProt; NX_Q8WUD1; -.
DR PharmGKB; PA134865942; -.
DR eggNOG; COG1100; -.
DR HOGENOM; HOG000233968; -.
DR HOVERGEN; HBG009351; -.
DR InParanoid; Q8WUD1; -.
DR KO; K07878; -.
DR OMA; EAYINTA; -.
DR OrthoDB; EOG7QK0CV; -.
DR PhylomeDB; Q8WUD1; -.
DR EvolutionaryTrace; Q8WUD1; -.
DR GenomeRNAi; 84932; -.
DR NextBio; 75368; -.
DR PRO; PR:Q8WUD1; -.
DR ArrayExpress; Q8WUD1; -.
DR Bgee; Q8WUD1; -.
DR CleanEx; HS_RAB2B; -.
DR Genevestigator; Q8WUD1; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0045921; P:positive regulation of exocytosis; IMP:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR003579; Small_GTPase_Rab_type.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Complete proteome; Endoplasmic reticulum;
KW ER-Golgi transport; Golgi apparatus; GTP-binding; Lipoprotein;
KW Membrane; Nucleotide-binding; Polymorphism; Prenylation;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1 216 Ras-related protein Rab-2B.
FT /FTId=PRO_0000121071.
FT NP_BIND 13 21 GTP.
FT NP_BIND 61 65 GTP (By similarity).
FT NP_BIND 119 122 GTP.
FT NP_BIND 149 151 GTP.
FT MOTIF 35 43 Effector region (By similarity).
FT LIPID 215 215 S-geranylgeranyl cysteine (By
FT similarity).
FT LIPID 216 216 S-geranylgeranyl cysteine (By
FT similarity).
FT VARIANT 212 212 N -> T (in dbSNP:rs17106411).
FT /FTId=VAR_051709.
FT CONFLICT 168 168 Y -> H (in Ref. 1; AAN86142).
FT STRAND 5 14
FT HELIX 19 28
FT STRAND 41 50
FT STRAND 53 60
FT HELIX 65 67
FT HELIX 73 76
FT STRAND 80 87
FT HELIX 91 95
FT HELIX 97 107
FT STRAND 113 119
FT HELIX 124 126
FT HELIX 131 141
FT STRAND 144 148
FT TURN 150 152
FT HELIX 156 172
SQ SEQUENCE 216 AA; 24214 MW; 80A73F6D259701D8 CRC64;
MTYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMVNI DGKQIKLQIW
DTAGQESFRS ITRSYYRGAA GALLVYDITR RETFNHLTSW LEDARQHSSS NMVIMLIGNK
SDLESRRDVK REEGEAFARE HGLIFMETSA KTACNVEEAF INTAKEIYRK IQQGLFDVHN
EANGIKIGPQ QSISTSVGPS ASQRNSRDIG SNSGCC
//
MIM
607466
*RECORD*
*FIELD* NO
607466
*FIELD* TI
*607466 RAS-ASSOCIATED PROTEIN RAB2B; RAB2B
*FIELD* TX
DESCRIPTION
Members of the Rab protein family are nontransforming monomeric
read moreGTP-binding proteins of the Ras superfamily that contain 4 highly
conserved regions involved in GTP binding and hydrolysis. Rab proteins
are prenylated, membrane-bound proteins involved in vesicular fusion and
trafficking; see 179508.
CLONING
During a large-scale sequencing analysis of human cDNA libraries, Ni et
al. (2002) cloned a full-length cDNA of a novel RAB gene, designated
RAB2B. The deduced 216-amino acid RAB2B protein shares 82% and 83%
sequence identity with human RAB2 (179509) and mouse Rab2, respectively.
RT-PCR analysis revealed expression of RAB2B in kidney, prostate, lung,
liver, thymus, colon, pancreas, and skeletal muscle, and at lower levels
in placenta. No transcript was detected in heart, brain, spleen, testis,
ovary, small intestine, and leukocyte. Overexpression was observed in a
colon adenocarcinoma.
GENE STRUCTURE
Ni et al. (2002) determined that the RAB2B gene contains 9 exons.
MAPPING
By sequence analysis, Ni et al. (2002) mapped the RAB2B gene to
chromosome 14q11.1-q11.2.
*FIELD* RF
1. Ni, X.; Ma, Y.; Cheng, H.; Jiang, M.; Guo, L.; Ji, C.; Gu, S.;
Cao, Y.; Xie, Y.; Mao, Y.: Molecular cloning and characterization
of a novel human Rab (Rab2B) gene. J. Hum. Genet. 47: 548-551, 2002.
*FIELD* CD
Victor A. McKusick: 1/8/2003
*FIELD* ED
carol: 03/14/2006
carol: 1/15/2003
cwells: 1/9/2003
*RECORD*
*FIELD* NO
607466
*FIELD* TI
*607466 RAS-ASSOCIATED PROTEIN RAB2B; RAB2B
*FIELD* TX
DESCRIPTION
Members of the Rab protein family are nontransforming monomeric
read moreGTP-binding proteins of the Ras superfamily that contain 4 highly
conserved regions involved in GTP binding and hydrolysis. Rab proteins
are prenylated, membrane-bound proteins involved in vesicular fusion and
trafficking; see 179508.
CLONING
During a large-scale sequencing analysis of human cDNA libraries, Ni et
al. (2002) cloned a full-length cDNA of a novel RAB gene, designated
RAB2B. The deduced 216-amino acid RAB2B protein shares 82% and 83%
sequence identity with human RAB2 (179509) and mouse Rab2, respectively.
RT-PCR analysis revealed expression of RAB2B in kidney, prostate, lung,
liver, thymus, colon, pancreas, and skeletal muscle, and at lower levels
in placenta. No transcript was detected in heart, brain, spleen, testis,
ovary, small intestine, and leukocyte. Overexpression was observed in a
colon adenocarcinoma.
GENE STRUCTURE
Ni et al. (2002) determined that the RAB2B gene contains 9 exons.
MAPPING
By sequence analysis, Ni et al. (2002) mapped the RAB2B gene to
chromosome 14q11.1-q11.2.
*FIELD* RF
1. Ni, X.; Ma, Y.; Cheng, H.; Jiang, M.; Guo, L.; Ji, C.; Gu, S.;
Cao, Y.; Xie, Y.; Mao, Y.: Molecular cloning and characterization
of a novel human Rab (Rab2B) gene. J. Hum. Genet. 47: 548-551, 2002.
*FIELD* CD
Victor A. McKusick: 1/8/2003
*FIELD* ED
carol: 03/14/2006
carol: 1/15/2003
cwells: 1/9/2003