Full text data of REEP6
REEP6
(C19orf32, DP1L1)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Receptor expression-enhancing protein 6 (Polyposis locus protein 1-like 1)
Receptor expression-enhancing protein 6 (Polyposis locus protein 1-like 1)
UniProt
Q96HR9
ID REEP6_HUMAN Reviewed; 184 AA.
AC Q96HR9; B2RE01; D6W5Z0; Q96LM0;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2001, sequence version 1.
DT 22-JAN-2014, entry version 84.
DE RecName: Full=Receptor expression-enhancing protein 6;
DE AltName: Full=Polyposis locus protein 1-like 1;
GN Name=REEP6; Synonyms=C19orf32, DP1L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15550249; DOI=10.1016/j.cell.2004.11.021;
RA Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.;
RT "RTP family members induce functional expression of mammalian odorant
RT receptors.";
RL Cell 119:679-691(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May enhance the cell surface expression of odorant
CC receptors (By similarity).
CC -!- SUBUNIT: Interacts with odorant receptor proteins (By similarity).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By
CC similarity).
CC -!- SIMILARITY: Belongs to the DP1 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY562244; AAT70689.1; -; mRNA.
DR EMBL; AK058112; BAB71670.1; -; mRNA.
DR EMBL; AK315744; BAG38098.1; -; mRNA.
DR EMBL; CH471139; EAW69492.1; -; Genomic_DNA.
DR EMBL; CH471139; EAW69493.1; -; Genomic_DNA.
DR EMBL; BC008201; AAH08201.1; -; mRNA.
DR RefSeq; NP_612402.1; NM_138393.1.
DR UniGene; Hs.76277; -.
DR ProteinModelPortal; Q96HR9; -.
DR IntAct; Q96HR9; 5.
DR MINT; MINT-5000264; -.
DR STRING; 9606.ENSP00000233596; -.
DR PhosphoSite; Q96HR9; -.
DR DMDM; 74762661; -.
DR PaxDb; Q96HR9; -.
DR PRIDE; Q96HR9; -.
DR DNASU; 92840; -.
DR Ensembl; ENST00000233596; ENSP00000233596; ENSG00000115255.
DR GeneID; 92840; -.
DR KEGG; hsa:92840; -.
DR UCSC; uc002ltc.3; human.
DR CTD; 92840; -.
DR GeneCards; GC19P001491; -.
DR HGNC; HGNC:30078; REEP6.
DR HPA; HPA003895; -.
DR MIM; 609346; gene.
DR neXtProt; NX_Q96HR9; -.
DR PharmGKB; PA134892881; -.
DR eggNOG; COG5052; -.
DR HOGENOM; HOG000172351; -.
DR HOVERGEN; HBG000796; -.
DR KO; K17279; -.
DR OMA; WNGSQII; -.
DR OrthoDB; EOG747PKP; -.
DR PhylomeDB; Q96HR9; -.
DR GenomeRNAi; 92840; -.
DR NextBio; 77900; -.
DR PRO; PR:Q96HR9; -.
DR ArrayExpress; Q96HR9; -.
DR Bgee; Q96HR9; -.
DR CleanEx; HS_REEP6; -.
DR Genevestigator; Q96HR9; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR InterPro; IPR004345; TB2_DP1_HVA22.
DR PANTHER; PTHR12300; PTHR12300; 1.
DR Pfam; PF03134; TB2_DP1_HVA22; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Membrane; Polymorphism; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1 184 Receptor expression-enhancing protein 6.
FT /FTId=PRO_0000101818.
FT TRANSMEM 44 64 Helical; (Potential).
FT TRANSMEM 89 109 Helical; (Potential).
FT VARIANT 150 150 A -> D (in dbSNP:rs2271412).
FT /FTId=VAR_048927.
FT CONFLICT 42 42 T -> A (in Ref. 2; BAB71670).
SQ SEQUENCE 184 AA; 20733 MW; 13BE0F61685211CA CRC64;
MDGLRQRVEH FLEQRNLVTE VLGALEAKTG VEKRYLAAGA VTLLSLYLLF GYGASLLCNL
IGFVYPAYAS IKAIESPSKD DDTVWLTYWV VYALFGLAEF FSDLLLSWFP FYYVGKCAFL
LFCMAPRPWN GALMLYQRVV RPLFLRHHGA VDRIMNDLSG RALDAAAGIT RNVKPSQTPQ
PKDK
//
ID REEP6_HUMAN Reviewed; 184 AA.
AC Q96HR9; B2RE01; D6W5Z0; Q96LM0;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2001, sequence version 1.
DT 22-JAN-2014, entry version 84.
DE RecName: Full=Receptor expression-enhancing protein 6;
DE AltName: Full=Polyposis locus protein 1-like 1;
GN Name=REEP6; Synonyms=C19orf32, DP1L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15550249; DOI=10.1016/j.cell.2004.11.021;
RA Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.;
RT "RTP family members induce functional expression of mammalian odorant
RT receptors.";
RL Cell 119:679-691(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May enhance the cell surface expression of odorant
CC receptors (By similarity).
CC -!- SUBUNIT: Interacts with odorant receptor proteins (By similarity).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By
CC similarity).
CC -!- SIMILARITY: Belongs to the DP1 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY562244; AAT70689.1; -; mRNA.
DR EMBL; AK058112; BAB71670.1; -; mRNA.
DR EMBL; AK315744; BAG38098.1; -; mRNA.
DR EMBL; CH471139; EAW69492.1; -; Genomic_DNA.
DR EMBL; CH471139; EAW69493.1; -; Genomic_DNA.
DR EMBL; BC008201; AAH08201.1; -; mRNA.
DR RefSeq; NP_612402.1; NM_138393.1.
DR UniGene; Hs.76277; -.
DR ProteinModelPortal; Q96HR9; -.
DR IntAct; Q96HR9; 5.
DR MINT; MINT-5000264; -.
DR STRING; 9606.ENSP00000233596; -.
DR PhosphoSite; Q96HR9; -.
DR DMDM; 74762661; -.
DR PaxDb; Q96HR9; -.
DR PRIDE; Q96HR9; -.
DR DNASU; 92840; -.
DR Ensembl; ENST00000233596; ENSP00000233596; ENSG00000115255.
DR GeneID; 92840; -.
DR KEGG; hsa:92840; -.
DR UCSC; uc002ltc.3; human.
DR CTD; 92840; -.
DR GeneCards; GC19P001491; -.
DR HGNC; HGNC:30078; REEP6.
DR HPA; HPA003895; -.
DR MIM; 609346; gene.
DR neXtProt; NX_Q96HR9; -.
DR PharmGKB; PA134892881; -.
DR eggNOG; COG5052; -.
DR HOGENOM; HOG000172351; -.
DR HOVERGEN; HBG000796; -.
DR KO; K17279; -.
DR OMA; WNGSQII; -.
DR OrthoDB; EOG747PKP; -.
DR PhylomeDB; Q96HR9; -.
DR GenomeRNAi; 92840; -.
DR NextBio; 77900; -.
DR PRO; PR:Q96HR9; -.
DR ArrayExpress; Q96HR9; -.
DR Bgee; Q96HR9; -.
DR CleanEx; HS_REEP6; -.
DR Genevestigator; Q96HR9; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR InterPro; IPR004345; TB2_DP1_HVA22.
DR PANTHER; PTHR12300; PTHR12300; 1.
DR Pfam; PF03134; TB2_DP1_HVA22; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Membrane; Polymorphism; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1 184 Receptor expression-enhancing protein 6.
FT /FTId=PRO_0000101818.
FT TRANSMEM 44 64 Helical; (Potential).
FT TRANSMEM 89 109 Helical; (Potential).
FT VARIANT 150 150 A -> D (in dbSNP:rs2271412).
FT /FTId=VAR_048927.
FT CONFLICT 42 42 T -> A (in Ref. 2; BAB71670).
SQ SEQUENCE 184 AA; 20733 MW; 13BE0F61685211CA CRC64;
MDGLRQRVEH FLEQRNLVTE VLGALEAKTG VEKRYLAAGA VTLLSLYLLF GYGASLLCNL
IGFVYPAYAS IKAIESPSKD DDTVWLTYWV VYALFGLAEF FSDLLLSWFP FYYVGKCAFL
LFCMAPRPWN GALMLYQRVV RPLFLRHHGA VDRIMNDLSG RALDAAAGIT RNVKPSQTPQ
PKDK
//
MIM
609346
*RECORD*
*FIELD* NO
609346
*FIELD* TI
*609346 RECEPTOR EXPRESSION-ENHANCING PROTEIN 6; REEP6
;;DELETED IN POLYPOSIS 1-LIKE 1; DP1L1;;
read moreTB2-LIKE 1; TB2L1;;
CHROMOSOME 19 OPEN READING FRAME 32; C19ORF32
*FIELD* TX
CLONING
Transport of G protein-coupled receptors (GPCRs) to the cell surface
membrane is critical for receptor-ligand recognition. However, mammalian
GPCR odorant receptors (ORs), when heterologously expressed in cells,
are poorly expressed on the cell surface. By screening for genes that
induced cell surface expression of ORs expressed in human embryonic
kidney cells, Saito et al. (2004) identified mouse and human REEP1
(609139). They searched databases for homologs of REEP1 and identified
several other REEP genes, including REEP6. In situ hybridization of
mouse olfactory epithelium revealed expression of Reep6 in supporting
cells, but not in olfactory neurons.
By subtractive hybridization to identify novel mouse genes expressed in
retina, Sato et al. (2005) cloned Dp1l1. The deduced 201-amino acid
protein shares 57% identity with mouse and human DP1 (DP1; 125265).
Northern blot analysis detected high expression of Dp1l1 in mouse retina
and liver, with lower levels in kidney and testis, and RT-PCR showed low
expression in spleen and lung. No expression was detected in brain. In
situ hybridization and immunohistochemical analyses showed that Dp1l1
mRNA and protein were localized richly in retinal ganglion cells (RGCs).
Dp1l1 was present in the cytoplasm in a punctate pattern. Sato et al.
(2005) concluded that Dp1l1 is a membrane protein that likely plays a
role in intracellular membrane trafficking in RGCs.
MAPPING
The International Radiation Hybrid Mapping Consortium mapped the REEP6
gene to chromosome 19 (TMAP RH92355).
By radiation hybrid analysis, Sato et al. (2005) mapped the mouse Dp1l1
gene to chromosome 10 in a region that shows homology of synteny to
human chromosome 19p13.3.
*FIELD* RF
1. Saito, H.; Kubota, M.; Roberts, R. W.; Chi, Q.; Matsunami, H.:
RTP family members induce functional expression of mammalian odorant
receptors. Cell 119: 679-691, 2004.
2. Sato, H.; Tomita, H.; Nakazawa, T.; Wakana, S.; Tamai, M.: Deleted
in polyposis 1-like 1 gene (Dp1l1): a novel gene richly expressed
in retinal ganglion cells. Invest. Ophthal. Vis. Sci. 46: 791-796,
2005.
*FIELD* CN
Matthew B. Gross - updated: 4/29/2005
*FIELD* CD
Jane Kelly: 4/29/2005
*FIELD* ED
alopez: 07/13/2006
mgross: 4/29/2005
*RECORD*
*FIELD* NO
609346
*FIELD* TI
*609346 RECEPTOR EXPRESSION-ENHANCING PROTEIN 6; REEP6
;;DELETED IN POLYPOSIS 1-LIKE 1; DP1L1;;
read moreTB2-LIKE 1; TB2L1;;
CHROMOSOME 19 OPEN READING FRAME 32; C19ORF32
*FIELD* TX
CLONING
Transport of G protein-coupled receptors (GPCRs) to the cell surface
membrane is critical for receptor-ligand recognition. However, mammalian
GPCR odorant receptors (ORs), when heterologously expressed in cells,
are poorly expressed on the cell surface. By screening for genes that
induced cell surface expression of ORs expressed in human embryonic
kidney cells, Saito et al. (2004) identified mouse and human REEP1
(609139). They searched databases for homologs of REEP1 and identified
several other REEP genes, including REEP6. In situ hybridization of
mouse olfactory epithelium revealed expression of Reep6 in supporting
cells, but not in olfactory neurons.
By subtractive hybridization to identify novel mouse genes expressed in
retina, Sato et al. (2005) cloned Dp1l1. The deduced 201-amino acid
protein shares 57% identity with mouse and human DP1 (DP1; 125265).
Northern blot analysis detected high expression of Dp1l1 in mouse retina
and liver, with lower levels in kidney and testis, and RT-PCR showed low
expression in spleen and lung. No expression was detected in brain. In
situ hybridization and immunohistochemical analyses showed that Dp1l1
mRNA and protein were localized richly in retinal ganglion cells (RGCs).
Dp1l1 was present in the cytoplasm in a punctate pattern. Sato et al.
(2005) concluded that Dp1l1 is a membrane protein that likely plays a
role in intracellular membrane trafficking in RGCs.
MAPPING
The International Radiation Hybrid Mapping Consortium mapped the REEP6
gene to chromosome 19 (TMAP RH92355).
By radiation hybrid analysis, Sato et al. (2005) mapped the mouse Dp1l1
gene to chromosome 10 in a region that shows homology of synteny to
human chromosome 19p13.3.
*FIELD* RF
1. Saito, H.; Kubota, M.; Roberts, R. W.; Chi, Q.; Matsunami, H.:
RTP family members induce functional expression of mammalian odorant
receptors. Cell 119: 679-691, 2004.
2. Sato, H.; Tomita, H.; Nakazawa, T.; Wakana, S.; Tamai, M.: Deleted
in polyposis 1-like 1 gene (Dp1l1): a novel gene richly expressed
in retinal ganglion cells. Invest. Ophthal. Vis. Sci. 46: 791-796,
2005.
*FIELD* CN
Matthew B. Gross - updated: 4/29/2005
*FIELD* CD
Jane Kelly: 4/29/2005
*FIELD* ED
alopez: 07/13/2006
mgross: 4/29/2005