Full text data of RELL1
RELL1
[Confidence: high (present in two of the MS resources)]
RELT-like protein 1; Flags: Precursor
RELT-like protein 1; Flags: Precursor
UniProt
Q8IUW5
ID RELL1_HUMAN Reviewed; 271 AA.
AC Q8IUW5; Q8NBK1;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2003, sequence version 1.
DT 22-JAN-2014, entry version 73.
DE RecName: Full=RELT-like protein 1;
DE Flags: Precursor;
GN Name=RELL1; ORFNames=PSEC0162;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-
RT length human cDNAs encoding secretion or membrane proteins from oligo-
RT capped cDNA libraries.";
RL DNA Res. 12:117-126(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH RELT; RELL2
RP AND OXSR1, AND PHOSPHORYLATION.
RX PubMed=16389068; DOI=10.1016/j.bbrc.2005.12.033;
RA Cusick J.K., Xu L.-G., Bin L.-H., Han K.-J., Shu H.-B.;
RT "Identification of RELT homologues that associate with RELT and are
RT phosphorylated by OSR1.";
RL Biochem. Biophys. Res. Commun. 340:535-543(2006).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244 AND SER-247, AND
RP MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109 AND SER-114, AND
RP MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
CC -!- SUBUNIT: Interacts with RELT, RELL2 and OXSR1.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC protein.
CC -!- TISSUE SPECIFICITY: Widely expressed. Expressed at highest levels
CC in the placenta, skeletal muscle, spleen and testis.
CC -!- PTM: Phosphorylated in vitro by OXSR1.
CC -!- SIMILARITY: Belongs to the RELT family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK075468; BAC11638.1; -; mRNA.
DR EMBL; CH471069; EAW92885.1; -; Genomic_DNA.
DR EMBL; BC039540; AAH39540.1; -; mRNA.
DR RefSeq; NP_001078868.1; NM_001085399.1.
DR RefSeq; NP_001078869.1; NM_001085400.1.
DR UniGene; Hs.283378; -.
DR ProteinModelPortal; Q8IUW5; -.
DR STRING; 9606.ENSP00000313385; -.
DR PhosphoSite; Q8IUW5; -.
DR DMDM; 74727997; -.
DR PaxDb; Q8IUW5; -.
DR PRIDE; Q8IUW5; -.
DR Ensembl; ENST00000314117; ENSP00000313385; ENSG00000181826.
DR Ensembl; ENST00000454158; ENSP00000398778; ENSG00000181826.
DR GeneID; 768211; -.
DR KEGG; hsa:768211; -.
DR UCSC; uc003gsz.2; human.
DR CTD; 768211; -.
DR GeneCards; GC04M037592; -.
DR HGNC; HGNC:27379; RELL1.
DR HPA; HPA013377; -.
DR MIM; 611212; gene.
DR neXtProt; NX_Q8IUW5; -.
DR PharmGKB; PA162401054; -.
DR eggNOG; NOG39210; -.
DR HOGENOM; HOG000035134; -.
DR HOVERGEN; HBG055552; -.
DR InParanoid; Q8IUW5; -.
DR OMA; NKSKEGR; -.
DR OrthoDB; EOG783MX4; -.
DR PhylomeDB; Q8IUW5; -.
DR ChiTaRS; RELL1; human.
DR GenomeRNAi; 768211; -.
DR NextBio; 135610; -.
DR PRO; PR:Q8IUW5; -.
DR ArrayExpress; Q8IUW5; -.
DR Bgee; Q8IUW5; -.
DR CleanEx; HS_RELL1; -.
DR Genevestigator; Q8IUW5; -.
DR GO; GO:0005737; C:cytoplasm; IDA:HPA.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0015630; C:microtubule cytoskeleton; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR InterPro; IPR022248; TNF_rcpt_RELT.
DR Pfam; PF12606; RELT; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Coiled coil; Complete proteome; Glycoprotein; Membrane;
KW Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1 23 Potential.
FT CHAIN 24 271 RELT-like protein 1.
FT /FTId=PRO_0000323590.
FT TOPO_DOM 24 57 Extracellular (Potential).
FT TRANSMEM 58 78 Helical; (Potential).
FT TOPO_DOM 79 271 Cytoplasmic (Potential).
FT COILED 89 113 Potential.
FT MOD_RES 109 109 Phosphoserine.
FT MOD_RES 114 114 Phosphoserine.
FT MOD_RES 244 244 Phosphoserine.
FT MOD_RES 247 247 Phosphoserine.
FT CARBOHYD 31 31 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 49 49 N-linked (GlcNAc...) (Potential).
FT CONFLICT 36 36 T -> A (in Ref. 1; BAC11638).
SQ SEQUENCE 271 AA; 29340 MW; D85AAA0E86349EA7 CRC64;
MAPRALPGSA VLAAAVFVGG AVSSPLVAPD NGSSRTLHSR TETTPSPSND TGNGHPEYIA
YALVPVFFIM GLFGVLICHL LKKKGYRCTT EAEQDIEEEK VEKIELNDSV NENSDTVGQI
VHYIMKNEAN ADVLKAMVAD NSLYDPESPV TPSTPGSPPV SPGPLSPGGT PGKHVCGHHL
HTVGGVVERD VCHRCRHKRW HFIKPTNKSR ESRPRRQGEV TVLSVGRFRV TKVEHKSNQK
ERRSLMSVSG AETVNGEVPA TPVKRERSGT E
//
ID RELL1_HUMAN Reviewed; 271 AA.
AC Q8IUW5; Q8NBK1;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2003, sequence version 1.
DT 22-JAN-2014, entry version 73.
DE RecName: Full=RELT-like protein 1;
DE Flags: Precursor;
GN Name=RELL1; ORFNames=PSEC0162;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-
RT length human cDNAs encoding secretion or membrane proteins from oligo-
RT capped cDNA libraries.";
RL DNA Res. 12:117-126(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH RELT; RELL2
RP AND OXSR1, AND PHOSPHORYLATION.
RX PubMed=16389068; DOI=10.1016/j.bbrc.2005.12.033;
RA Cusick J.K., Xu L.-G., Bin L.-H., Han K.-J., Shu H.-B.;
RT "Identification of RELT homologues that associate with RELT and are
RT phosphorylated by OSR1.";
RL Biochem. Biophys. Res. Commun. 340:535-543(2006).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244 AND SER-247, AND
RP MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109 AND SER-114, AND
RP MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
CC -!- SUBUNIT: Interacts with RELT, RELL2 and OXSR1.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC protein.
CC -!- TISSUE SPECIFICITY: Widely expressed. Expressed at highest levels
CC in the placenta, skeletal muscle, spleen and testis.
CC -!- PTM: Phosphorylated in vitro by OXSR1.
CC -!- SIMILARITY: Belongs to the RELT family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK075468; BAC11638.1; -; mRNA.
DR EMBL; CH471069; EAW92885.1; -; Genomic_DNA.
DR EMBL; BC039540; AAH39540.1; -; mRNA.
DR RefSeq; NP_001078868.1; NM_001085399.1.
DR RefSeq; NP_001078869.1; NM_001085400.1.
DR UniGene; Hs.283378; -.
DR ProteinModelPortal; Q8IUW5; -.
DR STRING; 9606.ENSP00000313385; -.
DR PhosphoSite; Q8IUW5; -.
DR DMDM; 74727997; -.
DR PaxDb; Q8IUW5; -.
DR PRIDE; Q8IUW5; -.
DR Ensembl; ENST00000314117; ENSP00000313385; ENSG00000181826.
DR Ensembl; ENST00000454158; ENSP00000398778; ENSG00000181826.
DR GeneID; 768211; -.
DR KEGG; hsa:768211; -.
DR UCSC; uc003gsz.2; human.
DR CTD; 768211; -.
DR GeneCards; GC04M037592; -.
DR HGNC; HGNC:27379; RELL1.
DR HPA; HPA013377; -.
DR MIM; 611212; gene.
DR neXtProt; NX_Q8IUW5; -.
DR PharmGKB; PA162401054; -.
DR eggNOG; NOG39210; -.
DR HOGENOM; HOG000035134; -.
DR HOVERGEN; HBG055552; -.
DR InParanoid; Q8IUW5; -.
DR OMA; NKSKEGR; -.
DR OrthoDB; EOG783MX4; -.
DR PhylomeDB; Q8IUW5; -.
DR ChiTaRS; RELL1; human.
DR GenomeRNAi; 768211; -.
DR NextBio; 135610; -.
DR PRO; PR:Q8IUW5; -.
DR ArrayExpress; Q8IUW5; -.
DR Bgee; Q8IUW5; -.
DR CleanEx; HS_RELL1; -.
DR Genevestigator; Q8IUW5; -.
DR GO; GO:0005737; C:cytoplasm; IDA:HPA.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0015630; C:microtubule cytoskeleton; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR InterPro; IPR022248; TNF_rcpt_RELT.
DR Pfam; PF12606; RELT; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Coiled coil; Complete proteome; Glycoprotein; Membrane;
KW Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1 23 Potential.
FT CHAIN 24 271 RELT-like protein 1.
FT /FTId=PRO_0000323590.
FT TOPO_DOM 24 57 Extracellular (Potential).
FT TRANSMEM 58 78 Helical; (Potential).
FT TOPO_DOM 79 271 Cytoplasmic (Potential).
FT COILED 89 113 Potential.
FT MOD_RES 109 109 Phosphoserine.
FT MOD_RES 114 114 Phosphoserine.
FT MOD_RES 244 244 Phosphoserine.
FT MOD_RES 247 247 Phosphoserine.
FT CARBOHYD 31 31 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 49 49 N-linked (GlcNAc...) (Potential).
FT CONFLICT 36 36 T -> A (in Ref. 1; BAC11638).
SQ SEQUENCE 271 AA; 29340 MW; D85AAA0E86349EA7 CRC64;
MAPRALPGSA VLAAAVFVGG AVSSPLVAPD NGSSRTLHSR TETTPSPSND TGNGHPEYIA
YALVPVFFIM GLFGVLICHL LKKKGYRCTT EAEQDIEEEK VEKIELNDSV NENSDTVGQI
VHYIMKNEAN ADVLKAMVAD NSLYDPESPV TPSTPGSPPV SPGPLSPGGT PGKHVCGHHL
HTVGGVVERD VCHRCRHKRW HFIKPTNKSR ESRPRRQGEV TVLSVGRFRV TKVEHKSNQK
ERRSLMSVSG AETVNGEVPA TPVKRERSGT E
//
MIM
611212
*RECORD*
*FIELD* NO
611212
*FIELD* TI
*611212 RELT-LIKE 1; RELL1
*FIELD* TX
CLONING
By EST database analysis to search for sequences with similarity to RELT
read more(611211), Cusick et al. (2006) cloned full-length RELL1 and RELL2
(611213). The predicted RELL1 sequence contains a transmembrane domain
but lacks extracellular cysteine-rich domains. RELL1 shares 32% and 40%
amino acid identity with RELT and RELL2, respectively. Northern blot
analysis detected an approximately 4-kb transcript in all human tissues
examined with highest expression in placenta, spleen, skeletal muscle,
and testis. Immunofluorescent confocal microscopy localized RELL1 to the
plasma membrane in COS-7 cells and colocalized RELL1 with RELL2 and
RELT.
GENE FUNCTION
Using yeast 2-hybrid analysis with the RELL1 intracellular domain as
bait to screen a B-cell library, Cusick et al. (2006) identified the
serine-threonine kinase OSR1 (OXSR1; 604046) as a RELL1-binding protein.
Coimmunoprecipitation studies showed that RELL1 interacted with RELL2,
RELT, and OSR1. By in vitro kinase assay, Cusick et al. (2006) showed
that RELL1, RELL2, and RELT were phosphorylated by OSR1.
MAPPING
The International Radiation Hybrid Mapping Consortium mapped the RELL1
gene to chromosome 4 (TMAP STS-H93265).
*FIELD* RF
1. Cusick, J. K.; Xu, L.-G.; Bin, L.-H.; Han, K.-J.; Shu, H.-B.:
Identification of RELT homologues that associate with RELT and are
phosphorylated by OSR1. Biochem. Biophys. Res. Commun. 340: 535-543,
2006.
*FIELD* CD
Dorothy S. Reilly: 7/17/2007
*FIELD* ED
wwang: 07/17/2007
*RECORD*
*FIELD* NO
611212
*FIELD* TI
*611212 RELT-LIKE 1; RELL1
*FIELD* TX
CLONING
By EST database analysis to search for sequences with similarity to RELT
read more(611211), Cusick et al. (2006) cloned full-length RELL1 and RELL2
(611213). The predicted RELL1 sequence contains a transmembrane domain
but lacks extracellular cysteine-rich domains. RELL1 shares 32% and 40%
amino acid identity with RELT and RELL2, respectively. Northern blot
analysis detected an approximately 4-kb transcript in all human tissues
examined with highest expression in placenta, spleen, skeletal muscle,
and testis. Immunofluorescent confocal microscopy localized RELL1 to the
plasma membrane in COS-7 cells and colocalized RELL1 with RELL2 and
RELT.
GENE FUNCTION
Using yeast 2-hybrid analysis with the RELL1 intracellular domain as
bait to screen a B-cell library, Cusick et al. (2006) identified the
serine-threonine kinase OSR1 (OXSR1; 604046) as a RELL1-binding protein.
Coimmunoprecipitation studies showed that RELL1 interacted with RELL2,
RELT, and OSR1. By in vitro kinase assay, Cusick et al. (2006) showed
that RELL1, RELL2, and RELT were phosphorylated by OSR1.
MAPPING
The International Radiation Hybrid Mapping Consortium mapped the RELL1
gene to chromosome 4 (TMAP STS-H93265).
*FIELD* RF
1. Cusick, J. K.; Xu, L.-G.; Bin, L.-H.; Han, K.-J.; Shu, H.-B.:
Identification of RELT homologues that associate with RELT and are
phosphorylated by OSR1. Biochem. Biophys. Res. Commun. 340: 535-543,
2006.
*FIELD* CD
Dorothy S. Reilly: 7/17/2007
*FIELD* ED
wwang: 07/17/2007